{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:20:58Z","timestamp":1780514458179,"version":"3.54.1"},"reference-count":72,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ANSES"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Electromagnetic hyper-sensitivity (EHS) and its causal link with radio-frequencies raise a major question of public health. In the frame of the clinical study DEMETER, 26 adult volunteers self-diagnosed as EHS-positive agreed to reply to a self-assessment questionnaire and to provide a skin biopsy sampling to establish a primary fibroblast cell line. The questionnaire and the biological data revealed, independently, 2 subsets of donors associated each with a low background, highly responsive (LBHR) and a high background, lowly responsive (HBLR) phenotype. A couple of subsets based on questionnaire data and based on the yield of spontaneous DNA double-strand breaks were found to be composed of the same donors at 64% identity. After exposure to X-rays, and application of anti-\u03b3H2AX, pATM, and MRE11 immunofluorescence, all the DEMETER fibroblasts (26\/26) elicited a delayed radiation-induced ATM nucleoshuttling (RIANS). The use of RIANS biomarkers showed that the 2 phenotypes described above corresponded to DEMETER donors with a high risk of cancer (LBHR) or high risk of accelerated aging (HBLR). By exposing DEMETER cells to H2O2 followed by an antioxidative agent, we confirmed that EHS may be related to the management of DNA strand breaks. A preliminary molecular model of EHS inspired by the RIANS model was proposed.<\/jats:p>","DOI":"10.3390\/ijms26104792","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T10:24:02Z","timestamp":1747391042000},"page":"4792","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Skin Fibroblasts from Individuals Self-Diagnosed as Electrosensitive Reveal Two Distinct Subsets with Delayed Nucleoshuttling of the ATM Protein in Common"],"prefix":"10.3390","volume":"26","author":[{"given":"Laur\u00e8ne","family":"Sonzogni","sequence":"first","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche (UMR)1296 \u00abRadiation: Defense, Health, Environment\u00bb, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre L\u00e9on-B\u00e9rard, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6772-6947","authenticated-orcid":false,"given":"Jo\u00eblle","family":"Al-Choboq","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche (UMR)1296 \u00abRadiation: Defense, Health, Environment\u00bb, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre L\u00e9on-B\u00e9rard, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Combemale","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche (UMR)1296 \u00abRadiation: Defense, Health, Environment\u00bb, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre L\u00e9on-B\u00e9rard, 69008 Lyon, France"},{"name":"Department of Dermatology, Centre L\u00e9on-B\u00e9rard, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Massardier-Pilonch\u00e9ry","sequence":"additional","affiliation":[{"name":"University Claude-Bernard Lyon 1, University Gustave-Eiffel, Unit\u00e9 Mixte de Recherche Epid\u00e9miologique et de Surveillance Transport Travail Environnement (UMRESTTE), UMR_T9405, 690008 Lyon, France"},{"name":"Department of Occupational Medicine and Occupational Diseases, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, 90008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7228-8830","authenticated-orcid":false,"given":"Audrey","family":"Bouchet","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche (UMR)1296 \u00abRadiation: Defense, Health, Environment\u00bb, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre L\u00e9on-B\u00e9rard, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"May","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 1 Place du G\u00e9n\u00e9rale Val\u00e9rie Andr\u00e9, BP 40073, 91223 Br\u00e9tigny-sur-Orge, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Dor\u00e9","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche (UMR)1296 \u00abRadiation: Defense, Health, Environment\u00bb, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Centre L\u00e9on-B\u00e9rard, 69008 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Debouzy","sequence":"additional","affiliation":[{"name":"Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 1 Place du G\u00e9n\u00e9rale Val\u00e9rie Andr\u00e9, BP 40073, 91223 Br\u00e9tigny-sur-Orge, 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