{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:44:39Z","timestamp":1787802279096,"version":"build-2784847793"},"reference-count":64,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy","award":["32154\/36\/16.12.2024"],"award-info":[{"award-number":["32154\/36\/16.12.2024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Preeclampsia (PE) remains a significant obstetric challenge, having complex pathophysiology and limited early diagnostic and therapeutic options. MicroRNAs (miRNAs) have emerged as critical regulators in PE, offering insight into the molecular mechanisms underlying placental dysfunction and impaired maternal adaptation. Differentially expressed miRNAs in both placental tissue and maternal circulation, such as miR-155, play key roles in regulating angiogenesis, trophoblast invasion, and inflammatory pathways, all of which are central to the development of PE. Ongoing investigations increasingly highlight miRNAs as promising non-invasive molecular indicators for the early diagnosis and risk stratification of PE. Furthermore, therapeutic strategies targeting miRNA pathways using mimics or inhibitors show promise in correcting molecular dysfunctions and improving maternal and fetal outcomes. However, clinical translation faces several challenges, including targeted delivery, off-target effects, and the assessment of long-term efficacy. Overall, miRNAs hold significant potential as both diagnostic tools and therapeutic agents, marking a promising direction for improving care in PE pregnancies.<\/jats:p>","DOI":"10.3390\/ijms26125607","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T11:18:40Z","timestamp":1749640720000},"page":"5607","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["MicroRNAs in Preeclampsia: An Overview of Biomarkers and Potential Therapeutic Targets"],"prefix":"10.3390","volume":"26","author":[{"given":"Mihaela","family":"Oancea","sequence":"first","affiliation":[{"name":"2nd Department of Obstetrics and Ginecology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Mihu","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Ginecology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Braicu","sequence":"additional","affiliation":[{"name":"Department of Genomics, MEDFUTURE Institute for Biomedical Research, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Isachesku","sequence":"additional","affiliation":[{"name":"Department of Genomics, MEDFUTURE Institute for Biomedical Research, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0187-3682","authenticated-orcid":false,"given":"Ionel-Daniel","family":"Nati","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Ginecology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6832-9898","authenticated-orcid":false,"given":"Dan","family":"Boitor-Borza","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology I, Mother and Child Department, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doru Mihai","family":"Diculescu","sequence":"additional","affiliation":[{"name":"2nd Department of Obstetrics and Ginecology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6112-0223","authenticated-orcid":false,"given":"Stefan","family":"Strilciuc","sequence":"additional","affiliation":[{"name":"Department of Genomics, MEDFUTURE Institute for Biomedical Research, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 400610 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6358-1098","authenticated-orcid":false,"given":"Adrian","family":"Pan\u0103","sequence":"additional","affiliation":[{"name":"Center for Health Outcomes & Evaluation, Splaiul Unirii 45, 030126 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,11]]},"reference":[{"key":"ref_1","first-page":"347","article-title":"Evaluation of serum \u03b2-hCG and PAPP-A levels in pregnant women at risk of developing preeclampsia","volume":"86","author":"Oancea","year":"2013","journal-title":"Clujul Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Oancea, M., Grigore, M., Ciortea, R., Diculescu, D., Bodean, D., Bucuri, C., Strilciuc, S., Rada, M., and Mihu, D. 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