{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:19:38Z","timestamp":1790601578745,"version":"4.1.0"},"reference-count":111,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T00:00:00Z","timestamp":1747440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004329","name":"Slovenian Research and Innovation Agency (ARIS) research project","doi-asserted-by":"publisher","award":["J3-2530"],"award-info":[{"award-number":["J3-2530"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004329","name":"Slovenian Research and Innovation Agency (ARIS) research project","doi-asserted-by":"publisher","award":["TP20240126"],"award-info":[{"award-number":["TP20240126"]}],"id":[{"id":"10.13039\/501100004329","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Medical Centre Ljubljana","award":["J3-2530"],"award-info":[{"award-number":["J3-2530"]}]},{"name":"University Medical Centre Ljubljana","award":["TP20240126"],"award-info":[{"award-number":["TP20240126"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Bisphenol A (BPA) is a high-production-volume industrial chemical and component of commonly used plastic products. However, it is also an endocrine-disrupting chemical that can negatively affect human health. It is not yet known whether it is associated with the development of epithelial ovarian cancer (EOC), a severe and highly fatal human disease. Therefore, the purpose of this study was to determine the concentrations of BPA in the urine of women with EOC or epithelial borderline ovarian tumors (EBOTs) using gas chromatography tandem mass spectrometry (GC-MS\/MS) and find their possible associations with kidney function at the molecular level, urine and blood biochemical parameters related to metabolism, anti-M\u00fcllerian hormone (AMH) (a marker of ovarian reserve\/fertility), and lifestyle habits determined via a questionnaire in comparison to healthy controls. The results suggest that the unadjusted or urine-specific-gravity-adjusted BPA levels were significantly increased in women with EOC\/EBOT. The unadjusted BPA was significantly positively associated with urinary creatinine (p = 0.007) in all women with EOC\/EBOT after adjustment for age, body mass index, and pregnancy using multiple linear regression analysis. This may be related to kidney injury. However, no association was found between urinary BPA and serum AMH levels in women. Women with ovarian malignancies were more exposed to plastic products for storing foods and drinks. Some lifestyle habits, including refilling plastic bottles, correlate with higher urinary BPA levels across the entire cohort of women. When considering EOC or EBOT, it is necessary to consider the potential higher exposure of women to BPA, as reflected in their urine and lifestyle habits.<\/jats:p>","DOI":"10.3390\/ijms26104811","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T07:34:03Z","timestamp":1747640043000},"page":"4811","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Bisphenol A in the Urine: Association with Urinary Creatinine, Impaired Kidney Function, Use of Plastic Food and Beverage Storage Products but Not with Serum Anti-M\u00fcllerian Hormone in Ovarian Malignancies"],"prefix":"10.3390","volume":"26","author":[{"given":"Mateja","family":"Sladi\u010d","sequence":"first","affiliation":[{"name":"Division of Gynaecology and Obstetrics, University Medical Centre, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9698-2130","authenticated-orcid":false,"given":"\u0160pela","family":"Smrkolj","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Obstetrics, University Medical Centre, 1000 Ljubljana, Slovenia"},{"name":"Medical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gorazd","family":"Kav\u0161ek","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Obstetrics, University Medical Centre, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senka","family":"Imamovic-Kumalic","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Obstetrics, University Medical Centre, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6249-5799","authenticated-orcid":false,"given":"Ivan","family":"Verdenik","sequence":"additional","affiliation":[{"name":"Division of Gynaecology and Obstetrics, University Medical Centre, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma","family":"Virant-Klun","sequence":"additional","affiliation":[{"name":"Clinical Research Centre, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,17]]},"reference":[{"key":"ref_1","first-page":"209","article-title":"Bisphenol A\u2014Application, sources of exposure and potential risks in infants, children and pregnant women","volume":"28","author":"Stragierowicz","year":"2015","journal-title":"Int. J. Occup. Med. Environ. Health"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.reprotox.2007.07.010","article-title":"Human exposure to bisphenol A (BPA)","volume":"24","author":"Vandenberg","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1016\/j.fct.2012.07.059","article-title":"A review of dietary and non-dietary exposure to bisphenol-A","volume":"50","author":"Geens","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1080\/10408444.2019.1701986","article-title":"Substitution of bisphenol A: A review of the carcinogenicity, reproductive toxicity, and endocrine disruption potential of alternative substances","volume":"50","author":"Hessel","year":"2020","journal-title":"Crit. Rev. Toxicol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1515\/reveh-2019-0034","article-title":"A review on sources and health impacts of bisphenol A","volume":"35","author":"Abraham","year":"2020","journal-title":"Rev. Environ. Health"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.envres.2018.09.004","article-title":"Urinary bisphenol A in children, mothers and fathers from Slovenia: Overall results and determinants of exposure","volume":"168","author":"Kosjek","year":"2019","journal-title":"Environ. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/23337931.2018.1476869","article-title":"Presence and leaching of bisphenol a (BPA) from dental materials","volume":"4","author":"Becher","year":"2018","journal-title":"Acta Biomater. Odontol. Scand."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Buoso, E., Masi, M., Limosani, R.V., Oliviero, C., Saeed, S., Iulini, M., Passoni, F.C., Racchi, M., and Corsini, E. (2025). Endocrine Disrupting Toxicity of Bisphenol A and Its Analogs: Implications in the Neuro-Immune Milieu. J. Xenobiot., 15.","DOI":"10.3390\/jox15010013"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s42834-024-00219-9","article-title":"Human metabolic effects of BPA and the application of a hybrid photocatalytic membrane for BPA contaminated water","volume":"34","author":"Kamaludin","year":"2024","journal-title":"Sustain. Environ. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"122073","DOI":"10.1016\/j.envpol.2023.122073","article-title":"Single and multispecies microalgae toxicological tests assessing the impact of several BPA analogues used by industry","volume":"333","author":"Sendra","year":"2023","journal-title":"Environ. Pollut."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.gene.2018.01.016","article-title":"The molecular mechanisms of action of the endocrine disrupting chemical bisphenol A in the development of cancer","volume":"647","author":"Shafei","year":"2018","journal-title":"Gene"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Manzoor, M.F., Tariq, T., Fatima, B., Sahar, A., Tariq, F., Munir, S., Khan, S., Nawaz Ranjha, M.M.A., Sameen, A., and Zeng, X.A. (2022). An insight into bisphenol A, food exposure and its adverse effects on health: A review. Front. Nutr., 9.","DOI":"10.3389\/fnut.2022.1047827"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.chemosphere.2010.09.058","article-title":"Viable skin efficiently absorbs and metabolizes bisphenol A","volume":"82","author":"Zalko","year":"2011","journal-title":"Chemosphere"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12940-016-0131-2","article-title":"Direct measurement of Bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: A cross-sectional study","volume":"15","author":"Gerona","year":"2016","journal-title":"Environ. Health"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1289\/ehp.10753","article-title":"Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003\u20132004","volume":"116","author":"Calafat","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1476-069X-11-10","article-title":"Social disparities in exposures to bisphenol A and polyfluoroalkyl chemicals: A cross-sectional study within NHANES 2003\u20132006","volume":"11","author":"Nelson","year":"2012","journal-title":"Environ. Health"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.ygcen.2016.05.025","article-title":"Detection of phenolic endocrine disrupting chemicals (EDCs) from maternal blood plasma and amniotic fluid in Indian population","volume":"241","author":"Shekhar","year":"2017","journal-title":"Gen. Comp. Endocrinol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1021\/acs.jafc.0c06938","article-title":"Bisphenol Analogues and Their Chlorinated Derivatives in Breast Milk in China: Occurrence and Exposure Assessment","volume":"69","author":"Niu","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0303-7207(98)00084-7","article-title":"Bisphenol A interacts with the estrogen receptor alpha in a distinct manner from estradiol","volume":"142","author":"Gould","year":"1998","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"230","DOI":"10.2174\/1874467212666190306164507","article-title":"The Endocrine Disruptor Bisphenol A (BPA) Exerts a Wide Range of Effects in Carcinogenesis and Response to Therapy","volume":"12","author":"Hafezi","year":"2019","journal-title":"Curr. Mol. Pharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ando.2013.04.002","article-title":"Bisphenol A: An endocrine and metabolic disruptor","volume":"74","author":"Fenichel","year":"2013","journal-title":"Ann. Endocrinol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1559325815610582","DOI":"10.1177\/1559325815610582","article-title":"Molecular Mechanisms of Action of BPA","volume":"13","author":"Acconcia","year":"2015","journal-title":"Dose Response"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.mce.2011.12.012","article-title":"Bisphenol-A acts as a potent estrogen via non-classical estrogen triggered pathways","volume":"355","author":"Ropero","year":"2012","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"114610","DOI":"10.1016\/j.taap.2019.114610","article-title":"Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors","volume":"377","author":"Liu","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"123549","DOI":"10.1016\/j.envpol.2024.123549","article-title":"Structural insight into the mechanisms and interacting features of endocrine disruptor Bisphenol A and its analogs with human estrogen-related receptor gamma","volume":"345","author":"Pathak","year":"2024","journal-title":"Environ. Pollut."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/j.fct.2006.06.013","article-title":"Effect of bisphenol A, tetrachlorobisphenol A and pentachlorophenol on the transcriptional activities of androgen receptor-mediated reporter gene","volume":"44","author":"Sun","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Buoso, E., Kenda, M., Masi, M., Linciano, P., Galbiati, V., Racchi, M., Dolenc, M.S., and Corsini, E. (2021). Effects of Bisphenols on RACK1 Expression and Their Immunological Implications in THP-1 Cells. Front. Pharmacol., 12.","DOI":"10.3389\/fphar.2021.743991"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1111\/bph.15218","article-title":"Ribosomes as a nexus between translation and cancer progression: Focus on ribosomal Receptor for Activated C Kinase 1 (RACK1) in breast cancer","volume":"179","author":"Buoso","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/978-3-030-49844-3_6","article-title":"Role of Protein Kinase C in Immune Cell Activation and Its Implication Chemical-Induced Immunotoxicity","volume":"1275","author":"Corsini","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Buoso, E., Masi, M., Racchi, M., and Corsini, E. (2020). Endocrine-Disrupting Chemicals\u2019 (EDCs) Effects on Tumour Microenvironment and Cancer Progression: Emerging Contribution of RACK1. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21239229"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Masi, M., Racchi, M., Travelli, C., Corsini, E., and Buoso, E. (2021). Molecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers. Cells, 10.","DOI":"10.3390\/cells10112999"},{"key":"ref_32","first-page":"e06857","article-title":"Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs","volume":"21","author":"Bolognesi","year":"2023","journal-title":"EFSA J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.2174\/1871530323666230216150614","article-title":"In Vitro Effects of Bisphenol Analogs on Immune Cells Activation and Th Differentiation","volume":"23","author":"Iulini","year":"2023","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/0140-6736(93)90953-E","article-title":"Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract?","volume":"341","author":"Sharpe","year":"1993","journal-title":"Lancet"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1210\/en.2005-0340","article-title":"Perinatal exposure to bisphenol-A alters peripubertal mammary gland development in mice","volume":"146","author":"Markey","year":"2005","journal-title":"Endocrinology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1699-0463.1998.tb01314.x","article-title":"Germ cell cancer and disorders of spermatogenesis: An environmental connection?","volume":"106","author":"Skakkebaek","year":"1998","journal-title":"Apmis"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: An Endocrine Society scientific statement","volume":"30","author":"Bourguignon","year":"2009","journal-title":"Endocr. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1590\/0004-2730000003031","article-title":"Effects of endocrine disruptors in the development of the female reproductive tract","volume":"58","author":"Costa","year":"2014","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Czubacka, E., Wielgomas, B., Klimowska, A., Radwan, M., Radwan, P., Karwacka, A., Ka\u0142u\u017cny, P., and Jurewicz, J. (2021). Urinary Bisphenol A Concentrations and Parameters of Ovarian Reserve among Women from a Fertility Clinic. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18158041"},{"key":"ref_40","first-page":"326","article-title":"Thyroid disruption: Mechanism and clinical implications in human health","volume":"14","author":"Patrick","year":"2009","journal-title":"Altern. Med. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Xing, J., Zhang, S., Zhang, M., and Hou, J. (2022). A critical review of presence, removal and potential impacts of endocrine disruptors bisphenol A. Comp. Biochem. Physiol. C Toxicol. Pharmacol., 254.","DOI":"10.1016\/j.cbpc.2022.109275"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.reprotox.2016.10.001","article-title":"Metabolism disrupting chemicals and metabolic disorders","volume":"68","author":"Heindel","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mce.2009.02.024","article-title":"Environmental estrogens and obesity","volume":"304","author":"Newbold","year":"2009","journal-title":"Mol. Cell Endocrinol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.reprotox.2006.10.002","article-title":"Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure","volume":"23","author":"Murray","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1158\/1535-7163.MCT-06-0272","article-title":"Bisphenol A facilitates bypass of androgen ablation therapy in prostate cancer","volume":"5","author":"Wetherill","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"107858","DOI":"10.1016\/j.envint.2023.107858","article-title":"Bisphenol B and bisphenol AF exposure enhances uterine diseases risks in mouse","volume":"173","author":"Wu","year":"2023","journal-title":"Environ. Int."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1002\/ijc.30676","article-title":"International patterns and trends in ovarian cancer incidence, overall and by histologic subtype","volume":"140","author":"Coburn","year":"2017","journal-title":"Int. J. Cancer"},{"key":"ref_48","first-page":"9","article-title":"Actualities in Ovarian Cancer in the Perspective of 2015 (ASCO and ECCO)","volume":"111","author":"Stanculeanu","year":"2016","journal-title":"Chirurgia"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1158\/1940-6207.CAPR-19-0184","article-title":"Reducing Ovarian Cancer Mortality Through Early Detection: Approaches Using Circulating Biomarkers","volume":"13","author":"Trinidad","year":"2020","journal-title":"Cancer Prev. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpobgyn.2016.08.006","article-title":"Epidemiology of epithelial ovarian cancer","volume":"41","author":"Webb","year":"2017","journal-title":"Best. Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.ygyno.2016.10.019","article-title":"The histology of ovarian cancer: Worldwide distribution and implications for international survival comparisons (CONCORD-2)","volume":"144","author":"Matz","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/1933719117711261","article-title":"Effects of Endocrine-Disrupting Chemicals and Epigenetic Modifications in Ovarian Cancer: A Review","volume":"25","author":"Samtani","year":"2018","journal-title":"Reprod. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2147\/IJWH.S197604","article-title":"Ovarian cancer in the world: Epidemiology and risk factors","volume":"11","author":"Momenimovahed","year":"2019","journal-title":"Int. J. Womens Health"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1158\/1055-9965.1521.13.9","article-title":"A case-control study of diet and the risk of ovarian cancer","volume":"13","author":"Pan","year":"2004","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1007\/s11095-008-9661-9","article-title":"Cancer is a preventable disease that requires major lifestyle changes","volume":"25","author":"Anand","year":"2008","journal-title":"Pharm. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1262\/jrd.20094","article-title":"Cell growth of ovarian cancer cells is stimulated by xenoestrogens through an estrogen-dependent pathway, but their stimulation of cell growth appears not to be involved in the activation of the mitogen-activated protein kinases ERK-1 and p38","volume":"55","author":"Park","year":"2009","journal-title":"J. Reprod. Dev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.toxlet.2011.01.015","article-title":"Effect of bisphenol-A on the expression of selected genes involved in cell cycle and apoptosis in the OVCAR-3 cell line","volume":"202","author":"Ptak","year":"2011","journal-title":"Toxicol. Lett."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/j.tiv.2013.06.017","article-title":"Cooperation of bisphenol A and leptin in inhibition of caspase-3 expression and activity in OVCAR-3 ovarian cancer cells","volume":"27","author":"Ptak","year":"2013","journal-title":"Toxicol. In Vitro"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.toxlet.2014.07.001","article-title":"Bisphenol A induce ovarian cancer cell migration via the MAPK and PI3K\/Akt signalling pathways","volume":"229","author":"Ptak","year":"2014","journal-title":"Toxicol. Lett."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10565-015-9303-z","article-title":"Effects of bisphenol A and 17\u03b2-estradiol on vascular endothelial growth factor A and its receptor expression in the non-cancer and cancer ovarian cell lines","volume":"31","author":"Ptak","year":"2015","journal-title":"Cell Biol. Toxicol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.reprotox.2007.07.006","article-title":"Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract","volume":"24","author":"Newbold","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3892\/ol.2020.12145","article-title":"Carcinogenic effects of bisphenol A in breast and ovarian cancers","volume":"20","author":"Dumitrascu","year":"2020","journal-title":"Oncol. Lett."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.toxlet.2012.02.003","article-title":"Bisphenol A induces leptin receptor expression, creating more binding sites for leptin, and activates the JAK\/Stat, MAPK\/ERK and PI3K\/Akt signalling pathways in human ovarian cancer cell","volume":"210","author":"Ptak","year":"2012","journal-title":"Toxicol. Lett."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.reprotox.2007.03.006","article-title":"Effects of some endocrine disruptors on the proliferation and viability of human endometrial endothelial cells in vitro","volume":"23","author":"Bredhult","year":"2007","journal-title":"Reprod. Toxicol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/mc.21913","article-title":"Endocrine disrupting chemicals promote the growth of ovarian cancer cells via the ER-CXCL12-CXCR4 signaling axis","volume":"52","author":"Hall","year":"2013","journal-title":"Mol. Carcinog."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.2353\/ajpath.2010.100105","article-title":"Ovarian cancer development and metastasis","volume":"177","author":"Lengyel","year":"2010","journal-title":"Am. J. Pathol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"683","DOI":"10.4161\/cc.8.5.7703","article-title":"MMP-2 functions as an early response protein in ovarian cancer metastasis","volume":"8","author":"Kenny","year":"2009","journal-title":"Cell Cycle"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1158\/0008-5472.CAN-06-2808","article-title":"Engagement of collagen-binding integrins promotes matrix metalloproteinase-9-dependent E-cadherin ectodomain shedding in ovarian carcinoma cells","volume":"67","author":"Symowicz","year":"2007","journal-title":"Cancer Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"108724","DOI":"10.1016\/j.reprotox.2024.108724","article-title":"Bisphenol A-induced oxidative stress increases the production of ovarian cancer stem cells in mice","volume":"130","author":"Rajaura","year":"2024","journal-title":"Reprod. Toxicol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"108909","DOI":"10.1016\/j.reprotox.2025.108909","article-title":"Bisphenol-A-induced ovarian cancer: Changes in epithelial diversity, apoptosis, antioxidant and anti-inflammatory mechanisms","volume":"135","author":"Bhardwaj","year":"2025","journal-title":"Reprod. Toxicol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.envres.2014.08.008","article-title":"Urinary BPA measurements in children and mothers from six European member states: Overall results and determinants of exposure","volume":"141","author":"Covaci","year":"2015","journal-title":"Environ. Res."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.yrtph.2010.06.005","article-title":"Biomonitoring Equivalents for bisphenol A (BPA)","volume":"58","author":"Krishnan","year":"2010","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1590\/S1413-81232012000200015","article-title":"Urinary, circulating, and tissue biomonitoring studies indicate widespread exposure to bisphenol A","volume":"17","author":"Vandenberg","year":"2012","journal-title":"Cien Saude Colet."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"108373","DOI":"10.1016\/j.envint.2023.108373","article-title":"Urinary concentrations of environmental phenol among pregnant women in the Japan Environment and Children\u2019s Study","volume":"183","author":"Suwannarin","year":"2024","journal-title":"Environ. Int."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"106563","DOI":"10.1016\/j.envint.2021.106563","article-title":"Human biomonitoring initiative (HBM4EU): Human biomonitoring guidance values (HBM-GVs) derived for bisphenol A","volume":"154","author":"Ougier","year":"2021","journal-title":"Environ. Int."},{"key":"ref_76","unstructured":"CDC (2017). National Report on Human Exposure to Environmental Chemicals, Centers for Disease Control and Prevention."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/ki.2011.1","article-title":"The meaning of urinary creatinine concentration","volume":"79","author":"Ortiz","year":"2011","journal-title":"Kidney Int."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"e24769","DOI":"10.1002\/jcla.24769","article-title":"Urinary N-acetyl-\u03b2-d-glucosaminidase-creatine ratio is a valuable predictor for advanced diabetic kidney disease","volume":"37","author":"Huang","year":"2023","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12933-017-0497-7","article-title":"The renal tubular damage marker urinary N-acetyl-\u03b2-D-glucosaminidase may be more closely associated with early detection of atherosclerosis than the glomerular damage marker albuminuria in patients with type 2 diabetes","volume":"16","author":"Kim","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1093\/ndt\/gfs265","article-title":"Normal reference values for glomerular filtration rate: What do we really know?","volume":"27","author":"Delanaye","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_81","first-page":"29","article-title":"Estimated glomerular filtration rate explained","volume":"108","author":"Tarwater","year":"2011","journal-title":"MO Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"109684","DOI":"10.1016\/j.ecoenv.2019.109684","article-title":"Bisphenol A analogs in patients with chronic kidney disease and dialysis therapy","volume":"185","author":"Shen","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"148343","DOI":"10.1016\/j.scitotenv.2021.148343","article-title":"Exposure to phthalates and environmental phenols in association with chronic kidney disease (CKD) among the general US population participating in multi-cycle NHANES (2005-2016)","volume":"791","author":"Kang","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"105877","DOI":"10.1016\/j.envint.2020.105877","article-title":"Association of exposure to phthalates and environmental phenolics with markers of kidney function: Korean National Environmental Health Survey (KoNEHS) 2015\u20132017","volume":"143","author":"Lee","year":"2020","journal-title":"Environ. Int."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.envres.2018.08.006","article-title":"Renal Function and exposure to Bisphenol A and phthalates in children with Chronic Kidney Disease","volume":"167","author":"Malits","year":"2018","journal-title":"Environ. Res."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Jacobson, M.H., Wu, Y., Liu, M., Attina, T.M., Naidu, M., Karthikraj, R., Kannan, K., Warady, B.A., Furth, S., and Vento, S. (2020). Serially assessed bisphenol A and phthalate exposure and association with kidney function in children with chronic kidney disease in the US and Canada: A longitudinal cohort study. PLoS Med., 17.","DOI":"10.1371\/journal.pmed.1003384"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1289\/ehp.1002572","article-title":"Renal function, bisphenol A, and alkylphenols: Results from the National Health and Nutrition Examination Survey (NHANES 2003\u20132006)","volume":"119","author":"You","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/ijlh.12084","article-title":"Platelets: Bridging hemostasis, inflammation, and immunity","volume":"35","author":"Jenne","year":"2013","journal-title":"Int. J. Lab. Hematol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2174\/138161211795049804","article-title":"Mean platelet volume: A link between thrombosis and inflammation?","volume":"17","author":"Gasparyan","year":"2011","journal-title":"Curr. Pharm. Des."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/13697137.2020.1781078","article-title":"The association of bisphenol A exposure with premature ovarian insufficiency: A case-control study","volume":"24","author":"Li","year":"2021","journal-title":"Climacteric"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Stavridis, K., Triantafyllidou, O., Pisimisi, M., and Vlahos, N. (2022). Bisphenol-A and Female Fertility: An Update of Existing Epidemiological Studies. J. Clin. Med., 11.","DOI":"10.3390\/jcm11237227"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Pomeroy, D.E., Tooley, K.L., Probert, B., Wilson, A., and Kemps, E. (2020). A Systematic Review of the Effect of Dietary Supplements on Cognitive Performance in Healthy Young Adults and Military Personnel. Nutrients, 12.","DOI":"10.3390\/nu12020545"},{"key":"ref_93","unstructured":"(2008). IARC monographs on the evaluation of carcinogenic risks to humans. Volume 97. 1,3-butadiene, ethylene oxide and vinyl halides (vinyl fluoride, vinyl chloride and vinyl bromide). IARC Monogr. Eval. Carcinog. Risks Hum., 97, 3\u2013471."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1097\/00001648-200111000-00021","article-title":"Update of the follow-up of mortality and cancer incidence among European workers employed in the vinyl chloride industry","volume":"12","author":"Ward","year":"2001","journal-title":"Epidemiology"},{"key":"ref_95","first-page":"37","article-title":"Efficiency of Multispecies Probiotic Supplements in Bioremoval of Bisphenol A: An In Vitro Study","volume":"5","author":"Solouki","year":"2018","journal-title":"Appl. Food Biotechnol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1289\/ehp.5993","article-title":"Bisphenol A is released from used polycarbonate animal cages into water at room temperature","volume":"111","author":"Howdeshell","year":"2003","journal-title":"Environ. Health Perspect."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.toxlet.2007.11.001","article-title":"Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons","volume":"176","author":"Le","year":"2008","journal-title":"Toxicol. Lett."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.envres.2006.04.006","article-title":"An observational study of the potential exposures of preschool children to pentachlorophenol, bisphenol-A, and nonylphenol at home and daycare","volume":"103","author":"Wilson","year":"2007","journal-title":"Environ. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1289\/ehp.0800376","article-title":"Bisphenol A data in NHANES suggest longer than expected half-life, substantial nonfood exposure, or both","volume":"117","author":"Stahlhut","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1021\/tx025548t","article-title":"Metabolism and kinetics of bisphenol a in humans at low doses following oral administration","volume":"15","author":"Colnot","year":"2002","journal-title":"Chem. Res. Toxicol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1124\/dmd.105.005454","article-title":"Quantitation of bisphenol A and bisphenol A glucuronide in biological samples by high performance liquid chromatography-tandem mass spectrometry","volume":"33","author":"Bittner","year":"2005","journal-title":"Drug Metab. Dispos."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"100629","DOI":"10.1016\/j.ctarc.2022.100629","article-title":"Epithelial ovarian cancer: Review article","volume":"33","author":"Sambasivan","year":"2022","journal-title":"Cancer Treat. Res. Commun."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s13193-017-0680-z","article-title":"Ovarian Cancer in Young Women","volume":"8","author":"Lalrinpuii","year":"2017","journal-title":"Indian. J. Surg. Oncol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1098\/rstb.2008.0208","article-title":"Human body burdens of chemicals used in plastic manufacture","volume":"364","author":"Koch","year":"2009","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1265\/ehpm.9.22","article-title":"Daily urinary excretion of bisphenol A","volume":"9","author":"Arakawa","year":"2004","journal-title":"Environ. Health Prev. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1289\/ehp.10605","article-title":"Temporal variability and predictors of urinary bisphenol A concentrations in men and women","volume":"116","author":"Mahalingaiah","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1289\/ehp.1002701","article-title":"Variability of urinary concentrations of bisphenol A in spot samples, first morning voids, and 24-hour collections","volume":"119","author":"Ye","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13048-023-01196-0","article-title":"Tumor metabolism rewiring in epithelial ovarian cancer","volume":"16","author":"Wang","year":"2023","journal-title":"J. Ovarian Res."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0301-2115(02)00234-8","article-title":"Renal impairment in patients with ovarian cancer","volume":"106","author":"Donadio","year":"2003","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"109548","DOI":"10.1016\/j.envres.2020.109548","article-title":"Urinary phthalate concentrations in the slovenian population: An attempt to exposure assessment of family units","volume":"186","author":"Runkel","year":"2020","journal-title":"Environ. Res."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"106172","DOI":"10.1016\/j.envint.2020.106172","article-title":"Exposure of Slovenian children and adolescents to bisphenols, parabens and triclosan: Urinary levels, exposure patterns, determinants of exposure and susceptibility","volume":"146","author":"Tkalec","year":"2021","journal-title":"Environ. Int."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/10\/4811\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:34:24Z","timestamp":1760031264000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/10\/4811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,17]]},"references-count":111,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["ijms26104811"],"URL":"https:\/\/doi.org\/10.3390\/ijms26104811","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,17]]}}}