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Using the specific inhibitor imatinib and targeted RNA interference, we show that c-ABL is necessary for viral entry and subsequent ENV (DENV envelope protein) accumulation in infected cells. In addition, c-ABL targeting attenuates F-actin reorganization induced by DENV infection. Together with the involvement of c-ABL in endothelial dysfunction induced by DENV and host secreted factors, our findings strongly suggest that c-ABL is a potential host-targeted antiviral that could control DENV infection and\/or its evolution to more severe forms of the disease.<\/jats:p>","DOI":"10.3390\/ijms26094206","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T07:49:36Z","timestamp":1745912976000},"page":"4206","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Role of c-ABL in DENV-2 Infection and Actin Remodeling in Vero Cells"],"prefix":"10.3390","volume":"26","author":[{"given":"Grace Paola","family":"Carre\u00f1o-Fl\u00f3rez","sequence":"first","affiliation":[{"name":"Translational Medicine Group\u2014School of Medicine, Universidad de Antioquia, Medell\u00edn 050010, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra Milena","family":"Cuartas-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Translational Medicine Group\u2014School of Medicine, Universidad de Antioquia, Medell\u00edn 050010, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9800-5349","authenticated-orcid":false,"given":"Ryan L.","family":"Boudreau","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5943-3220","authenticated-orcid":false,"given":"Miguel","family":"Vicente-Manzanares","sequence":"additional","affiliation":[{"name":"Molecular Mechanisms Program, Centro de Investigaci\u00f3n del C\u00e1ncer, Instituto de Biolog\u00eda Molecular y Celular del C\u00e1ncer, Consejo Superior de Investigaciones Cient\u00edficas (CSIC)-University of Salamanca, 37007 Salamanca, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-2569","authenticated-orcid":false,"given":"Juan Carlos","family":"Gallego-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Translational Medicine Group\u2014School of Medicine, Universidad de Antioquia, Medell\u00edn 050010, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.7861\/clinmed.2021-0791","article-title":"Dengue infection: Global importance, immunopathology and management","volume":"22","author":"Kularatne","year":"2022","journal-title":"Clin. 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