{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:23:57Z","timestamp":1777591437547,"version":"3.51.4"},"reference-count":51,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T00:00:00Z","timestamp":1746576000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute on Minority Health and Health Disparities","award":["P20 MD000170"],"award-info":[{"award-number":["P20 MD000170"]}]},{"name":"National Institute on Minority Health and Health Disparities","award":["1U54RR023417-01"],"award-info":[{"award-number":["1U54RR023417-01"]}]},{"name":"National Institute on Minority Health and Health Disparities","award":["R01 DK127084"],"award-info":[{"award-number":["R01 DK127084"]}]},{"name":"National Center for Research Resources","award":["P20 MD000170"],"award-info":[{"award-number":["P20 MD000170"]}]},{"name":"National Center for Research Resources","award":["1U54RR023417-01"],"award-info":[{"award-number":["1U54RR023417-01"]}]},{"name":"National Center for Research Resources","award":["R01 DK127084"],"award-info":[{"award-number":["R01 DK127084"]}]},{"name":"NIH","award":["P20 MD000170"],"award-info":[{"award-number":["P20 MD000170"]}]},{"name":"NIH","award":["1U54RR023417-01"],"award-info":[{"award-number":["1U54RR023417-01"]}]},{"name":"NIH","award":["R01 DK127084"],"award-info":[{"award-number":["R01 DK127084"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Research on the relationship between resistin levels, metabolic health, and obesity has produced inconsistent findings across different ethnic groups, making it unclear whether lower resistin levels are associated with these conditions in Mexican-Americans. This cross-sectional study investigated the relationship between resistin, metabolic health, and obesity in an adult Mexican-American cohort (n = 1511) using multivariable linear regression analysis. Related adipokines (leptin and adiponectin) were measured simultaneously. Participants were categorized into four groups by metabolic health (healthy\/unhealthy) and obesity (obese\/non-obese) status. \u201cMetabolically unhealthy\u201d was defined as \u22652 cardiometabolic abnormalities. Obesity was defined as a BMI \u2265 30 kg\/m2. We also investigated the associations of related proinflammatory cytokines, demographic\/anthropometric variables, and medications with each outcome variable of interest. The results showed no statistically significant differences in resistin levels between the groups. Leptin was higher and adiponectin was lower in groups with obesity and\/or metabolically unhealthy status. The resistin findings contrast studies in other populations, while other leptin and adiponectin findings confirm those seen in many ethnic groups. Thiazolidinedione use was associated with lower resistin, confirming earlier research. These findings suggest that resistin\u2019s role in metabolic health may be different in Mexican-Americans compared to other populations.<\/jats:p>","DOI":"10.3390\/ijms26094443","type":"journal-article","created":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T08:20:53Z","timestamp":1746606053000},"page":"4443","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Association of Resistin with Metabolic Health and Obesity in a Mexican-American Population"],"prefix":"10.3390","volume":"26","author":[{"given":"Reem","family":"Al-Dallal","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The University of Texas Health Science Center, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2783-2662","authenticated-orcid":false,"given":"Keziah","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The University of Texas Health Science Center, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4329-506X","authenticated-orcid":false,"given":"MinJae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Health Data Science & Biostatistics, Peter O\u2019Donnell Jr. School of Public Health, University of Texas Southwestern, Dallas, TX 75390, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aysha","family":"Chaudhri","sequence":"additional","affiliation":[{"name":"Department of Endocrine Neoplasia and Hormonal Disorders, Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The University of Texas Health Science Center, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Vaidya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The University of Texas Health Science Center, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4088-304X","authenticated-orcid":false,"given":"Miryoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Brownsville Regional Campus, Brownsville, TX 78520, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph B.","family":"McCormick","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Brownsville Regional Campus, Brownsville, TX 78520, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan P.","family":"Fisher-Hoch","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Brownsville Regional Campus, Brownsville, TX 78520, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Absalon D.","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, The University of Texas Health Science Center, Houston, TX 77030, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35053000","article-title":"The hormone resistin links obesity to diabetes","volume":"409","author":"Steppan","year":"2001","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3904\/kjim.2016.229","article-title":"Linking resistin, inflammation, and cardiometabolic diseases","volume":"32","author":"Park","year":"2017","journal-title":"Korean J. 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