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Photothermal therapy (PTT) offers an innovative method for tumor treatment, leveraging photothermal agents to convert light into hyperthermia, ultimately leading to tumor ablation. PTT offers unique advantages in treating oral cancer due to its superficial anatomical location and consequent accessibility to laser irradiation. PTT\u2019s advantage is further enhanced by its capacity to facilitate drug release and promote tissue regeneration. Consequently, the application of PTT for oral cancer has garnered widespread interest and has undergone rapid development. This review outlines advances in PTT for oral cancer, emphasizing strategies to improve efficacy and combination therapy approaches. The key challenges, including temperature control and long-term biosafety, are discussed alongside future directions. The review also encompasses PTT\u2019s role in managing oral potentially malignant disorders and postoperative defects, conditions intimately linked with oral cancer. We aim to provide guidance for emerging PTT research in oral cancer and to promote the development of precise and efficient treatment strategies.<\/jats:p>","DOI":"10.3390\/ijms26094344","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:28:11Z","timestamp":1746174491000},"page":"4344","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Advances in Photothermal Therapy for Oral Cancer"],"prefix":"10.3390","volume":"26","author":[{"given":"Jian","family":"Liang","sequence":"first","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Jiangxi Provincial Key Laboratory of Oral Diseases, Nanchang 330006, China"},{"name":"Jiangxi Provincial Clinical Research Center for Oral Diseases, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Jiangxi Provincial Key Laboratory of Oral Diseases, Nanchang 330006, China"},{"name":"Jiangxi Provincial Clinical Research Center for Oral Diseases, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Jiangxi Provincial Key Laboratory of Oral Diseases, Nanchang 330006, China"},{"name":"Jiangxi Provincial Clinical Research Center for Oral Diseases, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9500-8667","authenticated-orcid":false,"given":"Ao","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Jiangxi Provincial Key Laboratory of Oral Diseases, Nanchang 330006, China"},{"name":"Jiangxi Provincial Clinical Research Center for Oral Diseases, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Tong","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Jiangxi Provincial Key Laboratory of Oral Diseases, Nanchang 330006, China"},{"name":"Jiangxi Provincial Clinical Research Center for Oral Diseases, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Li","sequence":"additional","affiliation":[{"name":"School of Stomatology, Jiangxi Medical College, Nanchang University, Nanchang 330006, China"},{"name":"Jiangxi Provincial Key Laboratory of Oral Diseases, Nanchang 330006, China"},{"name":"Jiangxi Provincial Clinical Research Center for Oral Diseases, Nanchang 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jormas.2019.02.004","article-title":"Quality of life related to oral health and its impact in adults","volume":"120","author":"Spanemberg","year":"2019","journal-title":"J. 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