{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T21:22:27Z","timestamp":1780521747277,"version":"3.54.1"},"reference-count":112,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI20\/0471"],"award-info":[{"award-number":["PI20\/0471"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Myo-inositol-1,2,3,4,5,6-hexakisphosphate (IP6) is commonly found in plant-derived foods and has important pharmacological properties against many pathologies. One of them appears to be neurodegeneration, which is notably stimulated by dysregulated metal metabolism. Consequently, we explore the role of IP6 in mitigating neurodegenerative events catalyzed by dysregulated free iron. More precisely, we performed spectrophotometric measurements in aqueous solutions to investigate the ability of IP6 to chelate Fe3+ and inhibit its role in catalyzing the oxidative degradation of dopamine and ascorbic acid, two key molecules in neuronal redox systems. Our results demonstrate that IP6 effectively prevents the formation of harmful intermediates, such as neuromelanin and reactive oxygen species, which are linked to neuronal damage. Additionally, we assessed the effect of IP6 on Fe3+-induced protein aggregation, focusing on \u03b1-synuclein, which is closely associated with Parkinson\u2019s disease. Our data reveal that IP6 accelerates the conversion of toxic \u03b1-synuclein oligomers into less harmful amyloid fibrils, thereby reducing their neurotoxic potential. Our findings highlight the dual function of IP6 as a potent Fe3+ chelator and modulator of protein aggregation pathways, reinforcing its potential as a neuroprotective agent. Consequently, IP6 offers promising therapeutic potential for mitigating the progression of neurodegenerative disorders such as Parkinson\u2019s and Alzheimer\u2019s diseases.<\/jats:p>","DOI":"10.3390\/ijms26104799","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T07:34:03Z","timestamp":1747640043000},"page":"4799","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["On the Potential Role of Phytate Against Neurodegeneration: It Protects Against Fe3+-Catalyzed Degradation of Dopamine and Ascorbate and Against Fe3+-Induced Protein Aggregation"],"prefix":"10.3390","volume":"26","author":[{"given":"Samantha Rebeca","family":"Godoy","sequence":"first","affiliation":[{"name":"Interdisciplinary Group on Neurodegeneration, Vascular and Metabolic Diseases (INNoVAM), Departament de Qu\u00edmica, Universitat de les Illes Balears, Ctra. Valldemossa km 7.5, E-07122 Palma de Mallorca, Spain"},{"name":"Health Research Institute of the Balearic Islands (IdISBa), Ctra. Valldemossa 79, E-07010 Palma de Mallorca, Spain"},{"name":"Institut Universitari d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa km 7.5, E-07122 Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8565-1811","authenticated-orcid":false,"given":"Pilar","family":"Sanchis","sequence":"additional","affiliation":[{"name":"Interdisciplinary Group on Neurodegeneration, Vascular and Metabolic Diseases (INNoVAM), Departament de Qu\u00edmica, Universitat de les Illes Balears, Ctra. Valldemossa km 7.5, E-07122 Palma de Mallorca, Spain"},{"name":"Health Research Institute of the Balearic Islands (IdISBa), Ctra. Valldemossa 79, E-07010 Palma de Mallorca, Spain"},{"name":"Institut Universitari d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa km 7.5, E-07122 Palma de Mallorca, Spain"},{"name":"CIBER Fisiopatolog\u00eda de la Obesidad y Nutrici\u00f3n (CIBERObn), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2562-9975","authenticated-orcid":false,"given":"Juan","family":"Frau","sequence":"additional","affiliation":[{"name":"Interdisciplinary Group on Neurodegeneration, Vascular and Metabolic Diseases (INNoVAM), Departament de Qu\u00edmica, Universitat de les Illes Balears, Ctra. Valldemossa km 7.5, E-07122 Palma de Mallorca, Spain"},{"name":"Health Research Institute of the Balearic Islands (IdISBa), Ctra. Valldemossa 79, E-07010 Palma de Mallorca, Spain"},{"name":"Institut Universitari d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa km 7.5, E-07122 Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9464-9238","authenticated-orcid":false,"given":"Bartolom\u00e9","family":"Vilanova","sequence":"additional","affiliation":[{"name":"Interdisciplinary Group on Neurodegeneration, Vascular and Metabolic Diseases (INNoVAM), Departament de Qu\u00edmica, Universitat de les Illes Balears, Ctra. Valldemossa km 7.5, E-07122 Palma de Mallorca, Spain"},{"name":"Health Research Institute of the Balearic Islands (IdISBa), Ctra. Valldemossa 79, E-07010 Palma de Mallorca, Spain"},{"name":"Institut Universitari d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa km 7.5, E-07122 Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4211-9013","authenticated-orcid":false,"given":"Miquel","family":"Adrover","sequence":"additional","affiliation":[{"name":"Interdisciplinary Group on Neurodegeneration, Vascular and Metabolic Diseases (INNoVAM), Departament de Qu\u00edmica, Universitat de les Illes Balears, Ctra. Valldemossa km 7.5, E-07122 Palma de Mallorca, Spain"},{"name":"Health Research Institute of the Balearic Islands (IdISBa), Ctra. Valldemossa 79, E-07010 Palma de Mallorca, Spain"},{"name":"Institut Universitari d\u2019Investigaci\u00f3 en Ci\u00e8ncies de la Salut (IUNICS), Universitat de les Illes Balears, Ctra. Valldemossa km 7.5, E-07122 Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"110284","DOI":"10.1016\/j.foodres.2021.110284","article-title":"Review of the beneficial and anti-nutritional qualities of phytic acid, and procedures for removing it from food products","volume":"143","author":"Feizollahi","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"105856","DOI":"10.1016\/j.jff.2023.105856","article-title":"Neuroprotection of phytic acid in Parkinson\u2019s and Alzheimer\u2019s disease","volume":"110","author":"Chen","year":"2023","journal-title":"J. Funct. 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