{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:30:57Z","timestamp":1789381857120,"version":"build-2803163510"},"reference-count":28,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:00:00Z","timestamp":1748390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wroclaw Medical University","award":["SUBZ.D230.24.00"],"award-info":[{"award-number":["SUBZ.D230.24.00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The local treatment of deep burn wounds involves the excision of the necrosis and covering the wounds with skin grafts. Surgical procedures are thought to have an impact on the inflammatory response, especially in severe burn patients requiring treatment in an intensive care unit. Currently, there are no available data in the literature regarding the correlation of the type of surgical procedure and the levels of the inflammatory markers. This study investigates the importance of monitoring c-reactive protein (CRP) around the time of surgical burn procedures and how it can aid in assessing the inflammatory response. Of the 810 burn patients, 93 patients aged 20 to 74 years with IIb- and III-degree burns covering 20% to 50% of the total burned body surface were included in this prospective study. Three subgroups were recognized based on the surgical procedure performed: fascial necrectomy, tangential necrectomy, and skin grafting. The research material included blood samples collected in the early postoperative hours. A total of 270 CRP level measurements were performed. A reduction in CRP levels was observed three hours post-procedure in patients who underwent skin harvesting for grafting. Conversely, a significant increase in CRP levels was noted between postoperative timepoints in patients who underwent tangential necrectomy.<\/jats:p>","DOI":"10.3390\/ijms26115158","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T03:52:08Z","timestamp":1748404328000},"page":"5158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Influence of Surgical Procedures on C-Reactive Protein Levels in Severely Burned Patients: Preliminary Analysis on Implications for Early Sepsis Diagnosis"],"prefix":"10.3390","volume":"26","author":[{"given":"Ma\u0142gorzata Barbara","family":"Makowska-Rezaie","sequence":"first","affiliation":[{"name":"Malopolska Burn and Plastic Surgery Center, Ludwik Rydygier Specialized Hospital, 31-826 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u0142","family":"Jele\u0144","sequence":"additional","affiliation":[{"name":"Department of Immunopathology, Molecular Biology Faculty of Pharmacy, Wroclaw Medical University, 50-368 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6542-2525","authenticated-orcid":false,"given":"Marzenna","family":"Bartoszewicz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Microbiology and Parasitology, Faculty of Pharmacy, Wroclaw Medical University, 50-368 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7610-1460","authenticated-orcid":false,"given":"Tomasz","family":"Korzeniowski","sequence":"additional","affiliation":[{"name":"East Center of Burns Treatment and Reconstructive Surgery, 21-010 \u0141e\u0328czna, Poland"},{"name":"Department of Plastic, Reconstructive Surgery and Burn Treatment Medical University of Lublin, 20-059 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9014-0389","authenticated-orcid":false,"given":"Maria Kamila","family":"Klimeczek-Chrapusta","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Medical College, Jagiellonian University, 30-688 Krak\u00f3w, Poland"},{"name":"Department of Pediatric Surgery, University Children\u2019s Hospital of Krakow, 30-663 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7820-974X","authenticated-orcid":false,"given":"Anna Marta","family":"Chrapusta","sequence":"additional","affiliation":[{"name":"Malopolska Burn and Plastic Surgery Center, Ludwik Rydygier Specialized Hospital, 31-826 Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,28]]},"reference":[{"key":"ref_1","unstructured":"Baker, S.P., O\u2019Neill, B., Ginsburg, M.J., and Guohua, L. (1992). The Injury Fact Book, Lexington Books. [2nd ed.]."},{"key":"ref_2","unstructured":"Stru\u017cyna, J. (2006). Wczesne Leczenie Oparze\u0144, Wydawnictwo Lekarskie PZWL. [1st ed.]."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.burns.2016.08.013","article-title":"Recent Trends in Burn Epidemiology Worldwide: A Systematic Review","volume":"43","author":"Smolle","year":"2017","journal-title":"Burns"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1097\/00005373-197012000-00001","article-title":"A new concept in the early excision and immediate grafting of burns","volume":"10","author":"Janzekovic","year":"1970","journal-title":"J. Trauma Inj. Infect. Crit. Care"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1089\/sur.2010.024","article-title":"The Surviving Sepsis Campaign: A history and a perspective","volume":"11","author":"Marshall","year":"2010","journal-title":"Surg. Infect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S1473-3099(17)30117-2","article-title":"Application of the Third International Consensus Definitions for Sepsis (Sepsis-3) classification: A retrospective population-based cohort","volume":"17","author":"Donnelly","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving Sepsis Campaign: International guidelines for the management of sepsis and septic shock: 2016","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensive Care Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1177\/095952874202500119","article-title":"On acute ulceration of the duodenum, in cases of burn","volume":"25","author":"Curling","year":"1842","journal-title":"Med. Chir. Trans."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1161\/01.CIR.102.18.2165","article-title":"Direct proinflammatory effect of C-reactive protein on human endothelial cells","volume":"102","author":"Pasceri","year":"2000","journal-title":"Circulation"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s13054-020-02993-5","article-title":"Biomarkers of sepsis: Time for a reappraisal","volume":"24","author":"Pierrakos","year":"2020","journal-title":"Crit. Care"},{"key":"ref_11","first-page":"29","article-title":"Early Onset Sepsis","volume":"69","author":"Johnson","year":"2016","journal-title":"S. D. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1097\/CCM.0000000000005820","article-title":"Comparison of the Diagnostic Accuracies of Monocyte Distribution Width, Procalcitonin, and C-Reactive Protein for Sepsis: A Systematic Review and Meta-Analysis","volume":"51","author":"Huang","year":"2023","journal-title":"Crit. Care Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.7754\/Clin.Lab.2022.220737","article-title":"Application of PCT, IL-6, CRP, and WBC for Diagnosing Neonatal Sepsis","volume":"69","author":"An","year":"2023","journal-title":"Clin. Lab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e499","DOI":"10.1002\/ams2.499","article-title":"Reevaluation for prognostic value of prognostic burn index in severe burn patients","volume":"7","author":"Kaita","year":"2020","journal-title":"Acute Med. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.5152\/TJAR.2017.93753","article-title":"Changing definitions of sepsis","volume":"45","author":"Cinel","year":"2017","journal-title":"Turk. J. Anaesthesiol. Reanim."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI200318921","article-title":"C-reactive protein: A critical update","volume":"111","author":"Pepys","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1194\/jlr.P600014-JLR200","article-title":"Effects of CRP infusion on endothelial function and coagulation in normocholesterolemic and hypercholesterolemic subjects","volume":"48","author":"Bisoendial","year":"2007","journal-title":"J. Lipid Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","article-title":"Role of C-Reactive Protein at Sites of Inflammation and Infection","volume":"9","author":"Sproston","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1097\/BCR.0b013e31826fc506","article-title":"Effect of acute thermal injury in status of serum vitamins, inflammatory markers, and oxidative stress markers: Preliminary data","volume":"34","author":"Vinha","year":"2013","journal-title":"J. Burn Care Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"321S","DOI":"10.1378\/chest.112.6_Supplement.321S","article-title":"Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock","volume":"112","author":"Dinarello","year":"1997","journal-title":"Chest"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.intimp.2019.05.002","article-title":"Inflammation research sails through the sea of immunology to reach immunometabolism","volume":"73","author":"Kumar","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s002689900064","article-title":"Mediators of Injury and Inflammation","volume":"20","author":"Schlag","year":"1996","journal-title":"World J. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/(SICI)1096-9896(200002)190:3<343::AID-PATH522>3.0.CO;2-M","article-title":"Regulation of inflammatory vascular damage","volume":"190","author":"Lentsch","year":"2000","journal-title":"J. Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0278-2391(91)90168-L","article-title":"Changes in C-reactive protein associated with surgical treatment of mandibular fractures","volume":"49","author":"Iizuka","year":"1991","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1080\/17453670610013006","article-title":"C-reactive Protein as a parameter of surgical trauma","volume":"77","author":"Neumaier","year":"2006","journal-title":"Acta Orthop."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0020-1383(92)90070-9","article-title":"Serum c-reactive protein in patients with serious trauma","volume":"23","author":"Gosling","year":"1992","journal-title":"Injury"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1080\/17453670710015355","article-title":"C-reactive protein levels for early detection of postoperative infection after fracture surgery in 787 patients","volume":"79","author":"Neumaier","year":"2008","journal-title":"Acta Orthop."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1308\/003588408X285865","article-title":"Clinical utility of peri-operative C-reactive protein testing in general surgery","volume":"90","author":"Cole","year":"2008","journal-title":"Ann. 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