{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:14:12Z","timestamp":1791227652355,"version":"4.1.0"},"reference-count":148,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The skin is the body\u2019s largest organ. It serves various functions, including protection and metabolism. Due to its structure and location, it is more vulnerable to external physical and chemical damage than internal organs. Additionally, certain endogenous diseases can cause pathological changes to appear on the skin and nerves. When skin tissue breaks down or sustains severe trauma, the cells, blood vessels, and nerves across all layers can suffer varying degrees of damage. This often results in pain, itching, sensory disturbances, and other discomforts, causing significant distress to patients. Stem-cell-derived exosome therapy has emerged as a promising treatment for skin injuries due to its safety, non-toxicity, and precision medicine benefits. Research has shown that stem-cell-derived exosomes regulate nerve cells by mediating MicroRNA (miRNA) transport and expression between cells, promoting axon growth. This exosome-driven miRNA exchange serves as a vital mode of intercellular communication, playing a crucial role in nervous system repair. Nerves play a critical role in skin wound healing and tissue regeneration, with sensory and autonomic nerves influencing key skin functions such as inflammation, immune defense, apoptosis, proliferation, and wound repair. Exosomes may aid in treating cutaneous nerve injuries by directly or indirectly promoting axon regeneration, nerve cell proliferation, and the release of protective neurofactors.<\/jats:p>","DOI":"10.3390\/ijms26115323","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T11:40:32Z","timestamp":1748864432000},"page":"5323","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Exosomes: A Promising Cell-Free Therapeutic Tool for Treating Cutaneous Nerve Injuries and Promoting Wound Healing"],"prefix":"10.3390","volume":"26","author":[{"given":"Yujie","family":"Mu","sequence":"first","affiliation":[{"name":"School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruting","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1213-1126","authenticated-orcid":false,"given":"Le","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 410198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danting","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenkai","family":"Jin","sequence":"additional","affiliation":[{"name":"BTBU-YHZK Bioengineering Raw Material Development Laboratory, Beijing Technology and Business University, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[{"name":"BTBU-YHZK Bioengineering Raw Material Development Laboratory, Beijing Technology and Business University, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 102401, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/exd.12832","article-title":"The dynamic anatomy and patterning of skin","volume":"25","author":"Wong","year":"2016","journal-title":"Exp. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jamcollsurg.2008.12.023","article-title":"Abdominal complications after severe burns","volume":"208","author":"Markell","year":"2009","journal-title":"J. Am. Coll. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1097\/SLA.0000000000006146","article-title":"Neuropathic Pain After Burn Injury: A Severe and Common Problem in Recovery","volume":"279","author":"Stanton","year":"2024","journal-title":"Ann. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.2174\/1570159X19666210203161559","article-title":"Exosomes as a Promising Therapeutic Strategy for Peripheral Nerve Injury","volume":"19","author":"Yu","year":"2021","journal-title":"Curr. Neuropharmacol."},{"key":"ref_5","first-page":"4262","article-title":"Tanning-Elicited Variations in the Ultraviolet Absorption Spectra of the Cutaneous Tissues: Skin Photobiology and Photomedicine Implications","volume":"2021","author":"Baranoski","year":"2021","journal-title":"Annu. Int. Conf. IEEE Eng. Med. Biol. Soc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"113968","DOI":"10.1016\/j.expneurol.2021.113968","article-title":"Extracellular vesicles and their role in peripheral nerve regeneration","volume":"350","author":"Hercher","year":"2022","journal-title":"Exp. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1186\/s13287-023-03467-5","article-title":"Cell-free therapy based on extracellular vesicles: A promising therapeutic strategy for peripheral nerve injury","volume":"14","author":"Namini","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1111\/apha.12442","article-title":"Calcitonin gene-related peptide: Key regulator of cutaneous immunity","volume":"213","author":"Granstein","year":"2015","journal-title":"Acta Physiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.0906-6705.2004.00185.x","article-title":"The role of calcitonin gene-related peptide in cutaneous immunosuppression induced by repeated subinflammatory ultraviolet irradiation exposure","volume":"13","author":"Legat","year":"2004","journal-title":"Exp. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/00015550310022899","article-title":"Phototherapy reduces the number of epidermal and CGRP-positive dermal nerve fibres","volume":"84","author":"Wallengren","year":"2004","journal-title":"Acta Derm. Venereol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s12035-014-8706-9","article-title":"Peripheral nerve injury modulates neurotrophin signaling in the peripheral and central nervous system","volume":"50","author":"Richner","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF02256438","article-title":"Trophic interactions between sensory nerves and their targets","volume":"6","author":"Chen","year":"1999","journal-title":"J. Biomed. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1365-2184.2011.00795.x","article-title":"Neuroprotective effects of a new skin care formulation following ultraviolet exposure","volume":"45","author":"Fonseca","year":"2012","journal-title":"Cell Prolif."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.burns.2015.08.002","article-title":"Epidemiology and outcome analysis of burn patients admitted to an Intensive Care Unit in a University Hospital","volume":"42","author":"Queiroz","year":"2016","journal-title":"Burns"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.burns.2015.10.011","article-title":"Epidemiology and outcomes of pediatric burns over 35 years at Parkland Hospital","volume":"42","author":"Saeman","year":"2016","journal-title":"Burns"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.burns.2022.11.012","article-title":"Defining numerical cut points for mild, moderate, and severe pain in adult burn survivors: A northwest regional burn model system investigation","volume":"49","author":"Carrougher","year":"2023","journal-title":"Burns"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1089\/ten.tec.2023.0151","article-title":"Characterization of Nerve Damage After an Injury to the Adjacent Soft Tissue: A Pilot Animal Study","volume":"29","author":"Deister","year":"2023","journal-title":"Tissue Eng. Part C Methods"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1177\/15459683231215331","article-title":"Functional Brain Changes Following Burn Injury: A Narrative Review","volume":"38","author":"Rowe","year":"2024","journal-title":"Neurorehabil. Neural Repair"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"tkad037","DOI":"10.1093\/burnst\/tkad037","article-title":"The impact of burn injury on the central nervous system","volume":"12","author":"Allahham","year":"2024","journal-title":"Burn. Trauma"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41401-019-0338-1","article-title":"Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration","volume":"41","author":"Li","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_21","first-page":"135","article-title":"Enhanced peripheral nerve regeneration by acidic fibroblast growth factor","volume":"12","author":"Walter","year":"1993","journal-title":"Lymphokine Cytokine Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1016\/j.biomaterials.2006.01.014","article-title":"In vivo enhancement of sensory perception recovery in a tissue-engineered skin enriched with laminin","volume":"27","author":"Caissie","year":"2006","journal-title":"Biomaterials"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/scrt30","article-title":"Topical delivery of mesenchymal stem cells and their function in wounds","volume":"1","author":"Sorrell","year":"2010","journal-title":"Stem Cell Res. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/B978-0-7020-4087-0.00065-6","article-title":"Lightning and thermal injuries","volume":"120","author":"Sanford","year":"2014","journal-title":"Handb. Clin. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1097\/00000433-199512000-00005","article-title":"Airplane crash. Traumatologic findings in cases of extreme body disintegration","volume":"16","author":"Hellerich","year":"1995","journal-title":"Am. J. Forensic Med. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/PHM.0b013e318190b7f8","article-title":"Median palmar cutaneous nerve injury in a volleyball player","volume":"88","author":"Gitkind","year":"2009","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1097\/00007611-199210000-00007","article-title":"Archery-related injuries of the hand, forearm, and elbow","volume":"85","author":"Rayan","year":"1992","journal-title":"South Med. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4161\/derm.3.1.14617","article-title":"Neuroendocrinology of the skin: An overview and selective analysis","volume":"3","author":"Zmijewski","year":"2011","journal-title":"Dermatoendocrinol"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Jin, R., Luo, L., and Zheng, J. (2022). The Trinity of Skin: Skin Homeostasis as a Neuro-Endocrine-Immune Organ. Life, 12.","DOI":"10.3390\/life12050725"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-19683-6_1","article-title":"Sensing the environment: Regulation of local and global homeostasis by the skin\u2019s neuroendocrine system","volume":"212","author":"Slominski","year":"2012","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"ref_31","first-page":"83","article-title":"Dermatological and immunological conditions due to nerve lesions","volume":"28","author":"Bove","year":"2013","journal-title":"Funct. Neurol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00726-011-1185-7","article-title":"The intriguing mission of neuropeptide Y in the immune system","volume":"45","year":"2013","journal-title":"Amino Acids"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5941957","DOI":"10.1155\/2016\/5941957","article-title":"Prevalence and Risk Factors for Diabetic Lower Limb Amputation: A Clinic-Based Case Control Study","volume":"2016","author":"Rodrigues","year":"2016","journal-title":"J. Diabetes Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Jaul, E., Barron, J., Rosenzweig, J.P., and Menczel, J. (2018). An overview of co-morbidities and the development of pressure ulcers among older adults. BMC Geriatr., 18.","DOI":"10.1186\/s12877-018-0997-7"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1177\/1479164117694463","article-title":"Skin microvascular function in patients with type 1 diabetes: An observational study from the onset of diabetes","volume":"14","author":"Santesson","year":"2017","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"903","DOI":"10.2337\/dc06-2209","article-title":"The use of medical hyperspectral technology to evaluate microcirculatory changes in diabetic foot ulcers and to predict clinical outcomes","volume":"30","author":"Khaodhiar","year":"2007","journal-title":"Diabetes Care"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"S451","DOI":"10.1055\/s-2001-18602","article-title":"Small fiber neuropathy and neurovascular disturbances in diabetes mellitus","volume":"109","author":"Vinik","year":"2001","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1046\/j.1365-2133.1999.02908.x","article-title":"Cellular changes in denervated tissue during wound healing in a rat model","volume":"140","author":"Richards","year":"1999","journal-title":"Br. J. Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2340\/00015555-2321","article-title":"The Role of Neuromediators and Innervation in Cutaneous Wound Healing","volume":"96","author":"Ashrafi","year":"2016","journal-title":"Acta Derm. Venereol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Ivanov, E., Akhmetshina, M., Erdiakov, A., and Gavrilova, S. (2023). Sympathetic System in Wound Healing: Multistage Control in Normal and Diabetic Skin. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24032045"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1067-1927.2005.130208.x","article-title":"Wound healing in denervated rat skin","volume":"13","author":"Fukai","year":"2005","journal-title":"Wound Repair Regen."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/00006534-200001000-00024","article-title":"Nerve dependency in scarless fetal wound healing","volume":"105","author":"Stelnicki","year":"2000","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s12264-019-00352-1","article-title":"More than Scratching the Surface: Recent Progress in Brain Mechanisms Underlying Itch and Scratch","volume":"36","author":"Liu","year":"2020","journal-title":"Neurosci. Bull."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1152\/physrev.00017.2019","article-title":"Physiology and Pathophysiology of Itch","volume":"100","author":"Cevikbas","year":"2020","journal-title":"Physiol. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jaad.2021.07.078","article-title":"Itch: Pathogenesis and treatment","volume":"86","author":"Sutaria","year":"2022","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e22586","DOI":"10.1097\/MD.0000000000022586","article-title":"Cupping for neurodermatitis: A protocol of systematic review and meta-analysis","volume":"99","author":"Peng","year":"2020","journal-title":"Medicine"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"adv00796","DOI":"10.2340\/actadv.v102.4367","article-title":"Lichen Simplex Chronicus Itch: An Update","volume":"102","author":"Ju","year":"2022","journal-title":"Acta Derm. Venereol."},{"key":"ref_48","first-page":"E75","article-title":"Neurodermatitis and emotions","volume":"185","author":"Altunay","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/1523-1747.ep12497887","article-title":"A key to the classification of cutaneous mechanoreceptors","volume":"69","author":"Horch","year":"1977","journal-title":"J. Investig. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jaad.2015.04.059","article-title":"Neurocutaneous disease: Neurocutaneous dysesthesias","volume":"74","author":"Shumway","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.burns.2005.06.007","article-title":"Sensory perception and neuroanatomical structures in normal and grafted skin of burn survivors","volume":"31","author":"Nedelec","year":"2005","journal-title":"Burns"},{"key":"ref_52","first-page":"758","article-title":"Leprosy: A precipitating factor for complex regional pain syndrome","volume":"76","author":"Garg","year":"2010","journal-title":"Minerva Anestesiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/09546630701364750","article-title":"Management of complications following leprosy: An evolving scenario","volume":"18","author":"Sehgal","year":"2007","journal-title":"J. Dermatol. Treat."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.4103\/1673-5374.303008","article-title":"Cortical plasticity and nerve regeneration after peripheral nerve injury","volume":"16","author":"Li","year":"2021","journal-title":"Neural Regen. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/ar.24106","article-title":"Cranial Nerves: Morphology and Clinical Relevance","volume":"302","year":"2019","journal-title":"Anat. Rec."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1586\/erv.10.30","article-title":"Herpes zoster and postherpetic neuralgia","volume":"9","author":"Johnson","year":"2010","journal-title":"Expert Rev. Vaccines"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"148","DOI":"10.2340\/00015555-1206","article-title":"Chronic herpes zoster duplex bilateralis","volume":"92","author":"Castronovo","year":"2012","journal-title":"Acta Derm. Venereol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"378","DOI":"10.2340\/00015555-1284","article-title":"Beyond zoster: Sensory and immune changes in zoster-affected dermatomes: A review*","volume":"92","author":"Ruocco","year":"2012","journal-title":"Acta Derm. Venereol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1007\/s00701-020-04292-y","article-title":"Primary peripheral nerve tumors associated with nerve-territory herpes zoster","volume":"162","author":"Murthy","year":"2020","journal-title":"Acta Neurochir."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2165\/00128071-200304050-00003","article-title":"Cutaneous manifestations of endocrine disorders: A guide for dermatologists","volume":"4","author":"Jabbour","year":"2003","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.autrev.2010.02.013","article-title":"Current remedies for vitiligo","volume":"9","author":"Pramod","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"ref_62","first-page":"160","article-title":"Neuropeptide and neuronal marker studies in vitiligo","volume":"131","author":"Senior","year":"1994","journal-title":"Br. J. Dermatol."},{"key":"ref_63","first-page":"53","article-title":"Markers for vitiligo related neuropeptides in human skin nerve fibers","volume":"54","author":"Hristakieva","year":"2000","journal-title":"Acta Med. Croat."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1177\/120347541201600404","article-title":"Potential role of neurogenic inflammatory factors in the pathogenesis of vitiligo","volume":"16","author":"Yu","year":"2012","journal-title":"J. Cutan. Med. Surg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1076\/1381345520000710831ZFT262","article-title":"Vitiligo-related neuropeptides in nerve fibers of the skin","volume":"108","author":"Lazarova","year":"2000","journal-title":"Arch. Physiol. Biochem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2340\/00015555-1350","article-title":"Decreased expression of semaphorin-3A, a neurite-collapsing factor, is associated with itch in psoriatic skin","volume":"92","author":"Kou","year":"2012","journal-title":"Acta Derm. Venereol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s00018-022-04299-x","article-title":"Cutaneous nerve fibers participate in the progression of psoriasis by linking epidermal keratinocytes and immunocytes","volume":"79","author":"Chen","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/sj.gene.6364409","article-title":"A compass that points to lupus: Genetic studies on type I interferon pathway","volume":"8","author":"Kyogoku","year":"2007","journal-title":"Genes Immun."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00296-020-04610-8","article-title":"Systemic lupus erythematosus may have an early effect on peripheral nerve function in patients without clinical or electrophysiological neuropathy: Comparison with age- and gender-matched controls","volume":"41","author":"Fong","year":"2021","journal-title":"Rheumatol. Int."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s42358-020-00133-9","article-title":"Small fiber neuropathy and related factors in patients with systemic lupus erythematosus; the results of cutaneous silent period and skin biopsy","volume":"60","author":"Tekatas","year":"2020","journal-title":"Adv. Rheumatol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3949\/ccjm.76a.08070","article-title":"Small fiber neuropathy: A burning problem","volume":"76","author":"Tavee","year":"2009","journal-title":"Clevel. Clin. J. Med."},{"key":"ref_73","first-page":"100299","article-title":"From monogenic lupus to TLR7\/MyD88-targeted therapy","volume":"3","author":"Wang","year":"2022","journal-title":"Innovation"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/DAD.0b013e3181fe4c3c","article-title":"Retrospective study of intraepidermal nerve fiber distribution in biopsies of patients with nummular eczema","volume":"33","author":"Maddison","year":"2011","journal-title":"Am. J. Dermatopathol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1067\/mjd.2002.120625","article-title":"Standard classification of rosacea: Report of the National Rosacea Society Expert Committee on the Classification and Staging of Rosacea","volume":"46","author":"Wilkin","year":"2002","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jaad.2017.08.037","article-title":"Standard classification and pathophysiology of rosacea: The 2017 update by the National Rosacea Society Expert Committee","volume":"78","author":"Gallo","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/bjd.14819","article-title":"Shortcomings in rosacea diagnosis and classification","volume":"176","author":"Tan","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMcp042829","article-title":"Clinical practice. Rosacea","volume":"352","author":"Powell","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/jidsymp.2011.6","article-title":"Neurovascular and neuroimmune aspects in the pathophysiology of rosacea","volume":"15","author":"Schwab","year":"2011","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1038\/jid.2014.222","article-title":"Mast cells are key mediators of cathelicidin-initiated skin inflammation in rosacea","volume":"134","author":"Muto","year":"2014","journal-title":"J. Investig. Dermatol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1152\/physrev.00026.2005","article-title":"Neuronal control of skin function: The skin as a neuroimmunoendocrine organ","volume":"86","author":"Roosterman","year":"2006","journal-title":"Physiol. Rev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.bjps.2004.12.017","article-title":"Nerve fibre and sensory end organ density in the epidermis and papillary dermis of the human hand","volume":"58","author":"Kelly","year":"2005","journal-title":"Br. J. Plast. Surg."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s10286-003-0107-5","article-title":"Sympathetic skin response: Basic mechanisms and clinical applications","volume":"13","author":"Vetrugno","year":"2003","journal-title":"Clin. Auton. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1017\/S1462399409000945","article-title":"Inflammation and neuropeptides: The connection in diabetic wound healing","volume":"11","author":"Pradhan","year":"2009","journal-title":"Expert Rev. Mol. Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jdermsci.2014.02.001","article-title":"Influence of sensory neuropeptides on human cutaneous wound healing process","volume":"74","author":"Lebonvallet","year":"2014","journal-title":"J. Dermatol. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/S0140-6736(02)11726-0","article-title":"Blood vessels and nerves: Together or not?","volume":"360","author":"Hogg","year":"2002","journal-title":"Lancet"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/wrr.12059","article-title":"Direct contact of fibroblasts with neuronal processes promotes differentiation to myofibroblasts and induces contraction of collagen matrix in vitro","volume":"21","author":"Fujiwara","year":"2013","journal-title":"Wound Repair Regen."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1600-0625.2010.01113.x","article-title":"Cutaneous wound healing of chronically stressed mice is improved through catecholamines blockade","volume":"19","author":"Porto","year":"2010","journal-title":"Exp. Dermatol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1046\/j.1365-4362.1999.00767.x","article-title":"Neuropeptides and skin disorders. The new frontiers of neuro-endocrine-cutaneous immunology","volume":"38","author":"Lotti","year":"1999","journal-title":"Int. J. Dermatol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0165-6147(90)90237-3","article-title":"Sensory neuron-specific actions of capsaicin: Mechanisms and applications","volume":"11","author":"Bevan","year":"1990","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1016\/0024-3205(92)90045-Q","article-title":"Mechanism of action of capsaicin-like molecules on sensory neurons","volume":"51","author":"Dray","year":"1992","journal-title":"Life Sci."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/jidsymp.1997.15","article-title":"Neurogenic inflammation in skin and airways","volume":"2","author":"Baluk","year":"1997","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s10753-013-9796-7","article-title":"Transcutaneous electrical nerve stimulation (TENS) accelerates cutaneous wound healing and inhibits pro-inflammatory cytokines","volume":"37","author":"Cetin","year":"2014","journal-title":"Inflammation"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1111\/wrr.12101","article-title":"Role of neuropeptides, neurotrophins, and neurohormones in skin wound healing","volume":"21","author":"Lebonvallet","year":"2013","journal-title":"Wound Repair Regen."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10735-017-9711-x","article-title":"Exosomes derived from human amniotic epithelial cells accelerate wound healing and inhibit scar formation","volume":"48","author":"Zhao","year":"2017","journal-title":"J. Mol. Histol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s12015-020-09992-7","article-title":"Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Accelerate Cutaneous Wound Healing by Enhancing Angiogenesis through Delivering Angiopoietin-2","volume":"17","author":"Liu","year":"2021","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Zhu, Z., Zhang, X., Hao, H., Xu, H., Shu, J., Hou, Q., and Wang, M. (2022). Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Treat Cutaneous Nerve Damage and Promote Wound Healing. Front. Cell. Neurosci., 16.","DOI":"10.3389\/fncel.2022.913009"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"7154327","DOI":"10.1155\/2016\/7154327","article-title":"Gingival Mesenchymal Stem\/Progenitor Cells: A Unique Tissue Engineering Gem","volume":"2016","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Shi, Q., Qian, Z., Liu, D., Sun, J., Wang, X., Liu, H., Xu, J., and Guo, X. (2017). GMSC-Derived Exosomes Combined with a Chitosan\/Silk Hydrogel Sponge Accelerates Wound Healing in a Diabetic Rat Skin Defect Model. Front. Physiol., 8.","DOI":"10.3389\/fphys.2017.00904"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Zhang, H., Shao, Z., Zhu, Y., Shi, L., Li, Z., Hou, R., Zhang, C., and Yao, D. (2018). Toll-Like Receptor 4 (TLR4) Expression Affects Schwann Cell Behavior in vitro. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-28516-5"},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Jiang, L., Jones, S., and Jia, X. (2017). Stem Cell Transplantation for Peripheral Nerve Regeneration: Current Options and Opportunities. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010094"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1002\/glia.22558","article-title":"Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system","volume":"61","author":"Picou","year":"2013","journal-title":"Glia"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neuroscience.2016.01.061","article-title":"Mesenchymal stem cell-derived exosomes from different sources selectively promote neuritic outgrowth","volume":"320","author":"Caviedes","year":"2016","journal-title":"Neuroscience"},{"key":"ref_104","first-page":"33","article-title":"Protection of Nerve Injury with Exosome Extracted from Mesenchymal Stem Cell","volume":"38","author":"Wei","year":"2016","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1089\/ten.tea.2018.0176","article-title":"Gingiva-Derived Mesenchymal Stem Cell-Extracellular Vesicles Activate Schwann Cell Repair Phenotype and Promote Nerve Regeneration","volume":"25","author":"Mao","year":"2019","journal-title":"Tissue Eng. Part A"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Dong, R., Liu, Y., Yang, Y., Wang, H., Xu, Y., and Zhang, Z. (2019). MSC-Derived Exosomes-Based Therapy for Peripheral Nerve Injury: A Novel Therapeutic Strategy. Biomed. Res. Int., 2019.","DOI":"10.1155\/2019\/6458237"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Aswad, H., Jalabert, A., and Rome, S. (2016). Depleting extracellular vesicles from fetal bovine serum alters proliferation and differentiation of skeletal muscle cells in vitro. BMC Biotechnol., 16.","DOI":"10.1186\/s12896-016-0262-0"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1186\/s13287-021-02475-7","article-title":"Exosomes derived from adipose-derived stem cells overexpressing glyoxalase-1 protect endothelial cells and enhance angiogenesis in type 2 diabetic mice with limb ischemia","volume":"12","author":"Zhang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1038\/mt.2016.126","article-title":"Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing","volume":"24","author":"Didiot","year":"2016","journal-title":"Mol. Ther."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.jcms.2018.03.015","article-title":"Evaluation of nerve growth factor (NGF) treated mesenchymal stem cells for recovery in neurotmesis model of peripheral nerve injury","volume":"46","author":"Moattari","year":"2018","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1007\/s12035-018-1172-z","article-title":"Effect of Exosomes from Rat Adipose-Derived Mesenchymal Stem Cells on Neurite Outgrowth and Sciatic Nerve Regeneration After Crush Injury","volume":"56","author":"Bucan","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"16086","DOI":"10.1073\/pnas.1902513116","article-title":"Exosomes regulate neurogenesis and circuit assembly","volume":"116","author":"Sharma","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1533-2500.2010.00367.x","article-title":"The role of glia and the immune system in the development and maintenance of neuropathic pain","volume":"10","author":"Vallejo","year":"2010","journal-title":"Pain Pract."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1111\/j.1460-9568.2011.07643.x","article-title":"MicroRNA miR-133b is essential for functional recovery after spinal cord injury in adult zebrafish","volume":"33","author":"Yu","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/j.pain.0000000000001395","article-title":"Mesenchymal stem cell exosomes as a cell-free therapy for nerve injury-induced pain in rats","volume":"160","author":"Shiue","year":"2019","journal-title":"Pain"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"7366","DOI":"10.1523\/JNEUROSCI.1739-04.2004","article-title":"BDNF regulates the translation of a select group of mRNAs by a mammalian target of rapamycin-phosphatidylinositol 3-kinase-dependent pathway during neuronal development","volume":"24","author":"Schratt","year":"2004","journal-title":"J. Neurosci."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s12031-016-0792-x","article-title":"Role of Nectin-1\/c-Src Signaling in the Analgesic Effect of GDNF on a Rat Model of Chronic Constrictive Injury","volume":"60","author":"Gao","year":"2016","journal-title":"J. Mol. Neurosci."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Yu, X., Fu, X., Yang, J., Chen, L., Leng, F., Yang, Z., and Yu, C. (2022). Glucose\/ROS cascade-responsive ceria nanozymes for diabetic wound healing. Mater. Today Bio, 15.","DOI":"10.1016\/j.mtbio.2022.100308"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.7150\/thno.52570","article-title":"Engineering exosomes for targeted drug delivery","volume":"11","author":"Liang","year":"2021","journal-title":"Theranostics"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.apsb.2016.02.001","article-title":"Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: Current perspectives and future challenges","volume":"6","author":"Ha","year":"2016","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12964-021-00730-1","article-title":"The exosome journey: From biogenesis to uptake and intracellular signalling","volume":"19","author":"Gurung","year":"2021","journal-title":"Cell Commun. Signal"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"101858","DOI":"10.1016\/j.arr.2023.101858","article-title":"The effectiveness of cell-derived exosome therapy for diabetic wound: A systematic review and meta-analysis","volume":"85","author":"Qiao","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00125-019-05043-0","article-title":"Mesenchymal stromal cell-derived exosomes ameliorate peripheral neuropathy in a mouse model of diabetes","volume":"63","author":"Fan","year":"2020","journal-title":"Diabetologia"},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Shen, J., Zhao, X., Zhong, Y., Yang, P., Gao, P., Wu, X., Wang, X., and An, W. (2022). Exosomal ncRNAs: The pivotal players in diabetic wound healing. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1005307"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"103323","DOI":"10.1016\/j.drudis.2022.07.008","article-title":"Exosome-cargoed microRNAs: Potential therapeutic molecules for diabetic wound healing","volume":"27","author":"Lou","year":"2022","journal-title":"Drug Discov. Today"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1097\/01.j.pain.0000460344.54470.20","article-title":"Complex regional pain syndrome-significant progress in understanding","volume":"156","author":"Birklein","year":"2015","journal-title":"Pain"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"h2730","DOI":"10.1136\/bmj.h2730","article-title":"Complex regional pain syndrome","volume":"351","author":"Bruehl","year":"2015","journal-title":"Br. Med. J."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.pain.2010.09.024","article-title":"TNF-\u03b1 in CRPS and \u2018normal\u2019 trauma\u2013significant differences between tissue and serum","volume":"152","author":"Eberle","year":"2011","journal-title":"Pain"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/cdd.2014.112","article-title":"The complexity of miRNA-mediated repression","volume":"22","author":"Wilczynska","year":"2015","journal-title":"Cell Death Differ."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"9739258","DOI":"10.1155\/2019\/9739258","article-title":"Stem Cell-Derived Exosomes Prevent Aging-Induced Cardiac Dysfunction through a Novel Exosome\/lncRNA MALAT1\/NF-\u03baB\/TNF-\u03b1 Signaling Pathway","volume":"2019","author":"Zhu","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/s13287-021-02384-9","article-title":"Bone marrow mesenchymal stem cells and their derived exosomes resolve doxorubicin-induced chemobrain: Critical role of their miRNA cargo","volume":"12","author":"Noureldein","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.it.2018.10.001","article-title":"The Itch-Scratch Cycle: A Neuroimmune Perspective","volume":"39","author":"Mack","year":"2018","journal-title":"Trends Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.jaci.2023.08.038","article-title":"IL-33 potentiates histaminergic itch","volume":"153","author":"Trier","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jaci.2013.10.048","article-title":"A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1","volume":"133","author":"Cevikbas","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Cho, K.A., Kwon, J., Kim, H.J., and Woo, S.Y. (2024). Mesenchymal stem cell exosomes differentially regulate gene expression of mast cells. Biochem. Biophys. Res. Commun., 696.","DOI":"10.1016\/j.bbrc.2024.149517"},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Xie, Y., Yu, L., Cheng, Z., Peng, Y., Cao, Z., Chen, B., Duan, Y., and Wang, Y. (2022). SHED-derived exosomes promote LPS-induced wound healing with less itching by stimulating macrophage autophagy. J. Nanobiotechnol., 20.","DOI":"10.1186\/s12951-022-01446-1"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1111\/bph.16201","article-title":"Pamoic acid-induced peripheral GPR35 activation improves pruritus and dermatitis","volume":"180","author":"Kim","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"adv4463","DOI":"10.2340\/actadv.v103.4463","article-title":"Neuroimmune Mediators of Pruritus in Hispanic Scalp Psoriatic Itch","volume":"103","author":"Nattkemper","year":"2023","journal-title":"Acta Derm. Venereol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2015.10.020","article-title":"Bovine milk-derived exosomes for drug delivery","volume":"371","author":"Munagala","year":"2016","journal-title":"Cancer Lett."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jcyt.2018.12.006","article-title":"Manufacturing and characterization of extracellular vesicles from umbilical cord-derived mesenchymal stromal cells for clinical testing","volume":"21","author":"Rohde","year":"2019","journal-title":"Cytotherapy"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1186\/s13287-022-03015-7","article-title":"Exosomes from mmu_circ_0001052-modified adipose-derived stem cells promote angiogenesis of DFU via miR-106a-5p and FGF4\/p38MAPK pathway","volume":"13","author":"Liang","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Jian, X., Han, J., Liu, X., Deng, Y., Gao, S., Xiao, S., Zhang, Y., Jian, S., Huang, Z., and Hou, Y. (2025). Exosome-carried miR-1248 from adipose-derived stem cells improves angiogenesis in diabetes-associated wounds. Int. J. Biol. Macromol., 297.","DOI":"10.1016\/j.ijbiomac.2025.139822"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Li, Y., Zhu, Z., Li, S., Xie, X., Qin, L., Zhang, Q., Yang, Y., Wang, T., and Zhang, Y. (2024). Exosomes: Compositions, biogenesis, and mechanisms in diabetic wound healing. J. Nanobiotechnol., 22.","DOI":"10.1186\/s12951-024-02684-1"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Wang, Z., Xu, H., Xue, B., Liu, L., Tang, Y., Wang, Z., and Yao, K. (2024). MSC-derived exosomal circMYO9B accelerates diabetic wound healing by promoting angiogenesis through the hnRNPU\/CBL\/KDM1A\/VEGFA axis. Commun. Biol., 7.","DOI":"10.1038\/s42003-024-07367-z"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"E851","DOI":"10.36076\/ppj.2023.26.E851","article-title":"Safety and Efficacy of Intravenous ExoFlo in the Treatment of Complex Regional Pain Syndrome","volume":"26","author":"Paicius","year":"2023","journal-title":"Pain Physician"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Chen, L.Y., Kao, T.W., Chen, C.C., Niaz, N., Lee, H.L., Chen, Y.H., Kuo, C.C., and Shen, Y.A. (2023). Frontier Review of the Molecular Mechanisms and Current Approaches of Stem Cell-Derived Exosomes. Cells, 12.","DOI":"10.3390\/cells12071018"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/11\/5323\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:45:13Z","timestamp":1760031913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/11\/5323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,1]]},"references-count":148,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["ijms26115323"],"URL":"https:\/\/doi.org\/10.3390\/ijms26115323","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,1]]}}}