{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:47:58Z","timestamp":1794008878176,"version":"4.8.0"},"reference-count":98,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T00:00:00Z","timestamp":1745020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Josette Robertson and Joan Johnston Family Foundation Fund","award":["JRJJ-2024-001"],"award-info":[{"award-number":["JRJJ-2024-001"]}]},{"name":"Josette Robertson and Joan Johnston Family Foundation Fund","award":["MTRF-23-567"],"award-info":[{"award-number":["MTRF-23-567"]}]},{"name":"Josette Robertson and Joan Johnston Family Foundation Fund","award":["DOS-2024-045"],"award-info":[{"award-number":["DOS-2024-045"]}]},{"name":"Josette Robertson and Joan Johnston Family Foundation Fund","award":["RUNN-2024-678"],"award-info":[{"award-number":["RUNN-2024-678"]}]},{"name":"Michael T. Richard Clinical Research Fellowship in Neurosurgery","award":["JRJJ-2024-001"],"award-info":[{"award-number":["JRJJ-2024-001"]}]},{"name":"Michael T. Richard Clinical Research Fellowship in Neurosurgery","award":["MTRF-23-567"],"award-info":[{"award-number":["MTRF-23-567"]}]},{"name":"Michael T. Richard Clinical Research Fellowship in Neurosurgery","award":["DOS-2024-045"],"award-info":[{"award-number":["DOS-2024-045"]}]},{"name":"Michael T. Richard Clinical Research Fellowship in Neurosurgery","award":["RUNN-2024-678"],"award-info":[{"award-number":["RUNN-2024-678"]}]},{"name":"Department of Surgery at the University of Ottawa","award":["JRJJ-2024-001"],"award-info":[{"award-number":["JRJJ-2024-001"]}]},{"name":"Department of Surgery at the University of Ottawa","award":["MTRF-23-567"],"award-info":[{"award-number":["MTRF-23-567"]}]},{"name":"Department of Surgery at the University of Ottawa","award":["DOS-2024-045"],"award-info":[{"award-number":["DOS-2024-045"]}]},{"name":"Department of Surgery at the University of Ottawa","award":["RUNN-2024-678"],"award-info":[{"award-number":["RUNN-2024-678"]}]},{"name":"Society of Neurological Surgeons, RUNN Course Resident Award","award":["JRJJ-2024-001"],"award-info":[{"award-number":["JRJJ-2024-001"]}]},{"name":"Society of Neurological Surgeons, RUNN Course Resident Award","award":["MTRF-23-567"],"award-info":[{"award-number":["MTRF-23-567"]}]},{"name":"Society of Neurological Surgeons, RUNN Course Resident Award","award":["DOS-2024-045"],"award-info":[{"award-number":["DOS-2024-045"]}]},{"name":"Society of Neurological Surgeons, RUNN Course Resident Award","award":["RUNN-2024-678"],"award-info":[{"award-number":["RUNN-2024-678"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Spinal cord injury (SCI) remains a major clinical challenge, with limited therapeutic options for restoring lost neurological function. While efforts to mitigate secondary damage have improved early-phase management, achieving sustained neurorepair and functional recovery remains elusive. Advances in stem cell engineering and regenerative medicine have opened new avenues for targeted interventions, particularly through the transplantation of neural stem\/progenitor cells (NSPCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs). However, patient-specific factors such as cellular senescence, genetic and epigenetic variability, injury microenvironment, and comorbidities influence the efficacy of stem cell therapies by affecting graft survival and differentiation. Overcoming these challenges necessitates cutting-edge technologies, including single-cell transcriptomics, CRISPR-mediated hypoimmunogenic engineering, and biomaterial-based delivery platforms, which enable personalized and precision-driven SCI repair. Leveraging these advancements may help stem cell therapies overcome translational barriers and establish clinically viable regenerative solutions. This review explores the intersection of patient-specific variability, bioengineering innovations, and transcriptomic-guided precision medicine to define the next frontier in SCI therapy.<\/jats:p>","DOI":"10.3390\/ijms26083874","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T20:24:16Z","timestamp":1745180656000},"page":"3874","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Personalized Stem Cell-Based Regeneration in Spinal Cord Injury Care"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3977-5367","authenticated-orcid":false,"given":"Sasi Kumar","family":"Jagadeesan","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada"},{"name":"Neuroscience Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7998-5505","authenticated-orcid":false,"given":"Ryan Vimukthie","family":"Sandarage","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada"},{"name":"Division of Neurosurgery, Department of Surgery, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathya","family":"Mathiyalagan","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve Chung","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada"},{"name":"Neuroscience Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada"},{"name":"Division of Neurosurgery, Department of Surgery, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Alizadeh, A., Dyck, S.M., and Karimi-Abdolrezaee, S. 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