{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:54:46Z","timestamp":1789541686538,"version":"build-2803163510"},"reference-count":40,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Technology Innovation Program","doi-asserted-by":"publisher","award":["20020268"],"award-info":[{"award-number":["20020268"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003052","name":"Technology Innovation Program","doi-asserted-by":"publisher","award":["20220134"],"award-info":[{"award-number":["20220134"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Trade, Industry &amp; Energy","award":["20020268"],"award-info":[{"award-number":["20020268"]}]},{"name":"Ministry of Trade, Industry &amp; Energy","award":["20220134"],"award-info":[{"award-number":["20220134"]}]},{"name":"Korea Institute of Marine Science &amp; Technology Promotion (KIMST)","award":["20020268"],"award-info":[{"award-number":["20020268"]}]},{"name":"Korea Institute of Marine Science &amp; Technology Promotion (KIMST)","award":["20220134"],"award-info":[{"award-number":["20220134"]}]},{"name":"Ministry of Oceans and Fisheries","award":["20020268"],"award-info":[{"award-number":["20020268"]}]},{"name":"Ministry of Oceans and Fisheries","award":["20220134"],"award-info":[{"award-number":["20220134"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alcoholic liver disease (ALD) is a condition resulting from liver damage linked to excessive drinking over a brief duration. It poses a significant public health challenge globally, with its prevalence and morbidity rising annually due to escalating rates of alcohol abuse, which adversely affect human health. Phaeodactylum tricornutum (PT), a diatom species of microalgae, is reported to possess active components that provide anti-inflammatory and antioxidant benefits. This study aimed to investigate the preventive and therapeutic effects of PT extract on ALD. To address our purpose, we used ethanol diet induced live disease model. Mice fed an ethanol diet showed less weight gain and higher levels of AST and ALT compared to those fed a regular diet. PT extract suppressed the inhibition of weight gain and the increase in AST\/ALT levels caused by an ethanol diet. In addition, PT extract also prevented liver tissue damage caused by an ethanol diet. Thus, the effect of PT on ALD was found to be related to the inhibition of mitogen-activated protein kinase (MAP kinases) phosphorylation and TNF-\u03b1 production.<\/jats:p>","DOI":"10.3390\/ijms26083851","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T08:24:07Z","timestamp":1744964647000},"page":"3851","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Beneficial Effects of Ethanol Extract of the Microalga Phaeodactylum tricornutum in Alcoholic Liver Disease"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8144-014X","authenticated-orcid":false,"given":"Dae Yoon","family":"Kim","sequence":"first","affiliation":[{"name":"College of Pharmacy, Chungbuk National University, Cheongju 28160, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Cheol","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Biology Education, College of Education, Chungbuk National University, Cheongju 28160, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gab Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biology Education, College of Education, Chungbuk National University, Cheongju 28160, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-In","family":"Eom","sequence":"additional","affiliation":[{"name":"Microalgae Ask Us Co., Ltd., Gangneung 25441, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol-Ho","family":"Han","sequence":"additional","affiliation":[{"name":"Microalgae Ask Us Co., Ltd., Gangneung 25441, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol-Ho","family":"Pan","sequence":"additional","affiliation":[{"name":"Microalgae Ask Us Co., Ltd., Gangneung 25441, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Kwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biology Education, College of Education, Chungbuk National University, Cheongju 28160, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.2174\/138920112804724828","article-title":"The potential of microalgae for the production of bioactive molecules of pharmaceutical interest","volume":"13","author":"Mimouni","year":"2012","journal-title":"Curr. 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