{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:51:20Z","timestamp":1785210680481,"version":"3.55.0"},"reference-count":51,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Centre (NCN, Poland)","award":["2019\/35\/B\/NZ5\/01445"],"award-info":[{"award-number":["2019\/35\/B\/NZ5\/01445"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Salinomycin (SAL), originally identified for its potent antibacterial properties, has recently garnered attention for its remarkable activity against a variety of cancer types. Beyond its direct cytotoxic effects on cancer cells, SAL can also enhance the efficacy of anti-CD20 immunotherapy in B-cell malignancies, both in vitro and in vivo. Despite these promising findings, the precise molecular mechanisms underlying SAL\u2019s anticancer action remain poorly understood. Here, we demonstrate that even at low concentrations (0.25\u20130.5 mM), SAL disrupts mitochondrial membrane potential and induces oxidative stress in Burkitt lymphoma. Further investigations uncovered that SAL shifts cellular metabolism from mitochondrial respiration to aerobic glycolysis. Additionally, metabolomic profiling identified SAL-induced arginine depletion as a key metabolic alteration. These findings provide new insights into SAL\u2019s multifaceted mechanisms of action and support its potential as an adjunctive therapy in cancer treatment.<\/jats:p>","DOI":"10.3390\/ijms26115125","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T03:52:08Z","timestamp":1748404328000},"page":"5125","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Low-Dose Salinomycin Alters Mitochondrial Function and Reprograms Global Metabolism in Burkitt Lymphoma"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0875-2608","authenticated-orcid":false,"given":"Aleksandra","family":"Zdanowicz","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland"},{"name":"Doctoral School, Medical University of Warsaw, Zwirki i Wigury 81 Str., 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandr","family":"Ilchenko","sequence":"additional","affiliation":[{"name":"Department of Forest Genetics and Plant Physiology, Ume\u00e5 Plant Science Centre, Swedish University of Agricultural Sciences, Skogsmarksgr\u00e4nd 17, 90183 Umea, Sweden"},{"name":"Department of Chemistry, Ume\u00e5 University, Linnaeus v\u00e4g 10B, 90187 Umea, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Ciechanowicz","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine, Center for Preclinical Research and Technology, Medical University of Warsaw, Banacha 1B Str., 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8954-6240","authenticated-orcid":false,"given":"Haoyu","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK"},{"name":"Consortium for Mitochondrial Research, University College London, Gower Street, London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0181-3607","authenticated-orcid":false,"given":"Marta","family":"Struga","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0490-618X","authenticated-orcid":false,"given":"Beata","family":"Pyrzynska","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Medical University of Warsaw, Banacha 1 Str., 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1039\/np9951200165","article-title":"Polyether ionophores","volume":"12","author":"Dutton","year":"1995","journal-title":"Nat. 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