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Hemograms and other blood indexes often show high percentages of values at the \u2018normal\u2019, low, or high limits and several values outside of the \u2018normal\u2019 ranges. On the other hand, vessels regulate blood arrival to tissues depending on many internal and external factors. Both aspects can interfere with tissue oxygenation and then with the numerous consequences induced by hypoxia. In this narrative review, efforts were made to highlight factors that are potentially able to affect oxygen arrival in cells, as well as other factors related to blood elements that can play a role in the chronic pain experienced by FM patients. Data strongly indicate that most of the symptoms commonly present in FM patients can find their physio-pathological basis in the blood, suggesting blood-related interventions in these patients.<\/jats:p>","DOI":"10.3390\/ijms26094153","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T11:48:33Z","timestamp":1745840913000},"page":"4153","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fibromyalgia: Chronic Pain Due to a Blood Dysfunction?"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9136-9983","authenticated-orcid":false,"given":"Anna Maria","family":"Aloisi","sequence":"first","affiliation":[{"name":"Stress and Pain Neurophysiology Laboratory, Department of Medicine, Surgery and Neuroscience University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilenia","family":"Casini","sequence":"additional","affiliation":[{"name":"Stress and Pain Neurophysiology Laboratory, Department of Medicine, Surgery and Neuroscience University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jurado-Priego, L.N., Cueto-Ure\u00f1a, C., Ram\u00edrez-Exp\u00f3sito, M.J., and Mart\u00ednez-Martos, J.M. 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