{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:30:36Z","timestamp":1791001836645,"version":"4.1.0"},"reference-count":219,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Research to Prevent Blindness to the Department of Ophthalmology and Visual Sciences","award":["P30 EY016665"],"award-info":[{"award-number":["P30 EY016665"]}]},{"name":"Research to Prevent Blindness to the Department of Ophthalmology and Visual Sciences","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}]},{"name":"Research to Prevent Blindness to the Department of Ophthalmology and Visual Sciences","award":["EY034646"],"award-info":[{"award-number":["EY034646"]}]},{"name":"Research to Prevent Blindness to the Department of Ophthalmology and Visual Sciences","award":["EY030076"],"award-info":[{"award-number":["EY030076"]}]},{"name":"Research to Prevent Blindness Steine Innovation Award","award":["P30 EY016665"],"award-info":[{"award-number":["P30 EY016665"]}]},{"name":"Research to Prevent Blindness Steine Innovation Award","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}]},{"name":"Research to Prevent Blindness Steine Innovation Award","award":["EY034646"],"award-info":[{"award-number":["EY034646"]}]},{"name":"Research to Prevent Blindness Steine Innovation Award","award":["EY030076"],"award-info":[{"award-number":["EY030076"]}]},{"name":"Retina Research Foundation","award":["P30 EY016665"],"award-info":[{"award-number":["P30 EY016665"]}]},{"name":"Retina Research Foundation","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}]},{"name":"Retina Research Foundation","award":["EY034646"],"award-info":[{"award-number":["EY034646"]}]},{"name":"Retina Research Foundation","award":["EY030076"],"award-info":[{"award-number":["EY030076"]}]},{"name":"RRF\/Daniel M. Albert chair","award":["P30 EY016665"],"award-info":[{"award-number":["P30 EY016665"]}]},{"name":"RRF\/Daniel M. Albert chair","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}]},{"name":"RRF\/Daniel M. Albert chair","award":["EY034646"],"award-info":[{"award-number":["EY034646"]}]},{"name":"RRF\/Daniel M. Albert chair","award":["EY030076"],"award-info":[{"award-number":["EY030076"]}]},{"name":"National Institutes of Health","award":["P30 EY016665"],"award-info":[{"award-number":["P30 EY016665"]}]},{"name":"National Institutes of Health","award":["P30 CA014520"],"award-info":[{"award-number":["P30 CA014520"]}]},{"name":"National Institutes of Health","award":["EY034646"],"award-info":[{"award-number":["EY034646"]}]},{"name":"National Institutes of Health","award":["EY030076"],"award-info":[{"award-number":["EY030076"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Pericytes (PCs), a heterogeneous population of perivascular supporting cells, are critical regulators of vascular stability, angiogenesis, and blood\u2013tissue barrier integrity. Increasing evidence highlights their active role in the pathophysiology of diabetic microangiopathies, including those affecting the retina, kidney, brain, heart, and peripheral nerves. In diabetes, hyperglycemia-induced PC dysfunction is a major contributor to vascular degeneration, impaired tissue repair, and disease progression across multiple organs. Pericytes also share many characteristics with mesenchymal stem cells (MSCs). They exhibit regenerative capacity, immunomodulatory activities, and multipotent capacities. This review explores the emerging role of PCs as tissue resident MSCs, emphasizing their pathophysiological involvement in diabetes complications, and their potential for utilization in regenerative medicine. We also discuss advances in PC-based therapies, tissue engineering strategies, and clinical applications. Thus, PCs are positioned as promising targets for therapeutic intervention and vascular tissue regeneration.<\/jats:p>","DOI":"10.3390\/ijms26115333","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T11:40:32Z","timestamp":1748864432000},"page":"5333","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pericytes and Diabetic Microangiopathies: Tissue Resident Mesenchymal Stem Cells with High Plasticity and Regenerative Capacity"],"prefix":"10.3390","volume":"26","author":[{"given":"Zeinab","family":"Shirbaghaee","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"},{"name":"McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Sorenson","sequence":"additional","affiliation":[{"name":"McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"},{"name":"Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2723-9217","authenticated-orcid":false,"given":"Nader","family":"Sheibani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"},{"name":"McPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"},{"name":"Department of Cell and Regenerative Biology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.devcel.2011.07.001","article-title":"Pericytes: Developmental, physiological, and pathological perspectives, problems, and promises","volume":"21","author":"Armulik","year":"2011","journal-title":"Dev. 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