{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T11:06:51Z","timestamp":1783508811918,"version":"3.55.0"},"reference-count":50,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82370944"],"award-info":[{"award-number":["82370944"]}]},{"name":"National Natural Science Foundation of China","award":["82401087"],"award-info":[{"award-number":["82401087"]}]},{"name":"National Natural Science Foundation of China","award":["2024A1515013047"],"award-info":[{"award-number":["2024A1515013047"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["82370944"],"award-info":[{"award-number":["82370944"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["82401087"],"award-info":[{"award-number":["82401087"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2024A1515013047"],"award-info":[{"award-number":["2024A1515013047"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Severe dental pulp inflammation can lead to tissue lysis and destruction, underscoring the necessity for effective treatment of pulpitis. N-acetyltransferase 10 (NAT10)-mediated N4-acetylcytidine (ac4C) modification has recently emerged as a key regulator in inflammatory processes. However, whether NAT10 affects the inflammatory response in human dental pulp stem cells (hDPSCs) remains unelucidated. In this study, elevated NAT10 expression was observed in pulpitis tissues and LPS-stimulated hDPSCs. Knockdown of NAT10 led to reduced inflammatory gene expression and lower reactive oxygen species (ROS) production in LPS-stimulated hDPSCs, while the chemotactic migration of macrophages was also suppressed. Similar results were observed when hDPSCs were treated with Remodelin, an inhibitor of NAT10. Differentially expressed genes identified through RNA sequencing were significantly enriched in inflammatory signaling pathways after NAT10 depletion. Among the differential genes, pentraxins 3 (PTX3) was identified as the potential target gene due to the presence of the ac4C modification site and its known ability to regulate dental pulp inflammation. The mRNA and protein levels of PTX3 were reduced in NAT10-deficient cells, along with a decrease in its mRNA stability. Exogenous PTX3 supplementation partially reversed the inflammatory inhibition induced by NAT10 knockdown. Further evidence in vivo revealed that Remodelin treatment attenuated the severity of dental pulp inflammation in rats with pulpitis. In summary, these data indicated that NAT10 deficiency inhibited the stability of PTX3 mRNA and further inhibited hDPSC inflammation, while Remodelin might be a potential therapeutic agent for pulp capping.<\/jats:p>","DOI":"10.3390\/ijms26094325","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T07:44:58Z","timestamp":1746171898000},"page":"4325","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["NAT10 Regulates LPS-Induced Inflammation via Stabilization of N4-Acetylated PTX3 mRNA in Human Dental Pulp Stem Cells"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-6050","authenticated-orcid":false,"given":"Zihan","family":"Ni","sequence":"first","affiliation":[{"name":"Hospital of Stomatology, Sun Yat-sen University, 56# Lingyuan West Road, Guangzhou 510055, China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China"},{"name":"Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luhui","family":"Cai","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Sun Yat-sen University, 56# Lingyuan West Road, Guangzhou 510055, China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China"},{"name":"Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Chen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Sun Yat-sen University, 56# Lingyuan West Road, Guangzhou 510055, China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China"},{"name":"Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5121-6628","authenticated-orcid":false,"given":"Wenqian","family":"Ding","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Sun Yat-sen University, 56# Lingyuan West Road, Guangzhou 510055, China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China"},{"name":"Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Tian","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Sun Yat-sen University, 56# Lingyuan West Road, Guangzhou 510055, China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China"},{"name":"Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Li","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Sun Yat-sen University, 56# Lingyuan West Road, Guangzhou 510055, China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China"},{"name":"Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7448-6723","authenticated-orcid":false,"given":"Qiong","family":"Xu","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, Sun Yat-sen University, 56# Lingyuan West Road, Guangzhou 510055, China"},{"name":"Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China"},{"name":"Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10753-023-01910-6","article-title":"LIF Aggravates Pulpitis by Promoting Inflammatory Response in Macrophages","volume":"47","author":"Guo","year":"2024","journal-title":"Inflammation"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Chang, M.C., Chang, S.H., Tsai, Y.L., Pan, Y.H., Yeung, S.Y., Chang, H.H., and Jeng, J.H. 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