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A comprehensive literature review was conducted to highlight the importance of mitochondrial activity in the early stages of life formation. Proper mitochondrial function provides energy, maintains genomic stability, and ensures optimal conditions for fertilisation and embryo progression. Understanding these processes is essential to optimise culture conditions and identify new mitochondrial biomarkers that improve reproductive success and improve assisted reproductive technologies (ARTs). Enhancing mitochondrial function in female reproductive cells is the key to improving oocyte and embryo quality, which can lead to better in vitro fertilisation and embryo transfer. Furthermore, advances in diagnostic techniques, such as mitochondrial genome sequencing, offer a more precise understanding of the relationship between mitochondrial health and oocyte quality. However, fully understanding mitochondrial functions is only part of the challenge. Expanding knowledge of the interactions between mitochondria and other cellular structures is crucial for future advancements in reproductive medicine. Understanding these complex relationships will provide deeper insight into improving reproductive outcomes and embryo development.<\/jats:p>","DOI":"10.3390\/ijms26094098","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T10:42:09Z","timestamp":1745577729000},"page":"4098","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["The Importance of Mitochondrial Processes in the Maturation and Acquisition of Competences of Oocytes and Embryo Culture"],"prefix":"10.3390","volume":"26","author":[{"given":"El\u017cbieta","family":"Ga\u0142\u0119ska","sequence":"first","affiliation":[{"name":"Department of Environment Hygiene and Animal Welfare, Wroc\u0142aw University of Environmental and Life Sciences, 51-630 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1908-2942","authenticated-orcid":false,"given":"Alicja","family":"Kowalczyk","sequence":"additional","affiliation":[{"name":"Department of Environment Hygiene and Animal Welfare, Wroc\u0142aw University of Environmental and Life Sciences, 51-630 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3529-8404","authenticated-orcid":false,"given":"Marcjanna","family":"Wrzeci\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Environment Hygiene and Animal Welfare, Wroc\u0142aw University of Environmental and Life Sciences, 51-630 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0179-7280","authenticated-orcid":false,"given":"Mercedes Cami\u00f1a","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Czerniawska-Pi\u0105tkowska","sequence":"additional","affiliation":[{"name":"Department of Ruminant Science, West Pomeranian University of Technology in Szczecin, 70-310 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szymon","family":"Gwo\u017adziewicz","sequence":"additional","affiliation":[{"name":"Institute of Animal Breeding, Wroc\u0142aw University of Environmental and Life Sciences, 51-630 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Witkiewicz","sequence":"additional","affiliation":[{"name":"Research and Development Center, Voivodeship Specialist Hospital in Wroc\u0142aw, 51-124 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbigniew","family":"Dobrza\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Environment Hygiene and Animal Welfare, Wroc\u0142aw University of Environmental and Life Sciences, 51-630 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.devcel.2024.02.011","article-title":"Synchronized assembly of the oxidative phosphorylation system controls mitochondrial respiration in yeast","volume":"59","author":"Peselj","year":"2024","journal-title":"Dev. Cell"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Masuda, D., Nakanishi, I., Ohkubo, K., Ito, H., Matsumoto, K., Ichikawa, H., Chatatikun, M., Klangbud, W.K., Kotepui, M., and Imai, M. (2024). Mitochondria Play Essential Roles in Intracellular Protection against Oxidative Stress\u2014Which Molecules among the ROS Generated in the Mitochondria Can Escape the Mitochondria and Contribute to Signal Activation in Cytosol?. Biomolecules, 14.","DOI":"10.3390\/biom14010128"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Schiaffarino, O., Valdivieso Gonz\u00e1lez, D., Garc\u00eda-P\u00e9rez, I.M., Pe\u00f1alva, D.A., Almendro-Vedia, V.G., Natale, P., and L\u00f3pez-Montero, I. (2022). Mitochondrial membrane models built from native lipid extracts: Interfacial and transport properties. Front. Mol. Biosci., 9.","DOI":"10.3389\/fmolb.2022.910936"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41467-023-44057-6","article-title":"Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease","volume":"15","author":"Dong","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1016\/j.cmet.2024.07.024","article-title":"Mitochondrial membrane lipids in the regulation of bioenergetic flux","volume":"36","author":"Decker","year":"2024","journal-title":"Cell Metab."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e14769","DOI":"10.14814\/phy2.14769","article-title":"Localization of myoglobin in mitochondria: Implication in regulation of mitochondrial respiration in rat skeletal muscle","volume":"9","author":"Koma","year":"2021","journal-title":"Physiol. Rep."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: Mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1021\/acscentsci.4c01941","article-title":"Cellular Discrepancy of Platinum Complexes in Interfering with Mitochondrial DNA","volume":"11","author":"Jin","year":"2025","journal-title":"ACS Cent. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.semcdb.2024.01.007","article-title":"The role of mitochondrial dynamics in oocyte and early embryo development","volume":"159\u2013160","author":"Yildirim","year":"2024","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Li, L.-F., Yu, J., Li, R., Li, S.-S., Huang, J.-Y., Wang, M.-D., Jiang, L.-N., Xu, J.-H., and Wang, Z. (2024). Apoptosis, Mitochondrial Autophagy, Fission, and Fusion Maintain Mitochondrial Homeostasis in Mouse Liver Under Tail Suspension Conditions. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252011196"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/febs.16138","article-title":"Mitochondrial fusion and fission are required for proper mitochondrial function and cell proliferation in fission yeast","volume":"289","author":"Dong","year":"2022","journal-title":"FEBS J."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Dubois, M., Boulghobra, D., Rochebloine, G., Pallot, F., Yehya, M., Bornard, I., Gayrard, S., Coste, F., Walther, G., and Meyer, G. (2024). Hyperglycemia triggers RyR2-dependent alterations of mitochondrial calcium homeostasis in response to cardiac ischemia-reperfusion: Key role of DRP1 activation. Redox Biol., 70.","DOI":"10.1016\/j.redox.2024.103044"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"eabq4835","DOI":"10.1126\/science.abq4835","article-title":"Mammalian oocytes store mRNAs in a mitochondria-associated membraneless compartment","volume":"378","author":"Cheng","year":"2022","journal-title":"Science"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Chuang, T.-H., Chou, H.-H., Kuan, C.-S., Liu, S.-C., Kao, C.-W., Wu, Y.-H., Lai, H.-H., Hsieh, C.-L., Liang, Y.-T., and Chen, C.-Y. (2024). Dependency of mitochondrial quantity on blastocyst timeline obscures its actual effect to pregnancy outcomes. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1415865"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Hao, X., Zhao, J., and Rodriguez-Wallberg, K.A. (2024). Comprehensive atlas of mitochondrial distribution and dynamics during oocyte maturation in mouse models. Biomark. Res., 12.","DOI":"10.1186\/s40364-024-00672-z"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"106582","DOI":"10.1016\/j.domaniend.2020.106582","article-title":"Effect of follicle size on hormonal status of follicular fluid, oocyte ATP content, and in vitro embryo production in prepubertal sheep","volume":"75","author":"Roura","year":"2021","journal-title":"Domest. Anim. Endocrinol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1007\/s43032-020-00371-8","article-title":"Cytoplasmic Transfer Improves Human Egg Fertilization and Embryo Quality: An Evaluation of Sibling Oocytes in Women with Low Oocyte Quality","volume":"28","author":"Sobek","year":"2021","journal-title":"Reprod. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/mrd.22042","article-title":"The importance of mitochondrial metabolic activity and mitochondrial DNA replication during oocyte maturation in vitro on oocyte quality and subsequent embryo developmental competence","volume":"79","author":"Ge","year":"2012","journal-title":"Mol. Reprod. Dev."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Cimadomo, D., Fabozzi, G., Vaiarelli, A., Ubaldi, N., Ubaldi, F.M., and Rienzi, L. (2018). Impact of Maternal Age on Oocyte and Embryo Competence. Front. Endocrinol., 9.","DOI":"10.3389\/fendo.2018.00327"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.mito.2010.09.012","article-title":"Mitochondrial function in the human oocyte and embryo and their role in developmental competence","volume":"11","year":"2011","journal-title":"Mitochondrion"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0070-2153(06)77002-8","article-title":"The Role of Mitochondrial Function in the Oocyte and Embryo","volume":"Volume 77","author":"Dumollard","year":"2007","journal-title":"Current Topics in Developmental Biology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1093\/humrep\/deae170","article-title":"Mitochondria as therapeutic targets in assisted reproduction","volume":"39","author":"Yildirim","year":"2024","journal-title":"Human Reprod."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1186\/s12967-024-05213-8","article-title":"A PCR-independent approach for mtDNA enrichment and next-generation sequencing: Comprehensive evaluation and clinical application","volume":"22","author":"Liang","year":"2024","journal-title":"J. Transl. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/joim.13027","article-title":"Mitochondrial DNA copy number is associated with all-cause mortality and cardiovascular events in patients with peripheral arterial disease","volume":"287","author":"Koller","year":"2020","journal-title":"J. Intern. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e69344","DOI":"10.7554\/eLife.69344","article-title":"The need for high-quality oocyte mitochondria at extreme ploidy dictates mammalian germline development","volume":"10","author":"Colnaghi","year":"2021","journal-title":"eLife"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"gaad028","DOI":"10.1093\/molehr\/gaad028","article-title":"Control of mitochondrial integrity influences oocyte quality during reproductive aging","volume":"29","author":"Khan","year":"2023","journal-title":"Mol. Human Reprod."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.fertnstert.2022.04.019","article-title":"Mitochondrial dysfunction in cumulus cells is related to decreased reproductive capacity in advanced-age women","volume":"118","author":"Lu","year":"2022","journal-title":"Fertil. Steril."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2409688","DOI":"10.1002\/advs.202409688","article-title":"A Single-Cell Atlas of Crab Ovary Provides New Insights into Oogenesis in Crustaceans","volume":"12","author":"Lu","year":"2025","journal-title":"Adv. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s12551-021-00891-w","article-title":"Uncovering the important role of mitochondrial dynamics in oogenesis: Impact on fertility and metabolic disorder transmission","volume":"13","author":"Chiaratti","year":"2021","journal-title":"Biophys. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00018-023-04898-2","article-title":"LSM14B controls oocyte mRNA storage and stability to ensure female fertility","volume":"80","author":"Shan","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2300043","DOI":"10.1002\/advs.202300043","article-title":"LSM14B is an Oocyte-Specific RNA-Binding Protein Indispensable for Maternal mRNA Metabolism and Oocyte Development in Mice","volume":"10","author":"Li","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e31156","DOI":"10.1002\/jcp.31156","article-title":"NAMPT regulates mitochondria function and lipid metabolism during porcine oocyte maturation","volume":"239","author":"Guo","year":"2024","journal-title":"J. Cell. Physiol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Lee, I.-W., Adhikari, D., and Carroll, J. (2022). Miro1 depletion disrupts spatial distribution of mitochondria and leads to oocyte maturation defects. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.986454"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1007\/s43032-022-01147-y","article-title":"Growth Hormone Promotes Oocyte Maturation In Vitro by Protecting Mitochondrial Function and Reducing Apoptosis","volume":"30","author":"Deng","year":"2023","journal-title":"Reprod. Sci."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Satouh, Y., and Sato, K. (2023). Reorganization, specialization, and degradation of oocyte maternal components for early development. Reprod. Med. Biol., 22.","DOI":"10.1002\/rmb2.12505"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10815-023-02994-7","article-title":"Risks of using mitoquinone during in vitro maturation and its potential protective effects against lipotoxicity-induced oocyte mitochondrial stress","volume":"41","author":"Marei","year":"2024","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Ju, W., Zhao, Y., Yu, Y., Zhao, S., Xiang, S., and Lian, F. (2024). Mechanisms of mitochondrial dysfunction in ovarian aging and potential interventions. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1361289"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.freeradbiomed.2022.06.243","article-title":"Melatonin protects against maternal diabetes-associated meiotic defects by maintaining mitochondrial function","volume":"188","author":"Li","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1210\/me.2009-0033","article-title":"Maternal Diabetes Causes Mitochondrial Dysfunction and Meiotic Defects in Murine Oocytes","volume":"23","author":"Wang","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Hou, X., Zhu, S., Zhang, H., Li, C., Qiu, D., Ge, J., Guo, X., and Wang, Q. (2019). Mitofusin1 in oocyte is essential for female fertility. Redox Biol., 21.","DOI":"10.1016\/j.redox.2019.101110"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"eabi4343","DOI":"10.1126\/science.abi4343","article-title":"Mitochondria shed their outer membrane in response to infection-induced stress","volume":"375","author":"Li","year":"2022","journal-title":"Science"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.bbrc.2023.01.044","article-title":"Mitofusin 1 and 2 differentially regulate mitochondrial function underlying Ca2+ signaling and proliferation in rat aortic smooth muscle cells","volume":"645","author":"Inagaki","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e00306-21","DOI":"10.1128\/IAI.00306-21","article-title":"Mitochondrial Fusion Mediated by Mitofusin 1 Regulates Macrophage Mycobactericidal Activity by Enhancing Autophagy","volume":"89","author":"Ning","year":"2021","journal-title":"Infect. Immun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/s41586-022-04979-5","article-title":"Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I","volume":"607","author":"Duran","year":"2022","journal-title":"Nature"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1038\/s41467-022-30169-y","article-title":"A reversible mitochondrial complex I thiol switch mediates hypoxic avoidance behavior in C. elegans","volume":"13","author":"Onukwufor","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"El\u00edas-L\u00f3pez, A.L., V\u00e1zquez-Mena, O., and Sferruzzi-Perri, A.N. (2023). Mitochondrial dysfunction in the offspring of obese mothers and it\u2019s transmission through damaged oocyte mitochondria: Integration of mechanisms. Biochim. Biophys. Acta (BBA)-Mol. Basis Dis., 1869.","DOI":"10.1016\/j.bbadis.2023.166802"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Wang, F., Meng, T.-G., Li, J., Hou, Y., Luo, S.-M., Schatten, H., Sun, Q.-Y., and Ou, X.-H. (2020). Mitochondrial Ca2+ Is Related to Mitochondrial Activity and Dynamic Events in Mouse Oocytes. Front. Cell Dev. Biol., 8.","DOI":"10.3389\/fcell.2020.585932"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Cheng, J., Wang, X., Luo, C., Mao, X., Qin, J., Chi, Y., He, B., Hao, Y., Niu, X., and Huang, B. (2024). Effects of intracellular Ca2+ on developmental potential and ultrastructure of cryopreserved-warmed oocyte in mouse. Cryobiology, 114.","DOI":"10.1016\/j.cryobiol.2023.104834"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Weiser, A., Hermant, A., Bermont, F., Sizzano, F., Karaz, S., Alvarez-Illera, P., Santo-Domingo, J., Sorrentino, V., Feige, J.N., and De Marchi, U. (2023). The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state. Redox Biol., 64.","DOI":"10.1016\/j.redox.2023.102759"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Morimoto, Y., Gamage, U.S.K., Yamochi, T., Saeki, N., Morimoto, N., Yamanaka, M., Koike, A., Miyamoto, Y., Tanaka, K., and Fukuda, A. (2023). Mitochondrial Transfer into Human Oocytes Improved Embryo Quality and Clinical Outcomes in Recurrent Pregnancy Failure Cases. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032738"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Winstanley, Y.E., Liu, J., Adhikari, D., Gonzalez, M.B., Russell, D.L., Carroll, J., and Robker, R.L. (2024). Dynamics of Mitochondrial DNA Copy Number and Membrane Potential in Mouse Pre-Implantation Embryos: Responses to Diverse Types of Oxidative Stress. Genes, 15.","DOI":"10.3390\/genes15030367"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.theriogenology.2021.02.022","article-title":"Low-level pyruvate inhibits early embryonic development and maternal mRNA clearance in mice","volume":"166","author":"Zhang","year":"2021","journal-title":"Theriogenology"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.theriogenology.2022.01.015","article-title":"Insufficient pyruvate in culture medium arrests mouse embryos at the first cleavage stage associated with abnormal epigenetic modifications","volume":"181","author":"Li","year":"2022","journal-title":"Theriogenology"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.theriogenology.2022.06.013","article-title":"Effects of pyruvate on early embryonic development and zygotic genome activation in pigs","volume":"189","author":"Zhang","year":"2022","journal-title":"Theriogenology"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Hong, J., Tong, H., Wang, X., Lv, X., He, L., Yang, X., Wang, Y., Xu, K., Liang, Q., and Feng, Q. (2023). Embryonic diapause due to high glucose is related to changes in glycolysis and oxidative phosphorylation, as well as abnormalities in the TCA cycle and amino acid metabolism. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1135837"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e38551","DOI":"10.1016\/j.heliyon.2024.e38551","article-title":"Regulation of glucose metabolism: Effects on oocyte, preimplantation embryo, assisted reproductive technology and embryonic stem cell","volume":"10","author":"Xiong","year":"2024","journal-title":"Heliyon"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Da Fonseca Junior, A.M., Ispada, J., Dos Santos, E.C., De Lima, C.B., Da Silva, J.V.A., Paulson, E., Goszczynski, D.E., Goissis, M.D., Ross, P.J., and Milazzotto, M.P. (2023). Adaptative response to changes in pyruvate metabolism on the epigenetic landscapes and transcriptomics of bovine embryos. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-38686-6"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1530\/jrf.0.0990087","article-title":"Effects of pyruvate and glucose on the development of human preimplantation embryos in vitro","volume":"99","author":"Conaghan","year":"1993","journal-title":"Reproduction"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ydbio.2024.02.004","article-title":"Energy metabolism disorders during in vitro maturation of bovine cumulus-oocyte complexes interfere with blastocyst quality and metabolism","volume":"509","author":"Pawlak","year":"2024","journal-title":"Dev. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13048-024-01427-y","article-title":"Ovarian aging: Energy metabolism of oocytes","volume":"17","author":"Bao","year":"2024","journal-title":"J. Ovarian Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s43032-021-00505-6","article-title":"Reprogramming of glucose metabolism of cumulus cells and oocytes and its therapeutic significance","volume":"29","author":"Imanaka","year":"2022","journal-title":"Reprod. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Okonkwo, E., Saha, B., Sahu, G., Bera, A., and Sharma, P. (2025). Blood-Based Lateral-Flow Immunoassays Dipstick Test for Damaged Mitochondrial Electron Transport Chain in Pyruvate Treated Rats with Combined Blast Exposure and Hemorrhagic Shock. J. Clin. Med., 14.","DOI":"10.3390\/jcm14030754"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"German, H.M., Ciapaite, J., Verhoeven-Duif, N.M., and Jans, J.J.M. (2025). Anaplerosis by medium-chain fatty acids through complex interplay with glucose and glutamine metabolism. J. Biol. Chem., 301.","DOI":"10.1016\/j.jbc.2025.108307"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/molehr\/gaz055","article-title":"The spatio-temporal dynamics of mitochondrial membrane potential during oocyte maturation","volume":"25","author":"Liu","year":"2019","journal-title":"Mol. Human Reprod."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1515\/revneuro-2024-0054","article-title":"Metabolic dysregulation of tricarboxylic acid cycle and oxidative phosphorylation in glioblastoma","volume":"35","year":"2024","journal-title":"Rev. Neurosci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e13794","DOI":"10.1111\/obr.13794","article-title":"Mitochondrial puzzle in muscle: Linking the electron transport system to overweight","volume":"25","author":"Casuso","year":"2024","journal-title":"Obes. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"C69","DOI":"10.1152\/ajpcell.00455.2021","article-title":"Mechanisms and mathematical modeling of ROS production by the mitochondrial electron transport chain","volume":"323","author":"Chenna","year":"2022","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.tem.2024.03.002","article-title":"Mitochondrial morphology, distribution and activity during oocyte development","volume":"35","author":"Bahety","year":"2024","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Fujii, J., Homma, T., and Osaki, T. (2022). Superoxide Radicals in the Execution of Cell Death. Antioxidants, 11.","DOI":"10.3390\/antiox11030501"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"101378","DOI":"10.1016\/j.arr.2021.101378","article-title":"Mitochondria: Their relevance during oocyte ageing","volume":"70","author":"Haigis","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Kuznetsov, A.V., Margreiter, R., Ausserlechner, M.J., and Hagenbuchner, J. (2022). The Complex Interplay between Mitochondria, ROS and Entire Cellular Metabolism. Antioxidants, 11.","DOI":"10.3390\/antiox11101995"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"G\u00fcnther, R., Pal, A., Williams, C., Zimyanin, V.L., Liehr, M., Von Neubeck, C., Krause, M., Parab, M.G., Petri, S., and Kalmbach, N. (2022). Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS. Cells, 11.","DOI":"10.3390\/cells11071246"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.freeradbiomed.2020.12.447","article-title":"Superoxide produced by mitochondrial site IQ inactivates cardiac succinate dehydrogenase and induces hepatic steatosis in Sod2 knockout mice","volume":"164","author":"Wong","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Boone, C., and Lewis, S.C. (2024). Bridging lipid metabolism and mitochondrial genome maintenance. J. Biol. Chem., 300.","DOI":"10.1016\/j.jbc.2024.107498"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"dev201516","DOI":"10.1242\/dev.201516","article-title":"Adipose triglyceride lipase promotes prostaglandin-dependent actin remodeling by regulating substrate release from lipid droplets","volume":"150","author":"Giedt","year":"2023","journal-title":"Development"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1080\/01652176.2017.1354561","article-title":"Disturbed bovine mitochondrial lipid metabolism: A review","volume":"37","author":"Gross","year":"2017","journal-title":"Vet. Q."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.mitoco.2024.07.001","article-title":"Mitochondrial lipid metabolism in metastatic breast cancer","volume":"2","author":"Ruidas","year":"2024","journal-title":"Mitochondrial Commun."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1194\/jlr.M072959","article-title":"Phosphatidylserine synthesis at membrane contact sites promotes its transport out of the ER","volume":"58","author":"Kannan","year":"2017","journal-title":"J. Lipid Res."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Panov, A.V., Mayorov, V.I., Dikalova, A.E., and Dikalov, S.I. (2022). Long-Chain and Medium-Chain Fatty Acids in Energy Metabolism of Murine Kidney Mitochondria. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010379"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"12380","DOI":"10.1074\/jbc.RA119.008680","article-title":"Mitochondrial fatty acid oxidation and the electron transport chain comprise a multifunctional mitochondrial protein complex","volume":"294","author":"Wang","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1210\/en.2005-0358","article-title":"Dominant Role of Mitochondria in Calcium Homeostasis of Single Rat Pituitary Corticotropes","volume":"146","author":"Lee","year":"2005","journal-title":"Endocrinology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s12403-023-00613-5","article-title":"The Mode of Action of Enniatins A and B is Mediated by Interaction with SOC Reservoirs (A) and Mitochondrial Permeability Transition Pore (B)","volume":"16","author":"Alfonso","year":"2024","journal-title":"Expo. Health"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Matuz-Mares, D., Gonz\u00e1lez-Andrade, M., Araiza-Villanueva, M.G., Vilchis-Landeros, M.M., and V\u00e1zquez-Meza, H. (2022). Mitochondrial Calcium: Effects of Its Imbalance in Disease. Antioxidants, 11.","DOI":"10.3390\/antiox11050801"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"114794","DOI":"10.1016\/j.celrep.2024.114794","article-title":"Mitotic ER-mitochondria contact enhances mitochondrial Ca2+ influx to promote cell division","volume":"43","author":"Zhao","year":"2024","journal-title":"Cell Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.4161\/auto.7.12.17909","article-title":"Ins(1,4,5) P3 receptor-mediated Ca2+ signaling and autophagy induction are interrelated","volume":"7","author":"Decuypere","year":"2011","journal-title":"Autophagy"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Duxfield, A., Munkley, J., Briggs, M.D., and Dennis, E.P. (2022). CRELD2 is a novel modulator of calcium release and calcineurin-NFAT signalling during osteoclast differentiation. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-17347-0"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/s41467-021-20993-z","article-title":"Calcium channel ITPR2 and mitochondria\u2013ER contacts promote cellular senescence and aging","volume":"12","author":"Ziegler","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Jing, S., Liu, S., Shen, X., Cai, L., Zhu, C., Zhao, Y., and Pang, M. (2022). Double-activation of mitochondrial permeability transition pore opening via calcium overload and reactive oxygen species for cancer therapy. J. Nanobiotechnol, 20.","DOI":"10.1186\/s12951-022-01392-y"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Zhang, I.X., Herrmann, A., Leon, J., Jeyarajan, S., Arunagiri, A., Arvan, P., Gilon, P., and Satin, L.S. (2023). ER stress increases expression of intracellular calcium channel RyR1 to modify Ca2+ homeostasis in pancreatic beta cells. J. Biol. Chem., 299.","DOI":"10.1016\/j.jbc.2023.105065"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbrc.2015.01.092","article-title":"Mitochondrial Ca2+ uniporter is critical for store-operated Ca2+ entry-dependent breast cancer cell migration","volume":"458","author":"Tang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"102743","DOI":"10.1016\/j.ceca.2023.102743","article-title":"The ER-mitochondria interface, where Ca2+ and cell death meet","volume":"112","author":"Kerkhofs","year":"2023","journal-title":"Cell Calcium"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12964-024-02014-w","article-title":"Regulation of calcium homeostasis in endoplasmic reticulum\u2013mitochondria crosstalk: Implications for skeletal muscle atrophy","volume":"23","author":"Li","year":"2025","journal-title":"Cell Commun. Signal"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Sun, C., Wang, Q., Li, P., Dong, R., Lei, Y., Hu, Y., Yan, Y., and Song, G. (2024). The ROS Mediates MCUb in Mitochondria-Regulated Apoptosis of TM4 Cells Induced by Titanium Dioxide Nanoparticles. Biol. Trace Elem. Res., 1\u201316.","DOI":"10.1007\/s12011-024-04339-6"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"6779","DOI":"10.1038\/s41467-022-34365-8","article-title":"Capture at the ER-mitochondrial contacts licenses IP3 receptors to stimulate local Ca2+ transfer and oxidative metabolism","volume":"13","author":"Katona","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1038\/s41467-020-16074-2","article-title":"Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer\u2019s disease","volume":"11","author":"Hou","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1007\/s12975-023-01173-1","article-title":"TRPC Channels Activated by G Protein-Coupled Receptors Drive Ca2+ Dysregulation Leading to Secondary Brain Injury in the Mouse Model","volume":"15","author":"Parmar","year":"2024","journal-title":"Transl. Stroke Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1038\/s41401-020-00580-6","article-title":"Interleukin-17 upregulation participates in the pathogenesis of heart failure in mice via NF-\u03baB-dependent suppression of SERCA2a and Cav1.2 expression","volume":"42","author":"Xue","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1073\/pnas.1513047112","article-title":"Mitochondrial calcium overload is a key determinant in heart failure","volume":"112","author":"Santulli","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1046\/j.1471-4159.2002.00827.x","article-title":"Oxygen and glucose deprivation induces mitochondrial dysfunction and oxidative stress in neurones but not in astrocytes in primary culture","volume":"81","author":"Almeida","year":"2002","journal-title":"J. Neurochem."},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"San-Mill\u00e1n, I. (2023). The Key Role of Mitochondrial Function in Health and Disease. Antioxidants, 12.","DOI":"10.3390\/antiox12040782"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00415-015-7884-3","article-title":"Mitochondrial disease: Genetics and management","volume":"263","author":"Ng","year":"2016","journal-title":"J. Neurol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e03171-19","DOI":"10.1128\/mBio.03171-19","article-title":"Listeria monocytogenes Exploits Mitochondrial Contact Site and Cristae Organizing System Complex Subunit Mic10 to Promote Mitochondrial Fragmentation and Cellular Infection","volume":"11","author":"Carvalho","year":"2020","journal-title":"mBio"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Lee, Y., Lee, S.-M., Choi, J., Kang, S., So, S., Kim, D., Ahn, J.-Y., Jung, H.-Y., Jeong, J.-Y., and Kang, E. (2021). Mitochondrial DNA Haplogroup Related to the Prevalence of Helicobacter pylori. Cells, 10.","DOI":"10.3390\/cells10092482"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Nevoit, G., Jarusevicius, G., Potyazhenko, M., Mintser, O., Bumblyte, I.A., and Vainoras, A. (2024). Mitochondrial Dysfunction and Risk Factors for Noncommunicable Diseases: From Basic Concepts to Future Prospective. Diseases, 12.","DOI":"10.3390\/diseases12110277"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Cuanalo-Contreras, K., Schulz, J., Mukherjee, A., Park, K.-W., Armijo, E., and Soto, C. (2023). Extensive accumulation of misfolded protein aggregates during natural aging and senescence. Front. Aging Neurosci., 14.","DOI":"10.3389\/fnagi.2022.1090109"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"102660","DOI":"10.1016\/j.arr.2025.102660","article-title":"The emerging role of oxygen redox in pathological progression of disorders","volume":"104","author":"Li","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/s41419-024-06691-w","article-title":"The crosstalk between mitochondrial quality control and metal-dependent cell death","volume":"15","author":"Zhou","year":"2024","journal-title":"Cell Death Dis."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.freeradbiomed.2024.02.005","article-title":"Coenzyme Q deficiency in endothelial mitochondria caused by hypoxia; remodeling of the respiratory chain and sensitivity to anoxia\/reoxygenation","volume":"214","author":"Dominiak","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.kint.2021.10.028","article-title":"Dephosphorylation of AMP-activated protein kinase exacerbates ischemia\/reperfusion-induced acute kidney injury via mitochondrial dysfunction","volume":"101","author":"Ma","year":"2022","journal-title":"Kidney Int."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Hu, L.-L., Liao, M.-H., Liu, Y.-X., Xing, C.-H., Nong, L.-L., Yang, F.-L., and Sun, S.-C. (2024). Loss of AMPK activity induces organelle dysfunction and oxidative stress during oocyte aging. Biol. Direct, 19.","DOI":"10.1186\/s13062-024-00471-4"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12964-021-00706-1","article-title":"Interactions among mTORC, AMPK and SIRT: A computational model for cell energy balance and metabolism","volume":"19","author":"Sadria","year":"2021","journal-title":"Cell Commun. Signal"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41392-024-01839-8","article-title":"Mitochondrial dysfunction: Mechanisms and advances in therapy","volume":"9","author":"Zong","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e16166","DOI":"10.1111\/jog.16166","article-title":"Exploring potential pathways from oxidative stress to ovarian aging","volume":"51","author":"Kobayashi","year":"2025","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"bqaa001","DOI":"10.1210\/endocr\/bqaa001","article-title":"Mitochondrial Dysfunction and Ovarian Aging","volume":"161","author":"Seli","year":"2020","journal-title":"Endocrinology"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Han, Y., Du, Z., Wu, H., Zhao, R., Liu, J., Gao, S., and Zeng, S. (2025). CALB1 and RPL23 Are Essential for Maintaining Oocyte Quality and Function During Aging. Aging Cell, e14466.","DOI":"10.1111\/acel.14466"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Chen, Y., Zhang, J., Tian, Y., Xu, X., Wang, B., Huang, Z., Lou, S., Kang, J., Zhang, N., and Weng, J. (2024). Iron accumulation in ovarian microenvironment damages the local redox balance and oocyte quality in aging mice. Redox Biol., 73.","DOI":"10.1016\/j.redox.2024.103195"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Vo, K.C.T., Sato, Y., and Kawamura, K. (2023). Improvement of oocyte quality through the SIRT signaling pathway. Reprod. Med. Biol., 22.","DOI":"10.1002\/rmb2.12510"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Kobayashi, H., and Imanaka, S. (2024). Mitochondrial DNA Damage and Its Repair Mechanisms in Aging Oocytes. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252313144"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1007\/s43032-024-01459-1","article-title":"Mitochondrial Morphology and Function Abnormality in Ovarian Granulosa Cells of Patients with Diminished Ovarian Reserve","volume":"31","author":"An","year":"2024","journal-title":"Reprod. Sci."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/j.celrep.2020.01.058","article-title":"NAD+ Repletion Rescues Female Fertility during Reproductive Aging","volume":"30","author":"Bertoldo","year":"2020","journal-title":"Cell Rep."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s10522-023-10054-x","article-title":"Evaluation of potential aging biomarkers in healthy individuals: Telomerase, AGEs, GDF11\/15, sirtuin 1, NAD+, NLRP3, DNA\/RNA damage, and klotho","volume":"24","author":"Borsky","year":"2023","journal-title":"Biogerontology"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"112421","DOI":"10.1016\/j.yexcr.2020.112421","article-title":"SIRT1 reduces epigenetic and non-epigenetic changes to maintain the quality of postovulatory aged oocytes in mice","volume":"399","author":"Xing","year":"2021","journal-title":"Exp. Cell Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"685","DOI":"10.18632\/aging.100911","article-title":"SIRT1, 2, 3 protect mouse oocytes from postovulatory aging","volume":"8","author":"Zhang","year":"2016","journal-title":"Aging"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1093\/biolre\/ioy248","article-title":"Alterations in oocyte mitochondrial number and function are related to spindle defects and occur with maternal aging in mice and humans\u2020","volume":"100","author":"Pasquariello","year":"2019","journal-title":"Biol. Reprod."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"glad222","DOI":"10.1093\/gerona\/glad222","article-title":"Aging-Related Mitochondrial Dysfunction Is Associated with Fibrosis in Benign Prostatic Hyperplasia","volume":"79","author":"Adrian","year":"2024","journal-title":"J. Gerontol. Ser. A"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Lu, J., Li, H., Yu, D., Zhao, P., and Liu, Y. (2023). Heat stress inhibits the proliferation and differentiation of myoblasts and is associated with damage to mitochondria. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1171506"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.3168\/jds.2023-24059","article-title":"Effects of heat stress on feed intake, milk yield, milk composition, and feed efficiency in dairy cows: A meta-analysis","volume":"107","author":"Chen","year":"2024","journal-title":"J. Dairy Sci."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.aninu.2023.12.008","article-title":"Selenomethionine alleviates chronic heat stress-induced breast muscle injury and poor meat quality in broilers via relieving mitochondrial dysfunction and endoplasmic reticulum stress","volume":"16","author":"Jing","year":"2024","journal-title":"Anim. Nutr."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Jo, J.-H., Nejad, J.G., Kim, H.-R., and Lee, H.-G. (2024). Effect of seven days heat stress on feed and water intake, milk characteristics, blood parameters, physiological indicators, and gene expression in Holstein dairy cows. J. Therm. Biol., 123.","DOI":"10.1016\/j.jtherbio.2024.103929"},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Wrzeci\u0144ska, M., Kowalczyk, A., Kordan, W., Cwynar, P., and Czerniawska-Pi\u0105tkowska, E. (2023). Disorder of Biological Quality and Autophagy Process in Bovine Oocytes Exposed to Heat Stress and the Effectiveness of In Vitro Fertilization. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241311164"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Guo, Z., Gao, S., Ouyang, J., Ma, L., and Bu, D. (2021). Impacts of Heat Stress-Induced Oxidative Stress on the Milk Protein Biosynthesis of Dairy Cows. Animals, 11.","DOI":"10.3390\/ani11030726"},{"key":"ref_132","doi-asserted-by":"crossref","unstructured":"Shi, J., Ji, Z., Yao, X., Yao, Y., Li, C., Liang, Q., and Zhang, X. (2024). HSP90 Enhances Mitophagy to Improve the Resistance of Car-Diomyocytes to Heat Stress in Wenchang Chickens. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252111695"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Havalov\u00e1, H., Ondrovi\u010dov\u00e1, G., Keresztesov\u00e1, B., Bauer, J.A., Pevala, V., Kutejov\u00e1, E., and Kunov\u00e1, N. (2021). Mitochondrial HSP70 Chaperone System\u2014The Influence of Post-Translational Modifications and Involvement in Human Diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158077"},{"key":"ref_134","doi-asserted-by":"crossref","unstructured":"Stamperna, K., Giannoulis, T., Dovolou, E., Kalemkeridou, M., Nanas, I., Dadouli, K., Moutou, K., Mamuris, Z., and Amiridis, G.S. (2021). Heat Shock Protein 70 Improves In Vitro Embryo Yield and Quality from Heat Stressed Bovine Oocytes. Animals, 11.","DOI":"10.3390\/ani11061794"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"103537","DOI":"10.1016\/j.psj.2024.103537","article-title":"Heat shock proteins as a key defense mechanism in poultry production under heat stress conditions","volume":"103","author":"Gouda","year":"2024","journal-title":"Poult. Sci."},{"key":"ref_136","doi-asserted-by":"crossref","unstructured":"Suzuki, N. (2023). Fine Tuning of ROS, Redox and Energy Regulatory Systems Associated with the Functions of Chloroplasts and Mitochondria in Plants under Heat Stress. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021356"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Lang, L.I., Wang, Z., Liu, B., Chang-qing, S.H.E.N., Jing-yi, T.U., Shi-cheng, W.A.N.G., Rui-ling, L.E.I., Si-qi, P.E.N.G., Xiong, X.I.A.O., and Yong-ju, Z.H.A.O. (2024). The effects and mechanisms of heat stress on mammalian oocyte and embryo development. J. Therm. Biol., 124.","DOI":"10.1016\/j.jtherbio.2024.103927"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41420-023-01539-2","article-title":"Aging-related aneuploidy is associated with mitochondrial imbalance and failure of spindle assembly","volume":"9","author":"Zhang","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"C218","DOI":"10.1152\/ajpcell.00360.2021","article-title":"Mitochondrial quality surveillance: Mitophagy in cardiovascular health and disease","volume":"322","author":"Diao","year":"2022","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Khan, I., Mesalam, A., Heo, Y.S., Lee, S.-H., Nabi, G., and Kong, I.-K. (2023). Heat Stress as a Barrier to Successful Reproduction and Potential Alleviation Strategies in Cattle. Animals, 13.","DOI":"10.3390\/ani13142359"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s40572-022-00371-7","article-title":"Environmental Chemical Exposures and Mitochondrial Dysfunction: A Review of Recent Literature","volume":"9","author":"Reddam","year":"2022","journal-title":"Curr. Environ. Health Rep."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Duarte-Hospital, C., T\u00eate, A., Brial, F., Benoit, L., Koual, M., Tomkiewicz, C., Kim, M.J., Blanc, E.B., Coumoul, X., and Bortoli, S. (2021). Mitochondrial Dysfunction as a Hallmark of Environmental Injury. Cells, 11.","DOI":"10.3390\/cells11010110"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Lim, E.Y., and Kim, G.-D. (2024). Particulate Matter-Induced Emerging Health Effects Associated with Oxidative Stress and Inflammation. Antioxidants, 13.","DOI":"10.3390\/antiox13101256"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"114829","DOI":"10.1016\/j.ecoenv.2023.114829","article-title":"Modulators of mitochondrial ATP-sensitive potassium channel affect cytotoxicity of heavy metals: Action on isolated rat liver mitochondria and AS-30D ascites hepatoma cells","volume":"256","author":"Belyaeva","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"09603271231216968","DOI":"10.1177\/09603271231216968","article-title":"Effects of polycyclic aromatic hydrocarbon exposure on mitochondrial DNA copy number","volume":"42","author":"Choi","year":"2023","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Jia, Y., Li, W., Li, Y., Zhao, L., Li, C., Wang, L., Fang, J., Song, S., Ji, Y., and Fang, T. (2023). The Levels of Polycyclic Aromatic Hydrocarbons and Their Derivatives in Plasma and Their Effect on Mitochondrial DNA Methylation in the Oilfield Workers. Toxics, 11.","DOI":"10.3390\/toxics11050466"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"113799","DOI":"10.1016\/j.ecoenv.2022.113799","article-title":"Association between mitochondrial DNA methylation and internal exposure to polycyclic aromatic hydrocarbons (PAHs), nitrated-PAHs (NPAHs) and oxygenated-PAHs (OPAHs) in young adults from Tianjin, China","volume":"241","author":"Guo","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"e13335","DOI":"10.1111\/cpr.13335","article-title":"Exposure to phenanthrene affects oocyte meiosis by inducing mitochondrial dysfunction and endoplasmic reticulum stress","volume":"56","author":"Wang","year":"2023","journal-title":"Cell Prolif."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3349\/ymj.2023.0048","article-title":"Health Effects of Microplastic Exposures: Current Issues and Perspectives in South Korea","volume":"64","author":"Lee","year":"2023","journal-title":"Yonsei Med. J."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"117622","DOI":"10.1016\/j.ecoenv.2024.117622","article-title":"Synergistic effects of PS-NPs and Cd on ovarian toxicity in adolescent rats: Ferroptosis by induction of mitochondrial redox imbalance via the SIRT3-SOD2\/Gpx4 pathway","volume":"290","author":"Wu","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Ahmad, W., Alharthy, R.D., Zubair, M., Ahmed, M., Hameed, A., and Rafique, S. (2021). Toxic and heavy metals contamination assessment in soil and water to evaluate human health risk. Sci. Rep., 11.","DOI":"10.1038\/s41598-021-94616-4"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/jat.4664","article-title":"Impact of oxidative stress induced by heavy metals on ovarian function","volume":"45","author":"Xiao","year":"2025","journal-title":"J. Appl. Toxicol."},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Wrzeci\u0144ska, M., Kowalczyk, A., Cwynar, P., and Czerniawska-Pi\u0105tkowska, E. (2021). Disorders of the Reproductive Health of Cattle as a Response to Exposure to Toxic Metals. Biology, 10.","DOI":"10.3390\/biology10090882"},{"key":"ref_154","doi-asserted-by":"crossref","unstructured":"Koyama, H., Kamogashira, T., and Yamasoba, T. (2024). Heavy Metal Exposure: Molecular Pathways, Clinical Implications, and Protective Strategies. Antioxidants, 13.","DOI":"10.3390\/antiox13010076"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"103038","DOI":"10.1016\/j.isci.2021.103038","article-title":"In situ observation of mitochondrial biogenesis as the early event of apoptosis","volume":"24","author":"Shao","year":"2021","journal-title":"iScience"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s43032-023-01331-8","article-title":"Spatiotemporal Distribution and Function of Mitochondria in Oocytes","volume":"31","author":"Kang","year":"2024","journal-title":"Reprod. Sci."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1002\/jcb.21247","article-title":"Metabolic syndrome and mitochondrial function: Molecular replacement and antioxidant supplements to prevent membrane peroxidation and restore mitochondrial function","volume":"100","author":"Nicolson","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/nature11800","article-title":"Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants","volume":"493","author":"Paull","year":"2013","journal-title":"Nature"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"20151704","DOI":"10.1098\/rspb.2015.1704","article-title":"Mitonuclear linkage disequilibrium in human populations","volume":"282","author":"Sloan","year":"2015","journal-title":"Proc. R. Soc. B."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nature11647","article-title":"Towards germline gene therapy of inherited mitochondrial diseases","volume":"493","author":"Tachibana","year":"2013","journal-title":"Nature"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Tatay, L., Hern\u00e1ndez-Andreu, J., and Aznar, J. (2017). Mitochondrial Modification Techniques and Ethical Issues. J. Clin. Med., 6.","DOI":"10.3390\/jcm6030025"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Pasquariello, R., Verdile, N., Brevini, T.A.L., Gandolfi, F., Boiti, C., Zerani, M., and Maranesi, M. (2020). The Role of Resveratrol in Mammalian Reproduction. Molecules, 25.","DOI":"10.20944\/preprints202009.0003.v1"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2147\/IJWH.S404660","article-title":"Review of the Potential Therapeutic Effects and Molecular Mechanisms of Resveratrol on Endometriosis","volume":"15","author":"Jiang","year":"2023","journal-title":"Int. J. Women\u2019s Health"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1080\/1071576031000083099","article-title":"Effects of Resveratrol and 4-hexylresorcinol on Hydrogen Peroxide-induced Oxidative DNA Damage in Human Lymphocytes","volume":"37","author":"Yen","year":"2003","journal-title":"Free Radic. Res."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Novakovic, R., Rajkovic, J., Gostimirovic, M., Gojkovic-Bukarica, L., and Radunovic, N. (2022). Resveratrol and Reproductive Health. Life, 12.","DOI":"10.3390\/life12020294"},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Zaychenko, G., Stryga, O., Sinitsyna, O., Doroshenko, A., Sulaieva, O., Falalyeyeva, T., and Kobyliak, N. (2022). Resveratrol Effects on the Reproductive System in Ovariectomized Rats: Deciphering Possible Mechanisms. Molecules, 27.","DOI":"10.3390\/molecules27154916"},{"key":"ref_167","doi-asserted-by":"crossref","unstructured":"Bartra, C., Yuan, Y., Vurai\u0107, K., Vald\u00e9s-Quiroz, H., Garcia-Baucells, P., Slevin, M., Pastorello, Y., Su\u00f1ol, C., and Sanfeliu, C. (2024). Resveratrol Activates Antioxidant Protective Mechanisms in Cellular Models of Alzheimer\u2019s Disease Inflammation. Antioxidants, 13.","DOI":"10.3390\/antiox13020177"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1007\/s11064-020-02997-1","article-title":"Additive Effect of Resveratrol on Astrocyte Swelling Post-exposure to Ammonia, Ischemia and Trauma In Vitro","volume":"45","author":"Taherian","year":"2020","journal-title":"Neurochem. Res."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"174380","DOI":"10.1016\/j.ejphar.2021.174380","article-title":"Effect of resveratrol on inflammatory cytokines: A meta-analysis of randomized controlled trials","volume":"908","author":"Omraninava","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_170","doi-asserted-by":"crossref","unstructured":"Chuang, Y.-C., Chen, S.-D., Hsu, C.-Y., Chen, S.-F., Chen, N.-C., and Jou, S.-B. (2019). Resveratrol Promotes Mitochondrial Biogenesis and Protects against Seizure-Induced Neuronal Cell Damage in the Hippocampus Following Status Epilepticus by Activation of the PGC-1\u03b1 Signaling Pathway. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20040998"},{"key":"ref_171","doi-asserted-by":"crossref","unstructured":"Nishigaki, A., Tsubokura, H., Tsuzuki-Nakao, T., and Okada, H. (2022). Hypoxia: Role of SIRT1 and the protective effect of resveratrol in ovarian function. Reprod. Med. Biol., 21.","DOI":"10.1002\/rmb2.12428"},{"key":"ref_172","doi-asserted-by":"crossref","unstructured":"Jiang, X., Ma, Y., Gong, S., Zi, X., and Zhang, D. (2024). Resveratrol Promotes Proliferation, Antioxidant Properties, and Progesterone Production in Yak (Bos grunniens) Granulosa Cells. Animals, 14.","DOI":"10.3390\/ani14020240"},{"key":"ref_173","doi-asserted-by":"crossref","unstructured":"Xu, G., Dong, Y., Wang, Z., Ding, H., Wang, J., Zhao, J., Liu, H., and Lv, W. (2023). Melatonin Attenuates Oxidative Stress-Induced Apoptosis of Bovine Ovarian Granulosa Cells by Promoting Mitophagy via SIRT1\/FoxO1 Signaling Pathway. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241612854"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1262\/jrd.2015-001","article-title":"Resveratrol-induced mitochondrial synthesis and autophagy in oocytes derived from early antral follicles of aged cows","volume":"61","author":"Sugiyama","year":"2015","journal-title":"J. Reprod. Dev."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Wang, J., Jia, R., Celi, P., Zhuo, Y., Ding, X., Zeng, Q., Bai, S., Xu, S., Yin, H., and Lv, L. (2022). Resveratrol Alleviating the Ovarian Function Under Oxidative Stress by Alternating Microbiota Related Tryptophan-Kynurenine Pathway. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.911381"},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"5628","DOI":"10.18632\/aging.204157","article-title":"Short-term resveratrol treatment restored the quality of oocytes in aging mice","volume":"14","author":"Okamoto","year":"2022","journal-title":"Aging"},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Higashida, K., Kim, S.H., Jung, S.R., Asaka, M., Holloszy, J.O., and Han, D.-H. (2013). Effects of Resveratrol and SIRT1 on PGC-1\u03b1 Activity and Mitochondrial Biogenesis: A Reevaluation. PLoS Biol., 11.","DOI":"10.1371\/journal.pbio.1001603"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/rmb2.12323","article-title":"Resveratrol protects mitochondrial quantity by activating SIRT1\/PGC-1\u03b1 expression during ovarian hypoxia","volume":"19","author":"Nishigaki","year":"2020","journal-title":"Reprod. Med. Biol."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Zou, W., Wang, X., Xia, X., Zhang, T., Nie, M., Xiong, J., and Fang, X. (2024). Resveratrol protected against the development of endometriosis by promoting ferroptosis through miR-21-3p\/p53\/SLC7A11 signaling pathway. Biochem. Biophys. Res. Commun., 692.","DOI":"10.1016\/j.bbrc.2023.149338"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3892\/ijmm.2020.4789","article-title":"Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes","volume":"47","author":"Sun","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"20190084","DOI":"10.1515\/jcim-2019-0084","article-title":"Phytotherapy in endometriosis: An up-to-date review","volume":"17","author":"Noventa","year":"2020","journal-title":"J. Complement. Integr. Med."},{"key":"ref_182","doi-asserted-by":"crossref","unstructured":"Wang, W., Zhou, M., Xu, Y., Peng, W., Zhang, S., Li, R., Zhang, H., Zhang, H., Cheng, S., and Wang, Y. (2021). Resveratrol-Loaded TPGS-Resveratrol-Solid Lipid Nanoparticles for Multidrug-Resistant Therapy of Breast Cancer: In Vivo and In Vitro Study. Front. Bioeng. Biotechnol., 9.","DOI":"10.3389\/fbioe.2021.762489"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1111\/rda.13274","article-title":"Resveratrol promotes in vitro activation of ovine primordial follicles by reducing DNA damage and enhancing granulosa cell proliferation via phosphatidylinositol 3-kinase pathway","volume":"53","author":"Bezerra","year":"2018","journal-title":"Reprod. Domest. Anim."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1111\/jog.13680","article-title":"Mechanism of resveratrol in improving ovarian function in a rat model of premature ovarian insufficiency","volume":"44","author":"Li","year":"2018","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.fertnstert.2020.08.016","article-title":"Resveratrol depolarizes the membrane potential in human granulosa cells and promotes mitochondrial biogenesis","volume":"115","author":"Ragonese","year":"2021","journal-title":"Fertil. Steril."},{"key":"ref_186","doi-asserted-by":"crossref","unstructured":"Li, R., Li, E., Kamili, G., Ou, S., and Yang, D. (2022). Effect of resveratrol on superovulation in mice. Biomed. Pharmacother., 146.","DOI":"10.1016\/j.biopha.2021.112565"},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.theriogenology.2022.11.006","article-title":"Effect of bovine oocyte vitrification with EGTA and post-warming recovery with resveratrol on meiotic spindle, mitochondrial function, reactive oxygen species, and developmental competence","volume":"196","author":"Diaz","year":"2023","journal-title":"Theriogenology"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.theriogenology.2023.01.010","article-title":"Leonurine improves bovine oocyte maturation and subsequent embryonic development by reducing oxidative stress and improving mitochondrial function","volume":"199","author":"Zheng","year":"2023","journal-title":"Theriogenology"},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.atherosclerosis.2012.06.066","article-title":"SCM-198 attenuates early atherosclerotic lesions in hypercholesterolemic rabbits via modulation of the inflammatory and oxidative stress pathways","volume":"224","author":"Zhang","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s13048-024-01504-2","article-title":"SCM-198 ameliorates the quality of postovulatory and maternally aged oocytes by reducing oxidative stress","volume":"17","author":"Ma","year":"2024","journal-title":"J. Ovarian Res."},{"key":"ref_191","doi-asserted-by":"crossref","unstructured":"Shao, Y., Luo, Y., Sun, Y., Jiang, J., Li, Z., Wang, Z., Wang, M., and Gu, X. (2024). Leonurine Exerts Anti-Inflammatory Effects in Lipopolysaccharide (LPS)-Induced Endometritis by Modulating Mouse JAK-STAT\/PI3K-Akt\/PPAR Signaling Pathways. Genes, 15.","DOI":"10.21203\/rs.3.rs-3917336\/v1"},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.theriogenology.2020.06.038","article-title":"Leonurine improves in vitro porcine embryo development competence by reducing reactive oxygen species production and protecting mitochondrial function","volume":"156","author":"Luo","year":"2020","journal-title":"Theriogenology"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"109520","DOI":"10.1016\/j.intimp.2022.109520","article-title":"Protective effects of leonurine hydrochloride on pyroptosis in premature ovarian insufficiency via regulating NLRP3\/GSDMD pathway","volume":"114","author":"Chi","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_194","first-page":"1934578X1601101","article-title":"Leonurine, a Potential Agent of Traditional Chinese Medicine: Recent Updates and Future Perspectives","volume":"11","author":"Yang","year":"2016","journal-title":"Nat. Product. Commun."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.bbrc.2020.05.184","article-title":"Leonurine protects against dexamethasone-induced cytotoxicity in pancreatic \u03b2-cells via PI3K\/Akt signaling pathway","volume":"529","author":"Xu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.theriogenology.2023.07.021","article-title":"Melatonin restores the declining maturation quality and early embryonic development of oocytes in aged mice","volume":"210","author":"Qu","year":"2023","journal-title":"Theriogenology"},{"key":"ref_197","doi-asserted-by":"crossref","unstructured":"Zhang, H., Li, C., Wen, D., Li, R., Lu, S., Xu, R., Tang, Y., Sun, Y., Zhao, X., and Pan, M. (2022). Melatonin improves the quality of maternally aged oocytes by maintaining intercellular communication and antioxidant metabolite supply. Redox Biol., 49.","DOI":"10.1016\/j.redox.2021.102215"},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbi.2021.01.034","article-title":"Anti-inflammatory effects of melatonin: A systematic review and meta-analysis of clinical trials","volume":"93","author":"Cho","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.theriogenology.2011.04.011","article-title":"L-carnitine enhances oocyte maturation and development of parthenogenetic embryos in pigs","volume":"76","author":"Wu","year":"2011","journal-title":"Theriogenology"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1017\/S0007114522000101","article-title":"Dietary L-carnitine regulates liver lipid metabolism via simultaneously activating fatty acid \u03b2-oxidation and suppressing endoplasmic reticulum stress in large yellow croaker fed with high-fat diets","volume":"129","author":"Li","year":"2023","journal-title":"Br. J. Nutr."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.theriogenology.2015.01.028","article-title":"Effects of acetyl-L-carnitine on lamb oocyte blastocyst rate, ultrastructure, and mitochondrial DNA copy number","volume":"83","author":"Reader","year":"2015","journal-title":"Theriogenology"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1002\/mrd.23542","article-title":"Biological roles of L-carnitine in oocyte and early embryo development","volume":"88","author":"Li","year":"2021","journal-title":"Mol. Reprod. Dev."},{"key":"ref_203","doi-asserted-by":"crossref","unstructured":"Lee, Y.-C.G., Chou, H.-C., Chen, Y.-T., Tung, S.-Y., Ko, T.-L., Buyandelger, B., Wen, L.-L., and Juan, S.-H. (2022). l-Carnitine reduces reactive oxygen species\/endoplasmic reticulum stress and maintains mitochondrial function during autophagy-mediated cell apoptosis in perfluorooctanesulfonate-treated renal tubular cells. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-08771-3"},{"key":"ref_204","doi-asserted-by":"crossref","unstructured":"Virmani, M.A., and Cirulli, M. (2022). The Role of l-Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052717"},{"key":"ref_205","doi-asserted-by":"crossref","unstructured":"Modak, A.K., Alam, M.H., Islam, M.N., Paul, N., Akter, I., Hashem, M.A., Kabir, A.A., and Moniruzzaman, M. (2022). L-Carnitine Supports the In Vitro Growth of Buffalo Oocytes. Animals, 12.","DOI":"10.3390\/ani12151957"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"107249","DOI":"10.1016\/j.anireprosci.2023.107249","article-title":"L-carnitine enhances developmental potential of bovine oocytes matured under high lipid concentrations in vitro","volume":"252","author":"Catandi","year":"2023","journal-title":"Anim. Reprod. Sci."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"343820","DOI":"10.1016\/j.aca.2025.343820","article-title":"A multi-step approach for the accurate screening and determination of Coenzyme Q10 (Nano)micelles","volume":"1348","author":"Zougagh","year":"2025","journal-title":"Anal. Chim. Acta"},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1007\/s43032-022-01136-1","article-title":"Association of Coenzyme Q10 with Premature Ovarian Insufficiency","volume":"30","author":"Ma","year":"2023","journal-title":"Reprod. Sci."},{"key":"ref_209","doi-asserted-by":"crossref","unstructured":"Cao, S., Yan, H., Tang, W., Zhang, H., and Liu, J. (2023). Effects of dietary coenzyme Q10 supplementation during gestation on the embryonic survival and reproductive performance of high-parity sows. J. Anim. Sci. Biotechnol., 14.","DOI":"10.1186\/s40104-023-00879-4"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jcm.2022.07.001","article-title":"Coenzyme Q10 Supplementation in Reducing Inflammation: An Umbrella Review","volume":"22","author":"McRae","year":"2023","journal-title":"J. Chiropr. Med."},{"key":"ref_211","doi-asserted-by":"crossref","unstructured":"Zhang, L., Li, Y., Hu, J., and Liu, Z. (2022). Overexpression of enzymes in glycolysis and energy metabolic pathways to enhance coenzyme Q10 production in Rhodobacter sphaeroides VK-2-3. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.931470"},{"key":"ref_212","doi-asserted-by":"crossref","unstructured":"Yen, H.-C., Yeh, W.-Y., Lee, S.-H., Feng, Y.-H., and Yang, S.-L. (2020). Characterization of human mitochondrial PDSS and COQ proteins and their roles in maintaining coenzyme Q10 levels and each other\u2019s stability. Biochim. Biophys. Acta (BBA)-Bioenerg., 1861.","DOI":"10.1016\/j.bbabio.2020.148192"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.18632\/aging.102681","article-title":"Ubiquinol-10 delays postovulatory oocyte aging by improving mitochondrial renewal in pigs","volume":"12","author":"Niu","year":"2020","journal-title":"Aging"},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.theriogenology.2020.10.009","article-title":"CoQ10 improves meiotic maturation of pig oocytes through enhancing mitochondrial function and suppressing oxidative stress","volume":"159","author":"Yang","year":"2021","journal-title":"Theriogenology"},{"key":"ref_215","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/mrd.23159","article-title":"Supplementation of maturation medium with CoQ10 enhances developmental competence of ovine oocytes through improvement of mitochondrial function","volume":"86","author":"Heydarnejad","year":"2019","journal-title":"Mol. Reprod. 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