{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:50:25Z","timestamp":1791517825564,"version":"4.3.4"},"reference-count":37,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Clinical Specialty Construction Project","award":["81872525"],"award-info":[{"award-number":["81872525"]}]},{"name":"National Key Clinical Specialty Construction Project","award":["82173422"],"award-info":[{"award-number":["82173422"]}]},{"name":"National Key Clinical Specialty Construction Project","award":["82270070"],"award-info":[{"award-number":["82270070"]}]},{"name":"National Key Clinical Specialty Construction Project","award":["30302149001"],"award-info":[{"award-number":["30302149001"]}]},{"name":"National Natural Science Foundation of China","award":["81872525"],"award-info":[{"award-number":["81872525"]}]},{"name":"National Natural Science Foundation of China","award":["82173422"],"award-info":[{"award-number":["82173422"]}]},{"name":"National Natural Science Foundation of China","award":["82270070"],"award-info":[{"award-number":["82270070"]}]},{"name":"National Natural Science Foundation of China","award":["30302149001"],"award-info":[{"award-number":["30302149001"]}]},{"name":"Shanghai Shenkang Hospital Development Center Technical Standardization Management and Promotion Project","award":["81872525"],"award-info":[{"award-number":["81872525"]}]},{"name":"Shanghai Shenkang Hospital Development Center Technical Standardization Management and Promotion Project","award":["82173422"],"award-info":[{"award-number":["82173422"]}]},{"name":"Shanghai Shenkang Hospital Development Center Technical Standardization Management and Promotion Project","award":["82270070"],"award-info":[{"award-number":["82270070"]}]},{"name":"Shanghai Shenkang Hospital Development Center Technical Standardization Management and Promotion Project","award":["30302149001"],"award-info":[{"award-number":["30302149001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Pemphigus-associated interstitial lung disease (P-ILD) is a severe complication observed in pemphigus patients that is characterized by pulmonary interstitial inflammation and fibrosis. This study investigated the role of anti-desmoglein (Dsg) 1\/3 antibodies in P-ILD pathogenesis and evaluated the therapeutic potential of molecular hydrogen (H2). Using a BALB\/cJGpt mouse model, we demonstrated that anti-Dsg 1 antibodies, but not anti-Dsg 3 antibodies, induced interstitial inflammation and fibrosis. Immunofluorescence staining confirmed IgG deposition in the alveolar epithelium, suggesting immune complex formation and epithelial damage. Gene expression analysis revealed elevated pro-inflammatory cytokines (IL-1\u03b2, IL-13) and upregulated pro-fibrotic markers (\u03b1-SMA, S100A4, TGF-\u03b2, and collagen genes) in P-ILD progression. Elevated oxidative stress and impaired ROS metabolism further implied the role of oxidative damage in disease pathogenesis. To assess H2\u2019s therapeutic potential, hydrogen-rich water was administered to P-ILD mice. H2 treatment significantly reduced oxidative stress, attenuated interstitial inflammation, and prevented pulmonary fibrosis. These protective effects were attributed to H2\u2019s antioxidant properties, which restored the pro-oxidant\u2013antioxidant balance. Our findings underscore the critical role of anti-Dsg 1 antibodies and oxidative stress in P-ILD and highlight H2 as a promising therapeutic agent for mitigating anti-Dsg 1 antibody-induced lung injury.<\/jats:p>","DOI":"10.3390\/ijms26094203","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T07:49:36Z","timestamp":1745912976000},"page":"4203","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Molecular Hydrogen Ameliorates Anti-Desmoglein 1 Antibody-Induced Pemphigus-Associated Interstitial Lung Disease by Inhibiting Oxidative Stress"],"prefix":"10.3390","volume":"26","author":[{"given":"Chang","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Allergy & Immunology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Research Center of Allergy and Diseases, Fudan University, Shanghai 200437, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Allergy & Immunology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Research Center of Allergy and Diseases, Fudan University, Shanghai 200437, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Allergy & Immunology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Research Center of Allergy and Diseases, Fudan University, Shanghai 200437, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangguang","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200437, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9797-429X","authenticated-orcid":false,"given":"Yahui","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai 200437, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Allergy & Immunology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Research Center of Allergy and Diseases, Fudan University, Shanghai 200437, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqing","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Allergy & Immunology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Research Center of Allergy and Diseases, Fudan University, Shanghai 200437, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggong","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Allergy & Immunology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Research Center of Allergy and Diseases, Fudan University, Shanghai 200437, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Allergy & Immunology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Research Center of Allergy and Diseases, Fudan University, Shanghai 200437, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Allergy & Immunology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Research Center of Allergy and Diseases, Fudan University, Shanghai 200437, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenyuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Allergy & Immunology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Research Center of Allergy and Diseases, Fudan University, Shanghai 200437, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanping","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Allergy & Immunology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Research Center of Allergy and Diseases, Fudan University, Shanghai 200437, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-An","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Allergy & Immunology, Huashan Hospital, Fudan University, Shanghai 200437, China"},{"name":"Department of Dermatology, Huashan Hospital, Fudan 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0140-6736(19)31778-7","article-title":"Pemphigus","volume":"394","author":"Schmidt","year":"2019","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kasperkiewicz, M., Ellebrecht, C.T., Takahashi, H., Yamagami, J., Zillikens, D., Payne, A.S., and Amagai, M. 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