{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:26:36Z","timestamp":1790310396574,"version":"4.1.0"},"reference-count":51,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This work was supported by the University of Medicine, Pharmacy, Science and Technology \u201cGeorge Emil Palade\u201d of Targu Mures","award":["510\/15\/17.01.2022"],"award-info":[{"award-number":["510\/15\/17.01.2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>(1) The link between periodontal disease (PD) and acute coronary syndromes (ACSs) is predominantly attributed to the atherosclerotic process, mediated by systemic inflammation. However, the correlation between the severity of PD, characterized by the presence of periodontal pathogens, and systemic inflammation in patients with ACS remains inadequately clarified. (2) This study aims to assess the association between the severity of PD and systemic inflammatory biomarkers, along with lipid profiles, in patients with ACS. (3) In total, 42 patients with ACS and concomitant PD were divided into two groups based on the presence of periodontal pathogens belonging to the red or red-orange complexes. Group 1\u201329 patients displayed pathogens from the red complex (RC) and group 2\u201313 patients displayed pathogens from the red-orange complex (ROC). All participants underwent a comprehensive dental examination, including DNA sampling from the periodontal pockets for pathogen detection. Systemic inflammation was evaluated alongside assessments of lipid profiles. (4) Inflammatory markers were more pronounced in the RC group compared with the ROC group. Moreover, patients in the RC group showed significantly higher monocyte-to-lymphocyte ratios (0.41 \u00b1 0.20 vs. 0.28 \u00b1 0.12; p = 0.002), platelet-to-lymphocyte ratios (139.50 \u00b1 33.85 vs. 100.90 \u00b1 8.84; p = 0.02), serum C-reactive protein levels (9.34 \u00b1 1.08 mg\/L vs. 5.46 \u00b1 1.03 mg\/L; p = 0.03), and serum uric acid levels (6.9 \u00b1 0.49 mg\/dL vs. 5.4 \u00b1 0.26 mg\/dL; p = 0.006). Concerning lipid profiles, the RC group exhibited significantly higher low-density lipoprotein cholesterol (LDL) levels (169.60 \u00b1 12.63 mg\/dL vs. 106.70 \u00b1 9.34 mg\/dL; p = 0.0007) and significantly lower high-density lipoprotein cholesterol (HDL) levels (29.29 \u00b1 3.50 mg\/dL vs. 39.56 \u00b1 2.07 mg\/dL; p = 0.002). (5) The severity of PD, indicated by the concomitant presence of pathogens from the red and orange complexes, is associated with an unfavorable lipid profile and elevated inflammatory biomarkers. These findings highlight the potential importance of periodontal intervention in the prevention of ACS.<\/jats:p>","DOI":"10.3390\/ijms26094360","type":"journal-article","created":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T20:10:27Z","timestamp":1746389427000},"page":"4360","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Periodontal Pathogens and Inflammation in Patients with Acute Coronary Syndromes"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7234-0088","authenticated-orcid":false,"given":"Ioana-Patricia","family":"Rodean","sequence":"first","affiliation":[{"name":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"},{"name":"Cardiology Department, Emergency Clinical County Hospital of Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6793-9248","authenticated-orcid":false,"given":"Vasile-Bogdan","family":"Hala\u021biu","sequence":"additional","affiliation":[{"name":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"},{"name":"Cardiology Department, Emergency Clinical County Hospital of Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodora Maria","family":"Popa","sequence":"additional","affiliation":[{"name":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"},{"name":"Cardiology Department, Emergency Clinical County Hospital of Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel","family":"Bl\u00eendu","sequence":"additional","affiliation":[{"name":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"},{"name":"Cardiology Department, Emergency Clinical County Hospital of Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9196-4491","authenticated-orcid":false,"given":"Theofana","family":"Mih\u0103il\u0103","sequence":"additional","affiliation":[{"name":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"},{"name":"Cardiology Department, Emergency Clinical County Hospital of Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"\u021aolescu","sequence":"additional","affiliation":[{"name":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"},{"name":"Cardiology Department, Emergency Clinical County Hospital of Targu Mures, 540136 Targu Mures, Romania"},{"name":"Center of Advanced Research in Multimodality Cardiac Imaging, CardioMed Medical Center, 540124 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0233-1677","authenticated-orcid":false,"given":"Andrei","family":"Modiga","sequence":"additional","affiliation":[{"name":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"},{"name":"Emergency Department, Emergency Clinical County Hospital of Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imre","family":"Benedek","sequence":"additional","affiliation":[{"name":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"},{"name":"Cardiology Department, Emergency Clinical County Hospital of Targu Mures, 540136 Targu Mures, Romania"},{"name":"Center of Advanced Research in Multimodality Cardiac Imaging, CardioMed Medical Center, 540124 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodora","family":"Benedek","sequence":"additional","affiliation":[{"name":"George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania"},{"name":"Cardiology Department, Emergency Clinical County Hospital of Targu Mures, 540136 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1002\/JPER.19-0723","article-title":"Periodontal disease classifications and incident coronary heart disease in the Atherosclerosis Risk in Communities study","volume":"91","author":"Beck","year":"2020","journal-title":"J. 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