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Although PSP is generally considered a sporadic disease, interest is growing in its genetics, with contemporary research focusing on familial backgrounds and neuroinflammation. Indeed, microglial activation and other inflammatory mechanisms of PSP pathogenesis have been extensively analyzed using genetic examinations to identify the factors impacting neurodegeneration. As such, this review aims to elaborate on recent findings in this field.<\/jats:p>","DOI":"10.3390\/ijms26093927","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T03:17:32Z","timestamp":1745291852000},"page":"3927","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Genetic Background of the Immunological and Inflammatory Aspects of Progressive Supranuclear Palsy"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-6817","authenticated-orcid":false,"given":"Piotr","family":"Alster","sequence":"first","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, Kondratowicza 8, 03-242 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8685-475X","authenticated-orcid":false,"given":"Natalia","family":"Madetko-Alster","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical University of Warsaw, Kondratowicza 8, 03-242 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/neup.12143","article-title":"Astrocytic inclusions in progressive supranuclear palsy and corticobasal degeneration","volume":"34","author":"Yoshida","year":"2014","journal-title":"Neuropathology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/mds.26987","article-title":"Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria","volume":"32","author":"Respondek","year":"2017","journal-title":"Mov. 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