{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:54:55Z","timestamp":1780725295482,"version":"3.54.1"},"reference-count":79,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T00:00:00Z","timestamp":1747958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Liberty University College of Osteopathic Medicine","award":["MR2402- MR2402-B3C98-711099-20"],"award-info":[{"award-number":["MR2402- MR2402-B3C98-711099-20"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Pathophysiological differences separating small vessel disease (SVD) from Alzheimer\u2019s disease (AD) may alter treatment approach. Investigating peak-arterial and late-capillary perfusion may differentiate SVD from AD. 14 Subjects with MoCA scores of 11\u201324 were divided into 2 groups. Group one: 6 AD likely subjects positive for 1 or 2 copies of APOE 4+. Group two: 8 SVD likely subjects APOE\u2212. Group three: 7 age-matched controls (MoCA 26\u201330). All underwent 3D PASL MRI, FLAIR, and SWI axial MRI. Arterial phase peak amplitude and latency, late capillary inflow\/clearance rates, and anatomic abnormalities quantitated using microhemorrhage count, Fazekas, Koedam, and Schelton scales were compared. Arterial perfusion demonstrated no statistical differences among SVD, AD, and controls, suggesting normal arterial flow. Late phase perfusion showed significant localized reduction in capillary flow\/clearance rates in SVD and AD compared to controls. Absent arterial phase but significant capillary inflow\/clearance differences from controls suggest SVD and AD share common impaired blood\u2013brain barrier origins.<\/jats:p>","DOI":"10.3390\/ijms26115040","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T09:58:09Z","timestamp":1747994289000},"page":"5040","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dementia from Small Vessel Disease Versus Alzheimer\u2019s Disease: Separate Diseases or Distinct Manifestations of Cerebral Capillopathy Due to Blood\u2013Brain Barrier Dysfunction? A Pilot Study"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8057-8704","authenticated-orcid":false,"given":"Charles R.","family":"Joseph","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Neurology, Liberty University College of Osteopathic Medicine, Lynchburg, VA 24502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8322-2287","authenticated-orcid":false,"given":"Davis A.","family":"Melin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Neurology, Liberty University College of Osteopathic Medicine, Lynchburg, VA 24502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5995-6467","authenticated-orcid":false,"given":"Lindsay K.","family":"Wanner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Neurology, Liberty University College of Osteopathic Medicine, Lynchburg, VA 24502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8865-9093","authenticated-orcid":false,"given":"Bryant","family":"Hartman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Neurology, Liberty University College of Osteopathic Medicine, Lynchburg, VA 24502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Badelita","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Neurology, Liberty University College of Osteopathic Medicine, Lynchburg, VA 24502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7475-842X","authenticated-orcid":false,"given":"Lucy C.","family":"Conser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Neurology, Liberty University College of Osteopathic Medicine, Lynchburg, VA 24502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison D.","family":"Kline","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Neurology, Liberty University College of Osteopathic Medicine, Lynchburg, VA 24502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav M.","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Neurology, Liberty University College of Osteopathic Medicine, Lynchburg, VA 24502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5912-9525","authenticated-orcid":false,"given":"Kim","family":"Love","sequence":"additional","affiliation":[{"name":"K. 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Neurodegener."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41582-018-0014-y","article-title":"Cerebral small vessel disease: From a focal to a global perspective","volume":"14","author":"Wiegertjes","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1212\/WNL.0000000000007654","article-title":"CNS small vessel disease: A clinical review","volume":"92","author":"Cannistraro","year":"2019","journal-title":"Neurology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1136\/svn-2016-000035","article-title":"Update on cerebral small vessel disease: A dynamic whole-brain disease","volume":"1","author":"Shi","year":"2016","journal-title":"Stroke Vasc. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S1474-4422(19)30079-1","article-title":"Small vessel disease: Mechanisms and clinical implications","volume":"18","author":"Wardlaw","year":"2019","journal-title":"Lancet Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Kim, S.E., Kim, H.J., Jang, H., Weiner, M.W., DeCarli, C., Na, D.L., and Seo, S.W. (2022). Interaction between Alzheimer\u2019s disease and cerebral small vessel disease: A review focused on neuroimaging markers. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810490"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1161\/STROKEAHA.124.047910","article-title":"Heterogeneity and Penumbra of White Matter Hyperintensities in Small Vessel Diseases Determined by Quantitative MRI","volume":"56","author":"Voorter","year":"2025","journal-title":"Stroke"},{"key":"ref_11","first-page":"7960","article-title":"Application of 3D-ASL in hemodynamic analysis and prognosis evaluation of vascular cognitive impairment","volume":"14","author":"Zhou","year":"2022","journal-title":"Am. J. Transl. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1161\/STROKEAHA.112.669994","article-title":"Blood\u2013brain barrier permeability and long-term clinical and imaging outcomes in cerebral small vessel disease","volume":"44","author":"Wardlaw","year":"2013","journal-title":"Stroke"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e01457","DOI":"10.1002\/brb3.1457","article-title":"White matter hypointensities and hyperintensities have equivalent correlations with age and CSF \u03b2-amyloid in the nondemented elderly","volume":"9","author":"Wei","year":"2019","journal-title":"Brain Behav."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.jalz.2017.02.007","article-title":"Capillary dysfunction is associated with symptom severity and neurodegeneration in Alzheimer\u2019s disease","volume":"13","author":"Nielsen","year":"2017","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5997","DOI":"10.1007\/s00415-024-12562-3","article-title":"Incidence of cerebral small vessel disease-related MR markers in the Swedish general population \u2018Good Aging in Sk\u00e5ne\u2019(G\u00c5S) study","volume":"271","year":"2024","journal-title":"J. Neurol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e13061","DOI":"10.1111\/bpa.13061","article-title":"Pathological changes within the cerebral vasculature in Alzheimer\u2019s disease: New perspectives","volume":"32","author":"Fisher","year":"2022","journal-title":"Brain Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Fang, C., Magaki, S.D., Kim, R.C., Kalaria, R.N., Vinters, H.V., and Fisher, M. (2023). Arteriolar neuropathology in cerebral microvascular disease. Neuropathol. Appl. Neurobiol., 49.","DOI":"10.1111\/nan.12875"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s10072-011-0783-1","article-title":"Pontine hemorrhage at a microbleed site in a patient with central pontine myelinolysis","volume":"32","author":"Kim","year":"2011","journal-title":"Neurol. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Lin, J., Wang, D., Lan, L., and Fan, Y. (2017). Multiple factors involved in the pathogenesis of white matter lesions. BioMed Res. Int., 2017.","DOI":"10.1155\/2017\/9372050"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1136\/svn-2017-000087","article-title":"Blood pressure gradients in cerebral arteries: A clue to pathogenesis of cerebral small vessel disease","volume":"2","author":"Blanco","year":"2017","journal-title":"Stroke Vasc. Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","article-title":"Cerebral small vessel disease: From pathogenesis and clinical characteristics to therapeutic challenges","volume":"9","author":"Pantoni","year":"2010","journal-title":"Lancet Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1212\/WNL.0000000000003556","article-title":"Blood\u2013brain barrier leakage is more widespread in patients with cerebral small vessel disease","volume":"88","author":"Zhang","year":"2017","journal-title":"Neurology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"110871","DOI":"10.1016\/j.jocn.2024.110871","article-title":"Associations between carotid plaques and white matter hyperintensities in cerebral small vessel disease","volume":"129","author":"Pan","year":"2024","journal-title":"J. Clin. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1002\/jmri.26906","article-title":"Changes of white matter integrity and structural network connectivity in nondemented cerebral small-vessel disease","volume":"51","author":"Liu","year":"2020","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1002\/hbm.25301","article-title":"White matter integrity and structural brain network topology in cerebral small vessel disease: The Hamburg city health study","volume":"42","author":"Frey","year":"2021","journal-title":"Hum. Brain Mapping"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Steinman, J., Sun, H.S., and Feng, Z.P. (2021). Microvascular alterations in Alzheimer\u2019s disease. Front. Cell. Neurosci., 14.","DOI":"10.3389\/fncel.2020.618986"},{"key":"ref_27","first-page":"663","article-title":"Pathophysiology of Alzheimer\u2019s disease","volume":"45","author":"Yarns","year":"2022","journal-title":"Psychiatr. Clin."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"105499","DOI":"10.1016\/j.neuint.2023.105499","article-title":"Pathophysiology, cellular and molecular mechanisms of large and small vessel diseases","volume":"164","author":"Koueik","year":"2023","journal-title":"Neurochem. Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/ijs.12466","article-title":"Pharmacological treatment and prevention of cerebral small vessel disease: A review of potential interventions","volume":"10","author":"Bath","year":"2015","journal-title":"Int. J. Stroke"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2022.12.006","article-title":"Capillary dysfunction correlates with cortical amyloid load in early Alzheimer\u2019s disease","volume":"123","author":"Madsen","year":"2023","journal-title":"Neurobiol. Aging"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Yu, L., Hu, X., Li, H., and Zhao, Y. (2022). Perivascular spaces, glymphatic system and MR. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.844938"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/jmri.27438","article-title":"Arterial spin labeling applications in pediatric and adult neurologic disorders","volume":"55","author":"Bambach","year":"2022","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"117996","DOI":"10.1016\/j.lfs.2020.117996","article-title":"Alzheimer\u2019s disease; a review of the pathophysiological basis and therapeutic interventions","volume":"256","author":"Abeysinghe","year":"2020","journal-title":"Life Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1002\/mrm.29572","article-title":"Current state and guidance on arterial spin labeling perfusion MRI in clinical neuroimaging","volume":"89","author":"Lindner","year":"2023","journal-title":"Magn. Reson. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1148\/radiol.2016150789","article-title":"Arterial spin labeling perfusion of the brain: Emerging clinical applications","volume":"281","author":"Haller","year":"2016","journal-title":"Radiology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1177\/0271678X17743240","article-title":"Arterial spin labeling for the measurement of cerebral perfusion and angiography","volume":"38","author":"Jezzard","year":"2018","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.08.025","article-title":"Arterial spin labeling perfusion magnetic resonance image with dual postlabeling delay: A correlative study with acetazolamide loading 123I-iodoamphetamine single-photon emission computed tomography","volume":"25","author":"Haga","year":"2016","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000530980","article-title":"Utilizing Reduced Labeled Proton Clearance to Identify Preclinical Alzheimer Disease with 3D ASL MRI","volume":"15","author":"Joseph","year":"2023","journal-title":"Case Rep. Neurol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jmri.24565","article-title":"An introduction to ASL labeling techniques","volume":"40","author":"Wong","year":"2014","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neubiorev.2016.11.023","article-title":"Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer\u2019s disease","volume":"72","author":"Zhang","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Kim, H.W., Hong, J., and Jeon, J.C. (2020). Cerebral small vessel disease and Alzheimer\u2019s disease: A review. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.00927"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/mrm.20390","article-title":"Four-phase single-capillary stepwise model for kinetics in arterial spin labeling MRI","volume":"53","author":"Li","year":"2005","journal-title":"Magn. Reson. Med. Off. J. Int. Soc. Magn. Reson. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e20190062","DOI":"10.1084\/jem.20190062","article-title":"The blood\u2013brain barrier in health and disease: Important unanswered questions","volume":"217","author":"Profaci","year":"2020","journal-title":"J. Exp. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s10334-019-00818-3","article-title":"Pilot study utilizing MRI 3D TGSE PASL (arterial spin labeling) differentiating clearance rates of labeled protons in the CNS of patients with early Alzheimer disease from normal subjects","volume":"33","author":"Joseph","year":"2020","journal-title":"Magn. Reson. Mater. Phys. Biol. Med."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Joseph, C.R., Lim, J.K., Grohol, B.N., Zivcevska, M., Lencke, J., Rich, E.D., Arrasmith, C.J., Dorman, I.S., Clark, B.W., and Love, K. (2024). Identifying delay in glymphatic clearance of labeled protons post-acute head trauma utilizing 3D ASL MRI (arterial spin labeling): A pilot study. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-56236-6"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/RLI.0000000000000723","article-title":"A comprehensive view on MRI techniques for imaging blood-brain barrier integrity","volume":"56","author":"Elschot","year":"2021","journal-title":"Investig. Radiol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"\u017divanovi\u0107, M., Trenki\u0107, A.A., Milo\u0161evi\u0107, V., Stojanov, D., Mi\u0161i\u0107, M., Radovanovi\u0107, M., and Radovanovi\u0107, V. (2023). The role of magnetic resonance imaging in the diagnosis and prognosis of dementia. Biomol. Biomed., 23.","DOI":"10.17305\/bjbms.2022.8085"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1177\/0271678X15606723","article-title":"Cerebral small vessel disease: Capillary pathways to stroke and cognitive decline","volume":"36","author":"Engedal","year":"2016","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_49","first-page":"266","article-title":"Amyloid-\u03b2 in Alzheimer\u2019s disease: Structure, toxicity, distribution, treatment, and prospects","volume":"10","author":"Yu","year":"2024","journal-title":"ibrain"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"13S","DOI":"10.2967\/jnumed.121.263195","article-title":"The role of amyloid PET in imaging neurodegenerative disorders: A review","volume":"63","author":"Chapleau","year":"2022","journal-title":"J. Nucl. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1001\/jama.2019.2000","article-title":"Association of amyloid positron emission tomography with subsequent change in clinical management among medicare beneficiaries with mild cognitive impairment or dementia","volume":"321","author":"Rabinovici","year":"2019","journal-title":"JAMA"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1001\/jama.2015.4669","article-title":"Prevalence of amyloid PET positivity in dementia syndromes: A meta-analysis","volume":"313","author":"Ossenkoppele","year":"2015","journal-title":"JAMA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/s41583-020-0322-2","article-title":"Neuronal regulation of the blood\u2013brain barrier and neurovascular coupling","volume":"21","author":"Kaplan","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1038\/s41380-022-01511-z","article-title":"The blood-brain barrier in aging and neurodegeneration","volume":"27","author":"Knox","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neubiorev.2018.03.028","article-title":"Interaction between blood-brain barrier and glymphatic system in solute clearance","volume":"90","author":"Verheggen","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/2045-8118-9-23","article-title":"Tight junctions at the blood brain barrier: Physiological architecture and disease-associated dysregulation","volume":"9","author":"Luissint","year":"2012","journal-title":"Fluids Barriers CNS"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-0716-2289-6_1","article-title":"Cells of the blood\u2013brain barrier: An overview of the neurovascular unit in health and disease","volume":"2492","author":"McConnell","year":"2022","journal-title":"Blood-Brain Barrier Methods Protoc."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Erickson, M.A., and Banks, W.A. (2019). Age-associated changes in the immune system and blood\u2013brain barrier functions. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20071632"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3233\/JAD-190764","article-title":"Vascular risk factors and Alzheimer\u2019s disease: Blood-brain barrier disruption, metabolic syndromes, and molecular links","volume":"73","author":"He","year":"2020","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Litak, J., Mazurek, M., Kulesza, B., Szmygin, P., Litak, J., Kamieniak, P., and Grochowski, C. (2020). Cerebral small vessel disease. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249729"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e28229","DOI":"10.1097\/MD.0000000000028229","article-title":"Risk factors of cerebral small vessel disease: A systematic review and meta-analysis","volume":"100","author":"Wang","year":"2021","journal-title":"Medicine"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S2215-0366(20)30431-4","article-title":"Neuropsychiatric symptoms associated with cerebral small vessel disease: A systematic review and meta-analysis","volume":"8","author":"Clancy","year":"2021","journal-title":"Lancet Psychiatry"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Sorby-Adams, A.J., Marcoionni, A.M., Dempsey, E.R., Woenig, J.A., and Turner, R.J. (2017). The role of neurogenic inflammation in blood-brain barrier disruption and development of cerebral oedema following acute central nervous system (CNS) injury. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18081788"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e140966","DOI":"10.1172\/JCI140966","article-title":"Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging","volume":"131","author":"Propson","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3233\/JAD-150949","article-title":"Aquaporin-4 and Alzheimer\u2019s disease","volume":"52","author":"Yang","year":"2016","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neuroscience.2021.08.003","article-title":"Magnetic resonance imaging of blood\u2013brain barrier permeability in dementia","volume":"474","author":"Chagnot","year":"2021","journal-title":"Neuroscience"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Yamazaki, Y., and Kanekiyo, T. (2017). Blood-brain barrier dysfunction and the pathogenesis of Alzheimer\u2019s disease. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18091965"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Chen, Y., He, Y., Han, J., Wei, W., and Chen, F. (2023). Blood-brain barrier dysfunction and Alzheimer\u2019s disease: Associations, pathogenic mechanisms, and therapeutic potential. Front. Aging Neurosci., 15.","DOI":"10.3389\/fnagi.2023.1258640"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1084\/jem.20171406","article-title":"Alzheimer\u2019s disease: A matter of blood\u2013brain barrier dysfunction?","volume":"214","author":"Montagne","year":"2017","journal-title":"J. Exp. Med."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Joseph, C.R. (2024). Assessing Mild Traumatic Brain Injury-Associated Blood\u2013Brain Barrier (BBB) Damage and Restoration Using Late-Phase Perfusion Analysis by 3D ASL MRI: Implications for Predicting Progressive Brain Injury in a Focused Review. Int. J. Mol. Sci., 25.","DOI":"10.20944\/preprints202410.0282.v1"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/s44161-021-00014-4","article-title":"Blood\u2013brain barrier link to human cognitive impairment and Alzheimer\u2019s disease","volume":"1","author":"Barisano","year":"2022","journal-title":"Nat. Cardiovasc. Res."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Huang, Z., Wong, L.W., Su, Y., Huang, X., Wang, N., Chen, H., and Yi, C. (2020). Blood-brain barrier integrity in the pathogenesis of Alzheimer\u2019s disease. Front. Neuroendocrinol., 59.","DOI":"10.1016\/j.yfrne.2020.100857"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Hussain, B., Fang, C., and Chang, J. (2021). Blood\u2013brain barrier breakdown: An emerging biomarker of cognitive impairment in normal aging and dementia. Front. Neurosci., 15.","DOI":"10.3389\/fnins.2021.688090"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1007\/s11357-020-00211-2","article-title":"Increase in blood\u2013brain barrier leakage in healthy, older adults","volume":"42","author":"Verheggen","year":"2020","journal-title":"Geroscience"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1148\/radiol.2018170575","article-title":"Alzheimer disease and mild cognitive impairment: Integrated pulsed arterial spin-labeling MRI and 18F-FDG PET","volume":"288","author":"Riederer","year":"2018","journal-title":"Radiology"},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Joseph, C.R. (2024). Progressive Age-Associated Blood\u2013Brain Barrier Leak\/Dysfunction-Nexus of Neurodegenerative Disease Using MRI Markers to Identify Preclinical Disease and Potential New Targets for Future Treatments. Diagnostics, 14.","DOI":"10.20944\/preprints202401.1793.v1"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/ncpcardio1397","article-title":"Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology","volume":"6","author":"Davies","year":"2009","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.05.006","article-title":"Pathophysiology of lacunar stroke: History\u2019s mysteries and modern interpretations","volume":"28","author":"Regenhardt","year":"2019","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/11\/5040\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:39:16Z","timestamp":1760031556000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/11\/5040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,23]]},"references-count":79,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["ijms26115040"],"URL":"https:\/\/doi.org\/10.3390\/ijms26115040","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,23]]}}}