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A comprehensive literature review was conducted using recent studies and clinical trials focused on nanotechnology-based cisplatin delivery systems. The analysis covered various types of nanocarriers, their mechanisms, and advantages. Additionally, the limitations of nanotechnology-based cisplatin delivery systems were discussed. Findings indicate that lipid-based nanoparticles, polymeric nanoparticles, inorganic nanoparticles, and extracellular vesicles have demonstrated improved drug targeting, bioavailability, and reduced systemic toxicity in preclinical and clinical studies. Nanocarriers also offer potential for overcoming drug resistance and enabling combination therapy. However, challenges related to biocompatibility, scalability, and regulatory approval remain significant barriers to widespread clinical adoption. Nanotechnology offers a novel and promising approach to optimizing cisplatin delivery for ORL cancers. While preclinical studies demonstrate significant potential, further research and clinical validation are essential to translate these advancements into routine clinical practice. Addressing manufacturing and regulatory challenges will be critical for future research.<\/jats:p>","DOI":"10.3390\/ijms26115261","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:14:27Z","timestamp":1748585667000},"page":"5261","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Advances in Nanotechnology-Based Cisplatin Delivery for ORL Cancers: A Comprehensive Review"],"prefix":"10.3390","volume":"26","author":[{"given":"Anda Ioana","family":"Morgovan","sequence":"first","affiliation":[{"name":"Department of Ear, Nose and Throat, Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugen Radu","family":"Boia","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat, Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru Catalin","family":"Motofelea","sequence":"additional","affiliation":[{"name":"Center for Molecular Research in Nephrology and Vascular Disease, Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru","family":"Orasan","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat, Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3002-7656","authenticated-orcid":false,"given":"Mihaela Cristina","family":"Negru","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat, Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine","family":"Guran","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat, Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Maria","family":"Para","sequence":"additional","affiliation":[{"name":"Department of Ear, Nose and Throat, Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Sq., 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Sandu","sequence":"additional","affiliation":[{"name":"OncoHelp Cancer Centre, Radiation Oncology Department, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Str. 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