{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T09:27:25Z","timestamp":1769506045328,"version":"3.49.0"},"reference-count":41,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Brazilian agency Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro\u2014FAPERJ","doi-asserted-by":"publisher","award":["E-26\/210.949\/2021"],"award-info":[{"award-number":["E-26\/210.949\/2021"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Brazilian agency Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro\u2014FAPERJ","doi-asserted-by":"publisher","award":["309065\/2021-6"],"award-info":[{"award-number":["309065\/2021-6"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014CNPq","award":["E-26\/210.949\/2021"],"award-info":[{"award-number":["E-26\/210.949\/2021"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014CNPq","award":["309065\/2021-6"],"award-info":[{"award-number":["309065\/2021-6"]}]},{"name":"Rio de Janeiro State University","award":["E-26\/210.949\/2021"],"award-info":[{"award-number":["E-26\/210.949\/2021"]}]},{"name":"Rio de Janeiro State University","award":["309065\/2021-6"],"award-info":[{"award-number":["309065\/2021-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Developmental dysplasia of the hip (DDH) is a multifactorial and polygenic abnormal hip joint development, with a prognosis influenced by environmental and genetic factors, potentially leading to complete dislocation. Growth differentiation factor 5 is a signaling molecule, encoded by a polymorphic gene (GDF5), promoting the development, repair, and maintenance of bone, cartilage, and other synovial joint tissues. The GDF5 rs143384 G&gt;A polymorphism affects GDF5 expression and may be associated with a susceptibility to DDH. The aim of this study was to determine the frequency of the GDF5 rs143384 polymorphism in Brazilian individuals and its influence on the development of DDH. This case\u2013control study included 50 DDH cases and 150 controls without hip disease. Genotyping was performed by real-time PCR using the TaqMan system. The GDF5 AA variant genotype frequency was significantly higher in DDH cases (32%) compared to controls (14%, p-value = 0.01) and showed a marginal association with disease risk (OR = 1.47; CI 95% = 0.96\u20132.26). The GDF5 rs143384 polymorphism could be useful in identifying individuals at risk, guiding personalized treatment strategies, and contributing to diagnosis and clinical management.<\/jats:p>","DOI":"10.3390\/ijms26115012","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T06:16:03Z","timestamp":1747980963000},"page":"5012","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["GDF5 rs143384 Polymorphism Associated with Developmental Dysplasia of the Hip in Brazilian Patients: A Case-Control Study"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7683-0698","authenticated-orcid":false,"given":"Jamila Alessandra","family":"Perini","sequence":"first","affiliation":[{"name":"Research Laboratory of Pharmaceutical Sciences (LAPESF), Rio de Janeiro State University (UERJ), Rio de Janeiro 23070-200, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael Wallace Campos","family":"Cunha","sequence":"additional","affiliation":[{"name":"Hip Surgery Center, National Institute of Traumatology and Orthopaedics (INTO), Rio de Janeiro 20940-070, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Bernardo","family":"Cury Fernandes","sequence":"additional","affiliation":[{"name":"Hip Surgery Center, National Institute of Traumatology and Orthopaedics (INTO), Rio de Janeiro 20940-070, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louren\u00e7o Pinto","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Hip Surgery Center, National Institute of Traumatology and Orthopaedics (INTO), Rio de Janeiro 20940-070, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Ant\u00f4nio Matheus","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Research Division, INTO, Rio de Janeiro 20940-070, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8792-7524","authenticated-orcid":false,"given":"Amanda dos Santos","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Research Laboratory of Pharmaceutical Sciences (LAPESF), Rio de Janeiro State University (UERJ), Rio de Janeiro 23070-200, RJ, Brazil"},{"name":"Research Division, INTO, Rio de Janeiro 20940-070, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica Vilarinho","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Research Laboratory of Pharmaceutical Sciences (LAPESF), Rio de Janeiro State University (UERJ), Rio de Janeiro 23070-200, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2106\/JBJS.O.00109","article-title":"Hip Dysplasia in the Young Adult","volume":"98","author":"Gala","year":"2016","journal-title":"J. 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