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Effective pain management is crucial, especially with RT being a key method for alleviating cancer pain, particularly in cases of bone and soft tissue metastases. RT provides relief for 60\u201380% of patients by reducing tumor size and mitigating associated pain. Radiotherapy itself can also induce pain, especially radiation-induced neuropathic pain, which may require further treatment. Despite these potential side effects, RT remains an essential tool in managing cancer pain, though careful management of its toxicities is necessary to improve patient QoL and survival.<\/jats:p>","DOI":"10.3390\/ijms26115223","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T06:25:04Z","timestamp":1748499904000},"page":"5223","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cancer Pain: Radiotherapy as a Double-Edged Sword"],"prefix":"10.3390","volume":"26","author":[{"given":"Monika","family":"Konopka-Filippow","sequence":"first","affiliation":[{"name":"Department of Oncology, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5584-6519","authenticated-orcid":false,"given":"Barbara","family":"Politynska","sequence":"additional","affiliation":[{"name":"Department of Psychology and Philosophy, Medical University of Bialystok,15-420 Bialystok, Poland"},{"name":"Robinson College, University of Cambridge, Cambridge CB3 9AN, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Wojtukiewicz","sequence":"additional","affiliation":[{"name":"Department of Psychology and Philosophy, Medical University of Bialystok,15-420 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7604-8188","authenticated-orcid":false,"given":"Marek Z.","family":"Wojtukiewicz","sequence":"additional","affiliation":[{"name":"Department of Oncology, Medical University of Bialystok, 15-089 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.clon.2006.09.007","article-title":"The Role of External Beam Radiotherapy in the Management of Bone Metastases","volume":"8","author":"Agarawal","year":"2006","journal-title":"Clin. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1111\/ajco.13095","article-title":"Satisfaction with pain management and impact of pain on quality of life in cancer patients","volume":"16","author":"Lin","year":"2020","journal-title":"Asia Pac. J. Clin. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Sierko, E., Hempel, D., Zuzda, K., and Wojtukiewicz, M.Z. (2019). Personalized Radiation Therapy in Cancer Pain Management. Cancers, 11.","DOI":"10.3390\/cancers11030390"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.clon.2011.11.004","article-title":"Update on the Systematic Review of Palliative Radiotherapy Trials for Bone Metastases","volume":"24","author":"Chow","year":"2012","journal-title":"Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.7150\/ijms.3635","article-title":"Cancer and radiation therapy: Current advances and future directions","volume":"9","author":"Baskar","year":"2012","journal-title":"Int. J. Med. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.brachy.2022.07.008","article-title":"Systematic review of brachytherapy for symptom palliation","volume":"6","author":"Jooya","year":"2022","journal-title":"Brachytherapy"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Becerra-Bola\u00f1os, \u00c1., Jim\u00e9nez-Gil, M., Federico, M., Dom\u00ednguez-D\u00edaz, Y., Valencia, L., and Rodr\u00edguez-P\u00e9rez, A. (2023). Pain in High-Dose-Rate Brachytherapy for Cervical Cancer: A Retrospective Cohort Study. J. Pers. Med., 13.","DOI":"10.3390\/jpm13081187"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1093\/neuonc\/noac094","article-title":"Spinal brachytherapy","volume":"24","author":"Mao","year":"2022","journal-title":"Neuro Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/S0140-6736(24)01865-8","article-title":"Efficacy and safety of prostate radiotherapy in de novo metastatic castration-sensitive prostate cancer (PEACE-1): A multicentre, open-label, randomised, phase 3 study with a 2 \u00d7 2 factorial design","volume":"404","author":"Bossi","year":"2024","journal-title":"Lancet"},{"key":"ref_10","first-page":"e15675","article-title":"High dose rate brachytherapy in nonmelanoma skin cancer\u2014Systematic review","volume":"9","author":"Krzysztofiak","year":"2022","journal-title":"Dermatol. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s13014-014-0301-8","article-title":"CT-guidance interstitial 125Iodine seed brachytherapy as a salvage therapy for recurrent spinal primary tumors","volume":"9","author":"Cao","year":"2014","journal-title":"Radiat. Oncol."},{"key":"ref_12","first-page":"271","article-title":"Effect of pedicle fixation combined with 125I seed implantation for metastatic thoracolumbar tumors","volume":"9","author":"Qian","year":"2016","journal-title":"J. Pain Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S1055-3207(03)00092-9","article-title":"Intraoperative high-dose-rate brachytherapy","volume":"4","author":"Nag","year":"2003","journal-title":"Surg. Oncol. Clin. N. Am."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"He, J., Mai, Q., Yang, F., Zhuang, W., Gou, Q., Zhou, Z., Xu, R., Chen, X., and Mo, Z. (2021). Feasibility and Clinical Value of CT-Guided 125I Brachytherapy for Pain Palliation in Patients with Breast Cancer and Bone Metastases After External Beam Radiotherapy Failure. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.627158"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e235","DOI":"10.1016\/j.wneu.2018.06.166","article-title":"Brachytherapy in Spinal Tumors: A Systematic Review","volume":"118","author":"Zuckerman","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e30708","DOI":"10.1002\/pbc.30708","article-title":"Delivery of re-irradiation and complex palliative radiotherapy using proton therapy in pediatric cancer patients","volume":"70","author":"Berlin","year":"2023","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1200\/OP.24.00132","article-title":"Proton Therapy: Current Status and Controversies","volume":"20","author":"Press","year":"2024","journal-title":"JCO Oncol. Pract."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1120\/jacmp.v16i6.5618","article-title":"Intensity-modulated radiotherapy versus proton radiotherapy versus carbon ion radiotherapy for spinal bone metastases: A treatment planning study","volume":"16","author":"Rief","year":"2015","journal-title":"J. Appl. Clin. Med. Phys."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.hoc.2024.11.007","article-title":"Heavy Ion Particle Therapy in Modern Day Radiation Oncology","volume":"39","author":"Liang","year":"2025","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Worawongsakul, R., Steinmeier, T., Lin, Y.L., Bauer, S., Hardes, J., Hecker-Nolting, S., Dirksen, U., and Timmermann, B. (2022). Proton Therapy for Primary Bone Malignancy of the Pelvic and Lumbar Region\u2014Data From the Prospective Registries ProReg and KiProReg. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.805051"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Gaito, S., Marvaso, G., Ortiz, R., Crellin, A., Aznar, M.C., Indelicato, D.J., Pan, S., Whitfield, G., Alongi, F., and Jereczek-Fossa, B.A. (2023). Proton Beam Therapy in the Oligometastatic\/Oligorecurrent Setting: Is There a Role? A Literature Review. Cancers, 26.","DOI":"10.3390\/cancers15092489"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1002\/1878-0261.12677","article-title":"Particle therapy in Europe","volume":"14","author":"Grau","year":"2020","journal-title":"Mol. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.ijrobp.2024.01.214","article-title":"Improving Access to Proton Therapy in the United States and Around the World","volume":"119","author":"Tsang","year":"2024","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"10943","DOI":"10.1073\/pnas.1901777116","article-title":"Long-term neurocognitive benefits of FLASH radiotherapy driven by reduced reactive oxygen species","volume":"116","author":"Acharya","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e41812","DOI":"10.2196\/41812","article-title":"FLASH Radiotherapy for the Treatment of Symptomatic Bone Metastases (FAST-01): Protocol for the First Prospective Feasibility Study","volume":"12","author":"Daugherty","year":"2023","journal-title":"JMIR Res. Protoc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13014-024-02419-4","article-title":"FLASH radiotherapy for the treatment of symptomatic bone metastases in the thorax (FAST-02): Protocol for a prospective study of a novel radiotherapy approach","volume":"19","author":"Daugherty","year":"2024","journal-title":"Radiat. Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"245ra93","DOI":"10.1126\/scitranslmed.3008973","article-title":"Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice","volume":"6","author":"Favaudon","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_28","first-page":"226","article-title":"Comparative clinical efficacy and safety of Phosphorus-32 and Strontium-89 in the palliative treatment of metastatic bone pain: Results of an IAEA Coordinated Research Project","volume":"34","author":"Fettich","year":"2003","journal-title":"World J. Nucl. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0959-8049(11)70100-9","article-title":"Sartor Overall survival benefit of radium-223 chloride (Alpharadin) in the treatment of patients with symptomatic bone metastases in Castration-resistant Prostate Cancer (CRPC): A phase III randomized trial (ALSYMPCA)","volume":"47","author":"Parker","year":"2011","journal-title":"Eur. J. Cancer."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s13139-017-0509-2","article-title":"Treatment of Bone Metastasis with Bone-Targeting Radiopharmaceuticals","volume":"52","author":"Choi","year":"2018","journal-title":"Nucl. Med. Mol. Imaging"},{"key":"ref_31","first-page":"819","article-title":"Strontium-89: A desirable therapeutic for bone metastases of prostate cancer","volume":"14","author":"Ma","year":"2008","journal-title":"Zhonghua Nan Ke Xue"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.2174\/092986712801215865","article-title":"Bone Target Radiotracers for Palliative Therapy of Bone Metastases","volume":"19","author":"Ogawa","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S1470-2045(05)70206-0","article-title":"Radioisotopes for the palliation of metastatic bone cancer: A systematic review","volume":"6","author":"Finlay","year":"2005","journal-title":"Lancet Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1056\/NEJMoa1213755","article-title":"Alpha Emitter Radium-223 and Survival in Metastatic Prostate Cancer","volume":"369","author":"Parker","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1159\/000096935","article-title":"Prospective evaluation of samarium-153-EDTMP radionuclide treatment for bone metastases in patients with hormone-refractory prostate cancer","volume":"78","author":"Dolezal","year":"2007","journal-title":"Urol. Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1007\/s002590100533","article-title":"A multicentre observational study of radionuclide therapy in patients with painful bone metastases of prostate cancer","volume":"28","author":"Dafermou","year":"2001","journal-title":"Eur. J. Nucl. Med."},{"key":"ref_37","first-page":"364","article-title":"The effectivness of strontium 89 in palliative therapy of painful prostate cancer bone metastases","volume":"5","author":"Baczyk","year":"2003","journal-title":"Ortop. Traumatol. Rehabil."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s10147-013-0597-7","article-title":"Strontium-89 (Sr-89) chloride in the treatment of various cancer patients with multiple bone metastases","volume":"19","author":"Zenda","year":"2014","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1023\/A:1010658522847","article-title":"Metastatic bone pain palliation with 89-Sr and 186-Re-HEDP in breast cancer patients","volume":"66","author":"Sciuto","year":"2001","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1259\/0007-1285-64-765-816","article-title":"Strontium-89 chloride for pain palliation in prostatic skeletal malignancy","volume":"64","author":"Laing","year":"1991","journal-title":"Br. J. Radiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.urology.2004.01.034","article-title":"Samarium-153-lexidronam complex for treatment of painful bone metastases in hormone-refractory prostate cancer","volume":"63","author":"Sartor","year":"2004","journal-title":"Urology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1200\/JCO.1998.16.4.1574","article-title":"Palliation of pain associated with metastatic bone cancer using samarium-153 lexidronam: A double-blind placebo-controlled clinical trial","volume":"16","author":"Serafini","year":"1998","journal-title":"J. Clin. Oncol."},{"key":"ref_43","first-page":"1150","article-title":"The PLACORHEN study: A double-blind, placebo-controlled, randomized radionuclide study with (186) Re-etidronate in hormone-resistant prostate cancer patients with painful bone metastases. Placebo Controlled Rhenium Study","volume":"43","author":"Han","year":"2002","journal-title":"J. Nucl. Med."},{"key":"ref_44","first-page":"639","article-title":"186Re-etidronate in breast cancer patients with metastatic bone pain","volume":"40","author":"Han","year":"1999","journal-title":"J. Nucl. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s002590050017","article-title":"Dose escalation study with rhenium-188 hydroxyethylidene diphosphonate in prostate cancer patients with osseous metastases","volume":"27","author":"Palmedo","year":"2000","journal-title":"Eur. J. Nucl. Med."},{"key":"ref_46","first-page":"261","article-title":"Rhenium-188-HEDP in the palliative treatment of bone metastases","volume":"15","author":"Liepe","year":"2000","journal-title":"Cancer Biother. Radiopharm."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"6231s","DOI":"10.1158\/1078-0432.CCR-06-0682","article-title":"Biology of Bone Cancer Pain","volume":"12","author":"Goblirsch","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1667\/RR3108","article-title":"Radiation treatment decreases bone cancer pain, osteolysis and tumor size","volume":"161","author":"Goblirsch","year":"2004","journal-title":"Radiat. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e203","DOI":"10.1016\/j.clon.2020.03.010","article-title":"Predicting Response to Radiotherapy in Cancer-Induced Bone Pain: Cytokines as a Potential Biomarker?","volume":"32","author":"MacLeod","year":"2020","journal-title":"Clin. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1119014","DOI":"10.1155\/2022\/1119014","article-title":"Study on the Correlation between Pain and Cytokine Expression in the Peripheral Blood of Patients with Bone Metastasis of Malignant Cancer Treated Using External Radiation Therapy","volume":"2022","author":"Lou","year":"2022","journal-title":"Pain Res. Manag."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1744806919849201","DOI":"10.1177\/1744806919849201","article-title":"X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation","volume":"15","author":"Xu","year":"2019","journal-title":"Mol. Pain"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jpainsymman.2022.06.018","article-title":"Inflammatory Markers and Radiotherapy Response in Patients With Painful Bone Metastases","volume":"64","author":"Habberstad","year":"2022","journal-title":"J. Pain Symptom Manag."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/bs.ircmb.2022.11.005","article-title":"Radiation-induced immune response in novel radiotherapy approaches FLASH and spatially fractionated radiotherapies","volume":"376","author":"Bertho","year":"2023","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.semradonc.2019.12.006","article-title":"Novel Radiation Therapy Paradigms and Immunomodulation: Heresies and Hope","volume":"30","author":"Dutt","year":"2020","journal-title":"Semin. Radiat. Oncol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1152\/jn.00503.2005","article-title":"cAMP and cGMP contribute to sensory neuron hyperexcitability and hyperalgesia in rats with dorsal root ganglia compression","volume":"95","author":"Song","year":"2006","journal-title":"J. Neurophysiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1152\/jn.00559.2006","article-title":"Dissociation of dorsal root ganglion neurons induces hyperexcitability that is maintained by increased responsiveness to cAMP and cGMP","volume":"97","author":"Zheng","year":"2007","journal-title":"J. Neurophysiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1016\/j.pain.2013.08.017","article-title":"EphrinB-EphB receptor signaling contributes to bone cancer pain via Toll-like receptor and proinflammatory cytokines in rat spinal cord","volume":"154","author":"Liu","year":"2013","journal-title":"Pain"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zhu, G., Dong, Y., He, X., Zhao, P., Yang, A., Zhou, R., Ma, J., Xie, Z., and Song, X.J. (2016). Radiotherapy Suppresses Bone Cancer Pain through Inhibiting Activation of cAMP Signaling in Rat Dorsal Root Ganglion and Spinal Cord. Mediat. Inflamm., 5093095.","DOI":"10.1155\/2016\/5093095"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s000660050061","article-title":"Remineralization and pain relief in bone metastases after after different radiotherapy fractions (10 times 3 Gy vs. 1 time 8 Gy). A prospective study","volume":"175","author":"Koswig","year":"1999","journal-title":"Strahlenther. Onkol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s13014-018-1161-4","article-title":"Bone density and pain response following intensity-modulated radiotherapy versus three-dimensional conformal radiotherapy for vertebral metastases\u2014Secondary results of a randomized trial","volume":"13","author":"Sprave","year":"2018","journal-title":"Radiat. Oncol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.prro.2016.08.017","article-title":"Attitudes of radiation oncologists toward palliative and supportive care in the United States: Report on national membership survey by the American Society for Radiation Oncology (ASTRO)","volume":"7","author":"Wei","year":"2017","journal-title":"Pract. Radiat. Oncol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-3-030-81526-4_10","article-title":"Palliative Radiation for Cancer Pain Management","volume":"182","author":"Amini","year":"2021","journal-title":"Cancer Treat. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.clon.2010.11.011","article-title":"Radiotherapy for pain","volume":"6","author":"Culleton","year":"2011","journal-title":"Clin. Oncol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"18","DOI":"10.21037\/apm-23-571","article-title":"Increased pain after palliative radiotherapy: Not only due to cancer progression","volume":"13","author":"Murakami","year":"2024","journal-title":"Ann. Palliat. Med."},{"key":"ref_65","first-page":"103","article-title":"Cancer Pain And Therapy","volume":"61","author":"Lesar","year":"2022","journal-title":"Acta Clin. Croat."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"22","DOI":"10.21037\/apc.2018.07.03","article-title":"Current and emerging radiotherapy strategies for pancreatic adenocarcinoma: Stereotactic, intensity modulated and particle radiotherapy","volume":"1","author":"Ng","year":"2018","journal-title":"Ann. Pancreat. Cancer."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"16427","DOI":"10.18632\/oncotarget.24713","article-title":"Stereotactic body radiation therapy for palliative management of pancreatic adenocarcinoma in elderly and medically inoperable patients","volume":"9","author":"Ryan","year":"2018","journal-title":"Oncotarget"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.hoc.2019.09.009","article-title":"Palliative Radiotherapy: Inpatients, Outpatients, and the Changing Role of Supportive Care in Radiation Oncology","volume":"34","author":"Arscott","year":"2020","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1200\/JCO.2007.15.3312","article-title":"Palliative thoracic radiotherapy for lung cancer: A systematic review","volume":"26","author":"Fairchild","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41572-020-00216-3","article-title":"Bone metastases","volume":"6","author":"Coleman","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ijrobp.2005.06.040","article-title":"A phase III randomized study on the sequencing of radiotherapy and chemotherapy in the conservative management of early-stage breast cancer","volume":"64","author":"Arcangeli","year":"2006","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"6337","DOI":"10.1007\/s11033-020-05684-0","article-title":"Bone metastases: A comprehensive review of the literature","volume":"47","author":"Migliorini","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_73","first-page":"1778","article-title":"Palliation of bone metastases","volume":"Volume 1","author":"Halperin","year":"2013","journal-title":"Principles and Practice of Radiation Oncology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2967\/jnumed.119.234260","article-title":"Molecular Imaging of Bone Metastases and Their Response to Therapy","volume":"61","author":"Cook","year":"2020","journal-title":"J. Nucl. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"66","DOI":"10.5603\/NMR.2013.0037","article-title":"Pattern and distribution of bone metastases in common malignant tumors","volume":"16","author":"Kakhki","year":"2013","journal-title":"Nucl. Med. Rev. Cent. East. Eur."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1152\/physrev.00012.2019","article-title":"Bone metastasis: Mechanisms, therapies, and biomarkers","volume":"101","author":"Coleman","year":"2021","journal-title":"Physiol. Rev."},{"key":"ref_77","first-page":"834","article-title":"Mechanisms of osteolytic bone metastases in breast carcinoma","volume":"1","author":"Mundy","year":"2003","journal-title":"Cancer"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"6213s","DOI":"10.1158\/1078-0432.CCR-06-1007","article-title":"Basic mechanisms responsible for osteolytic and osteoblastic bone metastases","volume":"12","author":"Guise","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.clon.2020.07.010","article-title":"Spine and Non-spine Bone Metastases\u2014Current Controversies and Future Direction","volume":"32","author":"Challapalli","year":"2020","journal-title":"Clin. Oncol. R Coll. Radiol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1097\/j.pain.0000000000000895","article-title":"Prevalence and incidence of chronic pain with or without neuropathic characteristics in patients with cancer","volume":"158","author":"Bouhassira","year":"2017","journal-title":"Pain"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3344\/kjp.22392","article-title":"Neuropathic pain feature in cancer-induced bone pain: Does it matter? A prospective observational study","volume":"36","author":"Zinboonyahgoon","year":"2023","journal-title":"Korean J. Pain"},{"key":"ref_82","first-page":"220","article-title":"Radiotherapy for neuropathic pain due to bone metastases","volume":"4","author":"Roos","year":"2015","journal-title":"Ann. Palliat. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.radonc.2021.07.022","article-title":"Advances in radiotherapy in bone metastases in the context of new target therapies and ablative alternatives: A critical review","volume":"163","author":"Gouveia","year":"2021","journal-title":"Radiother. Oncol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.3390\/curroncol30070500","article-title":"Cancer Pain Management: A Narrative Review of Current Concepts, Strategies, and Techniques","volume":"30","author":"Mestdagh","year":"2023","journal-title":"Curr. Oncol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00774-022-01382-y","article-title":"Management of cancer pain due to bone metastasis","volume":"41","author":"Takei","year":"2023","journal-title":"J. Bone Miner. Metab."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.ijrobp.2010.11.026","article-title":"Palliative radiotherapy for bone metastases: An ASTRO evidence-based guideline","volume":"79","author":"Lutz","year":"2011","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.semradonc.2022.11.004","article-title":"Radiation Therapy for Painful Bone Metastases: Fractionation, Recalcification, and Symptom Control","volume":"2","author":"Tseng","year":"2023","journal-title":"Semin. Radiat. Oncol."},{"key":"ref_88","first-page":"1002","article-title":"Defining the radiation oncologist\u2019s role in palliative care and radiotherapy","volume":"7","author":"Lam","year":"2018","journal-title":"Ann. Palliat. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.radonc.2008.05.018","article-title":"Randomized clinical trial with two palliative radiotherapy regimens in painful bone metastases: 30 Gy in 10 fractions compared with 8 Gy in single fraction","volume":"89","author":"Fontanals","year":"2008","journal-title":"Radiother. Oncol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"91","DOI":"10.14740\/wjon1118w","article-title":"Comparison of Single Versus Multifraction Radiotherapy in Palliation of Painful Bone Metastases","volume":"9","author":"Nongkynrih","year":"2018","journal-title":"World J. Oncol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s12032-023-02238-9","article-title":"Short-term pain control after palliative radiotherapy for uncomplicated bone metastases: A prospective cohort study","volume":"41","author":"Bianchi","year":"2023","journal-title":"Med. Oncol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1093\/jnci\/dji166","article-title":"Palliative Single-Fraction Radiation Therapy: How Much More Evidence Is Needed?","volume":"97","author":"Kachnic","year":"2005","journal-title":"JNCI"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S1470-2045(13)70556-4","article-title":"Single versus multiple fractions of repeat radiation for painful bone metastases: A randomised, controlled, non-inferiority trial","volume":"15","author":"Chow","year":"2014","journal-title":"Lancet Oncol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.radonc.2004.09.017","article-title":"Randomized trial of 8 Gy in 1 versus 20 Gy in 5 fractions of radiotherapy for neuropathic pain due to bone metastases (Trans-Tasman Radiation Oncology Group, TROG 96.05)","volume":"75","author":"Roos","year":"2005","journal-title":"Radiother. Oncol."},{"key":"ref_95","first-page":"34","article-title":"A neuropathic pain component as a predictor of improvement in pain interference after radiotherapy for painful tumors: A secondary analysis of a prospective observational study","volume":"12","author":"Saito","year":"2018","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"865","DOI":"10.21873\/anticanres.16229","article-title":"Time to Pain Relapse After Palliative Radiotherapy for Bone Metastasis: A Prospective Multi-institutional Study","volume":"43","author":"Saito","year":"2023","journal-title":"Anticancer Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.ijrobp.2022.10.017","article-title":"Stereotactic Body Radiation Therapy Versus Conventional Radiation Therapy in Pain Relief for Bone Metastases: A Systematic Review and Meta-Analysis","volume":"115","author":"Song","year":"2023","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Ito, K., Taguchi, K., Nakajima, Y., Ogawa, H., and Murofushi, K.N. (2022). Palliative Efficacy of High-Dose Stereotactic Body Radiotherapy Versus Conventional Radiotherapy for Painful Non-Spine Bone Metastases: A Propensity Score-Matched Analysis. Cancers, 14.","DOI":"10.3390\/cancers14164014"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"103775","DOI":"10.1016\/j.critrevonc.2022.103775","article-title":"Stereotactic body radiation therapy versus conventional external beam radiation therapy for painful bone metastases: A systematic review and meta-analysis of randomized trials","volume":"178","author":"Lee","year":"2022","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1093\/jnci\/djz101","article-title":"Systematic Review of the Role of Stereotactic Radiotherapy for Bone Metastases","volume":"111","author":"Spencer","year":"2019","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s11912-024-01515-8","article-title":"An Update on the Management of Bone Metastases","volume":"26","author":"Grosinger","year":"2024","journal-title":"Curr. Oncol. Rep."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"109914","DOI":"10.1016\/j.radonc.2023.109914","article-title":"Stereotactic body radiation therapy versus conventional external beam radiotherapy for spinal metastases: A systematic review and meta-analysis of randomized controlled trials","volume":"189","author":"Wong","year":"2023","journal-title":"Radiother. Oncol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"101411","DOI":"10.1016\/j.adro.2023.101411","article-title":"A Prospective Study Assessing the Efficacy and Toxicity of Stereotactic Body Radiation Therapy for Oligometastatic Bone Metastases","volume":"9","author":"Lee","year":"2023","journal-title":"Adv. Radiat. Oncol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.prro.2016.08.001","article-title":"Palliative radiation therapy for bone metastases: Update of an ASTRO Evidence-Based Guideline","volume":"7","author":"Lutz","year":"2017","journal-title":"Pract. Radiat. Oncol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.radonc.2022.05.024","article-title":"ESTRO ACROP guidelines for external beam radiotherapy of patients with uncomplicated bone metastases","volume":"173","author":"Willmann","year":"2022","journal-title":"Radiother. Oncol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.radonc.2022.06.002","article-title":"ESTRO ACROP guidelines for external beam radiotherapy of patients with complicated bone metastases","volume":"173","author":"Oldenburger","year":"2022","journal-title":"Radiother. Oncol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0167-8140(99)00110-3","article-title":"The effect of a single fraction compared to multiple fractions on painful bone metastases: A global analysis of the Dutch Bone Metastasis Study","volume":"2","author":"Steenland","year":"1999","journal-title":"Radiother. Oncol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s000660050062","article-title":"Palliative Strahlentherapie von Knochenmetastasen. Eine retrospective Analyse von 176 Patienten [Palliative radiotherapy of bone metastases. A retrospective analysis of 176 patients]","volume":"175","author":"Koswig","year":"1999","journal-title":"Strahlenther. Onkol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1093\/jnci\/dji139","article-title":"Randomized trial of short- versus long-course radiotherapy for palliation of painful bone metastases","volume":"97","author":"Hartsell","year":"2005","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1001\/jamaoncol.2019.0192","article-title":"Single-Fraction Stereotactic vs Conventional Multifraction Radiotherapy for Pain Relief in Patients With Predominantly Nonspine Bone Metastases: A Randomized Phase 2 Trial","volume":"5","author":"Nguyen","year":"2019","journal-title":"JAMA Oncol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11060-023-04327-1","article-title":"Stereotactic body radiotherapy for spine metastases: A review of 24 Gy in 2 daily fractions","volume":"163","author":"Nguyen","year":"2023","journal-title":"J. Neurooncol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1001\/jamaoncol.2023.0356","article-title":"Stereotactic Radiosurgery vs Conventional Radiotherapy for Localized Vertebral Metastases of the Spine: Phase 3 Results of NRG Oncology\/RTOG 0631 Randomized Clinical Trial","volume":"9","author":"Ryu","year":"2023","journal-title":"JAMA Oncol."},{"key":"ref_113","first-page":"100845","article-title":"Half body irradiation (HBI) for bone metastases in the modern radiotherapy technique era\u2014A systematic review","volume":"49","author":"Bilski","year":"2024","journal-title":"Clin. Transl. Radiat. Oncol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejmp.2017.12.022","article-title":"A novel Hemi-Body Irradiation technique using electron beams (HBIe\u2212)","volume":"46","author":"Delinikolas","year":"2018","journal-title":"Phys. Medica"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"28","DOI":"10.4103\/2278-330X.126513","article-title":"Hemi body irradiation: An economical way of palliation of pain in bone metastasis in advanced cancer","volume":"3","author":"Pal","year":"2014","journal-title":"South Asian J. Cancer."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nrclinonc.2014.96","article-title":"The oligometastatic state-separating truth from wishful thinking","volume":"11","author":"Palma","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"1533033818802304","DOI":"10.1177\/1533033818802304","article-title":"Stereotactic Body Radiation Therapy for Spinal Malignancies","volume":"17","author":"Osborn","year":"2018","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"e2355409","DOI":"10.1001\/jamanetworkopen.2023.55409","article-title":"Stereotactic Body and Conventional Radiotherapy for Painful Bone Metastases: A Systematic Review and Meta-Analysis","volume":"7","author":"Bindels","year":"2024","journal-title":"JAMA Netw. Open."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.radonc.2017.12.011","article-title":"Palliative radiotherapy for locally advanced non-metastatic head and neck cancer: A systematic review","volume":"126","author":"Kelly","year":"2018","journal-title":"Radiother. Oncol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e2300253","DOI":"10.1200\/GO.23.00253","article-title":"Outcome of Hypofractionated Palliative Radiotherapy Regimens for Patients with Advanced Head and Neck Cancer in Tikur Anbessa Hospital, Ethiopia: A Prospective Cohort Study","volume":"10","author":"Zingeta","year":"2024","journal-title":"JCO Glob. Oncol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1515\/sjpain-2020-0067","article-title":"Pain management in patients undergoing radiation therapy for head and neck cancer\u2014A descriptive study","volume":"21","author":"Schaller","year":"2020","journal-title":"Scand. J. Pain"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0167-8140(99)00066-3","article-title":"Radiobiological mechanisms of anti-inflammatory radiotherapy","volume":"51","author":"Trott","year":"1999","journal-title":"Radiother. Oncol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s00066-012-0170-8","article-title":"Anti-inflammatory effects of low-dose radiotherapy. Indications, dose, and radiobiological mechanisms involved","volume":"188","author":"Arenas","year":"2012","journal-title":"Strahlenther. Onkol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s00066-021-01816-y","article-title":"Low-dose radiotherapy for painful osteoarthritis of the elderly: A multicenter analysis of 970 patients with 1185 treated sites","volume":"197","author":"Tkotsch","year":"2021","journal-title":"Strahlenther. Onkol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1017\/S1460396923000067","article-title":"The analgesic effect of low-dose radiotherapy in treating benign musculoskeletal painful disorders using different energies: A retrospective cohort study","volume":"22","author":"Abdelmaqsoud","year":"2023","journal-title":"JRP"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Weissmann, T., R\u00fcckert, M., Zhou, J.G., Seeling, M., Lettmaier, S., Donaubauer, A.J., Nimmerjahn, F., Ott, O.J., Hecht, M., and Putz, F. (2022). Low-Dose Radiotherapy Leads to a Systemic Anti-Inflammatory Shift in the Pre-Clinical K\/BxN Serum Transfer Model and Reduces Osteoarthritic Pain in Patients. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.777792"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1080\/09553002.2021.1956000","article-title":"Low-dose radiation therapy for osteoarthritis and enthesopathies: A review of current data","volume":"97","author":"Javadinia","year":"2021","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.ijrobp.2017.07.029","article-title":"Development and Internal Validation of a Clinical Risk Score to Predict Pain Response After Palliative Radiation Therapy in Patients With Bone Metastases","volume":"99","author":"Peters","year":"2017","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/papr.12823","article-title":"Pain Flare-Effect Prophylaxis With Corticosteroids on Bone Radiotherapy Treatment: A Systematic Review","volume":"20","author":"Fabregat","year":"2020","journal-title":"Pain Pract."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jpainsymman.2021.03.022","article-title":"Clinical Predictors for Analgesic Response to Radiotherapy in Patients with Painful Bone Metastases","volume":"62","author":"Habberstad","year":"2021","journal-title":"J. Pain Symptom Manag."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Donati, C.M., Maggiore, C.M., Maltoni, M., Rossi, R., Nardi, E., Zamagni, A., Siepe, G., Mammini, F., Cellini, F., and Di Rito, A. (2023). Adequacy of Pain Management in Patients Referred for Radiation Therapy: A Subanalysis of the Multicenter ARISE-1 Study. Cancers, 16.","DOI":"10.3390\/cancers16010109"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.radonc.2012.10.012","article-title":"Radiation-induced neuropathy in cancer survivors","volume":"105","author":"Delanian","year":"2012","journal-title":"Radiother. Oncol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1191\/0269215502cr470oa","article-title":"Radiation-induced brachial plexopathy in women treated for carcinoma of the breast","volume":"16","author":"Fathers","year":"2002","journal-title":"Clin. Rehabil."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S1470-2045(10)70026-7","article-title":"Defining pelvic-radiation disease for the survivorship era","volume":"11","author":"Andreyev","year":"2010","journal-title":"Lancet Oncol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"E793","DOI":"10.36076\/ppj.2013\/16\/E793","article-title":"Pudendal entrapment neuropathy: A rare complication of pelvic radiation therapy","volume":"16","author":"Elahi","year":"2013","journal-title":"Pain Physician"},{"key":"ref_136","unstructured":"WHO (2018). WHO Guidelines for the Pharmacological and Radiotherapeutic Management of Cancer Pain in Adults and Adolescents."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"545","DOI":"10.2147\/JPR.S155070","article-title":"Radiation-induced neuropathic pain successfully treated with systemic lidocaine administration","volume":"11","author":"Doo","year":"2018","journal-title":"J. Pain Res."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"104232","DOI":"10.1016\/j.lpm.2024.104232","article-title":"Neuropathic pain: Evidence based recommendations","volume":"53","author":"Moisset","year":"2024","journal-title":"Presse Med."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Tsai, J.H., Liu, I.T., Su, P.F., Huang, Y.T., Chiu, G.L., Chen, Y.Y., Lai, W.S., and Lin, P.C. (2023). Lidocaine transdermal patches reduced pain intensity in neuropathic cancer patients already receiving opioid treatment. BMC Palliat. Care., 22.","DOI":"10.1186\/s12904-023-01126-3"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1007\/s12094-024-03460-1","article-title":"Evolution of radiation-induced dermatitis treatment","volume":"26","author":"Guangmei","year":"2024","journal-title":"Clin. Transl. Oncol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3747\/co.27.6233","article-title":"Radiotherapy side effects: Integrating a survivorship clinical lens to better serve patients","volume":"2","author":"Dilalla","year":"2020","journal-title":"Curr. Oncol."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Stubblefield, M.D. (2018). Cancer Rehabilitation: Principles and Practice, Demos Medical. [2nd ed.].","DOI":"10.1891\/9780826121646"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/mus.21370","article-title":"Sciatic nerve moneuropathy: An unusual late effect of radiotherapy","volume":"40","author":"Pradat","year":"2009","journal-title":"Muscle Nerve"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"e198","DOI":"10.1097\/PHM.0000000000001809","article-title":"Sciatic Neuropathy After Radiation Treatment","volume":"100","author":"Zhu","year":"2021","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1177\/19714009221096824","article-title":"Manifestations of radiation toxicity in the head, neck, and spine: An image-based review","volume":"4","author":"Carr","year":"2022","journal-title":"Neuroradiol. J."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/hed.21654","article-title":"Factors predictive of severity of osteoradionecrosis of the mandible","volume":"33","author":"Chopra","year":"2011","journal-title":"Head Neck"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.3174\/ajnr.A3879","article-title":"Osteoradionecrosis after radiation therapy for head and neck cancer: Differentiation from recurrent disease with CT and PET\/CT imaging","volume":"35","author":"Alhilali","year":"2014","journal-title":"Am. J. Neuroradiol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/jjco\/hyab164","article-title":"Fracture risk following stereotactic body radiotherapy for long bone metastases","volume":"52","author":"Ito","year":"2022","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"E514","DOI":"10.1097\/BRS.0000000000004282","article-title":"Effects of Radiation on the Bone Strength of Spinal Vertebrae in Rats","volume":"47","author":"Igarashi","year":"2022","journal-title":"Spine Phila Pa 1976"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3857\/roj.2023.00969","article-title":"The effects of high-dose radiation therapy on bone: A scoping review","volume":"42","author":"Berk","year":"2024","journal-title":"Radiat. Oncol. J."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1186\/s12885-018-4899-z","article-title":"Osteoporosis development and vertebral fractures after abdominal irradiation in patients with gastric cancer","volume":"11","author":"Yaprak","year":"2018","journal-title":"BMC Cancer"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"731","DOI":"10.3904\/kjim.2023.386","article-title":"Cancer treatment-induced bone loss","volume":"39","author":"Choi","year":"2024","journal-title":"Korean J. Intern. Med."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.4103\/jcrt.JCRT_1793_20","article-title":"Comparison of two schedules of hypo-fractionated radiotherapy in locally advanced head-and-neck cancers","volume":"18","author":"Adlakha","year":"2022","journal-title":"J. Cancer Res. Ther."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ijrobp.2019.05.024","article-title":"Palliative Radiation Therapy for Head and Neck Cancers","volume":"1","author":"Grewal","year":"2019","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"183","DOI":"10.12788\/j.suponc.0009","article-title":"Characterization of skin reactions and pain reported by patients receiving radiation therapy for cancer at different sites","volume":"11","author":"Gewandter","year":"2013","journal-title":"J. Support. Oncol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3857\/roj.2023.00626","article-title":"Comparison between 1-week and 2-week palliative radiotherapy courses for superior vena cava syndrome","volume":"41","author":"Park","year":"2023","journal-title":"Radiat. Oncol. J."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1002\/hed.27313","article-title":"Correlations between the severity of radiation-induced oral mucositis and salivary epidermal growth factor as well as inflammatory cytokines in patients with head and neck cancer","volume":"45","author":"Xu","year":"2023","journal-title":"Head Neck"},{"key":"ref_158","first-page":"1","article-title":"Pain management for persistent pain post radiotherapy in head and neck cancers: Systematic review","volume":"15","author":"Young","year":"2023","journal-title":"Scand. J. Pain"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00520-020-05462-5","article-title":"Self-reported pain in breast cancer patients receiving adjuvant radiotherapy","volume":"29","author":"Lam","year":"2021","journal-title":"Support. Care Cancer"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.pmn.2020.12.007","article-title":"Patient-Reported Pain in Patients with Breast Cancer Who Receive Radiotherapy","volume":"22","author":"Wan","year":"2021","journal-title":"Pain Manag. Nurs."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.2147\/JPR.S167994","article-title":"Stereotactic radiotherapy of pancreatic cancer: A systematic review on pain relief","volume":"4","author":"Buwenge","year":"2018","journal-title":"J. Pain Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21037\/apm-23-560","article-title":"Palliative radiotherapy for pancreatic cancer","volume":"13","author":"Friedes","year":"2024","journal-title":"Ann. Palliat. Med."},{"key":"ref_163","doi-asserted-by":"crossref","unstructured":"Biran, A., Bolnykh, I., Rimmer, B., Cunliffe, A., Durrant, L., Hancock, J., Ludlow, H., Pedley, I., Rees, C., and Sharp, L. (2023). A Systematic Review of Population-Based Studies of Chronic Bowel Symptoms in Cancer Survivors following Pelvic Radiotherapy. Cancers, 15.","DOI":"10.3390\/cancers15164037"},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.dld.2024.07.026","article-title":"Palliative pelvic radiotherapy for symptomatic frail or metastatic patients with rectal adenocarcinoma: A systematic review","volume":"57","author":"Bisson","year":"2025","journal-title":"Dig. Liver Dis."},{"key":"ref_165","first-page":"1729","article-title":"Early neurological complications after stereotactic radiosurgery\/radiotherapy","volume":"84","author":"Dhanachai","year":"2001","journal-title":"J. Med. Assoc. Thai."},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.21037\/apm-23-342","article-title":"Emergent radiotherapy for spinal cord compression\/impingement\u2014A narrative review","volume":"12","author":"Zaki","year":"2023","journal-title":"Ann. Palliat. Med."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1007\/s00520-023-08186-4","article-title":"Quality of life in patients with malignant spinal cord compression: A systematic review","volume":"31","author":"Gojsevic","year":"2023","journal-title":"Support. Care Cancer"},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s11764-011-0172-z","article-title":"A study of chronic pelvic pain after radiotherapy in survivors of locally advanced cervical cancer","volume":"5","author":"Vistad","year":"2011","journal-title":"J. Cancer Surviv."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1080\/01443615.2022.2035329","article-title":"Vaginal mucositis in patients with gynaecological cancer undergoing (chemo-)radiotherapy: A retrospective analysis","volume":"42","author":"Robijns","year":"2022","journal-title":"J. Obstet. Gynaecol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s00520-006-0166-y","article-title":"Pain flare in patients with bone metastases after palliative radiotherapy\u2014A nested randomized control trial","volume":"15","author":"Loblaw","year":"2007","journal-title":"Support. Care Cancer"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.radonc.2004.12.016","article-title":"Pain flare following external beam radiotherapy and meaningful change in pain scores in the treatment of bone metastases","volume":"75","author":"Chow","year":"2005","journal-title":"Radiother. Oncol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ijrobp.2008.10.044","article-title":"Determining the incidence of pain flare following palliative radiotherapy for symptomatic bone metastases: Results from three canadian cancer centers","volume":"75","author":"Hird","year":"2009","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/S1470-2045(15)00199-0","article-title":"Dexamethasone in the prophylaxis of radiation-induced pain flare after palliative radiotherapy for bone metastases: A double-blind, randomised placebo-controlled, phase 3 trial","volume":"16","author":"Chow","year":"2015","journal-title":"Lancet Oncol."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11684-020-0761-1","article-title":"Artificial intelligence in radiotherapy: A technological review","volume":"14","author":"Sheng","year":"2020","journal-title":"Front. Med."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.diii.2024.06.001","article-title":"Artificial intelligence in radiotherapy: Current applications and future trends","volume":"105","author":"Giraud","year":"2024","journal-title":"Diagn. Interv. Imaging."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"e14559","DOI":"10.1002\/acm2.14559","article-title":"Machine learning in image-based outcome prediction after radiotherapy: A review","volume":"26","author":"Yuan","year":"2025","journal-title":"J. Appl. Clin. Med. Phys."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/11\/5223\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:42:57Z","timestamp":1760031777000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/11\/5223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,29]]},"references-count":176,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["ijms26115223"],"URL":"https:\/\/doi.org\/10.3390\/ijms26115223","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,29]]}}}