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However, not all individuals with depression respond equally to stressors. We aimed to determine whether the PrRP system could underlie stress coping, an important aspect of depression. The forced swim test was used both as a stressor and as a method to assess coping strategy. Based on immobility time, active coping and passive coping subgroups were identified, and 10 brain regions were studied using qPCR to measure the mRNA expression levels of PrRP and its receptors (specific: GPR10; non-specific: NPFFR2). Passive coping animals spent more time in an immobile posture and exhibited altered mRNA expression levels in the medullary A1 region, the habenula, and the arcuate nucleus than control or active coping rats. Additionally, we identified corticotropin-releasing hormone and vesicular glutamate transporter 2 positive neurons in the A1 medullary region that contained Prrp, suggesting a modulatory role of PrRP in these excitatory neurons involved in stress regulation. Our findings reinforce the hypothesis that PrRP plays a role in stress coping, a process closely linked to depression. However its effect is brain region-specific.<\/jats:p>","DOI":"10.3390\/ijms26094155","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T11:48:33Z","timestamp":1745840913000},"page":"4155","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prolactin-Releasing Peptide System as a Potential Mechanism of Stress Coping: Studies in Male Rats"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5832-8832","authenticated-orcid":false,"given":"Evelin","family":"Szab\u00f3","sequence":"first","affiliation":[{"name":"Institute of Physiology, Medical School, University of P\u00e9cs, Centre for Neuroscience, Szent\u00e1gothai Research Centre, H7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3360-2425","authenticated-orcid":false,"given":"Vikt\u00f3ria","family":"Kormos","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacotherapy, Medical School, University of P\u00e9cs, H7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-1320","authenticated-orcid":false,"given":"Zsuzsanna E.","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Semmelweis University, H1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5616-1100","authenticated-orcid":false,"given":"D\u00f3ra","family":"Zelena","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Medical School, University of P\u00e9cs, Centre for Neuroscience, Szent\u00e1gothai Research Centre, H7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0237-0780","authenticated-orcid":false,"given":"Anita","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Institute of Physiology, Medical School, University of P\u00e9cs, Centre for Neuroscience, Szent\u00e1gothai Research Centre, H7624 P\u00e9cs, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jpsychires.2019.08.002","article-title":"Changes in the Global Burden of Depression from 1990 to 2017: Findings from the Global Burden of Disease Study","volume":"126","author":"Liu","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"06035","DOI":"10.7189\/jogh.13.06035","article-title":"Impact of Covid-19 Mitigations on Anxiety and Depression Amongst University Students: A Systematic Review and Meta-Analysis","volume":"13","author":"Lee","year":"2023","journal-title":"J. Glob. Health"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Radulovic, D., Masic, S., Stanisavljevic, D., Bokonjic, D., Radevic, S., Rajovic, N., Milic, N.V., Vukomanovic, I.S., Mijovic, B., and Vukovic, M. (2024). A Complex Relationship between Quality of Life, Anxiety, and Depression among General Population during Second Year of Covid-19 Pandemic: A Population-Based Study. J. Clin. Med., 13.","DOI":"10.3390\/jcm13133874"},{"key":"ref_4","first-page":"189","article-title":"Longitudinal Associations between Resilience and Mental Health during the Covid-19 Pandemic","volume":"21","author":"Lenzo","year":"2024","journal-title":"Clin. Neuropsychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Chang, O., Levitt, A., Khalid, M., Kodeeswaran, S., and Markoulakis, R. (2024). The Prevalence of Mental Health and Addiction Concerns and Factors Associated with Depression and Anxiety during the Covid-19 Pandemic in Ontario, Canada: A Cross-Sectional Study. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0305229"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1037\/bul0000110","article-title":"Coping, Emotion Regulation, and Psychopathology in Childhood and Adolescence: A Meta-Analysis and Narrative Review","volume":"143","author":"Compas","year":"2017","journal-title":"Psychol. Bull."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1037\/0022-3514.52.5.946","article-title":"Personal and Contextual Determinants of Coping Strategies","volume":"52","author":"Holahan","year":"1987","journal-title":"J. Pers. Soc. Psychol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1037\/0022-3514.46.4.877","article-title":"Coping, Stress, and Social Resources among Adults with Unipolar Depression","volume":"46","author":"Billings","year":"1984","journal-title":"J. Pers. Soc. Psychol"},{"key":"ref_9","unstructured":"World Health, Assembly (2012). Global Burden of Mental Disorders and the Need for a Comprehensive, Coordinated Response from Health and Social Sectors at the Country Level: Report by the Secretariat, World Health Organization."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2147\/NDT.S198774","article-title":"Management of Treatment-Resistant Depression: Challenges and Strategies","volume":"16","author":"Voineskos","year":"2020","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kovacs, A., Szabo, E., Laszlo, K., Kertes, E., Zagoracz, O., Mintal, K., Toth, A., Galosi, R., Berta, B., and Lenard, L. (2024). Brain Rfamide Neuropeptides in Stress-Related Psychopathologies. Cells, 13.","DOI":"10.3390\/cells13131097"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1523\/JNEUROSCI.2139-21.2022","article-title":"Prolactin-Releasing Peptide Contributes to Stress-Related Mood Disorders and Inhibits Sleep\/Mood Regulatory Melanin-Concentrating Hormone Neurons in Rats","volume":"43","author":"Vas","year":"2023","journal-title":"J. Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1471-4159.2007.05069.x","article-title":"Chronic Repeated Restraint Stress Increases Prolactin-Releasing Peptide\/Tyrosine-Hydroxylase Ratio with Gender-Related Differences in the Rat Brain","volume":"104","author":"Toth","year":"2008","journal-title":"J. Neurochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s00429-020-02049-y","article-title":"Colocalized Neurotransmitters in the Hindbrain Cooperate in Adaptation to Chronic Hypernatremia","volume":"225","author":"Matuska","year":"2020","journal-title":"Brain Struct. Funct."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-0115(99)00028-2","article-title":"Tissue Distribution of Prolactin-Releasing Peptide (Prrp) and Its Receptor","volume":"83","author":"Fujii","year":"1999","journal-title":"Regul. Pept."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0006-8993(99)01153-1","article-title":"Prolactin-Releasing Peptide-Immunoreactivity in A1 and A2 Noradrenergic Neurons of the Rat Medulla","volume":"822","author":"Chen","year":"1999","journal-title":"Brain Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/frne.1995.1004","article-title":"Stress-Induced Norepinephrine Release in the Hypothalamic Paraventricular Nucleus and Pituitary-Adrenocortical and Sympathoadrenal Activity: In Vivo Microdialysis Studies","volume":"16","author":"Pacak","year":"1995","journal-title":"Front. Neuroendocrinol."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Dodd, G.T., and Luckman, S.M. (2013). Physiological Roles of Gpr10 and Prrp Signaling. Front. Endocrinol., 4.","DOI":"10.3389\/fendo.2013.00020"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/30515","article-title":"A Prolactin-Releasing Peptide in the Brain","volume":"393","author":"Hinuma","year":"1998","journal-title":"Nature"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/sj.bjp.0703617","article-title":"Characterization of the Binding of [(125)I]-Human Prolactin Releasing Peptide (Prrp) to Gpr10, a Novel G Protein Coupled Receptor","volume":"131","author":"Langmead","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1111\/j.1460-9568.2009.06956.x","article-title":"Prolactin-Releasing Peptide Effects in the Rat Brain Are Mediated through the Neuropeptide Ff Receptor","volume":"30","author":"Ma","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1176\/ajp.152.9.1372","article-title":"Corticotropin-Releasing Hormone Mrna Levels in the Paraventricular Nucleus of Patients with Alzheimer\u2019s Disease and Depression","volume":"152","author":"Raadsheer","year":"1995","journal-title":"Am. J. Psychiatry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1210\/en.2013-1411","article-title":"The Medial Amygdala-Medullary Prrp-Synthesizing Neuron Pathway Mediates Neuroendocrine Responses to Contextual Conditioned Fear in Male Rodents","volume":"155","author":"Yoshida","year":"2014","journal-title":"Endocrinology"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0304-3940(99)00831-9","article-title":"Central Administration of Prolactin-Releasing Peptide Stimulates Oxytocin Release in Rats","volume":"276","author":"Maruyama","year":"1999","journal-title":"Neurosci. Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0006-8993(99)02451-8","article-title":"A Novel Action of the Newly Described Prolactin-Releasing Peptides: Cardiovascular Regulation","volume":"858","author":"Samson","year":"2000","journal-title":"Brain Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0304-3940(00)01077-6","article-title":"Stimulation of Corticotropin-Releasing Hormone-Mediated Adrenocorticotropin Secretion by Central Administration of Prolactin-Releasing Peptide in Rats","volume":"285","author":"Matsumoto","year":"2000","journal-title":"Neurosci. Lett."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.neuroscience.2006.04.023","article-title":"Prolactin-Releasing Peptide Is a Potent Mediator of Stress Responses in the Brain through the Hypothalamic Paraventricular Nucleus","volume":"141","author":"Mera","year":"2006","journal-title":"Neuroscience"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ibror.2018.11.008","article-title":"The Human Hypothalamus in Mood Disorders: The Hpa Axis in the Center","volume":"6","author":"Bao","year":"2019","journal-title":"IBRO Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural Despair in Rats: A New Model Sensitive to Antidepressant Treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"key":"ref_30","first-page":"327","article-title":"Behavioral Despair in Mice: A Primary Screening Test for Antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1111\/ejn.15139","article-title":"Forced Swim Stressor: Trends in Usage and Mechanistic Consideration","volume":"55","author":"Molendijk","year":"2022","journal-title":"Eur. J. Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/nn.2647","article-title":"Animal Models of Neuropsychiatric Disorders","volume":"13","author":"Nestler","year":"2010","journal-title":"Nat. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.psyneuen.2015.08.028","article-title":"Immobility in the Forced Swim Test Is Adaptive and Does Not Reflect Depression","volume":"62","author":"Molendijk","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"ref_34","first-page":"6503162","article-title":"Coping with the Forced Swim Stressor: Towards Understanding an Adaptive Mechanism","volume":"2016","author":"Molendijk","year":"2016","journal-title":"Neural Plast"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Becker, L., Mallien, A.S., Pfeiffer, N., Brandwein, C., Talbot, S.R., Bleich, A., Palme, R., Potschka, H., and Gass, P. (2023). Evidence-Based Severity Assessment of the Forced Swim Test in the Rat. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0292816"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Ruiz-Sanchez, E., Lopez-Ramirez, A.M., Ruiz-Chow, A., Calvillo, M., Resendiz-Albor, A.A., Anguiano, B., and Rojas, P. (2021). Variability in Behavioral Phenotypes after Forced Swimming-Induced Stress in Rats Is Associated with Expression of the Glucocorticoid Receptor, Nurr1, and Il-1beta in the Hippocampus. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222312700"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.neuropharm.2015.03.016","article-title":"Forced Swim Test: What About Females?","volume":"99","author":"Kokras","year":"2015","journal-title":"Neuropharmacology"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/10253890.2015.1013531","article-title":"Role of Nucleus of the Solitary Tract Noradrenergic Neurons in Post-Stress Cardiovascular and Hormonal Control in Male Rats","volume":"18","author":"Ghosal","year":"2015","journal-title":"Stress"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0006-8993(03)02543-5","article-title":"Quantification of Prolactin-Releasing Peptide (Prrp) Mrna Expression in Specific Brain Regions of the Rat during the Oestrous Cycle and in Lactation","volume":"973","author":"Anderson","year":"2003","journal-title":"Brain Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1210\/endo.142.5.8118","article-title":"Prolactin-Releasing Peptide as a Novel Stress Mediator in the Central Nervous System","volume":"142","author":"Maruyama","year":"2001","journal-title":"Endocrinology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1046\/j.1365-2826.2000.00428.x","article-title":"Prolactin-Releasing Peptide Is Expressed in Afferents to the Endocrine Hypothalamus, but Not in Neurosecretory Neurones","volume":"12","author":"Morales","year":"2000","journal-title":"J. Neuroendocrinol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0006-8993(86)91198-4","article-title":"A1 Noradrenergic Neurons Tonically Inhibit Sympathoexcitatory Neurons of C1 Area in Rat Brainstem","volume":"377","author":"Granata","year":"1986","journal-title":"Brain Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"172595","DOI":"10.1016\/j.ejphar.2019.172595","article-title":"Vulnerability to Stress Consequences Induced by Repeated Social Defeat in Rats: Contribution of the Angiotensin Ii Type 1 Receptor in Cardiovascular Alterations Associated to Low Brain Derived Neurotrophic Factor","volume":"861","author":"Brouillard","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Zahner, M.R., Hillard, K.J., and Chandley, M.C. (2024). The Role of the Dorsomedial Hypothalamus in the Cardiogenic Sympathetic Reflex in the Sprague Dawley Rat. Front. Physiol., 15.","DOI":"10.3389\/fphys.2024.1479892"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"R816","DOI":"10.1152\/ajpregu.00415.2014","article-title":"Blockade of the Dorsomedial Hypothalamus and the Perifornical Area Inhibits Respiratory Responses to Arousing and Stressful Stimuli","volume":"308","author":"Bondarenko","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.1460-9568.2009.07053.x","article-title":"Activation of Neurons in the Hypothalamic Dorsomedial Nucleus Via Hypothalamic Projections of the Nucleus of the Solitary Tract Following Refeeding of Fasted Rats","volume":"31","author":"Renner","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Teng, T., Fan, L., Yan, W., Li, X., Zhang, Y., Xiang, Y., Jiang, Y., Yuan, K., Yin, B., and Shi, L. (2022). A Diathesis-Stress Rat Model Induced Suicide-Implicated Endophenotypes and Prefrontal Cortex Abnormalities in the Pka and Gaba Receptor Signaling Pathways. Prog. Neuropsychopharmacol. Biol. Psychiatry, 116.","DOI":"10.1016\/j.pnpbp.2022.110538"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0026-895X(24)12500-X","article-title":"The Carboxyl Terminus of the Prolactin-Releasing Peptide Receptor Interacts with Pdz Domain Proteins Involved in Alpha-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptor Clustering","volume":"60","author":"Lin","year":"2001","journal-title":"Mol. Pharmacol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/cne.902740107","article-title":"Anatomical Specificity of Noradrenergic Inputs to the Paraventricular and Supraoptic Nuclei of the Rat Hypothalamus","volume":"274","author":"Cunningham","year":"1988","journal-title":"J. Comp. Neurol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/0006-8993(87)90722-0","article-title":"Neurons in the Paraventricular Nucleus Projecting to the Median Eminence: A Study of Their Afferent Connections from Peripheral Baroreceptors, and from the A1-Catecholaminergic Area in the Ventrolateral Medulla","volume":"409","author":"Kannan","year":"1987","journal-title":"Brain Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.yfrne.2011.08.002","article-title":"The Molecular Physiology of Crh Neurons","volume":"33","author":"Aguilera","year":"2012","journal-title":"Front. Neuroendocrinol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Chaves, T., Fazekas, C.L., Horvath, K., Correia, P., Szabo, A., Torok, B., Banrevi, K., and Zelena, D. (2021). Stress Adaptation and the Brainstem with Focus on Corticotropin-Releasing Hormone. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22169090"},{"key":"ref_53","first-page":"4718850","article-title":"A Hypothalamic Circuit for Circadian Regulation of Corticosterone Secretion","volume":"3","author":"Machado","year":"2024","journal-title":"Res. Sq."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Levit-Binnun, N., and Golland, Y. (2011). Finding Behavioral and Network Indicators of Brain Vulnerability. Front. Hum. Neurosci., 6.","DOI":"10.3389\/fnhum.2012.00010"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.bbi.2024.07.035","article-title":"Molecular Mechanisms Underlying Stress Vulnerability and Resilience in the Chronic Mild Stress Model: New Insights from Mrna and Mirnas Data Combining","volume":"121","author":"Cattane","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"109404","DOI":"10.1016\/j.neuropharm.2022.109404","article-title":"Lasting Impact of Postnatal Maternal Separation on the Developing Bnst: Lifelong Socioemotional Consequences","volume":"225","author":"Halladay","year":"2023","journal-title":"Neuropharmacology"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0006-8993(02)03183-9","article-title":"Neurochemical Properties of the Prolactin Releasing Peptide (Prrp) Receptor Expressing Neurons: Evidence for a Role of Prrp as a Regulator of Stress and Nociception","volume":"952","author":"Lin","year":"2002","journal-title":"Brain Res."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Vadovicova, K. (2014). Affective and Cognitive Prefrontal Cortex Projections to the Lateral Habenula in Humans. Front. Hum. Neurosci., 8.","DOI":"10.3389\/fnhum.2014.00819"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.biopsych.2017.10.032","article-title":"Identification of a Corticohabenular Circuit Regulating Socially Directed Behavior","volume":"83","author":"Benekareddy","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"eabj2225","DOI":"10.1126\/sciadv.abj2225","article-title":"Networks of Habenula-Projecting Cortical Neurons Regulate Cocaine Seeking","volume":"7","author":"Mathis","year":"2021","journal-title":"Sci. Adv."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e3511","DOI":"10.1002\/brb3.3511","article-title":"Modulation of Habenular and Nucleus Accumbens Functional Connectivity by Ketamine in Major Depression","volume":"14","author":"Taraku","year":"2024","journal-title":"Brain Behav."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1016\/j.neuron.2024.09.009","article-title":"Heightened Lateral Habenula Activity during Stress Produces Brainwide and Behavioral Substrates of Susceptibility","volume":"112","author":"Zhukovskaya","year":"2024","journal-title":"Neuron"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1038\/s41467-023-37601-x","article-title":"Lateral Septum Adenosine a(2a) Receptors Control Stress-Induced Depressive-Like Behaviors Via Signaling to the Hypothalamus and Habenula","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"148966","DOI":"10.1016\/j.gene.2024.148966","article-title":"Interleukin-11ralpha2 in the Hypothalamic Arcuate Nucleus Affects Depression-Related Behaviors and the Akt-Bdnf Pathway","volume":"933","author":"Yang","year":"2025","journal-title":"Gene"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/s41380-022-01872-5","article-title":"Increased Intrinsic and Synaptic Excitability of Hypothalamic Pomc Neurons Underlies Chronic Stress-Induced Behavioral Deficits","volume":"28","author":"Fang","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/s41380-019-0506-1","article-title":"A Pomc-Originated Circuit Regulates Stress-Induced Hypophagia, Depression, and Anhedonia","volume":"25","author":"Qu","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1159\/000054702","article-title":"In Vivo Release of Prolactin-Releasing Peptide in Rat Hypothalamus in Association with Luteinizing Hormone and Prolactin Surges","volume":"74","author":"Watanobe","year":"2001","journal-title":"Neuroendocrinology"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/BF02256021","article-title":"Effects of Prolactin-Releasing Peptide on Tuberoinfundibular Dopaminergic Neuronal Activity and Prolactin Secretion in Estrogen-Treated Female Rats","volume":"9","author":"Yuan","year":"2002","journal-title":"J. Biomed. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.neuropharm.2013.03.033","article-title":"Electroconvulsive Seizures Activate Anorexigenic Signals in the Ventromedial Nuclei of the Hypothalamus","volume":"71","author":"Sukeno","year":"2013","journal-title":"Neuropharmacology"},{"key":"ref_70","unstructured":"Paxinos, G., and Watson, C. (2014). The Rat Brain in Stereotaxic Coordinates, Academic Press."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative Pcr and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Konkoly, J., Kormos, V., Gaszner, B., Sandor, Z., Kecskes, A., Alomari, A., Szilagyi, A., Szilagyi, B., Zelena, D., and Pinter, E. (2021). The Role of Trpa1 Channels in the Central Processing of Odours Contributing to the Behavioural Responses of Mice. Pharmaceuticals, 14.","DOI":"10.3390\/ph14121336"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Nemes, B., Bolcskei, K., Kecskes, A., Kormos, V., Gaszner, B., Aczel, T., Hegedus, D., Pinter, E., Helyes, Z., and Sandor, Z. (2021). Human Somatostatin Sst(4) Receptor Transgenic Mice: Construction and Brain Expression Pattern Characterization. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22073758"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/9\/4155\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:22:53Z","timestamp":1760030573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/9\/4155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,27]]},"references-count":73,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["ijms26094155"],"URL":"https:\/\/doi.org\/10.3390\/ijms26094155","relation":{},"ISSN":["1422-0067"],"issn-type":[{"type":"electronic","value":"1422-0067"}],"subject":[],"published":{"date-parts":[[2025,4,27]]}}}