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OP mainly results from alterations in the balance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation. Currently, there are several molecular mechanisms underlying the development of OP that are not entirely clear. One such mechanism is the role of long non-coding RNAs, which are key regulators of gene expression through various mechanisms. In the last decade, it has been shown that these molecules participate in multiple biological processes and play essential roles in the pathogenesis of different diseases. In this review, we address recent advances on the relationship of long non-coding RNAs with OP, mainly over their regulatory functions during osteoclastogenesis and osteogenesis. Furthermore, we analyze their potential application as clinical or therapeutic resources focused on OP.<\/jats:p>","DOI":"10.3390\/ijms26094273","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T07:00:21Z","timestamp":1745996421000},"page":"4273","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Regulatory Role of Long Non-Coding RNAs in the Development and Progression of Osteoporosis"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3976-4759","authenticated-orcid":false,"given":"Rogelio F.","family":"Jim\u00e9nez-Ortega","sequence":"first","affiliation":[{"name":"Cl\u00ednica Integral Universitaria (CIU), Universidad Estatal del Valle de Ecatepec (UNEVE), Ecatepec de Morelos 55210, Mexico"},{"name":"Programa Investigadoras e Investigadores, Consejo Mexiquense de Ciencia y Tecnolog\u00eda (COMECYT), Toluca 50120, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana I.","family":"Aparicio-Bautista","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00f3mica del Metabolismo \u00d3seo, Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN), Mexico City 14610, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Becerra-Cervera","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00f3mica del Metabolismo \u00d3seo, Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN), Mexico City 14610, Mexico"},{"name":"Secretar\u00eda de Ciencias, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n (SECIHTI), Ciudad de M\u00e9xico 03940, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra I.","family":"Ortega-Mel\u00e9ndez","sequence":"additional","affiliation":[{"name":"Unidad Acad\u00e9mica de Ciencias de la Salud, Universidad ETAC Campus Coacalco, Coacalco de Berrioz\u00e1bal 55700, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Pati\u00f1o","sequence":"additional","affiliation":[{"name":"Unidad de Citometr\u00eda de Flujo (UCiF), Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN), Mexico City 14610, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice","family":"Rivera-Paredez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Pol\u00edticas, Poblaci\u00f3n y Salud, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2506-8784","authenticated-orcid":false,"given":"Alberto","family":"Hidalgo-Bravo","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Gen\u00f3mica, Instituto Nacional de Rehabilitaci\u00f3n (INR), Mexico City 14389, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4515-0777","authenticated-orcid":false,"given":"Rafael","family":"Vel\u00e1zquez-Cruz","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00f3mica del Metabolismo \u00d3seo, Instituto Nacional de Medicina Gen\u00f3mica (INMEGEN), Mexico City 14610, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41413-019-0048-9","article-title":"Long noncoding RNAs: A missing link in osteoporosis","volume":"7","author":"Silva","year":"2019","journal-title":"Bone Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1007\/s00198-015-3154-6","article-title":"Burden of high fracture probability worldwide: Secular increases 2010\u20132040","volume":"26","author":"McCloskey","year":"2015","journal-title":"Osteoporos. 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