{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:37:46Z","timestamp":1789213066499,"version":"build-2803163510"},"reference-count":164,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Natural Science Foundation of China","award":["82260940"],"award-info":[{"award-number":["82260940"]}]},{"name":"the National Natural Science Foundation of China","award":["2024Y404"],"award-info":[{"award-number":["2024Y404"]}]},{"name":"the Scientific Research Foundation of Yunnan Provincial Education Department","award":["82260940"],"award-info":[{"award-number":["82260940"]}]},{"name":"the Scientific Research Foundation of Yunnan Provincial Education Department","award":["2024Y404"],"award-info":[{"award-number":["2024Y404"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Psoriasis and atopic dermatitis (AD) are both chronic inflammatory skin diseases. Their pathogenesis remains incompletely understood. The polarization states of macrophages, as a crucial part of the innate immune system, are influenced by various factors such as cytokines, inflammatory mediators, and epigenetics. Research has demonstrated that macrophages play a \u201cdouble-edged sword\u201d role in the pathological process of inflammatory skin diseases: they both drive inflammation progression and participate in tissue repair. This article summarizes the roles of macrophages in the inflammatory development and tissue homeostasis of psoriasis and atopic dermatitis. It explores the impact of different factors on macrophages and inflammatory skin diseases. In conclusion, understanding the classification and plasticity of macrophages is crucial for a deeper understanding of the pathogenesis of psoriasis and AD and the development of personalized treatments.<\/jats:p>","DOI":"10.3390\/ijms26094287","type":"journal-article","created":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T09:16:12Z","timestamp":1746090972000},"page":"4287","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Decoding Macrophage Dynamics: A Pathway to Understanding and Treating Inflammatory Skin Diseases"],"prefix":"10.3390","volume":"26","author":[{"given":"Shengliang","family":"Gu","sequence":"first","affiliation":[{"name":"The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China"},{"name":"Yunnan Provincial Clinical Medical Centre for Traditional Chinese Medicine Project (Dermatology), Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5486-7924","authenticated-orcid":false,"given":"Bin","family":"Huang","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Xiong","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Guizhou University of Chinese Medicine, Guiyang 550025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuesong","family":"Yang","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China"},{"name":"Yunnan Provincial Clinical Medical Centre for Traditional Chinese Medicine Project (Dermatology), Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhou","family":"Ye","sequence":"additional","affiliation":[{"name":"The First School of Clinical Medicine, Yunnan University of Chinese Medicine, Kunming 650500, China"},{"name":"Yunnan Provincial Clinical Medical Centre for Traditional Chinese Medicine Project (Dermatology), Kunming 650500, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/bjd.19580","article-title":"The global burden of atopic dermatitis: Lessons from the Global Burden of Disease Study 1990\u20132017","volume":"184","author":"Laughter","year":"2021","journal-title":"Br. 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