{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T13:18:23Z","timestamp":1793971103564,"version":"4.8.0"},"reference-count":144,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science basic foundation in Shaanxi Province of China: Social Development Field","award":["S2023-YF-YBSF-1616"],"award-info":[{"award-number":["S2023-YF-YBSF-1616"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Bone-related diseases significantly diminish human happiness, adversely impacting overall quality of life. Optimizing bone tissue repair remains a prominent focus within the field of bone tissue regenerative medicine. N6-methyladenosine (m6A) is one of the most prevalent epigenetic modifications found in eukaryotic mRNA and non-coding RNA. The functions of m6A involve diverse components, including \u201cWriters\u201d, \u201cErasers\u201d, and \u201cReaders\u201d. Numerous studies have demonstrated that m6A plays a crucial role in the exchange of information and coordination among various cell types, bioactive factors, and the microenvironment, influencing the progression of diverse physiological and pathological processes within the human body. In recent years, many functions and molecular pathways associated with m6A have been identified. This review primarily discusses the relationship between the three components of m6A and osteogenesis, as well as other key genes and pathways involved in this process. Additionally, we provide an in-depth elucidation of the interaction network between m6A modifications, micro-RNAs, and long non-coding RNAs. In the final section, we address the current limitations in m6A and osteogenesis research and explore the prospects for the diagnosis and treatment of bone-related diseases.<\/jats:p>","DOI":"10.3390\/ijms26125620","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T03:59:17Z","timestamp":1749700757000},"page":"5620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["N6-Methyladenosine Modification of the Three Components \u201cWriters\u201d, \u201cErasers\u201d, and \u201cReaders\u201d in Relation to Osteogenesis"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4441-5237","authenticated-orcid":false,"given":"Qiannan","family":"Dong","sequence":"first","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Xi\u2019an 710000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xubin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, College of Stomatology, Xi\u2019an Jiaotong University, Xi\u2019an 710000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changze","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Xi\u2019an 710000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9819-5122","authenticated-orcid":false,"given":"Jianping","family":"Ruan","sequence":"additional","affiliation":[{"name":"Center of Oral Public Health, College of Stomatology, Xi\u2019an Jiaotong University, Xi\u2019an 710000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3215-9449","authenticated-orcid":false,"given":"Cheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Xi\u2019an 710000, China"},{"name":"Department of General Dentistry, College of Stomatology, Xi\u2019an Jiaotong University, Xi\u2019an 710000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nm1593","article-title":"Skeletal remodeling in health and disease","volume":"13","author":"Zaidi","year":"2007","journal-title":"Nat. Med."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Huang, M., Guo, J., Liu, L., Jin, H., Chen, X., and Zou, J. (2023). m6A demethylase FTO and osteoporosis: Potential therapeutic interventions. Front. Cell Dev. Biol., 11.","DOI":"10.3389\/fcell.2023.1275475"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00198-014-2655-z","article-title":"The clinical diagnosis of osteoporosis: A position statement from the National Bone Health Alliance Working Group","volume":"25","author":"Siris","year":"2014","journal-title":"Osteoporos. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"750","DOI":"10.5534\/wjmh.200099","article-title":"Gender Differences in Osteoporosis: A Single-Center Observational Study","volume":"39","author":"Sirufo","year":"2021","journal-title":"World J. Men\u2019s Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"16069","DOI":"10.1038\/nrdp.2016.69","article-title":"Postmenopausal osteoporosis","volume":"2","author":"Eastell","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1210\/endrev\/bnab028","article-title":"Secondary Osteoporosis","volume":"43","author":"Ebeling","year":"2022","journal-title":"Endocr. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41576-020-0270-8","article-title":"The evolving metabolic landscape of chromatin biology and epigenetics","volume":"21","author":"Dai","year":"2020","journal-title":"Nat. Rev. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"6656","DOI":"10.1021\/acs.chemrev.8b00008","article-title":"Chemical and Biochemical Perspectives of Protein Lysine Methylation","volume":"118","author":"Luo","year":"2018","journal-title":"Chem. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1038\/s41592-019-0550-4","article-title":"Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA","volume":"16","author":"Zhou","year":"2019","journal-title":"Nat. Methods"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nature18282","article-title":"Stem cell function and stress response are controlled by protein synthesis","volume":"534","author":"Blanco","year":"2016","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.molcel.2019.03.036","article-title":"Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA","volume":"74","author":"Zhang","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.tranon.2019.06.007","article-title":"m1A Regulated Genes Modulate PI3K\/AKT\/mTOR and ErbB Pathways in Gastrointestinal Cancer","volume":"12","author":"Zhao","year":"2019","journal-title":"Transl. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Zhang, M., Song, J., Yuan, W., Zhang, W., and Sun, Z. (2021). Roles of RNA Methylation on Tumor Immunity and Clinical Implications. Front. Immunol., 12.","DOI":"10.3389\/fimmu.2021.641507"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.1073\/pnas.71.10.3971","article-title":"Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells","volume":"71","author":"Desrosiers","year":"1974","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nsmb.3162","article-title":"N6-methyladenosine\u2013encoded epitranscriptomics","volume":"23","author":"Liu","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.molcel.2019.04.025","article-title":"Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers","volume":"74","author":"Shi","year":"2019","journal-title":"Mol. Cell"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7948","DOI":"10.1002\/jcp.28014","article-title":"A dynamic reversible RNA N6\u2014Methyladenosine modification: Current status and perspectives","volume":"234","author":"Bi","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41422-018-0040-8","article-title":"Dynamic transcriptomic m6A decoration: Writers, erasers, readers and functions in RNA metabolism","volume":"28","author":"Yang","year":"2018","journal-title":"Cell Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1007\/s12015-021-10245-4","article-title":"METTL3-Mediated lncRNA m6A Modification in the Osteogenic Differentiation of Human Adipose-Derived Stem Cells Induced by NEL-Like 1 Protein","volume":"17","author":"Song","year":"2021","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Gu, J., Zhan, Y., Zhuo, L., Zhang, Q., Li, G., Li, Q., Qi, S., Zhu, J., Lv, Q., and Shen, Y. (2021). Biological functions of m6A methyltransferases. Cell Biosci., 11.","DOI":"10.1186\/s13578-020-00513-0"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Chen, X., Hua, W., Huang, X., Chen, Y., Zhang, J., and Li, G. (2019). Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00911"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.omtn.2019.12.001","article-title":"m6A Methylation of Precursor-miR-320\/RUNX2 Controls Osteogenic Potential of Bone Marrow-Derived Mesenchymal Stem Cells","volume":"19","author":"Yan","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Jiao, X., Sun, X., Li, W., Chu, W., Zhang, Y., Li, Y., Wang, Z., Zhou, X., Ma, J., and Xu, C. (2022). 3D-Printed beta-Tricalcium Phosphate Scaffolds Promote Osteogenic Differentiation of Bone Marrow-Deprived Mesenchymal Stem Cells in an N6-methyladenosine-Dependent Manner. Int. J. Bioprint., 8.","DOI":"10.18063\/ijb.v8i2.544"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/odi.14526","article-title":"METTL3 potentiates osteogenic differentiation of bone marrow mesenchymal stem cells via IGF2BP1\/m6A\/RUNX2","volume":"30","author":"Zhou","year":"2024","journal-title":"Oral. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1038\/s41467-018-06898-4","article-title":"Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis","volume":"9","author":"Wu","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_26","first-page":"4376","article-title":"METTL3 induces bone marrow mesenchymal stem cells osteogenic differentiation and migration through facilitating M1 macrophage differentiation","volume":"13","author":"Lei","year":"2021","journal-title":"Am. J. Transl. Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Tian, C., Huang, Y., Li, Q., Feng, Z., and Xu, Q. (2019). Mettl3 Regulates Osteogenic Differentiation and Alternative Splicing of Vegfa in Bone Marrow Mesenchymal Stem Cells. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20030551"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e13234","DOI":"10.1111\/cpr.13234","article-title":"METTL3-m6 A methylase regulates the osteogenic potential of bone marrow mesenchymal stem cells in osteoporotic rats via the Wnt signalling pathway","volume":"55","author":"Wu","year":"2022","journal-title":"Cell Prolif."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"23","DOI":"10.14715\/cmb\/2023.69.6.4","article-title":"Role of METTL3-mediated m6A modification in osteogenic differentiation of periodontal ligament stem cells extracted from adult periodontal ligaments ex-vivo","volume":"69","author":"Yao","year":"2023","journal-title":"Cell. Mol. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"102081","DOI":"10.1016\/j.tice.2023.102081","article-title":"Role of N6-adenosine-methyltransferase subunits METTL3 and METTL14 in the biological properties of periodontal ligament cells","volume":"82","author":"Huang","year":"2023","journal-title":"Tissue Cell"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/jre.13297","article-title":"METTL3 promotes the osteogenic differentiation of human periodontal ligament cells by increasing YAP activity via IGF2BP1 and YTHDF1-mediated m6A modification","volume":"59","author":"Sun","year":"2024","journal-title":"J. Periodontal Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"664","DOI":"10.7150\/ijms.90485","article-title":"METTL3 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells through IGF2BP1-Mediated Regulation of Runx2 Stability","volume":"21","author":"Sun","year":"2024","journal-title":"Int. J. Med. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Yang, Y., Zeng, J., Jiang, C., Chen, J., Song, C., Chen, M., and Wu, B. (2022). METTL3-Mediated lncSNHG7 m6A Modification in the Osteogenic\/Odontogenic Differentiation of Human Dental Stem Cells. J. Clin. Med., 12.","DOI":"10.21203\/rs.3.rs-1525839\/v1"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1177\/00220345211051594","article-title":"METTL3-Dependent Glycolysis Regulates Dental Pulp Stem Cell Differentiation","volume":"101","author":"Cai","year":"2022","journal-title":"J. Dent. Res."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Chen, S., Duan, X., He, Y., and Chen, W. (2024). METTL3 promotes osteogenic differentiation of human umbilical cord mesenchymal stem cells by up-regulating m6A modification of circCTTN. Biosci. Rep., 44.","DOI":"10.1042\/BSR20231186"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/s41419-021-04312-4","article-title":"The m6A \u201creader\u201d YTHDF1 promotes osteogenesis of bone marrow mesenchymal stem cells through translational control of ZNF839","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"5563568","DOI":"10.1155\/2023\/5563568","article-title":"The m6A Reader YTHDF1 Accelerates the Osteogenesis of Bone Marrow Mesenchymal Stem Cells Partly via Activation of the Autophagy Signaling Pathway","volume":"2023","author":"Gao","year":"2023","journal-title":"Stem Cells Int."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Shi, D., Liu, X., Li, X., Li, T., Liu, J., and Wu, L. (2023). Yth m6A RNA-Binding Protein 1 Regulates Osteogenesis of MC3T3-E1 Cells under Hypoxia via Translational Control of Thrombospondin-1. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24021741"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"21134","DOI":"10.18632\/aging.203377","article-title":"RNA N6-methyladenosine demethylase FTO promotes osteoporosis through demethylating Runx2 mRNA and inhibiting osteogenic differentiation","volume":"13","author":"Wang","year":"2021","journal-title":"Aging"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Zheng, L., Li, Z., Wang, B., Sun, R., Sun, Y., Ren, J., and Zhao, J. (2023). M6A Demethylase Inhibits Osteogenesis of Dental Follicle Stem Cells via Regulating miR-7974\/FKBP15 Pathway. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216121"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1186\/s12967-023-04630-5","article-title":"Advanced glycation end products impair bone marrow mesenchymal stem cells osteogenesis in periodontitis with diabetes via FTO-mediated N6-methyladenosine modification of sclerostin","volume":"21","author":"Zhou","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Huang, Y., Wang, S., Hu, D., Zhang, L., and Shi, S. (2024). ALKBH5 regulates etoposide-induced cellular senescence and osteogenic differentiation in osteoporosis through mediating the m6A modification of VDAC3. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-75033-9"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e13607","DOI":"10.1111\/cpr.13607","article-title":"miR615\u20133p inhibited FBLN1 and osteogenic differentiation of umbilical cord mesenchymal stem cells by associated with YTHDF2 in a m6A-miRNA interaction manner","volume":"57","author":"Yang","year":"2024","journal-title":"Cell Prolif."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41419-023-05565-x","article-title":"WTAP-mediated m6A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis","volume":"14","author":"You","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/stcltm\/szad020","article-title":"WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p\/HDAC4 Axis","volume":"12","author":"Liu","year":"2023","journal-title":"Stem Cells Transl. Med."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Li, Y., Yang, Y., Niu, Y., Li, Y., Hu, Z., Sun, S., Chen, Y., Hu, B., Huang, Y., and Deng, X. (2024). The role of WTAP in regulating macrophage-mediated osteoimmune responses and tissue regeneration in periodontitis. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1423378"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00441-022-03588-y","article-title":"METTL3-mediated LINC00657 promotes osteogenic differentiation of mesenchymal stem cells via miR-144-3p\/BMPR1B axis","volume":"388","author":"Peng","year":"2022","journal-title":"Cell Tissue Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1080\/15384101.2022.2125751","article-title":"METTL3-mediated long non-coding RNA MIR99AHG methylation targets miR-4660 to promote bone marrow mesenchymal stem cell osteogenic differentiation","volume":"22","author":"Li","year":"2023","journal-title":"Cell Cycle"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s13577-022-00825-y","article-title":"METTL14 upregulates TCF1 through m6A mRNA methylation to stimulate osteogenic activity in osteoporosis","volume":"36","author":"Wang","year":"2023","journal-title":"Hum. Cell"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/s41419-022-05362-y","article-title":"Downregulation of METTL14 improves postmenopausal osteoporosis via IGF2BP1 dependent posttranscriptional silencing of SMAD1","volume":"13","author":"Huang","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"114138","DOI":"10.1016\/j.yexcr.2024.114138","article-title":"Icariin upregulates methyltransferase-like 14-mediated prolyl 4-hydroxylase beta subunit m6A modification to promote osteogenic differentiation of bone marrow stem cells","volume":"440","author":"Jin","year":"2024","journal-title":"Exp. Cell Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1093\/stcltm\/szac049","article-title":"METTL14 Regulates Osteogenesis of Bone Marrow Mesenchymal Stem Cells via Inducing Autophagy Through m6A\/IGF2BPs\/Beclin-1 Signal Axis","volume":"11","author":"He","year":"2022","journal-title":"Stem Cells Transl. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"116652","DOI":"10.1016\/j.bone.2022.116652","article-title":"METTL14 alleviates the development of osteoporosis in ovariectomized mice by upregulating m6A level of SIRT1 mRNA","volume":"168","author":"Wang","year":"2023","journal-title":"Bone"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/jleuko\/qiae021","article-title":"YTHDC1 inhibits osteoclast differentiation to alleviate osteoporosis by enhancing PTPN6 messenger RNA stability in an m6A-hUR-dependent manner","volume":"115","author":"Zhang","year":"2024","journal-title":"J. Leukoc. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1111\/odi.14763","article-title":"Influence of METTL3 knockdown on PDLSC osteogenesis in E. coli LPS-induced inflammation","volume":"30","author":"Chen","year":"2024","journal-title":"Oral. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1186\/s13018-023-04120-w","article-title":"FOXO1 regulates osteogenic differentiation of periodontal ligament stem cells through the METTL3 signaling pathway","volume":"18","author":"Wang","year":"2023","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Huang, J., Wang, Y., and Zhou, Y. (2024). METTL3 and METTL14 regulate IL-6 expression via RNA m6A modification of zinc transporter SLC39A9 and DNA methylation of IL-6 in periodontal ligament cells. Biochim. Biophys. Acta Mol. Cell Res., 1871.","DOI":"10.1016\/j.bbamcr.2023.119605"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"3361794","DOI":"10.1155\/2024\/3361794","article-title":"METTL3-Mediated m6A Modification Regulates the Osteogenic Differentiation through LncRNA CUTALP in Periodontal Mesenchymal Stem Cells of Periodontitis Patients","volume":"2024","author":"Chen","year":"2024","journal-title":"Stem Cells Int."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/odi.14467","article-title":"N6-methyladenosine promotes osteogenic differentiation of PDLSCs from periodontitis patients","volume":"30","author":"Zhang","year":"2024","journal-title":"Oral. Dis."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13148-024-01628-8","article-title":"METTL3 promotes osteoblast ribosome biogenesis and alleviates periodontitis","volume":"16","author":"Zhang","year":"2024","journal-title":"Clin. Epigenetics"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e2308786","DOI":"10.1002\/advs.202308786","article-title":"Inhibition of METTL3 Alleviates NLRP3 Inflammasome Activation via Increasing Ubiquitination of NEK7","volume":"11","author":"Zhou","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"6385","DOI":"10.1111\/jcmm.15284","article-title":"Methyltransferase-like 3-mediated N6-methyladenosine modification of miR-7212-5p drives osteoblast differentiation and fracture healing","volume":"24","author":"Mi","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"155220","DOI":"10.1016\/j.prp.2024.155220","article-title":"Unraveling IGFBP3-mediated m6A modification in fracture healing","volume":"255","author":"Lai","year":"2024","journal-title":"Pathol. Res. Pract."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1186\/s13018-024-05164-2","article-title":"METTL3 accelerates staphylococcal protein A (SpA)-induced osteomyelitis progression by regulating m6A methylation-modified miR-320a","volume":"19","author":"Gao","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"25903","DOI":"10.18632\/aging.203778","article-title":"METTL14 benefits the mesenchymal stem cells in patients with steroid-associated osteonecrosis of the femoral head by regulating the m6A level of PTPN6","volume":"13","author":"Cheng","year":"2021","journal-title":"Aging"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/s41368-024-00303-1","article-title":"METTL7A-mediated m6A modification of corin reverses bisphosphonates-impaired osteogenic differentiation of orofacial BMSCs","volume":"16","author":"Jin","year":"2024","journal-title":"Int. J. Oral. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1038\/s41467-021-25710-4","article-title":"TNF-\u03b1-mediated m6A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis","volume":"12","author":"Xie","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s00018-024-05460-4","article-title":"N6-methyladenosine-modified circCDK14 promotes ossification of the ligamentum flavum via epigenetic modulation by targeting AFF4","volume":"81","author":"Zhao","year":"2024","journal-title":"Cell Mol. Life Sci."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e146985","DOI":"10.1172\/JCI146985","article-title":"ALKBH1-demethylated DNA N6-methyladenine modification triggers vascular calcification via osteogenic reprogramming in chronic kidney disease","volume":"131","author":"Ouyang","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1038\/s12276-024-01256-5","article-title":"Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions","volume":"56","author":"Xian","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/jmcb\/mjz085","article-title":"Marking RNA: m6A writers, readers, and functions in Arabidopsis","volume":"11","author":"Reichel","year":"2019","journal-title":"J. Mol. Cell Biol."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Cao, G., Li, H.B., Yin, Z., and Flavell, R.A. (2016). Recent advances in dynamic m6A RNA modification. Open Biol., 6.","DOI":"10.1098\/rsob.160003"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1146\/annurev-cellbio-100616-060758","article-title":"Rethinking m6A Readers, Writers, and Erasers","volume":"33","author":"Meyer","year":"2017","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"e12573","DOI":"10.1111\/cpr.12573","article-title":"LncRNA Riken-201 and Riken-203 modulates neural development by regulating the Sox6 through sequestering miRNAs","volume":"52","author":"Zhang","year":"2019","journal-title":"Cell Prolif."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12943-020-01207-4","article-title":"Interaction between N6-methyladenosine (m6A) modification and noncoding RNAs in cancer","volume":"19","author":"Chen","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/cr.2014.3","article-title":"Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase","volume":"24","author":"Ping","year":"2014","journal-title":"Cell Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.omtn.2021.04.002","article-title":"The role of M6A modification in the regulation of tumor-related lncRNAs","volume":"24","author":"Lan","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Yan, C.P., Wang, X.K., Jiang, K., Yin, C., Xiang, C., Wang, Y., Pu, C., Chen, L., and Li, Y.L. (2022). \u03b2-Ecdysterone Enhanced Bone Regeneration Through the BMP-2\/SMAD\/RUNX2\/Osterix Signaling Pathway. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.883228"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/978-981-10-5203-3_10","article-title":"Technological Developments in lncRNA Biology","volume":"1008","author":"Jathar","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1111\/jcmm.16469","article-title":"m6A regulator-mediated RNA methylation modification patterns are involved in immune microenvironment regulation of periodontitis","volume":"25","author":"Zhang","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.biomaterials.2017.12.025","article-title":"Mesenchymal stem cell-macrophage crosstalk and bone healing","volume":"196","author":"Pajarinen","year":"2019","journal-title":"Biomaterials"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1159\/000485776","article-title":"Exendin-4 Induces Bone Marrow Stromal Cells Migration Through Bone Marrow-Derived Macrophages Polarization via PKA-STAT3 Signaling Pathway","volume":"44","author":"Wang","year":"2017","journal-title":"Cell Physiol. Biochem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/jbmr.2422","article-title":"Macrophages promote osteoblastic differentiation in-vivo: Implications in fracture repair and bone homeostasis","volume":"30","author":"Vi","year":"2015","journal-title":"J. Bone Miner. Res."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Gu, X., Li, D., Cai, L., and Xu, Q. (2019). METTL3 Regulates Osteoblast Differentiation and Inflammatory Response via Smad Signaling and MAPK Signaling. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21010199"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1083\/jcb.201906047","article-title":"Protein quality control in the secretory pathway","volume":"218","author":"Sun","year":"2019","journal-title":"J. Cell Biol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"110335","DOI":"10.1016\/j.cellsig.2022.110335","article-title":"METTL3 mediates osteoblast apoptosis by regulating endoplasmic reticulum stress during LPS-induced inflammation","volume":"95","author":"Kong","year":"2022","journal-title":"Cell Signal."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanisms, regulation and functions of the unfolded protein response","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.intimp.2017.12.016","article-title":"Inflammation induced ER stress affects absorptive intestinal epithelial cells function and integrity","volume":"55","author":"Chotikatum","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nature17041","article-title":"Protein misfolding in the endoplasmic reticulum as a conduit to human disease","volume":"529","author":"Wang","year":"2016","journal-title":"Nature"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1093\/jbmr\/zjae121","article-title":"One-carbon metabolism supports S-adenosylmethionine and m6A methylation to control the osteogenesis of bone marrow stem cells and bone formation","volume":"39","author":"Zhang","year":"2024","journal-title":"J. Bone Miner. Res."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Wang, Y., Yu, W., E, Y., Rui, L., Jia, C., and Zhu, W. (2024). Qianggu Decoction Alleviated Osteoporosis by Promoting Osteogenesis of BMSCs through Mettl3-Mediated m6A Methylation. Adv. Biol., 8.","DOI":"10.1002\/adbi.202400341"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"116433","DOI":"10.1016\/j.jep.2023.116433","article-title":"Chinese Ecliptae herba (Eclipta prostrata (L.) L.) extract and its component wedelolactone enhances osteoblastogenesis of bone marrow mesenchymal stem cells via targeting METTL3-mediated m6A RNA methylation","volume":"312","author":"Tian","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1172\/JCI97794","article-title":"Vhl deletion in osteoblasts boosts cellular glycolysis and improves global glucose metabolism","volume":"128","author":"Dirckx","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.reth.2024.04.004","article-title":"METTL3 promotes the osteogenic differentiation of periosteum-derived MSCs via regulation of the HOXD8\/ITGA5 axis in congenital pseudarthrosis","volume":"26","author":"Ye","year":"2024","journal-title":"Regen. Ther."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e163","DOI":"10.1016\/j.jtcvs.2019.10.039","article-title":"Factors influencing osteogenic differentiation of human aortic valve interstitial cells","volume":"161","author":"Zhou","year":"2021","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Yuan, X., Shi, L., Guo, Y., Sun, J., Miao, J., Shi, J., and Chen, Y. (2021). METTL3 Regulates Ossification of the Posterior Longitudinal Ligament via the lncRNA XIST\/miR-302a-3p\/USP8 Axis. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.629895"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.2174\/011574888X244047231012103752","article-title":"Compression Promotes the Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Regulating METTL14-mediated IGF1","volume":"19","author":"Wu","year":"2024","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.cell.2022.04.021","article-title":"Circular RNAs: Characterization, cellular roles, and applications","volume":"185","author":"Liu","year":"2022","journal-title":"Cell"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Xiang, Q., Kang, L., Wang, J., Liao, Z., Song, Y., Zhao, K., Wang, K., Yang, C., and Zhang, Y. (2020). CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p\/SIRT1 axis. EBioMedicine, 53.","DOI":"10.1016\/j.ebiom.2020.102679"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1016\/j.jds.2024.02.022","article-title":"Wilms tumor 1-associated protein mediated m6A modification promotes osteogenic differentiation of stem cells from human exfoliated deciduous teeth","volume":"19","author":"Gao","year":"2024","journal-title":"J. Dent. Sci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.fmre.2022.04.005","article-title":"METTL5 regulates cranial suture fusion via Wnt signaling","volume":"3","author":"Lei","year":"2023","journal-title":"Fundam. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"23361","DOI":"10.18632\/aging.203630","article-title":"piRNA-36741 regulates BMP2-mediated osteoblast differentiation via METTL3 controlled m6A modification","volume":"13","author":"Liu","year":"2021","journal-title":"Aging"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11010-019-03641-5","article-title":"The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-kappaB signaling","volume":"463","author":"Yu","year":"2020","journal-title":"Mol. Cell Biochem."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"166","DOI":"10.3892\/mmr.2023.13053","article-title":"METTL14 mediates m6a modification on osteogenic proliferation and differentiation of bone marrow mesenchymal stem cells by regulating the processing of pri-miR-873","volume":"28","author":"Dong","year":"2023","journal-title":"Mol. Med. Rep."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1186\/s13287-021-02508-1","article-title":"Transcriptome-wide m6A methylome during osteogenic differentiation of human adipose-derived stem cells","volume":"12","author":"Sun","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"101550","DOI":"10.1016\/j.jormas.2023.101550","article-title":"Dysregulated m6A methylation modification is associated with human peri-implantitis\u2014A pilot study","volume":"124","author":"Krishnamoorthy","year":"2023","journal-title":"J. Stomatol. Oral. Maxillofac. Surg."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nchembio.687","article-title":"N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1038\/s41467-019-10669-0","article-title":"m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade","volume":"10","author":"Yang","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.molcel.2012.10.015","article-title":"ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility","volume":"49","author":"Zheng","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12935-020-1105-6","article-title":"ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma","volume":"20","author":"Chen","year":"2020","journal-title":"Cancer Cell Int."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12943-019-1128-6","article-title":"m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling","volume":"19","author":"Tang","year":"2020","journal-title":"Mol. Cancer"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/s41401-021-00756-8","article-title":"The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG","volume":"43","author":"Chen","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/cbin.12134","article-title":"A novel PDIA3\/FTO\/USP20 positive feedback regulatory loop induces osteogenic differentiation of preosteoblast in osteoporosis","volume":"48","author":"Zhang","year":"2024","journal-title":"Cell Biol. Int."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"111098","DOI":"10.1016\/j.cellsig.2024.111098","article-title":"FTO regulates osteoclast development by modulating the proliferation and apoptosis of osteoclast precursors in inflammatory conditions","volume":"117","author":"He","year":"2024","journal-title":"Cell Signal"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S2213-8587(17)30134-1","article-title":"Bone disease in diabetes: Another manifestation of microvascular disease?","volume":"5","author":"Shanbhogue","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nrendo.2011.106","article-title":"Diabetes mellitus and periodontitis: A tale of two common interrelated diseases","volume":"7","author":"Lalla","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/prd.12318","article-title":"The impact of diabetes on periodontal diseases","volume":"82","author":"Graves","year":"2020","journal-title":"Periodontol 2000"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41419-021-03869-4","article-title":"The N6-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6","volume":"12","author":"Li","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1002\/1873-3468.14145","article-title":"The RNA demethylase ALKBH5 promotes osteoblast differentiation by modulating Runx2 mRNA stability","volume":"595","author":"Feng","year":"2021","journal-title":"FEBS Lett."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1177\/00220345241266775","article-title":"ALKBH5 Regulates Osteogenic Differentiation via the lncRNA\/mRNA Complex","volume":"103","author":"Song","year":"2024","journal-title":"J. Dent. Res."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"9974098","DOI":"10.1155\/2023\/9974098","article-title":"Abnormal Decrease of Macrophage ALKBH5 Expression Causes Abnormal Polarization and Inhibits Osteoblast Differentiation","volume":"2023","author":"Weng","year":"2023","journal-title":"Stem Cells Int."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e13178","DOI":"10.1111\/cpr.13178","article-title":"Alkbh1-mediated DNA N6-methyladenine modification regulates bone marrow mesenchymal stem cell fate during skeletal aging","volume":"55","author":"Cai","year":"2022","journal-title":"Cell Prolif."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1126\/science.aau1646","article-title":"RNA modifications modulate gene expression during development","volume":"361","author":"Frye","year":"2018","journal-title":"Science"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"N6-methyladenosine Modulates Messenger RNA Translation Efficiency","volume":"161","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12943-019-1082-3","article-title":"YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma","volume":"18","author":"Hou","year":"2019","journal-title":"Mol. Cancer"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/cr.2017.15","article-title":"YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA","volume":"27","author":"Shi","year":"2017","journal-title":"Cell Res."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Luxton, H.J., Simpson, B.S., Mills, I.G., Brindle, N.R., Ahmed, Z., Stavrinides, V., Heavey, S., Stamm, S., and Whitaker, H.C. (2019). The Oncogene Metadherin Interacts with the Known Splicing Proteins YTHDC1, Sam68 and T-STAR and Plays a Novel Role in Alternative mRNA Splicing. Cancers, 11.","DOI":"10.3390\/cancers11091233"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2015.10.012","article-title":"5\u2032 UTR m6A Promotes Cap-Independent Translation","volume":"163","author":"Meyer","year":"2015","journal-title":"Cell"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41580-019-0168-5","article-title":"Reading, writing and erasing mRNA methylation","volume":"20","author":"Zaccara","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.molcel.2016.03.021","article-title":"The m6A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells","volume":"62","author":"Lin","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"17249","DOI":"10.1021\/jacs.7b09213","article-title":"RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein-RNA Interactome","volume":"139","author":"Arguello","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"e18876","DOI":"10.1016\/j.heliyon.2023.e18876","article-title":"YTHDC2 inhibits rat bone mesenchymal stem cells osteogenic differentiation by accelerating RUNX2 mRNA degradation via m6A methylation","volume":"9","author":"Ma","year":"2023","journal-title":"Heliyon"},{"key":"ref_135","doi-asserted-by":"crossref","unstructured":"Yuan, T., Liu, H., Abudoukadier, M., Yang, Z., Zhou, Z., and Cui, Y. (2024). YTHDF2-Mediated m6A methylation inhibition by miR27a as a protective mechanism against hormonal osteonecrosis in BMSCs. BMC Musculoskelet. Disord., 25.","DOI":"10.1186\/s12891-024-07481-3"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1111\/os.14064","article-title":"Unraveling Key m6A Modification Regulators Signatures in Postmenopausal Osteoporosis through Bioinformatics and Experimental Verification","volume":"16","author":"Feng","year":"2024","journal-title":"Orthop. Surg."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"e2403412","DOI":"10.1002\/advs.202403412","article-title":"Quercetin-Loaded Bioglass Injectable Hydrogel Promotes m6A Alteration of Per1 to Alleviate Oxidative Stress for Periodontal Bone Defects","volume":"11","author":"Zhu","year":"2024","journal-title":"Adv. Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jobcr.2024.06.001","article-title":"Overexpression of insulin-like growth factor-2 mRNA-binding protein 1 is associated with periodontal disease","volume":"14","author":"Deepika","year":"2024","journal-title":"J. Oral. Biol. Craniofac. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/00220345231216115","article-title":"Dual Role of IGF2BP2 in Osteoimmunomodulation during Periodontitis","volume":"103","author":"Ma","year":"2024","journal-title":"J. Dent. Res."},{"key":"ref_140","first-page":"834","article-title":"N6-methyladenosine-mediated overexpression of TREM-1 is associated with periodontal disease","volume":"113","author":"Ramamurthy","year":"2024","journal-title":"Odontology"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1016\/j.cell.2024.03.032","article-title":"Hematopoietic stem cell niche generation and maintenance are distinguishable by an epitranscriptomic program","volume":"187","author":"Gao","year":"2024","journal-title":"Cell"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"37","DOI":"10.7326\/M19-0533","article-title":"Long-Term Drug Therapy and Drug Discontinuations and Holidays for Osteoporosis Fracture Prevention: A Systematic Review","volume":"171","author":"Fink","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1002\/jbmr.2918","article-title":"Managing Osteoporosis in Patients on Long-Term Bisphosphonate Treatment: Report of a Task Force of the American Society for Bone and Mineral Research","volume":"31","author":"Adler","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1001\/jama.2010.1360","article-title":"Atypical fractures as a potential complication of long-term bisphosphonate therapy","volume":"304","author":"Sellmeyer","year":"2010","journal-title":"JAMA"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/12\/5620\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:50:27Z","timestamp":1760032227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/12\/5620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,12]]},"references-count":144,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["ijms26125620"],"URL":"https:\/\/doi.org\/10.3390\/ijms26125620","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,12]]}}}