{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:59:54Z","timestamp":1790441994137,"version":"4.1.0"},"reference-count":278,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences","award":["075-00263-25-00"],"award-info":[{"award-number":["075-00263-25-00"]}]},{"name":"Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences","award":["FMRM-2025-0027"],"award-info":[{"award-number":["FMRM-2025-0027"]}]},{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["075-00263-25-00"],"award-info":[{"award-number":["075-00263-25-00"]}]},{"name":"Ministry of Science and Higher Education of the Russian Federation","award":["FMRM-2025-0027"],"award-info":[{"award-number":["FMRM-2025-0027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Serotonin (5-HT) is a neurotransmitter that also plays an important role in the regulation of vascular tone and angiogenesis. This review focuses on the involvement of the 5-HT system in pathological processes leading to the development of Alzheimer\u2019s disease (AD). There is evidence that damage or dysfunction of the 5-HT system contributes to the development of AD, and different subtypes of 5-HT receptors are a potential target for the treatment of AD. A link has been established between AD, depression, stress, and 5-HT deficiency in the brain. There are new data on the role of circadian rhythms in modulating stress, depression, and the 5-HT system; amyloid \u03b2 (A\u03b2) plaque clearance; and AD progression. Circadian disruption inhibits A\u03b2 plaque clearance and modulates AD progression. The properties and functions of 5-HT, its receptors, and serotonergic neurons are presented. Special attention is paid to the central role of 5-HT in brain development, including neurite outgrowth, regulation of somatic morphology, motility, synaptogenesis, control of dendritic spine shape and density, neuronal plasticity determining its role in network regeneration, and changes in innervation after brain damage. The results of different studies indicate that the interaction of amyloid \u03b2 oligomers (A\u03b2O) with mitochondria is a sufficient trigger for AD-related neurodegeneration. The action of 5-HT leads to an improvement in mitochondrial quality and the restoration of brain areas after traumatic brain injury, chronic stress, or developmental disorders in AD. The role of a healthy lifestyle and drugs acting on serotonin receptors in the prevention and treatment of AD is discussed.<\/jats:p>","DOI":"10.3390\/ijms26115218","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T06:25:04Z","timestamp":1748499904000},"page":"5218","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Serotonergic Regulation in Alzheimer\u2019s Disease"],"prefix":"10.3390","volume":"26","author":[{"given":"Lyudmila P.","family":"Dolgacheva","sequence":"first","affiliation":[{"name":"Federal Research Center \u201cPushchino Scientific Center for Biological Research of the Russian Academy of Sciences\u201d, Institute of Cell Biophysics of the Russian Academy of Sciences, Pushchino 142290, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1990-3803","authenticated-orcid":false,"given":"Valery P.","family":"Zinchenko","sequence":"additional","affiliation":[{"name":"Federal Research Center \u201cPushchino Scientific Center for Biological Research of the Russian Academy of Sciences\u201d, Institute of Cell Biophysics of the Russian Academy of Sciences, Pushchino 142290, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9312-6566","authenticated-orcid":false,"given":"Alexander D.","family":"Nadeev","sequence":"additional","affiliation":[{"name":"Federal Research Center \u201cPushchino Scientific Center for Biological Research of the Russian Academy of Sciences\u201d, Institute of Cell Biophysics of the Russian Academy of Sciences, Pushchino 142290, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay V.","family":"Goncharov","sequence":"additional","affiliation":[{"name":"Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Saint Petersburg 194223, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pneurobio.2012.06.010","article-title":"The Serotonergic System in Ageing and Alzheimer\u2019s Disease","volume":"99","author":"Noristani","year":"2012","journal-title":"Prog. 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