{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T08:08:00Z","timestamp":1771747680520,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["RF1AG075717"],"award-info":[{"award-number":["RF1AG075717"]}]},{"name":"NIH","award":["R01AR079484"],"award-info":[{"award-number":["R01AR079484"]}]},{"name":"NIH","award":["F32AG082458"],"award-info":[{"award-number":["F32AG082458"]}]},{"name":"NIH","award":["1S10 OD034302-01"],"award-info":[{"award-number":["1S10 OD034302-01"]}]},{"name":"NIH","award":["I01CX002211"],"award-info":[{"award-number":["I01CX002211"]}]},{"name":"Veterans Affairs Clinical Science Research and Development","award":["RF1AG075717"],"award-info":[{"award-number":["RF1AG075717"]}]},{"name":"Veterans Affairs Clinical Science Research and Development","award":["R01AR079484"],"award-info":[{"award-number":["R01AR079484"]}]},{"name":"Veterans Affairs Clinical Science Research and Development","award":["F32AG082458"],"award-info":[{"award-number":["F32AG082458"]}]},{"name":"Veterans Affairs Clinical Science Research and Development","award":["1S10 OD034302-01"],"award-info":[{"award-number":["1S10 OD034302-01"]}]},{"name":"Veterans Affairs Clinical Science Research and Development","award":["I01CX002211"],"award-info":[{"award-number":["I01CX002211"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Blast-induced mild traumatic brain injury (mTBI) occurs when shock waves travel through blood vessels and cerebrospinal fluid, leading to cerebral demyelination, which results in cognitive impairments and neuropsychiatric issues that impact quality of life. This study aims to evaluate myelin changes in white matter in mice with mTBI induced by an open-field low-intensity blast (LIB) using a newly implemented 3D adiabatic T1\u03c1 prepared fast spin echo (Adiab-T1\u03c1-FSE) sequence for quantitative T1\u03c1 MRI mapping. Thirty male C57BL\/6 mice, including 15 mTBI and 15 sham controls, were scanned on a 3T Bruker MRI scanner. Luxol fast blue (LFB) staining was performed to assess myelin content differences between the mTBI and sham control groups. A significantly higher T1\u03c1 value in the medial corpus callosum (MCC) was found in mTBI mice compared to controls (126.8 \u00b1 2.5 ms vs. 129.8 \u00b1 2.5 ms; p &lt; 0.001), consistent with the reduced myelin observed in LFB staining (0.80 \u00b1 0.14 vs. 1.02 \u00b1 0.06; p = 0.004). Moreover, a significant negative correlation between T1\u03c1 and histological myelin content measurements was observed (r = \u22120.57, p = 0.02). Our findings demonstrate that T1\u03c1 is a promising biomarker for detecting mTBI-associated demyelination in the brain.<\/jats:p>","DOI":"10.3390\/ijms26125431","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T06:11:08Z","timestamp":1749190268000},"page":"5431","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of White Matter Changes Using Quantitative T1\u03c1 Mapping in an Open-Field Low-Intensity Blast Mouse Model of Mild Traumatic Brain Injury (mTBI)"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8815-4535","authenticated-orcid":false,"given":"Dina","family":"Moazamian","sequence":"first","affiliation":[{"name":"Department of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengwen","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0866-1052","authenticated-orcid":false,"given":"Jiyo S.","family":"Athertya","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingbo","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5628-4151","authenticated-orcid":false,"given":"Roland R.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA"},{"name":"Radiology Service, VA San Diego Healthcare System, San Diego, CA 92161, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3633-5630","authenticated-orcid":false,"given":"Eric Y.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA"},{"name":"Radiology Service, VA San Diego Healthcare System, San Diego, CA 92161, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Tomlin","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Diego, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0670-8179","authenticated-orcid":false,"given":"Catherine E.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Explosive Engineering, Missouri University of Science and Technology, Rolla, MO 65409, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9203-2450","authenticated-orcid":false,"given":"Jiang","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA"},{"name":"Radiology Service, VA San Diego Healthcare System, San Diego, CA 92161, USA"},{"name":"Department of Bioengineering, University of California, San Diego, CA 92093, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of California, San Diego 9452 Medical Center, San Diego, CA 92037, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.wneu.2020.11.093","article-title":"Epidemiology of Blast Neurotrauma: A Meta-Analysis of Blast Injury Patterns in the Military and Civilian Populations","volume":"146","author":"Tovar","year":"2021","journal-title":"World Neurosurg."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Mahoney, S.O., Chowdhury, N.F., Ngo, V., Imms, P., and Irimia, A. (2022). Mild Traumatic Brain Injury Results in Significant and Lasting Cortical Demyelination. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.854396"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Walz, W. (2024). Traumatic Brain Injury, Springer.","DOI":"10.1007\/978-3-031-48105-5_16"},{"key":"ref_4","unstructured":"National Academies of Sciences, Engineering, and Medicine, Board on Health Care Services, and Committee on the Review of the Department of Veterans Affairs Examinations for Traumatic Brain Injury (2019). Diagnosis and Assessment of Traumatic Brain Injury, National Academies Press."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.2147\/NDT.S79174","article-title":"Functional Neuroimaging of Traumatic Brain Injury: Advances and Clinical Utility","volume":"11","author":"Irimia","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1212\/WNL.56.9.1133","article-title":"Practice Parameter: Early Detection of Dementia: Mild Cognitive Impairment (an Evidence-Based Review) [Retired]","volume":"56","author":"Petersen","year":"2001","journal-title":"Neurology"},{"key":"ref_7","first-page":"1257","article-title":"Neurological Effects of Blast Injury","volume":"68","author":"Hicks","year":"2010","journal-title":"J. Trauma"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Phipps, H., Mondello, S., Wilson, A., Dittmer, T., Rohde, N.N., Schroeder, P.J., Nichols, J., McGirt, C., Hoffman, J., and Tanksley, K. (2020). Characteristics and Impact of U.S. Military Blast-Related Mild Traumatic Brain Injury: A Systematic Review. Front. Neurol., 11.","DOI":"10.3389\/fneur.2020.559318"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S-44","DOI":"10.1089\/neu.2017.5317","article-title":"Modeling the Long-Term Consequences of Repeated Blast-Induced Mild Traumatic Brain Injuries","volume":"34","author":"Agoston","year":"2017","journal-title":"J. Neurotrauma"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Douglas, D.B., Ro, T., Toffoli, T., Krawchuk, B., Muldermans, J., Gullo, J., Dulberger, A., Anderson, A.E., Douglas, P.K., and Wintermark, M. (2018). Neuroimaging of Traumatic Brain Injury. Med. Sci., 7.","DOI":"10.3390\/medsci7010002"},{"key":"ref_11","first-page":"1583","article-title":"Prevalence of MR Evidence of Diffuse Axonal Injury in Patients with Mild Head Injury and Normal Head CT Findings","volume":"15","author":"Mittl","year":"1994","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/s40478-023-01636-4","article-title":"Low-Intensity Open-Field Blast Exposure Effects on Neurovascular Unit Ultrastructure in Mice","volume":"11","author":"Li","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S1474-4422(22)00309-X","article-title":"Traumatic Brain Injury: Progress and Challenges in Prevention, Clinical Care, and Research","volume":"21","author":"Maas","year":"2022","journal-title":"Lancet Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e1938","DOI":"10.1093\/milmed\/usae031","article-title":"Persistent MRI Findings Unique to Blast and Repetitive Mild TBI: Analysis of the CENC\/LIMBIC Cohort Injury Characteristics","volume":"189","author":"Tate","year":"2024","journal-title":"Mil. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1089\/neu.2011.1906","article-title":"Emerging Imaging Tools for Use with Traumatic Brain Injury Research","volume":"29","author":"Hunter","year":"2012","journal-title":"J. Neurotrauma"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"CNC35","DOI":"10.2217\/cnc-2016-0028","article-title":"White Matter Changes in Patients with Mild Traumatic Brain Injury: MRI Perspective","volume":"2","author":"Narayana","year":"2017","journal-title":"Concussion"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1136\/jnnp-2012-302742","article-title":"Diffusion Tensor Imaging Studies of Mild Traumatic Brain Injury: A Meta-Analysis","volume":"83","author":"Aoki","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e70029","DOI":"10.1111\/jon.70029","article-title":"Myelin Quantification Using Ultrashort Echo Time Magnetization Transfer Ratio in a Mouse Model of Traumatic Brain Injury","volume":"35","author":"Athertya","year":"2025","journal-title":"J. Neuroimaging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.2010.1578","article-title":"A Longitudinal Proton Magnetic Resonance Spectroscopy Study of Mild Traumatic Brain Injury","volume":"28","author":"Yeo","year":"2011","journal-title":"J. Neurotrauma"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11682-012-9156-5","article-title":"A Review of Magnetic Resonance Imaging and Diffusion Tensor Imaging Findings in Mild Traumatic Brain Injury","volume":"6","author":"Shenton","year":"2012","journal-title":"Brain Imaging Behav."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1006\/bbrc.2001.6058","article-title":"Proton Exchange as a Relaxation Mechanism for T1 in the Rotating Frame in Native and Immobilized Protein Solutions","volume":"289","author":"Kettunen","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1148\/radiol.16142535","article-title":"MR Imaging Applications in Mild Traumatic Brain Injury: An Imaging Update","volume":"279","author":"Wu","year":"2016","journal-title":"Radiology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.expneurol.2013.07.008","article-title":"Modeling Clinically Relevant Blast Parameters Based on Scaling Principles Produces Functional & Histological Deficits in Rats","volume":"248","author":"Turner","year":"2013","journal-title":"Exp. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1089\/neu.2012.2674","article-title":"Brain Injury: Neuro-Inflammation, Cognitive Deficit, and Magnetic Resonance Imaging in a Model of Blast Induced Traumatic Brain Injury","volume":"30","author":"Tompkins","year":"2013","journal-title":"J. Neurotrauma"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kwon, S.-K.C., Kovesdi, E., Gyorgy, A.B., Wingo, D., Kamnaksh, A., Walker, J., Long, J.B., and Agoston, D.V. (2011). Stress and Traumatic Brain Injury: A Behavioral, Proteomics, and Histological Study. Front. Neurol., 2.","DOI":"10.3389\/fneur.2011.00012"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/nbm.3351","article-title":"Multi-Echo Susceptibility-Weighted Imaging and Histology of Open-Field Blast-Induced Traumatic Brain Injury in a Rat Model","volume":"28","author":"Verma","year":"2015","journal-title":"NMR Biomed."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/jnen\/nlaa026","article-title":"Periventricular White Matter Alterations From Explosive Blast in a Large Animal Model: Mild Traumatic Brain Injury or \u201cSubconcussive\u201d Injury?","volume":"79","author":"Kim","year":"2020","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1097\/NEN.0b013e318235bef2","article-title":"Characteristics of an Explosive Blast-Induced Brain Injury in an Experimental Model","volume":"70","author":"Bandak","year":"2011","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/NEN.0000000000000165","article-title":"Components of Myelin Damage and Repair in the Progression of White Matter Pathology after Mild Traumatic Brain Injury","volume":"74","author":"Mierzwa","year":"2015","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/B978-0-444-52892-6.00020-9","article-title":"Advances in Imaging Explosive Blast Mild Traumatic Brain Injury","volume":"Volume 127","author":"Grafman","year":"2015","journal-title":"Handbook of Clinical Neurology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/mrm.24814","article-title":"MRSI of the Medial Temporal Lobe at 7 T in Explosive Blast Mild Traumatic Brain Injury","volume":"71","author":"Hetherington","year":"2014","journal-title":"Magn. Reson. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1089\/neu.2009.1073","article-title":"Diffusion Tensor Imaging of Mild to Moderate Blast-Related Traumatic Brain Injury and Its Sequelae","volume":"27","author":"Levin","year":"2010","journal-title":"J. Neurotrauma"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s11682-015-9432-2","article-title":"Brainstem White Matter Integrity Is Related to Loss of Consciousness and Postconcussive Symptomatology in Veterans with Chronic Mild to Moderate Traumatic Brain Injury","volume":"9","author":"Bangen","year":"2015","journal-title":"Brain Imaging Behav."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/hbm.23022","article-title":"White Matter Abnormalities Are Associated with Chronic Postconcussion Symptoms in Blast-Related Mild Traumatic Brain Injury","volume":"37","author":"Miller","year":"2015","journal-title":"Hum. Brain Mapp."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/j.neuroimage.2011.10.050","article-title":"Diffuse and Spatially Variable White Matter Disruptions Are Associated with Blast-Related Mild Traumatic Brain Injury","volume":"59","author":"Davenport","year":"2012","journal-title":"NeuroImage"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2174\/157341108783339115","article-title":"T2\u03c1 and T1\u03c1 Adiabatic Relaxations and Contrasts","volume":"4","author":"Michaeli","year":"2008","journal-title":"Curr. Anal. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Sharafi, A., Chang, G., and Regatte, R.R. (2017). Bi-Component T1\u03c1 and T2 Relaxation Mapping of Skeletal Muscle In-Vivo. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-14581-9"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.21037\/qims-20-651","article-title":"Collagen Deposition in the Liver Is Strongly and Positively Associated with T1rho Elongation While Fat Deposition Is Associated with T1rho Shortening: An Experimental Study of Methionine and Choline-Deficient (MCD) Diet Rat Model","volume":"10","author":"Zhao","year":"2020","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_39","first-page":"973","article-title":"Early Detection of Irreversible Cerebral Ischemia in the Rat Using Dispersion of the Magnetic Resonance Imaging Relaxation Time, T1\u03c1","volume":"18","author":"Kettunen","year":"2000","journal-title":"Magn. Reson. Imaging"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/mrm.10710","article-title":"T2 and T1\u03c1 MRI in Articular Cartilage Systems","volume":"51","author":"Menezes","year":"2004","journal-title":"Magn. Reson. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/jmri.24954","article-title":"In Vivo Quantitative Whole-Brain T1\u03c1 MRI of Multiple Sclerosis","volume":"42","author":"Gonyea","year":"2015","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s00415-010-5762-6","article-title":"T1rho (T1\u03c1) MR Imaging in Alzheimer\u2019s Disease and Parkinson\u2019s Disease with and without Dementia","volume":"258","author":"Haris","year":"2011","journal-title":"J. Neurol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.neuroimage.2008.03.030","article-title":"T1\u03c1 MRI of Alzheimer\u2019s Disease","volume":"41","author":"Borthakur","year":"2008","journal-title":"NeuroImage"},{"key":"ref_44","first-page":"583","article-title":"Errors in Quantitative T1rho Imaging and the Correction Methods","volume":"5","author":"Chen","year":"2015","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.joca.2017.01.013","article-title":"Magic Angle Effect Plays a Major Role in Both T1\u03c1 and T2 Relaxation in Articular Cartilage","volume":"25","author":"Shao","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"H\u00e4nninen, N., Rautiainen, J., Rieppo, L., Saarakkala, S., and Nissi, M.J. (2017). Orientation Anisotropy of Quantitative MRI Relaxation Parameters in Ordered Tissue. Sci. Rep., 7.","DOI":"10.1038\/s41598-017-10053-2"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1002\/mrm.28317","article-title":"Convincing Evidence for Magic Angle Less-Sensitive Quantitative T1\u03c1 Imaging of Articular Cartilage Using the 3D Ultrashort Echo Time Cones Adiabatic T1\u03c1 (3D UTE Cones-AdiabT1\u03c1) Sequence","volume":"84","author":"Wu","year":"2020","journal-title":"Magn. Reson. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/mds.21227","article-title":"Assessment of Brain Iron and Neuronal Integrity in Patients with Parkinson\u2019s Disease Using Novel MRI Contrasts","volume":"22","author":"Michaeli","year":"2007","journal-title":"Mov. Disord."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.parkreldis.2012.01.003","article-title":"Magnetization Transfer and Adiabatic R1\u03c1 MRI in the Brainstem of Parkinson\u2019s Disease","volume":"18","author":"Tuite","year":"2012","journal-title":"Park. Relat. Disord."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1002\/mrm.21600","article-title":"Water Spin Dynamics during Apoptotic Cell Death in Glioma Gene Therapy Probed by T1\u03c1 and T2\u03c1","volume":"59","author":"Sierra","year":"2008","journal-title":"Magn. Reson. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/jcbfm.2008.113","article-title":"Quantitative Assessment of Water Pools by T1\u03c1 and T2\u03c1 MRI in Acute Cerebral Ischemia of the Rat","volume":"29","author":"Jokivarsi","year":"2009","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jneumeth.2008.10.025","article-title":"Detection of Neuronal Loss Using T1\u03c1 MRI Assessment of \u00b9H\u2082O Spin Dynamics in the Aphakia Mouse","volume":"177","author":"Michaeli","year":"2009","journal-title":"J. Neurosci. Methods"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.expneurol.2011.09.018","article-title":"A Mouse Model of Blast-Induced Mild Traumatic Brain Injury","volume":"232","author":"Rubovitch","year":"2011","journal-title":"Exp. Neurol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1089\/neur.2021.0063","article-title":"Long-Term Effects of Low-Intensity Blast Non-Inertial Brain Injury on Anxiety-Like Behaviors in Mice: Home-Cage Monitoring Assessments","volume":"3","author":"Siedhoff","year":"2022","journal-title":"Neurotrauma Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1089\/neu.2008.0616","article-title":"Finite element analysis of controlled cortical impact-induced cell loss","volume":"27","author":"Mao","year":"2010","journal-title":"J. Neurotrauma"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/B978-0-444-52892-6.00004-0","article-title":"The neuropathology of traumatic brain injury","volume":"127","author":"McKee","year":"2015","journal-title":"Handb. Clin. Neurol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1089\/neu.2018.6360","article-title":"Patients with Mild Traumatic Brain Injury Recruited from Both Hospital and Primary Care Settings: A Controlled Longitudinal Magnetic Resonance Imaging Study","volume":"36","author":"Einarsen","year":"2019","journal-title":"J. Neurotrauma"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/jmre.2001.2340","article-title":"The return of the frequency sweep: Designing adiabatic pulses for contemporary NMR","volume":"153","author":"Garwood","year":"2001","journal-title":"J. Magn. Reson."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/12\/5431\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:47:29Z","timestamp":1760032049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/12\/5431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,6]]},"references-count":58,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["ijms26125431"],"URL":"https:\/\/doi.org\/10.3390\/ijms26125431","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,6]]}}}