{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T19:30:55Z","timestamp":1792438255389,"version":"4.5.0"},"reference-count":141,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:00:00Z","timestamp":1748649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Normal-Hong Kong Baptist University","award":["UICR0400015-24B"],"award-info":[{"award-number":["UICR0400015-24B"]}]},{"name":"Beijing Normal-Hong Kong Baptist University","award":["UICR0400016-24B"],"award-info":[{"award-number":["UICR0400016-24B"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Colon cancer is the second leading cause of cancer-related deaths in the world. This is commonly observed among older adults, and the occurrence of colon cancer is mainly influenced by unhealthy lifestyle factors. Edible medicinal mushrooms have been demonstrated to have anti-colon cancer effects both individually and in combination with conventional therapies, including synergistically enhancing the efficacy of chemotherapy medications such as 5-fluorouracil in preclinical models. Medicinal mushrooms such as Lentinus edodes, Phellinus linteus, Ganoderma lucidum, Inonotus obliquus, Pleurotus ostreatus, Hericium erinaceus, Pleurotus eryngii, Gloeostereum incarnatum, and Termitomyces heimii are emerging as promising candidates, not only because conventional treatments for colon cancer face significant limitations, including side effects, psychological impacts on patients, high cost, limited specificity toward cancer and healthy cells, and the development of drug resistance, but also due to the diverse array of bioactive compounds present within them. Therefore, there is a strong demand for innovative, affordable, and minimally invasive treatments such as medicinal mushrooms. Their bioactive compounds, including terpenoids, sterols, phenols, polysaccharides, acids, sesquiterpenes, alkaloids, lactones, metal-chelating agents, nucleotide analogs, glycoproteins, \u03b2-glucan, cerebrosides, steroids, terpenes, quinolones, anthraquinones, benzoic acid derivatives, linoleic acid, ascorbic acid, glycosides, organic acids, flavonoids, grifolin, tocopherols, proteins, indoles, lectin, and laccases, exert anti-colon cancer activities through various mechanisms, including anti-proliferative effects, cell cycle arrest, anti-inflammatory effects, antioxidant effects, induction of apoptosis, cytotoxic effects, and antimigratory effects. Further research is needed to elucidate the molecular mechanisms and confirm the safety and efficacy of medicinal mushrooms as a holistic anti-colon cancer treatment.<\/jats:p>","DOI":"10.3390\/ijms26115304","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T11:40:32Z","timestamp":1748864432000},"page":"5304","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Medicinal Mushrooms in Colon Cancer Therapy: Mechanisms of Action of Bioactive Compounds and Therapeutic Potential"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8657-6808","authenticated-orcid":false,"given":"Jinangi","family":"Bentharavithana","sequence":"first","affiliation":[{"name":"Food Science and Technology Program, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai 519085, China"},{"name":"Department of Food Science and Technology, Faculty of Agriculture, University of Peradeniya, Peradeniya 20400, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6792-0168","authenticated-orcid":false,"given":"Tahidul","family":"Islam","sequence":"additional","affiliation":[{"name":"Food Science and Technology Program, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai 519085, China"},{"name":"School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0739-3735","authenticated-orcid":false,"given":"Baojun","family":"Xu","sequence":"additional","affiliation":[{"name":"Food Science and Technology Program, Department of Life Sciences, Beijing Normal-Hong Kong Baptist University, Zhuhai 519085, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Chaturvedi, V.K., Agarwal, S., Gupta, K.K., Ramteke, P.W., and Singh, M.P. (2018). Medicinal mushroom: Boon for therapeutic applications. 3 Biotech., 8.","DOI":"10.1007\/s13205-018-1358-0"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Valverde, M.E., Hern\u00e1ndez-P\u00e9rez, T., and Paredes-L\u00f3pez, O. (2015). Edible mushrooms: Improving human health and promoting quality life. Int. J. Microbiol., 2015.","DOI":"10.1155\/2015\/376387"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1615\/IntJMedMushr.v14.i2.10","article-title":"The role of culinary-medicinal mushrooms on human welfare with a pyramid model for human health","volume":"14","author":"Chang","year":"2012","journal-title":"Int. J. Med. Mushrooms."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.fct.2018.01.015","article-title":"Apoptosis induction by Pleurotus sajor-caju (Fr.) Singer extracts on colorectal cancer cell lines","volume":"112","author":"Finimundy","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.phymed.2010.07.004","article-title":"A laccase with antiproliferative activity against tumor cells from an edible mushroom, white common Agrocybe cylindracea","volume":"18","author":"Hu","year":"2011","journal-title":"Phytomedicine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/ptr.2836","article-title":"Antitumor activity of water extract of a mushroom, Inonotus obliquus, against HT-29 human colon cancer cells","volume":"23","author":"Lee","year":"2009","journal-title":"Phytother. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1158\/1055-9965.EPI-15-0578","article-title":"Global cancer incidence and mortality rates and trends--an update","volume":"25","author":"Torre","year":"2016","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"ref_8","first-page":"89","article-title":"Epidemiology of colorectal cancer: Incidence, mortality, survival, and risk factors","volume":"14","author":"Rawla","year":"2019","journal-title":"Przeglad Gastroenterologiczny."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Singha, K., Hor, P.K., Soren, J.P., Mondal, J., Mondal, K.C., Pati, B.R., and Mohapatra, P.K.D. (2021). Exploration of bioactive prospects of a polysaccharide fraction from Termitomyces heimii against colorectal cancer and broad-spectrum bacteria. Bioact. Carbohydr. Diet. Fibre, 25.","DOI":"10.1016\/j.bcdf.2020.100255"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Abdel-Azeem, A.M., Abdel-Azeem, M.A., and Khalil, W.F. (2019). Endophytic fungi as a new source of antirheumatoid metabolites. Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases, Academic Press. [2nd ed.].","DOI":"10.1016\/B978-0-12-813820-5.00021-0"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jbiotec.2023.12.014","article-title":"An insight into the nutritional and medicinal value of edible mushrooms: A natural treasury for human health","volume":"381","author":"Hamza","year":"2024","journal-title":"J. Biotechnol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4236\/ojpm.2021.111002","article-title":"Biological active components of selected medical fungi","volume":"11","author":"Frljak","year":"2021","journal-title":"Open J. Prev. Med."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Kumar, K., Mehra, R., Guin\u00e9, R.P.F., Lima, M.J., Kumar, N., Kaushik, R., Ahmed, N., Yadav, A.N., and Kumar, H. (2021). Edible mushrooms: A comprehensive review on bioactive compounds with health benefits and processing aspects. Foods, 10.","DOI":"10.3390\/foods10122996"},{"key":"ref_14","first-page":"47","article-title":"Research on mushroom as a potential source of nutraceuticals: A review on Indian perspective","volume":"2","author":"Khatun","year":"2012","journal-title":"J. Exp. Agric Int."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"He, Z., Lin, J., He, Y., and Liu, S. (2022). Polysaccharide-peptide from Trametes versicolor: The potential medicine for colorectal cancer treatment. Biomedicines, 10.","DOI":"10.3390\/biomedicines10112841"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Sadowska, A., Zapora, E., Sawicka, D., Niemirowicz-Laskowska, K., Sura\u017cy \u0144ski, A., Su\u0142kowska-Ziaja, K., Ka\u0142a, K., Stocki, M., Wo\u0142kowycki, M., and Bakier, S. (2020). Heterobasidion annosum induces apoptosis in DLD-1 cells and decreases colon cancer growth in in vivo model. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21103447"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Zhang, N., Liu, Y., Tang, F.Y., Yang, L.Y., and Wang, J.H. (2023). Structural characterization and in vitro anti-colon cancer activity of a homogeneous polysaccharide from Agaricus bisporus. Int. J. Biol. Macromol., 251.","DOI":"10.1016\/j.ijbiomac.2023.126410"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2298\/ABS150427131S","article-title":"Cytotoxic, antimigratory, pro-and antioxidative activities of extracts from medicinal mushrooms on colon cancer cell lines","volume":"68","year":"2016","journal-title":"Arch. Biol. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1615\/IntJMedMushr.v15.i3.70","article-title":"Enhanced antiproliferative effects of aqueous extracts of some medicinal mushrooms on colon cancer cells","volume":"15","author":"Arora","year":"2013","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/IntJMedMushrooms.2022045181","article-title":"Anticancer properties of selenium-enriched oyster culinary-medicinal mushroom, Pleurotus ostreatus (Agaricomycetes), in colon cancer in vitro","volume":"24","author":"Fekry","year":"2022","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_21","first-page":"15","article-title":"Antitumor activity of combination treatment of Lentinus edodes mycelium extracts with 5-Fluorouracil against human colon cancer cells xenografted in nude mice","volume":"3","author":"Wu","year":"2007","journal-title":"J. Cancer Mol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"121069","DOI":"10.1016\/j.carbpol.2023.121069","article-title":"Effect of the \u03b2-glucan from Lentinus edodes on colitis-associated colorectal cancer and gut microbiota","volume":"316","author":"Liu","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/pcmedi\/pbab023","article-title":"Inhibitory activity of medicinal mushroom Ganoderma lucidum on colorectal cancer by attenuating inflammation","volume":"4","author":"Liu","year":"2021","journal-title":"Precis. Clin. Med."},{"key":"ref_24","unstructured":"Wachtel-Galor, S., Yuen, J., Buswell, J.A., and Benzie, I.F.F. (2025, March 15). Ganoderma lucidum (Lingzhi or Reishi), Herbal Medicine: Biomolecular and Clinical Aspects, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK92757\/."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ijbiomac.2020.04.162","article-title":"Isolation and structural characterization of a novel polysaccharide from Hericium erinaceus fruiting bodies and its arrest of the cell cycle at S-phage in colon cancer cells","volume":"157","author":"Liu","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.fshw.2021.04.008","article-title":"Anti-colon cancer activity of water-soluble polysaccharides extracted from Gloeostereum incarnatum via Wnt\/\u03b2-catenin signaling pathway","volume":"10","author":"He","year":"2021","journal-title":"Food Sci. Hum. Well."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/bab.2013","article-title":"In vitro and in silico anticancer evaluation of a medicinal mushroom, Ganoderma neo-japonicum Imazeki, against human colonic carcinoma cells","volume":"68","author":"Lau","year":"2021","journal-title":"Biotech. Appl. Biochem."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1039\/C7FO01794D","article-title":"Polyphenols-rich extract from Pleurotus eryngii with growth inhibitory of HCT116 colon cancer cells and anti-inflammatory function in RAW264.7 cells","volume":"9","author":"Hu","year":"2018","journal-title":"Food Funct."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.31665\/JFB.2020.12245","article-title":"Bioactive compounds and bioactive properties of Chaga (Inonotus obliquus) mushroom: A review","volume":"12","author":"Peng","year":"2020","journal-title":"J. Food Bioact."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.13057\/biodiv\/d210615","article-title":"Therapeutic potentials of n-hexane extracts of the three medicinal mushrooms regarding their anti-colon cancer, antioxidant, and hypocholesterolemic capabilities","volume":"21","author":"Daba","year":"2020","journal-title":"Biodiversitas"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.3892\/ijo.2017.3939","article-title":"Anticarcinogenic effects of water extract of sporoderm-broken spores of Ganoderma lucidum on colorectal cancer in vitro and in vivo","volume":"50","author":"Na","year":"2017","journal-title":"Int. J. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"610","DOI":"10.18632\/oncotarget.13481","article-title":"A polysaccharide from Lentinus edodes inhibits human colon cancer cell proliferation and suppresses tumor growth in athymic nude mice","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.2174\/092986710791698495","article-title":"Lentinus edodes: A macrofungus with pharmacological activities","volume":"17","author":"Bisen","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/ecam\/nem007","article-title":"The medicinal mushroom Agaricus blazei Murrill: Review of literature and pharmaco-toxicological problems","volume":"5","author":"Firenzuoli","year":"2007","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Hetland, G., Eide, D.M., Tangen, J.M., Haugen, M.H., Mirlashari, M.R., and Paulsen, J.E. (2016). The Agaricus blaze-based mushroom extract, AndosanTM, protects against intestinal tumorigenesis in the A\/J Min\/+ mouse. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0167754"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00253-010-3067-4","article-title":"Current findings, future trends, and unsolved problems in studies of medicinal mushrooms","volume":"89","author":"Wasser","year":"2011","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1186\/s12935-022-02798-2","article-title":"Are chemical compounds in medical mushrooms potent against colorectal cancer carcinogenesis and antimicrobial growth?","volume":"22","author":"Macharia","year":"2022","journal-title":"Cancer Cell Int."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.fct.2012.10.014","article-title":"In vitro and in vivo antioxidant activity of ethanolic extract of white button mushroom (Agaricus bisporus)","volume":"51","author":"Liu","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Mwangi, R.W., Macharia, J.M., Wagara, I.N., and Bence, R.L. (2022). The antioxidant potential of different edible and medicinal mushrooms. Biomed. Pharmacother., 147.","DOI":"10.1016\/j.biopha.2022.112621"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ijbiomac.2022.02.058","article-title":"Alginate\/\u03ba-carrageenan oral microcapsules loaded with Agaricus bisporus polysaccharides MH751906 for natural killer cells mediated colon cancer immunotherapy","volume":"205","author":"Ibrahim","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Xu, Y., Xu, T., Huang, C., Liu, L., Kwame, A.W., Zhu, Y., and Ren, J. (2024). Preventive intervention with Agaricus blazei murill polysaccharide exerts anti-tumor immune effect on intraperitoneal metastasis colorectal cancer. Int. J. Biol. Macromol., 282.","DOI":"10.1016\/j.ijbiomac.2024.136810"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Dong, K., Wang, J., Tang, F., Liu, Y., and Gao, L. (2024). A polysaccharide with a triple helix structure from Agaricus bisporus: Characterization and anti-colon cancer activity. Int. J. Biol. Macromol., 281.","DOI":"10.1016\/j.ijbiomac.2024.136521"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"He, Y.Y., Liu, S., and Newburg, D.S. (2021). Musarin, a novel protein with tyrosine kinase inhibitory activity from Trametes versicolor, inhibits colorectal cancer stem cell growth. Biomed. Pharmacother., 144.","DOI":"10.1016\/j.biopha.2021.112339"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.canlet.2005.12.007","article-title":"An aqueous polysaccharide extract from the edible mushroom Pleurotus ostreatus induces anti-proliferative and pro-apoptotic effects on HT-29 colon cancer cells","volume":"244","author":"Lavi","year":"2006","journal-title":"Cancer Lett."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"118968","DOI":"10.1016\/j.lfs.2020.118968","article-title":"Molecular mechanisms of action of Trehalose in cancer: A comprehensive review","volume":"269","author":"Chaitanya","year":"2021","journal-title":"Life Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Quero, J., Paesa, M., Morales, C., Mendoza, G., Osada, J., Teixeira, J.A., Ferreira-Santos, P., and Rodr\u00edguez-Yoldi, M.J. (2024). Biological properties of Boletus edulis extract on Caco-2 cells: Antioxidant, anticancer, and anti-inflammatory effects. Antioxidants, 13.","DOI":"10.3390\/antiox13080908"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jiec.2024.01.024","article-title":"Anticarcinogenic potential of the mushroom polysaccharide lentinan on gastric and colon cancer cells: Antiproliferative, antitumorigenic, Mu-2-related death-inducing gene, MUDENG ramifications","volume":"135","author":"Park","year":"2024","journal-title":"J. Ind. Eng. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/bs.pmbts.2019.02.013","article-title":"Mushroom polysaccharide lentinan for treating different types of cancers: A review of 12 years clinical studies in China","volume":"163","author":"Zhang","year":"2019","journal-title":"Prog. Mol. Biol. Translat. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/1534735415572883","article-title":"Polysaccharide K and Coriolus versicolor extracts for lung cancer: A systematic review","volume":"14","author":"Fritz","year":"2015","journal-title":"Integr. Cancer Ther."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1158\/1078-0432.CCR-10-1763","article-title":"Polysaccharide Krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells","volume":"17","author":"Lu","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.pan.2012.09.004","article-title":"Polysaccharide-K (PSK) increases p21(WAF\/Cip1) and promotes apoptosis in pancreatic cancer cells","volume":"12","author":"Rosendahl","year":"2012","journal-title":"Pancreatology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e30254","DOI":"10.1016\/j.heliyon.2024.e30254","article-title":"Unveiling the full spectrum of maitake mushrooms: A comprehensive review of their medicinal, therapeutic, nutraceutical, and cosmetic potential","volume":"10","author":"Camilleri","year":"2024","journal-title":"Heliyon"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.lwt.2013.06.016","article-title":"Antioxidant activities, total phenolics and metal contents in Pleurotus ostreatus mushrooms enriched with iron, zinc or lithium","volume":"54","author":"Gontijo","year":"2013","journal-title":"LWT"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1248\/bpb.25.1647","article-title":"Effects of D-Fraction, a polysaccharide from Grifola frondosa on tumor growth involve activation of NK cells","volume":"25","author":"Kodama","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"114395","DOI":"10.1016\/j.jep.2021.114395","article-title":"Antitumor activities of Grifola frondosa (Maitake) polysaccharide: A meta-analysis based on preclinical evidence and quality assessment","volume":"280","author":"Zhao","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/35092620","article-title":"Immune recognition. A new receptor for beta-glucans","volume":"413","author":"Brown","year":"2001","journal-title":"Nature"},{"key":"ref_57","first-page":"285","article-title":"Anticancer properties of polysaccharides isolated from fungi of the Basidiomycetes class","volume":"16","author":"Lemieszek","year":"2012","journal-title":"Contemp. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1039\/C7FO00895C","article-title":"In vitro and in vivo inhibitory effects of a Pleurotus eryngii protein on colon cancer cells","volume":"8","author":"Yuan","year":"2017","journal-title":"Food Funct."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1039\/C7FO00244K","article-title":"Isolation of a novel bioactive protein from an edible mushroom Pleurotus eryngii and its anti-inflammatory potential","volume":"8","author":"Yuan","year":"2017","journal-title":"Food Funct."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"982368","DOI":"10.1093\/ecam\/neq057","article-title":"Anti-cancer effects of protein extracts from Calvatia lilacina, Pleurotus ostreatus and Volvariella volvacea","volume":"2011","author":"Chen","year":"2011","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"6855","DOI":"10.1007\/s00253-020-10707-8","article-title":"Anticancer potentiality and mode of action of low-carbohydrate proteins and peptides from mushrooms","volume":"104","author":"Rezvani","year":"2020","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.etap.2008.03.009","article-title":"Antiproliferative and immunostimulatory protein fraction from edible mushrooms","volume":"26","author":"Maiti","year":"2008","journal-title":"Environ. Toxicol. Pharm."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"12P","DOI":"10.1042\/cs088012P","article-title":"Mushroom lectin inhibits invasion of a human colon cancer cell line into collagen gels","volume":"88","author":"Evans","year":"1995","journal-title":"Clin. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1053\/gast.2002.33659","article-title":"Diet and colorectal cancer: An investigation of the lectin\/galactose hypothesis","volume":"122","author":"Evans","year":"2002","journal-title":"Gastroenterology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.1074\/jbc.274.8.4890","article-title":"Edible mushroom (Agaricus bisporus) lectin, which reversibly inhibits epithelial cell proliferation, blocks nuclear localization sequence-dependent nuclear protein import","volume":"274","author":"Yu","year":"1999","journal-title":"J. Biol. Chem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2174\/1389203719666180613090710","article-title":"Research progress of bioactive proteins from the edible and medicinal mushrooms","volume":"20","author":"Zhou","year":"2018","journal-title":"Curr. Prot. Peptide Sci."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Singh, S.S., Wang, H., Chan, Y.S., Pan, W., Dan, X., Yin, C.M., Akkouh, O., and Ng, T.B. (2014). Lectins from edible mushrooms. Molecules, 20.","DOI":"10.3390\/molecules20010446"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s42452-024-05936-9","article-title":"A comprehensive review of the health benefits, phytochemicals, and enzymatic constituents for potential therapeutic and industrial applications of turkey tail mushrooms","volume":"6","author":"Camilleri","year":"2024","journal-title":"Discov. Appl. Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.molcatb.2013.10.004","article-title":"An extracellular laccase with antiproliferative activity from the Sanghuang mushroom Inonotus baumii","volume":"99","author":"Sun","year":"2014","journal-title":"J. Mol. Catal. B Enzym."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Yuzugullu Karakus, Y., Isik, S., Kale Bakir, E., Turkmenoglu, A., and Deveci Ozkan, A. (2025). Characterization of the three-phase partitioned laccase from Trametes versicolor strain with antiproliferative activity against breast cancer cells. Int. J. Biol. Macromol., 286.","DOI":"10.1016\/j.ijbiomac.2024.138504"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1021\/jf8008553","article-title":"Phenolic compound concentration and antioxidant activities of edible and medicinal mushrooms from Korea","volume":"56","author":"Kim","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Paloi, S., Kumla, J., Paloi, B.P., Srinuanpan, S., Hoijang, S., Karunarathna, S.C., Acharya, K., Suwannarach, N., and Lumyong, S. (2023). Termite mushrooms (Termitomyces), a potential source of nutrients and bioactive compounds exhibiting human health benefits: A review. J. Fungi, 9.","DOI":"10.3390\/jof9010112"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Silva, M., Lageiro, M., Ramos, A.C., Reboredo, F.H., and Gon\u00e7alves, E.M. (2024). Cultivated mushrooms: A comparative study of antioxidant activity and phenolic content. Biol. Life Sci. Forum, 40.","DOI":"10.3390\/blsf2024040013"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Chu, M., Khan, R.D., Zhou, Y., Agar, O.T., Barrow, C.J., Dunshea, F.R., and Suleria, H.A.R. (2023). LC-ESI-QTOF-MS\/MS characterization of phenolic compounds in common commercial mushrooms and their potential antioxidant activities. Processes, 11.","DOI":"10.3390\/pr11061711"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1615\/IntJMedMushr.v15.i5.20","article-title":"Cytotoxicity of blended versus single medicinal mushroom extracts on human cancer cell lines: Contribution of polyphenol and polysaccharide content","volume":"15","author":"Durgo","year":"2013","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.foodchem.2011.03.085","article-title":"Antioxidant properties of phenolic compounds occurring in edible mushrooms","volume":"128","author":"Palacios","year":"2011","journal-title":"Food Chem."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.jff.2015.06.015","article-title":"Antioxidant and anti-angiogenic effects of mushroom phenolics-rich fractions","volume":"17","author":"Lin","year":"2015","journal-title":"J. Funct. Foods"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Park, H.J. (2022). Current uses of mushrooms in cancer treatment and their anticancer mechanisms. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231810502"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.taap.2015.07.025","article-title":"4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype","volume":"288","author":"Chang","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Chu, Y.C., Tsai, T.-Y., Yadav, V.K., Deng, L., Huang, C.-C., Tzeng, Y.-M., Yeh, C.-T., and Chen, M.-Y. (2021). 4-Acetyl-Antroquinonol B improves the sensitization of cetuximab on both Kras mutant and wild type colorectal cancer by modulating the expression of Ras\/Raf\/miR-193a-3p signaling axis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22147508"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"7271509","DOI":"10.1155\/2018\/7271509","article-title":"Potential of mushroom compounds as immunomodulators in cancer immunotherapy: A review","volume":"2018","author":"Ayeka","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_82","first-page":"e37574","article-title":"Therapeutic effects of medicinal mushrooms on gastric, breast, and colorectal cancer: A scoping review","volume":"15","author":"Dan","year":"2023","journal-title":"Cureus"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13225-012-0151-3","article-title":"Medicinal mushrooms in supportive cancer therapies: An approach to anti-cancer effects and putative mechanisms of action","volume":"55","author":"Rapior","year":"2012","journal-title":"Fungal Divers."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s41110-017-0050-1","article-title":"Medicinal mushrooms in adjuvant cancer therapies: An approach to anticancer effects and presumed mechanisms of action","volume":"42","author":"Figueiredo","year":"2017","journal-title":"Nutrire"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.3892\/ijo.2012.1602","article-title":"Combination therapy targeting Raf-1 and MEK causes apoptosis of HCT116 colon cancer cells","volume":"41","author":"Subramanian","year":"2012","journal-title":"Int. J. Oncol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s00535-011-0514-7","article-title":"Glucans from the edible mushroom Pleurotus pulmonarius inhibit colitis-associated colon carcinogenesis in mice","volume":"47","author":"Lavi","year":"2012","journal-title":"J. Gastroenterol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/2210289201304020065","article-title":"Antiproliferative effect of Lignosus rhinocerotis, the Tiger Milk mushroom on HCT 116 human colorectal cancer cells","volume":"4","author":"Zaila","year":"2013","journal-title":"Open Conf. Proc. J."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1007\/s00384-015-2479-0","article-title":"Study on colorectal cancer presentation, treatment and follow-up","volume":"31","author":"Aakif","year":"2016","journal-title":"Int. J. Color. Dis."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Li, J., Huang, L., Zhao, H., Yan, Y., and Lu, J. (2020). The role of interleukins in colorectal cancer. Int. J. Biol. Sci., 16.","DOI":"10.7150\/ijbs.46651"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biopha.2012.10.008","article-title":"Resveratrol affects the cross talk between immune and colon cancer cells","volume":"67","author":"Bergman","year":"2013","journal-title":"Biomed. Pharmacother."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/s41385-019-0176-y","article-title":"The IL-33\/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer","volume":"12","author":"Pastille","year":"2019","journal-title":"Mucosal Immunol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"18390","DOI":"10.3748\/wjg.v20.i48.18390","article-title":"Increased expression of tumor necrosis factor-\u03b1 is associated with advanced colorectal cancer stages","volume":"20","author":"Alkhayal","year":"2014","journal-title":"World J. Gastroenterol. WJG"},{"key":"ref_93","first-page":"3820","article-title":"TNF-\u03b1 promotes colon cancer cell migration and invasion by upregulating TROP-2","volume":"15","author":"Zhao","year":"2018","journal-title":"Oncol. Lett."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.7150\/thno.24157","article-title":"Powerful anti-colon cancer effect of modified nanoparticle-mediated IL-15 immunogene therapy through activation of the host immune system","volume":"8","author":"Liu","year":"2018","journal-title":"Theranostics"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nri1901","article-title":"The biology of interleukin-2 and interleukin-15: Implications for cancer therapy and vaccine design","volume":"6","author":"Waldmann","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1053\/j.gastro.2017.11.276","article-title":"Pyrin inflammasome regulates tight junction integrity to restrict colitis and tumorigenesis","volume":"154","author":"Sharma","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1615\/IntJMedMushrooms.2018025408","article-title":"Anti-inflammatory potential of in vitro cultures of the white button mushroom, Agaricus bisporus (Agaricomycetes), in Caco-2 Cells","volume":"20","author":"Grzywacz","year":"2018","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Chaudhary, P., Janmeda, P., Docea, A.O., Yeskaliyeva, B., Abdull Razis, A.F., Modu, B., Calina, D., and Sharifi-Rad, J. (2023). Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases. Front. Chem., 11.","DOI":"10.3389\/fchem.2023.1158198"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Muchtaridi, M., Az-Zahra, F., Wongso, H., Setyawati, L.U., Novitasari, D., and Ikram, E.H.K. (2024). Molecular mechanism of natural food antioxidants to regulate ROS in treating cancer: A review. Antioxidants, 13.","DOI":"10.3390\/antiox13020207"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Pham-Huy, L.A., He, H., and Pham-Huy, C. (2008). Free radicals, antioxidants in disease and health. Int. J. Biomed. Sci., 4.","DOI":"10.59566\/IJBS.2008.4089"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.iy.12.040194.001041","article-title":"Function and activation of NF-KappaB in the immune system","volume":"12","author":"Baeuerle","year":"1994","journal-title":"Annu. Rev. Immunol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.1038\/sj.onc.1203238","article-title":"Control of apoptosis by Rel\/NF-\u03baB transcription factors","volume":"18","author":"Barkett","year":"1999","journal-title":"Oncogene"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00428-005-1264-9","article-title":"NF-kB in development and progression of human cancer","volume":"446","author":"Dolcet","year":"2005","journal-title":"Virchows Arch."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Wan, F., and Lenardo, M.J. (2009). Specification of DNA binding activity of NF- B proteins. Cold Spring Harb. Perspect. Biol., 1.","DOI":"10.1101\/cshperspect.a000067"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3892\/ijo.2022.5472","article-title":"Blocking the Wnt\/\u03b2-catenin signaling pathway to treat colorectal cancer: Strategies to improve current therapies (Review)","volume":"62","author":"Chen","year":"2022","journal-title":"Int. J. Oncol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"435","DOI":"10.2147\/CMAR.S411168","article-title":"Wnt\/\u03b2-Catenin signaling pathway in the development and progression of colorectal cancer","volume":"15","author":"He","year":"2023","journal-title":"Cancer Manag. Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1097\/00000658-200106000-00008","article-title":"Role of matrix metalloproteinases in colorectal carcinogenesis","volume":"233","author":"Heslin","year":"2001","journal-title":"Ann. Surg."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Said, A.H., Raufman, J.P., and Xie, G. (2014). The role of matrix metalloproteinases in colorectal cancer. Cancers, 6.","DOI":"10.3390\/cancers6010366"},{"key":"ref_109","doi-asserted-by":"crossref","unstructured":"Pfeffer, C.M., and Singh, A.T.K. (2018). Apoptosis: A target for anticancer therapy. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19020448"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Xu, J., Shen, R., Jiao, Z., Chen, W., Peng, D., Wang, L., Yu, N., Peng, C., Cai, B., and Song, H. (2022). Current advancements in antitumor properties and mechanisms of medicinal components in edible mushrooms. Nutrients, 14.","DOI":"10.3390\/nu14132622"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10495-020-01601-9","article-title":"BCL-2 family deregulation in colorectal cancer: Potential for BH3 mimetics in therapy","volume":"25","author":"Ramesh","year":"2020","journal-title":"Apoptosis"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"G\u00fcll\u00fcl\u00fc, \u00d6., Hehlgans, S., R\u00f6del, C., Fokas, E., and R\u00f6del, F. (2021). Tumor suppressor protein p53 and inhibitor of apoptosis proteins in colorectal cancer\u2014A promising signaling network for therapeutic interventions. Cancers, 13.","DOI":"10.3390\/cancers13040624"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/ijc.31374","article-title":"Caspase-3 regulates the migration, invasion, and metastasis of colon cancer cells","volume":"143","author":"Zhou","year":"2018","journal-title":"Int. J. Cancer"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1093\/carcin\/bgh255","article-title":"Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells","volume":"25","author":"Baek","year":"2004","journal-title":"Carcinogenesis"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s12272-011-0219-8","article-title":"Role of nonsteroidal anti-inflammatory drug-activated gene-1 in docetaxel-induced cell death of human colorectal cancer cells with different p53 status","volume":"34","author":"Kim","year":"2011","journal-title":"Arch. Pharm. Res."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Krieg, A., Werner, T.A., Verde, P.E., Stoecklein, N.H., and Knoefel, W.T. (2013). Prognostic and clinicopathological significance of survivin in colorectal cancer: A meta-analysis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0065338"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Li, G., Wang, Y., Wang, W., Lv, G., Li, X., Wang, J., Liu, X., Yuan, D., Deng, S., and You, D. (2024). BIRC5 as a prognostic and diagnostic biomarker in pan-cancer: An integrated analysis of expression, immune subtypes, and functional networks. Front. Genet., 15.","DOI":"10.3389\/fgene.2024.1509342"},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Gariboldi, M.B., Marras, E., Ferrario, N., Vivona, V., Prini, P., Vignati, F., and Perletti, G. (2023). Anti-cancer potential of edible\/medicinal mushrooms in breast cancer. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241210120"},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Jakopovic, B., Or\u0161oli\u0107, N., and Jakopovich, I. (2021). Proteomic research on the antitumor properties of medicinal mushrooms. Molecules, 26.","DOI":"10.3390\/molecules26216708"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"155875","DOI":"10.1016\/j.phymed.2024.155875","article-title":"New insights into signaling pathways of cancer prevention effects of polysaccharides from edible and medicinal mushrooms","volume":"132","author":"Randeni","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Jakopovic, B., Horvati\u0107, A., Klobu\u010dar, M., Gelemanovi\u0107, A., Grb\u010di\u0107, P., Or\u0161oli\u0107, N., Jakopovich, I., and Paveli\u0107, S.K. (2020). Treatment with medicinal mushroom extract mixture inhibits translation and reprograms metabolism in advanced colorectal cancer animal model as evidenced by tandem mass Tags proteomics analysis. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.01202"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.3748\/wjg.v9.i9.1981","article-title":"Telomerase activity and cell apoptosis in colon cancer cell by human telomerase reverse transcriptase gene antisense oligodeoxynucleotide","volume":"9","author":"Jiang","year":"2003","journal-title":"World J. Gastroenterol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.anndiagpath.2010.06.007","article-title":"Human telomerase reverse transcriptase expression in colorectal tumors: Correlations with immunohistochemical expression and clinicopathologic features","volume":"14","author":"Simsek","year":"2010","journal-title":"Ann. Diagn. Pathol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"119820","DOI":"10.1016\/j.jep.2025.119820","article-title":"Network pharmacology combined with transcriptomics reveals that Ganoderma lucidum spore and Sanghuangporus vaninii compound extract exerts anti-colorectal cancer effects via CYP24A1-mediated VDR pathway and TERT-mediated Wnt signaling pathway","volume":"348","author":"Huo","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/mc.20161","article-title":"Transcriptionally mediated inhibition of telomerase of fungal immunomodulatory protein from Ganoderma tsugae in A549 human lung adenocarcinoma cell line","volume":"45","author":"Liao","year":"2006","journal-title":"Mol. Carcinog."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1158\/0008-5472.CAN-05-2887","article-title":"Hypoxia-inducible factor-1alpha promotes nonhypoxia-mediated proliferation in colon cancer cells and xenografts","volume":"66","author":"Dang","year":"2006","journal-title":"Cancer Res."},{"key":"ref_127","first-page":"680","article-title":"HIF-1\u03b1 in colorectal carcinoma: Review of the literature","volume":"20","author":"Ioannou","year":"2015","journal-title":"J. Buon."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Kirdeeva, Y., Fedorova, O., Daks, A., Barlev, N., and Shuvalov, O. (2022). How should the worldwide knowledge of traditional cancer healing be integrated with herbs and mushrooms into modern molecular pharmacology?. Pharmaceuticals, 15.","DOI":"10.3390\/ph15070868"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1615\/IntJMedMushrooms.2025059009","article-title":"Lingzhi or Reishi medicinal mushroom (agaricomycetes) Ganoderma lucidum aqueous extract reverses hypoxia induced redox imbalance and inflammatory response in rat thymocytes","volume":"27","author":"Maithani","year":"2025","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.3892\/ol.2017.5741","article-title":"The role of MRP1 in the multidrug resistance of colorectal cancer","volume":"13","author":"Cao","year":"2017","journal-title":"Oncol. Lett."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.procbio.2011.02.023","article-title":"Effects of ganoderic acid Me on inhibiting multidrug resistance and inducing apoptosis in multidrug resistant colon cancer cells","volume":"46","author":"Jiang","year":"2011","journal-title":"Process Biochem."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1615\/IntJMedMushrooms.2018029378","article-title":"Current and future research trends in agricultural and biomedical applications of medicinal mushrooms and mushroom products (Review)","volume":"20","author":"Chang","year":"2018","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1615\/IntJMedMushr.v12.i1.10","article-title":"Medicinal mushroom science: History, current status, future trends, and unsolved problems","volume":"12","author":"Wasser","year":"2010","journal-title":"Int. J. Med. Mushrooms"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"580656","DOI":"10.3389\/fphar.2020.580656","article-title":"Significance of medicinal mushrooms in integrative oncology: A narrative review","volume":"11","author":"Jeitler","year":"2020","journal-title":"Fron. Pharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Islam, M.R., Akash, S., Rahman, M.M., Nowrin, F.T., Akter, T., Shohag, S., Rauf, A., Aljohani, A.S.M., and Simal-Gandara, J. (2022). Colon cancer and colorectal cancer: Prevention and treatment by potential natural products. Chem. Biol. Inter., 368.","DOI":"10.1016\/j.cbi.2022.110170"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13205-011-0036-2","article-title":"Recent developments in mushrooms as anti-cancer therapeutics: A review","volume":"2","author":"Patel","year":"2012","journal-title":"3 Biotech"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.drudis.2020.10.010","article-title":"Artificial intelligence in drug discovery and development","volume":"26","author":"Paul","year":"2021","journal-title":"Drug Discov. Today"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Leal, K., Rojas, E., Madariaga, D., Contreras, M.J., Nu\u00f1ez-Montero, K., Barrientos, L., Gom\u00e9z-Espinoza, O., and Iturrieta-Gonz\u00e1lez, I. (2024). Unlocking fungal potential: The CRISPR-Cas system as a strategy for secondary metabolite discovery. J. Fungi, 10.","DOI":"10.3390\/jof10110748"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Kwong, K.W., Xin, Y., Lai, N.C., Sung, J.C., Wu, K.C., Hamied, Y.K., Sze, E.T., and Lam, D.M. (2023). Oral Vaccines: A Better Future of Immunization. Vaccines, 11.","DOI":"10.3390\/vaccines11071232"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.vaccine.2014.10.059","article-title":"A perspective on the use of Pleurotus for the development of convenient fungi-made oral subunit vaccines","volume":"33","year":"2015","journal-title":"Vaccine"},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Uddin, M.S., Kaldis, A., Menassa, R., Ortiz Guluarte, J., Barreda, D.R., Guan, L.L., and Alexander, T.W. (2024). Mucosal immunization with spore-based vaccines against Mannheimia haemolytica enhances antigen-specific immunity. 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