{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:52:58Z","timestamp":1790362378066,"version":"4.1.0"},"reference-count":336,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:00:00Z","timestamp":1749945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Ferritin is important for cellular iron storage and metabolism. It consists of 24 ferritin heavy- or light-chain subunits surrounding an iron-containing core, but it is also released as an extracellular molecule that shows increased systemic levels during acute-phase reactions. Furthermore, acute myeloid leukemia (AML) is an aggressive bone marrow malignancy that can be associated with increased ferritin levels both at the time of first diagnosis but also during\/following anti-AML treatment due to an iron overload. Such high systemic ferritin levels at diagnosis or later allogeneic stem cell transplantation are associated with decreased long-term survival. Extracellular ferritin binds to several receptors expressed by AML cells (e.g., the transferrin receptor and CXCR4 chemokine receptor) and AML-supporting non-leukemic bone marrow cells (e.g., endothelial, mesenchymal or immunocompetent cells). Ferritin can thereby affect the AML cells directly as well as indirectly via AML-supporting neighboring cells. Finally, ferritin should be regarded as a regulator of the dysfunctional iron metabolism that causes increased iron levels in AML cells, and it is important for cell survival through its function during the initial steps of ferroptosis. Thus, ferritin is not only an adverse prognostic biomarker, but also an important regulator of AML cell proliferation, survival and chemosensitivity and the targeting of iron metabolism\/ferroptosis is, therefore, a possible strategy in AML therapy.<\/jats:p>","DOI":"10.3390\/ijms26125744","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T10:47:22Z","timestamp":1750070842000},"page":"5744","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ferritin in Acute Myeloid Leukemia: Not Only a Marker of Inflammation and Iron Overload, but Also a Regulator of Cellular Iron Metabolism, Signaling and Communication"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-8411","authenticated-orcid":false,"given":"H\u00e5kon","family":"Reikvam","sequence":"first","affiliation":[{"name":"Acute Leukemia Research Group, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"},{"name":"Section for Hematology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus Gramstad","family":"Rolfsnes","sequence":"additional","affiliation":[{"name":"Acute Leukemia Research Group, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linn","family":"Rolsdorph","sequence":"additional","affiliation":[{"name":"Department of Medicine, Akershus University Hospital, Postboks 1000, 1478 L\u00f8renskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Sandnes","sequence":"additional","affiliation":[{"name":"Acute Leukemia Research Group, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frode","family":"Selheim","sequence":"additional","affiliation":[{"name":"Proteomics Unit of University of Bergen (PROBE), University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9347-7841","authenticated-orcid":false,"given":"Maria","family":"Hernandez-Valladares","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, University of Granada, Avenida de la Fuente Nueva S\/N, 18071 Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs.GRANADA, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d8ystein","family":"Bruserud","sequence":"additional","affiliation":[{"name":"Acute Leukemia Research Group, Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"},{"name":"Section for Hematology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood.2022015850","article-title":"International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: Integrating morphologic, clinical, and genomic data","volume":"140","author":"Arber","year":"2022","journal-title":"Blood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0145-2126(88)90076-8","article-title":"Human AML colony growth in serum-free culture","volume":"12","author":"Salem","year":"1988","journal-title":"Leuk. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1089\/106161299320587","article-title":"In vitro culture of acute myelogenous leukemia blasts: A comparison of four different culture media","volume":"8","author":"Bruserud","year":"1999","journal-title":"J. Hematother."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/14728222.2017.1300255","article-title":"Patients with acute myeloid leukemia can be subclassified based on the constitutive cytokine release of the leukemic cells; the possible clinical relevance and the importance of cellular iron metabolism","volume":"21","author":"Brenner","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"mfab021","DOI":"10.1093\/mtomcs\/mfab021","article-title":"Chemistry and biology of ferritin","volume":"13","author":"Plays","year":"2021","journal-title":"Metallomics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ijbiomac.2022.10.126","article-title":"Ferritin self-assembly, structure, function, and biotechnological applications","volume":"224","author":"Sudarev","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/iub.1621","article-title":"Ferritin, cellular iron storage and regulation","volume":"69","author":"Arosio","year":"2017","journal-title":"IUBMB Life"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Moreira, A.C., Mesquita, G., and Gomes, M.S. (2020). Ferritin: An Inflammatory Player Keeping Iron at the Core of Pathogen-Host Interactions. Microorganisms, 8.","DOI":"10.3390\/microorganisms8040589"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/intimm\/dxx031","article-title":"Hyperferritinemia and inflammation","volume":"29","author":"Kernan","year":"2017","journal-title":"Int. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6804","DOI":"10.1038\/s41467-022-34560-7","article-title":"Ferritin triggers neutrophil extracellular trap-mediated cytokine storm through MSR1 contributing to adult-onset Still\u2019s disease pathogenesis","volume":"13","author":"Jia","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1021\/acs.biochem.5b01152","article-title":"Ferritin Assembly Revisited: A Time-Resolved Small-Angle X-ray Scattering Study","volume":"55","author":"Sato","year":"2016","journal-title":"Biochemistry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1182\/blood.V87.6.2525.bloodjournal8762525","article-title":"Ferritin translation by interleukin-1 and interleukin-6: The role of sequences upstream of the start codons of the heavy and light subunit genes","volume":"87","author":"Rogers","year":"1996","journal-title":"Blood"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/hep.1840180420","article-title":"Regulation of iron metabolism in HepG2 cells: A possible role for cytokines in the hepatic deposition of iron","volume":"18","author":"Hirayama","year":"1993","journal-title":"Hepatology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1073\/pnas.88.11.4946","article-title":"Iron-independent induction of ferritin H chain by tumor necrosis factor","volume":"88","author":"Miller","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1002\/hep.22716","article-title":"Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta\/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells","volume":"49","author":"Ruddell","year":"2009","journal-title":"Hepatology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6220","DOI":"10.1074\/jbc.275.9.6220","article-title":"Effects of interferon-gamma and lipopolysaccharide on macrophage iron metabolism are mediated by nitric oxide-induced degradation of iron regulatory protein 2","volume":"275","author":"Kim","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1182\/blood-2003-09-3050","article-title":"Regulated secretion of glycosylated human ferritin from hepatocytes","volume":"103","author":"Ghosh","year":"2004","journal-title":"Blood"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1182\/blood.V99.10.3505","article-title":"Regulation of ferritin genes and protein","volume":"99","author":"Torti","year":"2002","journal-title":"Blood"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1440-1746.1993.tb01170.x","article-title":"Differential regulation of ferritin H and L subunit mRNA during inflammation and long-term iron overload","volume":"8","author":"Leggett","year":"1993","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature13148","article-title":"Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy","volume":"509","author":"Mancias","year":"2014","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1080\/15548627.2016.1187366","article-title":"Autophagy promotes ferroptosis by degradation of ferritin","volume":"12","author":"Hou","year":"2016","journal-title":"Autophagy"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1182\/blood-2017-02-768580","article-title":"Ferritin is secreted via 2 distinct nonclassical vesicular pathways","volume":"131","author":"Berenbaum","year":"2018","journal-title":"Blood"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1182\/blood-2009-11-253815","article-title":"Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway","volume":"116","author":"Cohen","year":"2010","journal-title":"Blood"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"42","DOI":"10.15252\/embj.201695081","article-title":"Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy","volume":"36","author":"Kimura","year":"2017","journal-title":"EMBO J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.bbagen.2010.03.011","article-title":"Serum ferritin: Past, present and future","volume":"1800","author":"Wang","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"22010","DOI":"10.1074\/jbc.M112448200","article-title":"A proteomic approach identifies proteins in hepatocytes that bind nascent apolipoprotein B","volume":"277","author":"Rashid","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-2141.1989.tb04268.x","article-title":"Rabbit serum alpha-2-macroglobulin binds to liver ferritin: Association causes a heterogeneity of ferritin molecules","volume":"71","author":"Santambrogio","year":"1989","journal-title":"Br. J. Haematol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1292\/jvms.55.785","article-title":"Fibrinogen as a ferritin-binding protein in horse plasma","volume":"55","author":"Orino","year":"1993","journal-title":"J. Vet. Med. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.freeradbiomed.2018.06.037","article-title":"Transferrin and transferrin receptors update","volume":"133","author":"Kawabata","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1073\/pnas.0913192107","article-title":"Binding and uptake of H-ferritin are mediated by human transferrin receptor-1","volume":"107","author":"Li","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"15727","DOI":"10.1074\/jbc.RA120.014690","article-title":"Interactions of ferritin with scavenger receptor class A members","volume":"295","author":"Yu","year":"2020","journal-title":"J. Biol. Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.devcel.2008.12.002","article-title":"SCARA5 is a ferritin receptor mediating non-transferrin iron delivery","volume":"16","author":"Li","year":"2009","journal-title":"Dev. Cell"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1111\/cas.12188","article-title":"Tumor associated macrophage expressing CD204 is associated with tumor aggressiveness of esophageal squamous cell carcinoma","volume":"104","author":"Shigeoka","year":"2013","journal-title":"Cancer Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"20230627","DOI":"10.1515\/med-2023-0627","article-title":"SCARA5 inhibits oral squamous cell carcinoma via inactivating the STAT3 and PI3K\/AKT signaling pathways","volume":"18","author":"Huang","year":"2023","journal-title":"Open Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.3892\/mmr.2016.4857","article-title":"Overexpression of SCARA5 inhibits tumor proliferation and invasion in osteosarcoma via suppression of the FAK signaling pathway","volume":"13","author":"Wen","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1172\/JCI38012","article-title":"Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling","volume":"120","author":"Huang","year":"2010","journal-title":"J. Clin. Investig."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3892\/mmr.2021.11841","article-title":"SCARA5 suppresses the proliferation and migration, and promotes the apoptosis of human retinoblastoma cells by inhibiting the PI3K\/AKT pathway","volume":"23","author":"Wang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11010-017-3055-4","article-title":"SCARA5 plays a critical role in the progression and metastasis of breast cancer by inactivating the ERK1\/2, STAT3, and AKT signaling pathways","volume":"435","author":"You","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"110636","DOI":"10.1016\/j.ygeno.2023.110636","article-title":"SCARA5 in bone marrow stromal cell-derived exosomes inhibits colorectal cancer progression by inactivating the PI3K\/Akt pathway","volume":"115","author":"Fang","year":"2023","journal-title":"Genomics"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Mendes-Jorge, L., Ramos, D., Valen\u00e7a, A., L\u00f3pez-Luppo, M., Pires, V.M., Catita, J., Nacher, V., Navarro, M., Carretero, A., and Rodriguez-Baeza, A. (2014). L-ferritin binding to SCARA5: A new iron traffic pathway potentially implicated in retinopathy. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0106974"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Liu, Y., Xiong, R., Xiao, T., Xiong, L., Wu, J., Li, J., Feng, G., Song, G., and Liu, K. (2022). SCARA5 induced ferroptosis to effect ESCC proliferation and metastasis by combining with Ferritin light chain. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-10414-9"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Gudgeon, J., Mar\u00edn-Rubio, J.L., and Trost, M. (2022). The role of macrophage scavenger receptor 1 (MSR1) in inflammatory disorders and cancer. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1012002"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3960\/jslrt.23013","article-title":"Myeloid sarcoma incidentally found in lymph nodes dissected for advanced gastric cancer","volume":"63","author":"Yamada","year":"2023","journal-title":"J. Clin. Exp. Hematop."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Sheng, W., Ji, G., and Zhang, L. (2022). Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1050984"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e004794","DOI":"10.1136\/jitc-2022-004794","article-title":"TIGIT blockade repolarizes AML-associated TIGIT+ M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis","volume":"10","author":"Brauneck","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e133","DOI":"10.3324\/haematol.2018.210682","article-title":"Endocytosis by macrophages: Interplay of macrophage scavenger receptor-1 and LDL receptor-related protein-1","volume":"105","author":"Przeradzka","year":"2020","journal-title":"Haematologica"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1084\/jem.20042433","article-title":"TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis","volume":"202","author":"Chen","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/glia.23313","article-title":"Semaphorin4A and H-ferritin utilize TIM-1 on human oligodendrocytes: A novel neuro-immune axis","volume":"66","author":"Chiou","year":"2018","journal-title":"Glia"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"37616","DOI":"10.1074\/jbc.M607266200","article-title":"Chemokine CXCL12 induces binding of ferritin heavy chain to the chemokine receptor CXCR4, alters CXCR4 signaling, and induces phosphorylation and nuclear translocation of ferritin heavy chain","volume":"281","author":"Li","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.2147\/CMAR.S234883","article-title":"Significance of CXCL12\/CXCR4 Ligand\/Receptor Axis in Various Aspects of Acute Myeloid Leukemia","volume":"12","author":"Yazdani","year":"2020","journal-title":"Cancer Manag. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3904\/kjim.2016.244","article-title":"Targeting the CXCL12\/CXCR4 axis in acute myeloid leukemia: From bench to bedside","volume":"32","author":"Cho","year":"2017","journal-title":"Korean J. Intern. Med."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Bruserud, \u00d8., Vo, A.K., and Rekvam, H. (2022). Hematopoiesis, Inflammation and Aging-The Biological Background and Clinical Impact of Anemia and Increased C-Reactive Protein Levels on Elderly Individuals. J. Clin. Med., 11.","DOI":"10.3390\/jcm11030706"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Jiang, N., Zhang, X., Chen, Q., Kantawong, F., Wan, S., Liu, J., Li, H., Zhou, J., Lu, B., and Wu, J. (2022). Identification of a Mitochondria-Related Gene Signature to Predict the Prognosis in AML. Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.823831"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Tong, X., and Zhou, F. (2023). Integrated bioinformatic analysis of mitochondrial metabolism-related genes in acute myeloid leukemia. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1120670"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Ni, S., Yuan, Y., Kuang, Y., and Li, X. (2022). Iron Metabolism and Immune Regulation. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.816282"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1182\/blood.V73.1.74.74","article-title":"Suppressive effects in vivo of purified recombinant human H-subunit (acidic) ferritin on murine myelopoiesis","volume":"73","author":"Broxmeyer","year":"1989","journal-title":"Blood"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1182\/blood.V68.6.1257.1257","article-title":"The influence of purified recombinant human heavy-subunit and light-subunit ferritins on colony formation in vitro by granulocyte-macrophage and erythroid progenitor cells","volume":"68","author":"Broxmeyer","year":"1986","journal-title":"Blood"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1073\/pnas.88.3.770","article-title":"Mutated recombinant human heavy-chain ferritins and myelosuppression in vitro and in vivo: A link between ferritin ferroxidase activity and biological function","volume":"88","author":"Broxmeyer","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-2141.1988.tb04216.x","article-title":"Effects of recombinant human H-subunit and L-subunit ferritins on in vitro growth of human granulocyte-monocyte progenitors","volume":"68","author":"Dezza","year":"1988","journal-title":"Br. J. Haematol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1182\/blood.V78.4.1056.1056","article-title":"Specific binding sites for H-ferritin on human lymphocytes: Modulation during cellular proliferation and potential implication in cell growth control","volume":"78","author":"Fargion","year":"1991","journal-title":"Blood"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0008-8749(87)90293-0","article-title":"Ferritin selectively suppresses delayed-type hypersensitivity responses at induction or effector phase","volume":"109","author":"Harada","year":"1987","journal-title":"Cell. Immunol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/ijc.1269","article-title":"Immunosuppressive effects of melanoma-derived heavy-chain ferritin are dependent on stimulation of IL-10 production","volume":"92","author":"Gray","year":"2001","journal-title":"Int. J. Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0268-960X(88)90007-0","article-title":"Iron status and cellular immune competence","volume":"2","author":"Good","year":"1988","journal-title":"Blood Rev."},{"key":"ref_64","first-page":"354","article-title":"Effects of iron overload on the immune system","volume":"30","author":"Walker","year":"2000","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1182\/blood.V99.9.3326","article-title":"Heavy chain ferritin activates regulatory T cells by induction of changes in dendritic cells","volume":"99","author":"Gray","year":"2002","journal-title":"Blood"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Blissett, A.R., Deng, B., Wei, P., Walsh, K.J., Ollander, B., Sifford, J., Sauerbeck, A.D., McComb, D.W., McTigue, D.M., and Agarwal, G. (2018). Sub-cellular In-situ Characterization of Ferritin(iron) in a Rodent Model of Spinal Cord Injury. Sci. Rep., 8.","DOI":"10.1038\/s41598-018-21744-9"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.7150\/thno.82975","article-title":"Ferritin light chain promotes the reprogramming of glioma immune microenvironment and facilitates glioma progression","volume":"13","author":"Li","year":"2023","journal-title":"Theranostics"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Miari, K.E., Guzman, M.L., Wheadon, H., and Williams, M.T.S. (2021). Macrophages in Acute Myeloid Leukaemia: Significant Players in Therapy Resistance and Patient Outcomes. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.692800"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-3083.1993.tb01695.x","article-title":"Secretion of IL-2, IL-3, IL-4, IL-6 and GM-CSF by CD4+ and CD8+ TCR alpha beta+ T-cell clones derived early after allogeneic bone marrow transplantation","volume":"38","author":"Bruserud","year":"1993","journal-title":"Scand. J. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.3324\/haematol.2016.143180","article-title":"Acute myeloid leukemia cells polarize macrophages towards a leukemia supporting state in a Growth factor independence 1 dependent manner","volume":"101","author":"Botezatu","year":"2016","journal-title":"Haematologica"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1683347","DOI":"10.1080\/2162402X.2019.1683347","article-title":"The M2 macrophage marker CD206: A novel prognostic indicator for acute myeloid leukemia","volume":"9","author":"Xu","year":"2019","journal-title":"Oncoimmunology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e1412910","DOI":"10.1080\/2162402X.2017.1412910","article-title":"Repolarizing heterogeneous leukemia-associated macrophages with more M1 characteristics eliminates their pro-leukemic effects","volume":"7","author":"Yang","year":"2017","journal-title":"Oncoimmunology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"eadf8522","DOI":"10.1126\/sciadv.adf8522","article-title":"M2 macrophages drive leukemic transformation by imposing resistance to phagocytosis and improving mitochondrial metabolism","volume":"9","author":"Almeida","year":"2023","journal-title":"Sci. Adv."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Guo, R., L\u00fc, M., Cao, F., Wu, G., Gao, F., Pang, H., Li, Y., Zhang, Y., Xing, H., and Liang, C. (2021). Single-cell map of diverse immune phenotypes in the acute myeloid leukemia microenvironment. Biomark. Res., 9.","DOI":"10.1186\/s40364-021-00265-0"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.cell.2019.01.031","article-title":"Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity","volume":"176","author":"Hovestadt","year":"2019","journal-title":"Cell"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41420-024-01924-5","article-title":"Macrophage migration inhibitory factor blockade reprograms macrophages and disrupts prosurvival signaling in acute myeloid leukemia","volume":"10","author":"Spertini","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1161\/01.RES.82.9.1016","article-title":"Aspirin increases ferritin synthesis in endothelial cells: A novel antioxidant pathway","volume":"82","author":"Oberle","year":"1998","journal-title":"Circ. Res."},{"key":"ref_78","first-page":"782","article-title":"Ferritin protects endothelial cells from oxidized low density lipoprotein in vitro","volume":"147","author":"Juckett","year":"1995","journal-title":"Am. J. Pathol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Wang, P., Ren, Q., Shi, M., Liu, Y., Bai, H., and Chang, Y.Z. (2022). Overexpression of Mitochondrial Ferritin Enhances Blood-Brain Barrier Integrity Following Ischemic Stroke in Mice by Maintaining Iron Homeostasis in Endothelial Cells. Antioxidants, 11.","DOI":"10.3390\/antiox11071257"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1080\/15548627.2021.1911016","article-title":"Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells","volume":"17","author":"Qin","year":"2021","journal-title":"Autophagy"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1160\/TH07-04-0250","article-title":"Fifty years of research on the plasma kallikrein-kinin system: From protein structure and function to cell biology and in-vivo pathophysiology","volume":"98","author":"Sainz","year":"2007","journal-title":"Thromb. Haemost."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.2174\/138161206777698710","article-title":"Regulation of angiogenesis by the kallikrein-kinin system","volume":"12","author":"Colman","year":"2006","journal-title":"Curr. Pharm. Des."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1111\/j.1538-7836.2005.01218.x","article-title":"Two faces of high-molecular-weight kininogen (HK) in angiogenesis: Bradykinin turns it on and cleaved HK (HKa) turns it off","volume":"3","author":"Guo","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1042\/bj20011637","article-title":"Ferritin binds to light chain of human H-kininogen and inhibits kallikrein-mediated bradykinin release","volume":"365","author":"Parthasarathy","year":"2002","journal-title":"Biochem. J."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"L505","DOI":"10.1152\/ajplung.00347.2007","article-title":"Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin","volume":"294","author":"Coffman","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1073\/pnas.0812010106","article-title":"Regulatory effects of ferritin on angiogenesis","volume":"106","author":"Coffman","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1158\/2643-3230.BCD-23-0202","article-title":"Recent Advances in Immune-Based Therapies for Acute Myeloid Leukemia","volume":"5","author":"Restelli","year":"2024","journal-title":"Blood Cancer Discov."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1080\/10428194.2019.1639167","article-title":"Immunotherapy for acute myeloid leukemia: From allogeneic stem cell transplant to novel therapeutics","volume":"60","author":"Knorr","year":"2019","journal-title":"Leuk. Lymphoma"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Hao, F., Sholy, C., Wang, C., Cao, M., and Kang, X. (2021). The Role of T Cell Immunotherapy in Acute Myeloid Leukemia. Cells, 10.","DOI":"10.3390\/cells10123376"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1038\/leu.2009.175","article-title":"Contribution of bone microenvironmentto leukemogenesis and leukemia progression","volume":"23","author":"Ayala","year":"2009","journal-title":"Leukemia"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1182\/blood.V95.8.2637","article-title":"Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia","volume":"95","author":"Ruiz","year":"2000","journal-title":"Blood"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1182\/blood-2008-08-173104","article-title":"Bone marrow angiogenesis magnetic resonance imaging in patients with acute myeloid leukemia: Peak enhancement ratio is an independent predictor for overall survival","volume":"113","author":"Shih","year":"2009","journal-title":"Blood"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"101871","DOI":"10.1016\/j.molmet.2024.101871","article-title":"Adipose knockout of H-ferritin improves energy metabolism in mice","volume":"80","author":"Lu","year":"2024","journal-title":"Mol. Metab."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.1093\/nar\/gkad342","article-title":"Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity","volume":"51","author":"Suzuki","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"36708","DOI":"10.1074\/jbc.M004988200","article-title":"Overexpression of H ferritin and up-regulation of iron regulatory protein genes during differentiation of 3T3-L1 pre-adipocytes","volume":"275","author":"Festa","year":"2000","journal-title":"J. Biol. Chem."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11912-020-0885-0","article-title":"Acute Myeloid Leukaemia in Its Niche: The Bone Marrow Microenvironment in Acute Myeloid Leukaemia","volume":"22","author":"Ladikou","year":"2020","journal-title":"Curr. Oncol. Rep."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Brenner, A.K., Nepstad, I., and Bruserud, \u00d8. (2017). Mesenchymal Stem Cells Support Survival and Proliferation of Primary Human Acute Myeloid Leukemia Cells through Heterogeneous Molecular Mechanisms. Front. Immunol., 8.","DOI":"10.3389\/fimmu.2017.00106"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Aaseb\u00f8, E., Brenner, A.K., Hernandez-Valladares, M., Birkeland, E., Mjaavatten, O., Reikvam, H., Selheim, F., Berven, F.S., and Bruserud, \u00d8. (2021). Patient Heterogeneity in Acute Myeloid Leukemia: Leukemic Cell Communication by Release of Soluble Mediators and Its Effects on Mesenchymal Stem Cells. Diseases, 9.","DOI":"10.3390\/diseases9040074"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.scr.2015.09.008","article-title":"The cytokine-mediated crosstalk between primary human acute myeloid cells and mesenchymal stem cells alters the local cytokine network and the global gene expression profile of the mesenchymal cells","volume":"15","author":"Reikvam","year":"2015","journal-title":"Stem Cell Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1007\/s12015-023-10569-3","article-title":"Iron-Related Genes and Proteins in Mesenchymal Stem Cell Detection and Therapy","volume":"19","author":"Mehta","year":"2023","journal-title":"Stem Cell Rev. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"7266","DOI":"10.1002\/jcp.30383","article-title":"Role of iron and iron-related proteins in mesenchymal stem cells: Cellular and clinical aspects","volume":"236","author":"Mehta","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.bbagen.2016.01.025","article-title":"Iron overload enhances human mesenchymal stromal cell growth and hampers matrix calcification","volume":"1860","author":"Borriello","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Zhai, W., Zhao, M., Li, D., Chai, X., Cao, X., Meng, J., Chen, J., Xiao, X., and Li, Q. (2015). Effects of iron overload on the bone marrow microenvironment in mice. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0120219"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41419-018-0552-7","article-title":"Iron overload promotes mitochondrial fragmentation in mesenchymal stromal cells from myelodysplastic syndrome patients through activation of the AMPK\/MFF\/Drp1 pathway","volume":"9","author":"Zheng","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.bbadis.2016.06.003","article-title":"Iron overload inhibits osteogenic commitment and differentiation of mesenchymal stem cells via the induction of ferritin","volume":"1862","author":"Balogh","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/ejh.12309","article-title":"The bone marrow hematopoietic microenvironment is impaired in iron-overloaded mice","volume":"93","author":"Okabe","year":"2014","journal-title":"Eur. J. Haematol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1182\/blood-2009-12-260083","article-title":"Bone loss caused by iron overload in a murine model: Importance of oxidative stress","volume":"116","author":"Tsay","year":"2010","journal-title":"Blood"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1002\/ijc.22180","article-title":"Microvascular endothelial cells increase proliferation and inhibit apoptosis of native human acute myelogenous leukemia blasts","volume":"119","author":"Hatfield","year":"2006","journal-title":"Int. J. Cancer"},{"key":"ref_109","first-page":"391","article-title":"Osteoblasts increase proliferation and release of pro-angiogenic interleukin 8 by native human acute myelogenous leukemia blasts","volume":"89","author":"Bruserud","year":"2004","journal-title":"Haematologica"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1136\/gut.35.9.1163","article-title":"Hepatocyte and immune system: Acute phase reaction as a contribution to early defence mechanisms","volume":"35","author":"Trautwein","year":"1994","journal-title":"Gut"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.burns.2017.03.007","article-title":"The role of complement in the acute phase response after burns","volume":"43","author":"Korkmaz","year":"2017","journal-title":"Burns"},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Bruserud, \u00d8., Aarstad, H.H., and Tvedt, T.H.A. (2020). Combined C-Reactive Protein and Novel Inflammatory Parameters as a Predictor in Cancer-What Can We Learn from the Hematological Experience?. Cancers, 12.","DOI":"10.3390\/cancers12071966"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.bbmt.2019.10.005","article-title":"The Systemic Metabolic Profile Early after Allogeneic Stem Cell Transplantation: Effects of Adequate Energy Support Administered through Enteral Feeding Tube","volume":"26","author":"Tvedt","year":"2020","journal-title":"Biol. Blood Marrow Transpl."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2174\/138920101701151027163600","article-title":"Nutrition in Allogeneic Stem Cell Transplantion\u2014Clinical Guidelines and Immunobiological Aspects","volume":"17","author":"Tvedt","year":"2016","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1631\/jzus.2005.B1045","article-title":"Acute phase reaction and acute phase proteins","volume":"6","author":"Gruys","year":"2005","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00702-011-0582-0","article-title":"A possible role for secreted ferritin in tissue iron distribution","volume":"118","author":"Cohen","year":"2011","journal-title":"J. Neural. Transm."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Fauter, M., Mainbourg, S., El Jammal, T., Guerber, A., Zaepfel, S., Henry, T., Gerfaud-Valentin, M., S\u00e8ve, P., and Jamilloux, Y. (2022). Extreme Hyperferritinemia: Causes and Prognosis. J. Clin. Med., 11.","DOI":"10.3390\/jcm11185438"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"199","DOI":"10.4081\/reumatismo.2019.1221","article-title":"Extreme hyperferritinemia: Etiological spectrum and impact on prognosis","volume":"71","author":"Belfeki","year":"2020","journal-title":"Reumatismo"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"h3692","DOI":"10.1136\/bmj.h3692","article-title":"Interpreting raised serum ferritin levels","volume":"351","author":"Koperdanova","year":"2015","journal-title":"BMJ"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1182\/blood-2014-10-602607","article-title":"Marked hyperferritinemia does not predict for HLH in the adult population","volume":"125","author":"Schram","year":"2015","journal-title":"Blood"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3945\/ajcn.2010.29284","article-title":"Adjusting plasma ferritin concentrations to remove the effects of subclinical inflammation in the assessment of iron deficiency: A meta-analysis","volume":"92","author":"Thurnham","year":"2010","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_123","doi-asserted-by":"crossref","unstructured":"Sun, K., Li, C., Liao, S., Yao, X., Ouyang, Y., Liu, Y., Wang, Z., Li, Z., and Yao, F. (2022). Ferritinophagy, a form of autophagic ferroptosis: New insights into cancer treatment. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.1043344"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s13402-023-00858-x","article-title":"Ferritinophagy induced ferroptosis in the management of cancer","volume":"47","author":"Liu","year":"2024","journal-title":"Cell. Oncol."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Bruserud, \u00d8., Selheim, F., Hernandez-Valladares, M., and Reikvam, H. (2024). Monocytic Differentiation in Acute Myeloid Leukemia Cells: Diagnostic Criteria, Biological Heterogeneity, Mitochondrial Metabolism, Resistance to and Induction by Targeted Therapies. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25126356"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Zhang, H., Sun, C., Sun, Q., Li, Y., Zhou, C., and Sun, C. (2023). Susceptibility of acute myeloid leukemia cells to ferroptosis and evasion strategies. Front. Mol. Biosci., 10.","DOI":"10.3389\/fmolb.2023.1275774"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1007\/s00277-023-05293-4","article-title":"Basic mechanisms and novel potential therapeutic targets for ferroptosis in acute myeloid leukemia","volume":"102","author":"Tang","year":"2023","journal-title":"Ann. Hematol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1161\/01.RES.0000163015.67711.AB","article-title":"Activation of inflammation and coagulation after infusion of C-reactive protein in humans","volume":"96","author":"Bisoendial","year":"2005","journal-title":"Circ. Res."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Bruserud, \u00d8., Mosevoll, K.A., Bruserud, \u00d8., Reikvam, H., and Wendelbo, \u00d8. (2023). The Regulation of Neutrophil Migration in Patients with Sepsis: The Complexity of the Molecular Mechanisms and Their Modulation in Sepsis and the Heterogeneity of Sepsis Patients. Cells, 12.","DOI":"10.3390\/cells12071003"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.blre.2014.10.003","article-title":"Platelet secretion: From haemostasis to wound healing and beyond","volume":"29","author":"Golebiewska","year":"2015","journal-title":"Blood Rev."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/jpen.1451","article-title":"Hypoalbuminemia: Pathogenesis and Clinical Significance","volume":"43","author":"Soeters","year":"2019","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/ejh.12016","article-title":"Soluble mediators released by acute myeloid leukemia cells increase capillary-like networks","volume":"89","author":"Hatfield","year":"2012","journal-title":"Eur. J. Haematol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1365-2141.2008.07411.x","article-title":"Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators","volume":"144","author":"Hatfield","year":"2009","journal-title":"Br. J. Haematol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5507\/bp.2016.054","article-title":"Serum levels of soluble adhesion molecules in newly diagnosed acute myeloid leukemia and in complete remission suggest endothelial cell activation by myeloblasts","volume":"161","author":"Kupsa","year":"2017","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky Olomouc. Czech. Repub."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"155005","DOI":"10.1016\/j.cyto.2020.155005","article-title":"Serum levels of selected cytokines and soluble adhesion molecules in acute myeloid leukemia: Soluble receptor for interleukin-2 predicts overall survival","volume":"128","author":"Kupsa","year":"2020","journal-title":"Cytokine"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"94","DOI":"10.5507\/bp.2015.036","article-title":"Evaluation of cytokines and soluble adhesion molecules in patients with newly diagnosed acute myeloid leukemia: The role of TNF-alpha and FLT3-ITD","volume":"160","author":"Kupsa","year":"2016","journal-title":"Biomed. Pap. Med. Fac. Univ. Palacky Olomouc. Czech. Repub."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ccell.2017.08.001","article-title":"Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid Leukemia","volume":"32","author":"Passaro","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/rth2.12191","article-title":"Fibrinogen and fibrin: An illustrated review","volume":"3","author":"Pieters","year":"2019","journal-title":"Res. Pr. Thromb. Haemost."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1182\/blood-2018-07-818211","article-title":"The multifaceted role of fibrinogen in tissue injury and inflammation","volume":"133","author":"Luyendyk","year":"2019","journal-title":"Blood"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1056\/NEJMra2206346","article-title":"Humoral Innate Immunity and Acute-Phase Proteins","volume":"388","author":"Mantovani","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.thromres.2020.04.013","article-title":"Incidence of thrombotic complications in critically ill ICU patients with COVID-19","volume":"191","author":"Klok","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_142","doi-asserted-by":"crossref","unstructured":"Mosevoll, K.A., Johansen, S., Wendelbo, \u00d8., Nepstad, I., Bruserud, \u00d8., and Reikvam, H. (2018). Cytokines, Adhesion Molecules, and Matrix Metalloproteases as Predisposing, Diagnostic, and Prognostic Factors in Venous Thrombosis. Front. Med., 5.","DOI":"10.3389\/fmed.2018.00147"},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1172\/JCI20741","article-title":"Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2\/Mac-1 is critical for host inflammatory response in vivo","volume":"113","author":"Flick","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1111\/j.1538-7836.2005.01365.x","article-title":"Fibrinogen and fibrin structure and functions","volume":"3","author":"Mosesson","year":"2005","journal-title":"J. Thromb. Haemost."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1016\/j.jtha.2023.08.014","article-title":"Fibrinogen and fibrin: Synthesis, structure, and function in health and disease","volume":"21","author":"Wolberg","year":"2023","journal-title":"J. Thromb. Haemost."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1749-6632.2001.tb03535.x","article-title":"Fibrinogen biosynthesis. Assembly, intracellular degradation, and association with lipid synthesis and secretion","volume":"936","author":"Redman","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Selheim, F., Aaseb\u00f8, E., Reikvam, H., Bruserud, \u00d8., and Hernandez-Valladares, M. (2025). Proteomic Comparison of Acute Myeloid Leukemia Cells and Normal CD34+ Bone Marrow Cells: Studies of Leukemia Cell Differentiation and Regulation of Iron Metabolism\/Ferroptosis. Proteomes, 13.","DOI":"10.3390\/proteomes13010011"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Weber, S., Parmon, A., Kurrle, N., Schn\u00fctgen, F., and Serve, H. (2021). The Clinical Significance of Iron Overload and Iron Metabolism in Myelodysplastic Syndrome and Acute Myeloid Leukemia. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.627662"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/250584a0","article-title":"Ferritin synthesis in normal and leukaemic leukocytes","volume":"250","author":"White","year":"1974","journal-title":"Nature"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2141.1974.tb06637.x","article-title":"Ferritin in blood cells from normal subjects and patients with leukaemia","volume":"28","author":"Worwood","year":"1974","journal-title":"Br. J. Haematol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ajh.2830090103","article-title":"Serum ferritin in hematologic malignancies","volume":"9","author":"Matzner","year":"1980","journal-title":"Am. J. Hematol."},{"key":"ref_152","first-page":"297","article-title":"Ferritin\u2014A tumor marker in myeloid leukemia","volume":"8","author":"Aulbert","year":"1985","journal-title":"Cancer Detect. Prev."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.31557\/APJCP.2024.25.8.2951","article-title":"Impact of Serum Ferritin and Iron Overload on Acute Myeloid Leukemia Outcomes: A Systematic Review and Meta-Analysis","volume":"25","author":"Sadighi","year":"2024","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/10428194.2018.1461860","article-title":"AML: High serum ferritin at initial diagnosis has a negative impact on long-term survival","volume":"60","author":"Ihlow","year":"2019","journal-title":"Leuk. Lymphoma"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.jgo.2020.11.001","article-title":"Clinical outcome of older adults with acute myeloid Leukemia: An analysis of a large tertiary referral Center over two decades","volume":"12","author":"Ihlow","year":"2021","journal-title":"J. Geriatr. Oncol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.clml.2018.03.009","article-title":"Clinical Significance of Serum Ferritin at Diagnosis in Patients With Acute Myeloid Leukemia: A YACHT Multicenter Retrospective Study","volume":"18","author":"Tachibana","year":"2018","journal-title":"Clin. Lymphoma Myeloma Leuk."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.leukres.2015.05.001","article-title":"Hyperferritinemia at diagnosis predicts relapse and overall survival in younger AML patients with intermediate-risk cytogenetics","volume":"39","author":"Lebon","year":"2015","journal-title":"Leuk. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3233\/CBM-230040","article-title":"Can serum ferritin serve as a biomarker for the prognosis of gynecological malignant tumors? A retrospective cohort study","volume":"39","author":"Zhang","year":"2024","journal-title":"Cancer Biomark."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.freeradbiomed.2018.07.015","article-title":"Dysregulation of iron metabolism in cancer stem cells","volume":"133","author":"Recalcati","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"8097","DOI":"10.1007\/s11033-023-08675-z","article-title":"Overexpression of ferritin light chain as a poor prognostic factor for breast cancer","volume":"50","author":"Tang","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00277-021-04687-6","article-title":"Predictive factors associated with induction-related death in acute myeloid leukemia in a resource-constrained setting","volume":"101","author":"Mendes","year":"2022","journal-title":"Ann. Hematol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/10428194.2019.1686499","article-title":"Prognostic value of hypoalbuminemia at diagnosis in de novo non-M3 acute myeloid leukemia","volume":"61","author":"Wang","year":"2020","journal-title":"Leuk. Lymphoma"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/hon.2925","article-title":"Hypoalbuminemia as a prognostic biomarker for higher mortality and treatment complications in acute myeloid leukemia","volume":"39","author":"Doucette","year":"2021","journal-title":"Hematol. Oncol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2147\/CMAR.S343580","article-title":"The Prognostic Significance of C-Reactive Protein to Albumin Ratio in Newly Diagnosed Acute Myeloid Leukaemia Patients","volume":"14","author":"Dou","year":"2022","journal-title":"Cancer Manag. Res."},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Senjo, H., Onozawa, M., Hidaka, D., Yokoyama, S., Yamamoto, S., Tsutsumi, Y., Haseyama, Y., Nagashima, T., Mori, A., and Ota, S. (2022). High CRP-albumin ratio predicts poor prognosis in transplant ineligible elderly patients with newly diagnosed acute myeloid leukemia. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-12813-1"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1080\/10428194.2018.1535116","article-title":"Plasma fibrinogen levels correlate with prognosis and treatment outcome in patients with non-M3 acute myeloid leukemia","volume":"60","author":"Dai","year":"2019","journal-title":"Leuk. Lymphoma"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/hon.2307","article-title":"Increased fibrinogen levels at diagnosis are associated with adverse outcome in patients with acute myeloid leukemia","volume":"35","author":"Berger","year":"2017","journal-title":"Hematol. Oncol."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/hon.2696","article-title":"Simple acute phase protein score to predict long-term survival in patients with acute myeloid leukemia","volume":"38","author":"Heini","year":"2020","journal-title":"Hematol. Oncol."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"e3228","DOI":"10.1002\/hon.3228","article-title":"Prognostic significance of the CFA ratio for newly diagnosed acute myeloid leukemia: A multicenter retrospective study","volume":"42","author":"Sakuma","year":"2024","journal-title":"Hematol. Oncol."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1007\/s00277-018-3472-9","article-title":"Autoimmune manifestations associated with myelodysplastic syndromes","volume":"97","author":"Grignano","year":"2018","journal-title":"Ann. Hematol."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41572-022-00402-5","article-title":"Myelodysplastic syndromes","volume":"8","author":"Li","year":"2022","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev-pathmechdis-051222-122724","article-title":"Clonal Hematopoiesis, Inflammation, and Hematologic Malignancy","volume":"19","author":"Beck","year":"2024","journal-title":"Annu. Rev. Pathol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1182\/blood.2021014418","article-title":"Age-related diseases of inflammation in myelodysplastic syndrome and chronic myelomonocytic leukemia","volume":"139","author":"Weeks","year":"2022","journal-title":"Blood"},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"e20201544","DOI":"10.1084\/jem.20201544","article-title":"Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS","volume":"218","author":"Trowbridge","year":"2021","journal-title":"J. Exp. Med."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jgo.2019.03.014","article-title":"Inflammatory biomarkers, geriatric assessment, and treatment outcomes in acute myeloid leukemia","volume":"11","author":"Loh","year":"2020","journal-title":"J. Geriatr. Oncol."},{"key":"ref_176","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-med-043021-032816","article-title":"Hepcidin and Iron in Health and Disease","volume":"74","author":"Nemeth","year":"2023","journal-title":"Annu. Rev. Med."},{"key":"ref_177","doi-asserted-by":"crossref","unstructured":"Nemeth, E., and Ganz, T. (2021). Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126493"},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"491058","DOI":"10.1155\/2011\/491058","article-title":"Highly Elevated Serum Hepcidin in Patients with Acute Myeloid Leukemia prior to and after Allogeneic Hematopoietic Cell Transplantation: Does This Protect from Excessive Parenchymal Iron Loading?","volume":"2011","author":"Eisfeld","year":"2011","journal-title":"Adv. Hematol."},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2362.2011.02608.x","article-title":"Hepcidin expression in patients with acute leukaemia","volume":"42","author":"Cheng","year":"2012","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_180","doi-asserted-by":"crossref","unstructured":"S\u0142omka, A., \u0141\u0119cka, M., and Styczy\u0144ski, J. (2022). Hepcidin in Children and Adults with Acute Leukemia or Undergoing Hematopoietic Cell Transplantation: A Systematic Review. Cancers, 14.","DOI":"10.3390\/cancers14194936"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1097\/CCM.0000000000005361","article-title":"Consensus-Based Guidelines for the Recognition, Diagnosis, and Management of Hemophagocytic Lymphohistiocytosis in Critically Ill Children and Adults","volume":"50","author":"Hines","year":"2022","journal-title":"Crit. Care Med."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1177\/10600280221134719","article-title":"A Review of Current and Emerging Therapeutic Options for Hemophagocytic Lymphohistiocytosis","volume":"57","author":"Summerlin","year":"2023","journal-title":"Ann. Pharmacother."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/ejh.13779","article-title":"Validation of the HScore and the HLH-2004 diagnostic criteria for the diagnosis of hemophagocytic lymphohistiocytosis in a multicenter cohort","volume":"109","author":"Bilston","year":"2022","journal-title":"Eur. J. Haematol."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/s41375-022-01556-7","article-title":"Infectious complications of targeted drugs and biotherapies in acute leukemia. Clinical practice guidelines by the European Conference on Infections in Leukemia (ECIL), a joint venture of the European Group for Blood and Marrow Transplantation (EBMT), the European Organization for Research and Treatment of Cancer (EORTC), the International Immunocompromised Host Society (ICHS) and the European Leukemia Net (ELN)","volume":"36","author":"Maschmeyer","year":"2022","journal-title":"Leukemia"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/14787210.2020.1820863","article-title":"Management of fever and neutropenia in the adult patient with acute myeloid leukemia","volume":"19","author":"Peseski","year":"2021","journal-title":"Expert Rev. Anti. Infect. Ther."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00277-019-03622-0","article-title":"Management of sepsis in neutropenic cancer patients: 2018 guidelines from the Infectious Diseases Working Party (AGIHO) and Intensive Care Working Party (iCHOP) of the German Society of Hematology and Medical Oncology (DGHO)","volume":"98","author":"Kochanek","year":"2019","journal-title":"Ann. Hematol."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cca.2022.09.015","article-title":"Platelet-Acute Leukemia Interactions","volume":"536","author":"Zhang","year":"2022","journal-title":"Clin. Chim. Acta"},{"key":"ref_188","first-page":"83","article-title":"An unusual case of splenomegaly and increased lactate dehydrogenase heralding acute myeloid leukemia with eosinophilia and RUNX1-MECOM fusion transcripts","volume":"3","author":"Forghieri","year":"2014","journal-title":"Leuk. Res. Rep."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.gtc.2018.04.009","article-title":"Splenomegaly: A Combined Clinical and Radiologic Approach to the Differential Diagnosis","volume":"47","author":"Sjoberg","year":"2018","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1080\/10428194.2020.1780587","article-title":"The prognostic value of plasma fibrinogen level in patients with acute myeloid leukemia: A systematic review and meta-analysis","volume":"61","author":"Zhang","year":"2020","journal-title":"Leuk. Lymphoma"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.arcmed.2016.11.013","article-title":"Importance of Nutrition in the Treatment of Leukemia in Children and Adolescents","volume":"47","author":"Barr","year":"2016","journal-title":"Arch. Med. Res."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"474","DOI":"10.3324\/haematol.2013.097394","article-title":"Hemophagocytic syndrome in patients with acute myeloid leukemia undergoing intensive chemotherapy","volume":"99","author":"Delavigne","year":"2014","journal-title":"Haematologica"},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1186\/s13054-020-02941-3","article-title":"Hemophagocytic lymphohistiocytosis in critically ill patients: Diagnostic reliability of HLH-2004 criteria and HScore","volume":"24","author":"Knaak","year":"2020","journal-title":"Crit. Care"},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3109\/03009742.2016.1167951","article-title":"Assessment of the HScore for reactive haemophagocytic syndrome in patients with rheumatic diseases","volume":"46","author":"Batu","year":"2017","journal-title":"Scand. J. Rheumatol."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"e874","DOI":"10.1097\/CCM.0000000000005038","article-title":"Diagnostic Performance of Hemophagocytic Lymphohistiocytosis Criteria and HScore in Critically Ill Patients With Severe Hemophagocytic Syndrome","volume":"49","author":"Valade","year":"2021","journal-title":"Crit. Care Med."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1159\/000536287","article-title":"Prognostic Factors of Adult Hemophagocytic Lymphohistiocytosis and Clinical Utility of HLH-2004 Diagnostic Criteria and HScore: A Real-World Multicenter Study from Thailand","volume":"147","author":"Jongdee","year":"2024","journal-title":"Acta Haematol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1097\/01.CCM.0000147769.07699.E3","article-title":"Prospective validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation","volume":"32","author":"Bakhtiari","year":"2004","journal-title":"Crit. Care Med."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1532\/IJH97.06173","article-title":"Prevalence and clinical characteristics of acute myeloid leukemia associated with disseminated intravascular coagulation","volume":"86","author":"Uchiumi","year":"2007","journal-title":"Int. J. Hematol."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1182\/blood-2016-02-701094","article-title":"Disseminated intravascular coagulation at diagnosis is a strong predictor for thrombosis in acute myeloid leukemia","volume":"128","author":"Libourel","year":"2016","journal-title":"Blood"},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1182\/blood.V55.1.71.71","article-title":"Acute monoblastic leukemia: A clinical and biologic study of 74 cases","volume":"55","author":"Tobelem","year":"1980","journal-title":"Blood"},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1182\/blood-2008-08-175745","article-title":"Venous thromboembolism in patients with acute leukemia: Incidence, risk factors, and effect on survival","volume":"113","author":"Ku","year":"2009","journal-title":"Blood"},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s11864-023-01089-w","article-title":"Thrombosis in Acute Myeloid Leukemia: Pathogenesis, Risk Factors and Therapeutic Challenges","volume":"24","author":"Olivi","year":"2023","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.bbmt.2014.04.024","article-title":"Iron overload in allogeneic hematopoietic cell transplantation outcome: A meta-analysis","volume":"20","author":"Armand","year":"2014","journal-title":"Biol. Blood Marrow Transpl."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"e10310","DOI":"10.1097\/MD.0000000000010310","article-title":"Effect of pre-transplantation serum ferritin on outcomes in patients undergoing allogeneic hematopoietic stem cell transplantation: A meta-analysis","volume":"97","author":"Yan","year":"2018","journal-title":"Medicine"},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"e17406","DOI":"10.1097\/MD.0000000000017406","article-title":"The impact of iron chelation therapy on patients with lower\/intermediate IPSS MDS and the prognostic role of elevated serum ferritin in patients with MDS and AML: A meta-analysis","volume":"98","author":"Yang","year":"2019","journal-title":"Medicine"},{"key":"ref_206","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1080\/07357907.2016.1197236","article-title":"A Meta-Analysis for Effects of Elevated Pre-Transplantation Serum Ferritin on the Outcomes inPatients Undergoing Hematopoietic Stem Cell Transplantation","volume":"34","author":"Guo","year":"2016","journal-title":"Cancer Investig."},{"key":"ref_207","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/bmt.2010.62","article-title":"Serum ferritin and disease status at transplantation predict the outcome of allo-SCT in patients with AML or myelodysplastic syndrome","volume":"46","author":"Tachibana","year":"2011","journal-title":"Bone Marrow Transpl."},{"key":"ref_208","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/cam4.1928","article-title":"Improved survival outcomes and restoration of graft-vs-leukemia effect by deferasirox after allogeneic stem cell transplantation in acute myeloid leukemia","volume":"8","author":"Cho","year":"2019","journal-title":"Cancer Med."},{"key":"ref_209","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.3324\/haematol.2016.145847","article-title":"The prognostic value of serum C-reactive protein, ferritin, and albumin prior to allogeneic transplantation for acute myeloid leukemia and myelodysplastic syndromes","volume":"101","author":"Artz","year":"2016","journal-title":"Haematologica"},{"key":"ref_210","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s12032-010-9496-1","article-title":"Hyperferritinemia is associated with low incidence of graft versus host disease, high relapse rate, and impaired survival in patients with blood disorders receiving allogeneic hematopoietic stem cell grafts","volume":"28","author":"Wahlin","year":"2011","journal-title":"Med. Oncol."},{"key":"ref_211","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bbmt.2008.11.012","article-title":"Influence of pretransplantation serum ferritin on nonrelapse mortality after myeloablative and nonmyeloablative allogeneic hematopoietic stem cell transplantation","volume":"15","author":"Kataoka","year":"2009","journal-title":"Biol. Blood Marrow Transpl."},{"key":"ref_212","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3109\/10428194.2011.619607","article-title":"Pretransplant serum ferritin has a prognostic influence on allogeneic transplant regardless of disease risk","volume":"53","author":"Tachibana","year":"2012","journal-title":"Leuk. Lymphoma"},{"key":"ref_213","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.bbmt.2010.09.006","article-title":"Iron overload in patients with acute leukemia or MDS undergoing myeloablative stem cell transplantation","volume":"17","author":"Armand","year":"2011","journal-title":"Biol. Blood Marrow Transpl."},{"key":"ref_214","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/bmt.2008.262","article-title":"Iron overload adversely affects outcome of allogeneic hematopoietic cell transplantation","volume":"42","author":"Pullarkat","year":"2008","journal-title":"Bone Marrow Transpl."},{"key":"ref_215","doi-asserted-by":"crossref","unstructured":"Penack, O., Peczynski, C., van der Werf, S., Finke, J., Ganser, A., Schoemans, H., Pavlu, J., Niittyvuopio, R., Schroyens, W., and Kaynar, L. (2020). Association of Serum Ferritin Levels Before Start of Conditioning With Mortality After alloSCT\u2014A Prospective, Non-interventional Study of the EBMT Transplant Complications Working Party. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.00586"},{"key":"ref_216","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.bbmt.2012.10.012","article-title":"Prognostic impact of posttransplantation iron overload after allogeneic stem cell transplantation","volume":"19","author":"Meyer","year":"2013","journal-title":"Biol. Blood Marrow Transpl."},{"key":"ref_217","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/bmt.2010.108","article-title":"Pretransplant serum ferritin and C-reactive protein as predictive factors for early bacterial infection after allogeneic hematopoietic cell transplantation","volume":"46","author":"Kanda","year":"2011","journal-title":"Bone Marrow Transpl."},{"key":"ref_218","doi-asserted-by":"crossref","unstructured":"Kong, S.G., Jeong, S., Lee, S., Jeong, J.Y., Kim, D.J., and Lee, H.S. (2021). Early transplantation-related mortality after allogeneic hematopoietic cell transplantation in patients with acute leukemia. BMC Cancer, 21.","DOI":"10.1186\/s12885-021-07897-3"},{"key":"ref_219","doi-asserted-by":"crossref","first-page":"IJH36","DOI":"10.2217\/ijh-2021-0005","article-title":"Iron overload during the treatment of acute leukemia: Pretransplant transfusion experience","volume":"10","author":"Yokus","year":"2021","journal-title":"Int. J. Hematol. Oncol."},{"key":"ref_220","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s12185-011-0784-0","article-title":"Pretransplant serum ferritin is associated with bloodstream infections within 100 days of allogeneic stem cell transplantation for myeloid malignancies","volume":"93","author":"Tachibana","year":"2011","journal-title":"Int. J. Hematol."},{"key":"ref_221","doi-asserted-by":"crossref","first-page":"e37436","DOI":"10.1016\/j.heliyon.2024.e37436","article-title":"Association between the pre-transplantation serum ferritin level and outcomes of hematopoietic stem cell transplantation: A systematic review and meta-analysis","volume":"10","author":"Pan","year":"2024","journal-title":"Heliyon"},{"key":"ref_222","first-page":"CD002042","article-title":"Transfusion thresholds for guiding red blood cell transfusion","volume":"12","author":"Carson","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_223","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1001\/jama.2023.12914","article-title":"Red Blood Cell Transfusion: 2023 AABB International Guidelines","volume":"330","author":"Carson","year":"2023","journal-title":"JAMA"},{"key":"ref_224","first-page":"479","article-title":"A pilot randomized study for optimal red cell transfusion in acute myeloid leukemia patients with intensive chemotherapy","volume":"21","author":"Byun","year":"2023","journal-title":"Blood Transfus."},{"key":"ref_225","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1200\/JCO.19.01836","article-title":"Liberal Versus Restrictive Red Blood Cell Transfusion Thresholds in Hematopoietic Cell Transplantation: A Randomized, Open Label, Phase III, Noninferiority Trial","volume":"38","author":"Tay","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"ref_226","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1111\/trf.13658","article-title":"Red blood cell transfusion triggers in acute leukemia: A randomized pilot study","volume":"56","author":"DeZern","year":"2016","journal-title":"Transfusion"},{"key":"ref_227","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/vox.12919","article-title":"Reducing the red blood cell transfusion threshold from 8\u00b70 g\/dL to 7\u00b70 g\/dL in acute myeloid leukaemia patients undergoing induction chemotherapy reduces transfusion rates without adversely affecting patient outcome","volume":"115","author":"Ballo","year":"2020","journal-title":"Vox Sang."},{"key":"ref_228","doi-asserted-by":"crossref","first-page":"e14474","DOI":"10.1097\/MD.0000000000014474","article-title":"Pretransplant C-reactive protein as a prognostic marker in allogeneic stem cell transplantation: A PRISMA-compliant meta-analysis","volume":"98","author":"Wu","year":"2019","journal-title":"Medicine"},{"key":"ref_229","doi-asserted-by":"crossref","unstructured":"Tvedt, T.H., Lie, S.A., Reikvam, H., Rye, K.P., Lind\u00e5s, R., Gedde-Dahl, T., Ahmed, A.B., and Bruserud, \u00d8. (2016). Pretransplant Levels of CRP and Interleukin-6 Family Cytokines; Effects on Outcome after Allogeneic Stem Cell Transplantation. Int. J. Mol. Sci., 17.","DOI":"10.3390\/ijms17111823"},{"key":"ref_230","doi-asserted-by":"crossref","unstructured":"Wang, K., Jian, X., Xu, Z., and Wang, H. (2023). Pre-transplant CRP-albumin ratio as a biomarker in patients receiving haploidentical allogeneic hematopoietic transplantation: Developing a novel DRCI-based nomogram. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1128982"},{"key":"ref_231","doi-asserted-by":"crossref","first-page":"400.e1","DOI":"10.1016\/j.jtct.2024.01.068","article-title":"Pretransplantation Inflammatory and Nutritional Status in Elderly Allogeneic Hematopoietic Stem Cell Transplantation: Prognostic Value of C-Reactive Protein-to-Albumin Ratio","volume":"30","author":"Miyazaki","year":"2024","journal-title":"Transpl. Cell. Ther."},{"key":"ref_232","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1097\/TP.0000000000000471","article-title":"Pretransplant metabolic distress predicts relapse of acute myeloid leukemia after allogeneic stem cell transplantation","volume":"99","author":"Dietrich","year":"2015","journal-title":"Transplantation"},{"key":"ref_233","first-page":"584","article-title":"Leptin in human acute myelogenous leukemia: Studies of in vivo levels and in vitro effects on native functional leukemia blasts","volume":"87","author":"Bruserud","year":"2002","journal-title":"Haematologica"},{"key":"ref_234","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.beha.2004.10.003","article-title":"LPI-labile plasma iron in iron overload","volume":"18","author":"Cabantchik","year":"2005","journal-title":"Best Pract. Res. Clin. Haematol."},{"key":"ref_235","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1016\/S2352-3026(18)30036-X","article-title":"Enhanced labile plasma iron and outcome in acute myeloid leukaemia and myelodysplastic syndrome after allogeneic haemopoietic cell transplantation (ALLIVE): A prospective, multicentre, observational trial","volume":"5","author":"Wermke","year":"2018","journal-title":"Lancet Haematol."},{"key":"ref_236","doi-asserted-by":"crossref","first-page":"E250","DOI":"10.1002\/ajh.25201","article-title":"Non-transferrin-bound iron and oxidative stress during allogeneic hemopoietic stem cell transplantation in patients with or without iron overload","volume":"93","author":"Duca","year":"2018","journal-title":"Am. J. Hematol."},{"key":"ref_237","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1039\/C7MT00116A","article-title":"The elemental role of iron in DNA synthesis and repair","volume":"9","author":"Puig","year":"2017","journal-title":"Metallomics"},{"key":"ref_238","doi-asserted-by":"crossref","first-page":"12744","DOI":"10.1074\/jbc.R117.789537","article-title":"Biogenesis and functions of mammalian iron-sulfur proteins in the regulation of iron homeostasis and pivotal metabolic pathways","volume":"292","author":"Rouault","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_239","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41565-019-0406-1","article-title":"FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels","volume":"14","author":"Pratt","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"ref_240","doi-asserted-by":"crossref","unstructured":"Levi, S., Ripamonti, M., Dardi, M., Cozzi, A., and Santambrogio, P. (2021). Mitochondrial Ferritin: Its Role in Physiological and Pathological Conditions. Cells, 10.","DOI":"10.3390\/cells10081969"},{"key":"ref_241","doi-asserted-by":"crossref","unstructured":"Fuhrmann, D.C., Mondorf, A., Beifu\u00df, J., Jung, M., and Br\u00fcne, B. (2020). Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis. Redox Biol., 36.","DOI":"10.1016\/j.redox.2020.101670"},{"key":"ref_242","doi-asserted-by":"crossref","unstructured":"Bruno, S., Mancini, M., De Santis, S., Monaldi, C., Cavo, M., and Soverini, S. (2021). The Role of Hypoxic Bone Marrow Microenvironment in Acute Myeloid Leukemia and Future Therapeutic Opportunities. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22136857"},{"key":"ref_243","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/s41375-024-02169-y","article-title":"Ferritin-mediated mitochondrial iron homeostasis is essential for the survival of hematopoietic stem cells and leukemic stem cells","volume":"38","author":"Yi","year":"2024","journal-title":"Leukemia"},{"key":"ref_244","doi-asserted-by":"crossref","first-page":"eaaw2238","DOI":"10.1126\/sciadv.aaw2238","article-title":"Clockophagy is a novel selective autophagy process favoring ferroptosis","volume":"5","author":"Yang","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_245","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/cdd.2015.158","article-title":"Ferroptosis: Process and function","volume":"23","author":"Xie","year":"2016","journal-title":"Cell Death Differ."},{"key":"ref_246","doi-asserted-by":"crossref","first-page":"15330338221078728","DOI":"10.1177\/15330338221078728","article-title":"STEAP3 Affects Ferroptosis and Progression of Renal Cell Carcinoma Through the p53\/xCT Pathway","volume":"21","author":"Ye","year":"2022","journal-title":"Technol. Cancer Res. Treat."},{"key":"ref_247","doi-asserted-by":"crossref","unstructured":"Yan, Y., Liang, Q., Xu, Z., Huang, J., Chen, X., Cai, Y., Peng, B., and Yi, Q. (2021). DownregulatedFerroptosis-Related Gene STEAP3 as a Novel Diagnostic and Prognostic Target for Hepatocellular Carcinoma and Its Roles in Immune Regulation. Front. Cell Dev. Biol., 9.","DOI":"10.3389\/fcell.2021.743046"},{"key":"ref_248","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/ejh.13183","article-title":"Ferritin heavy\/light chain (FTH1\/FTL) expression, serum ferritin levels, and their functional as well as prognostic roles in acute myeloid leukemia","volume":"102","author":"Bertoli","year":"2019","journal-title":"Eur. J. Haematol."},{"key":"ref_249","doi-asserted-by":"crossref","first-page":"e436","DOI":"10.1038\/emm.2017.273","article-title":"Differential regulation of hepcidin in cancer and non-cancer tissues and its clinical implications","volume":"50","author":"Vela","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"ref_250","first-page":"4267","article-title":"Oxidative Stress-Induced Apoptosis in Chronic Myelogenous Leukemia K562 Cells by an Active Compound from the Dithio- Carbamate Family","volume":"17","author":"Khoshtabiat","year":"2016","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"ref_251","doi-asserted-by":"crossref","unstructured":"Kaweme, N.M., Zhou, S., Changwe, G.J., and Zhou, F. (2020). The significant role of redox system in myeloid leukemia: From pathogenesis to therapeutic applications. Biomark. Res., 8.","DOI":"10.1186\/s40364-020-00242-z"},{"key":"ref_252","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1089\/ars.2011.4258","article-title":"Redox control of leukemia: From molecular mechanisms to therapeutic opportunities","volume":"18","author":"Irwin","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"ref_253","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1189\/jlb.0113006","article-title":"Novel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia","volume":"94","author":"Zhou","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"ref_254","doi-asserted-by":"crossref","unstructured":"Sillar, J.R., Germon, Z.P., DeIuliis, G.N., and Dun, M.D. (2019). The Role of Reactive Oxygen Species in Acute Myeloid Leukaemia. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20236003"},{"key":"ref_255","doi-asserted-by":"crossref","unstructured":"Chen, J.Y., Lai, Y.S., Tsai, H.J., Kuo, C.C., Yen, B.L., Yeh, S.P., Sun, H.S., and Hung, W.C. (2016). The oncometabolite R-2-hydroxyglutarate activates NF-\u03baB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells. Sci. Rep., 6.","DOI":"10.1038\/srep32428"},{"key":"ref_256","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbacli.2017.03.002","article-title":"The plasma lipidome in acute myeloid leukemia at diagnosis in relation to clinical disease features","volume":"7","author":"Pabst","year":"2017","journal-title":"BBA Clin."},{"key":"ref_257","doi-asserted-by":"crossref","first-page":"4499","DOI":"10.1182\/blood-2011-02-336446","article-title":"Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1\/PTPRJ","volume":"119","author":"Godfrey","year":"2012","journal-title":"Blood"},{"key":"ref_258","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/leu.2010.263","article-title":"NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinases","volume":"25","author":"Reddy","year":"2011","journal-title":"Leukemia"},{"key":"ref_259","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: Death by Lipid Peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"ref_260","doi-asserted-by":"crossref","unstructured":"Rochette, L., Dogon, G., Rigal, E., Zeller, M., Cottin, Y., and Vergely, C. (2022). Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24010449"},{"key":"ref_261","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-019-1170-y","article-title":"CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy","volume":"569","author":"Wang","year":"2019","journal-title":"Nature"},{"key":"ref_262","doi-asserted-by":"crossref","unstructured":"Jiang, G., Jin, P., Xiao, X., Shen, J., Li, R., Zhang, Y., Li, X., Xue, K., and Li, J. (2023). Identification and validation of a novel CD8+ T cell-associated prognostic model based on ferroptosis in acute myeloid leukemia. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1149513"},{"key":"ref_263","doi-asserted-by":"crossref","unstructured":"Song, Y., Tian, S., Zhang, P., Zhang, N., Shen, Y., and Deng, J. (2022). Construction and Validation of a Novel Ferroptosis-Related Prognostic Model for Acute Myeloid Leukemia. Front. Genet., 12.","DOI":"10.3389\/fgene.2021.708699"},{"key":"ref_264","doi-asserted-by":"crossref","unstructured":"Han, C., Zheng, J., Li, F., Guo, W., and Cai, C. (2022). Novel Prognostic Signature for Acute Myeloid Leukemia: Bioinformatics Analysis of Combined CNV-Driven and Ferroptosis-Related Genes. Front. Genet., 13.","DOI":"10.3389\/fgene.2022.849437"},{"key":"ref_265","first-page":"608","article-title":"A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia","volume":"22","author":"Huang","year":"2022","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"ref_266","doi-asserted-by":"crossref","first-page":"e1054549","DOI":"10.1080\/23723556.2015.1054549","article-title":"The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents","volume":"2","author":"Yu","year":"2015","journal-title":"Mol. Cell. Oncol."},{"key":"ref_267","doi-asserted-by":"crossref","first-page":"42.e1","DOI":"10.1016\/j.jtct.2022.10.002","article-title":"Iron Chelation with Deferasirox Suppresses the Appearance of Labile Plasma Iron During Conditioning Chemotherapy Prior to Allogeneic Stem Cell Transplantation","volume":"29","author":"Essmann","year":"2023","journal-title":"Transpl. Cell. Ther."},{"key":"ref_268","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.bbmt.2010.01.004","article-title":"A prospective study of iron overload management in allogeneic hematopoietic cell transplantation survivors","volume":"16","author":"Majhail","year":"2010","journal-title":"Biol. Blood Marrow Transpl."},{"key":"ref_269","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/bmt.2015.204","article-title":"Efficacy and safety of deferasirox in non-thalassemic patients with elevated ferritin levels after allogeneic hematopoietic stem cell transplantation","volume":"51","author":"Jaekel","year":"2016","journal-title":"Bone Marrow Transpl."},{"key":"ref_270","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.3324\/haematol.2014.105908","article-title":"Phase IV open-label study of the efficacy and safety of deferasirox after allogeneic stem cell transplantation","volume":"99","author":"Vallejo","year":"2014","journal-title":"Haematologica"},{"key":"ref_271","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1007\/s12185-017-2396-9","article-title":"Deferasirox for the treatment of iron overload after allogeneic hematopoietic cell transplantation: Multicenter phase I study (KSGCT1302)","volume":"107","author":"Tachibana","year":"2018","journal-title":"Int. J. Hematol."},{"key":"ref_272","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/ijc.2910320314","article-title":"Effects of anti-transferrin receptor antibodies on growth of normal and malignant myeloid cells","volume":"32","author":"Taetle","year":"1983","journal-title":"Int. J. Cancer"},{"key":"ref_273","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/sj.leu.2404958","article-title":"Recent advances in adult T-cell leukemia therapy: Focus on a new anti-transferrin receptor monoclonal antibody","volume":"22","author":"Callens","year":"2008","journal-title":"Leukemia"},{"key":"ref_274","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1158\/0008-5472.CAN-10-0938","article-title":"Development of human single-chain antibodies to the transferrin receptor that effectively antagonize the growth of leukemias and lymphomas","volume":"70","author":"Goenaga","year":"2010","journal-title":"Cancer Res."},{"key":"ref_275","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1080\/19420862.2018.1564510","article-title":"A recycling anti-transferrin receptor-1 monoclonal antibody as an efficient therapy for erythroleukemia through target up-regulation and antibody-dependent cytotoxic effector functions","volume":"11","author":"Neiveyans","year":"2019","journal-title":"mAbs"},{"key":"ref_276","first-page":"1259","article-title":"Phase Ia trial of murine immunoglobulin A antitransferrin receptor antibody 42\/6","volume":"1","author":"Brooks","year":"1995","journal-title":"Clin. Cancer Res."},{"key":"ref_277","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/ejh.14243","article-title":"Pharmacokinetics, pharmacodynamics, and tolerability of an aqueous formulation of rusfertide (PTG-300), a hepcidin mimetic, in healthy volunteers: A double-blind first-in-human study","volume":"113","author":"Modi","year":"2024","journal-title":"Eur. J. Haematol."},{"key":"ref_278","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s40268-024-00497-z","article-title":"Pharmacokinetics and Pharmacodynamics of Rusfertide, a Hepcidin Mimetic, Following Subcutaneous Administration of a Lyophilized Powder Formulation in Healthy Volunteers","volume":"24","author":"Modi","year":"2024","journal-title":"Drugs R&D"},{"key":"ref_279","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13045-017-0427-x","article-title":"A first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, in cancer-associated anemia","volume":"10","author":"Abonour","year":"2017","journal-title":"J. Hematol. Oncol."},{"key":"ref_280","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1074\/jbc.M114.611913","article-title":"Low intracellular iron increases the stability of matriptase-2","volume":"290","author":"Zhao","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_281","doi-asserted-by":"crossref","first-page":"18354","DOI":"10.1074\/jbc.M117.801795","article-title":"Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway","volume":"292","author":"Wahedi","year":"2017","journal-title":"J. Biol. Chem."},{"key":"ref_282","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrd.2016.248","article-title":"Targeting iron metabolism in drug discovery and delivery","volume":"16","author":"Crielaard","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_283","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1182\/blood-2012-09-453977","article-title":"An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-\/-) mice and ameliorates anemia and iron overload in murine \u03b2-thalassemia intermedia","volume":"121","author":"Schmidt","year":"2013","journal-title":"Blood"},{"key":"ref_284","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/cbic.201500651","article-title":"En Route to New Therapeutic Options for Iron Overload Diseases: Matriptase-2 as a Target for Kunitz-Type Inhibitors","volume":"17","author":"Beckmann","year":"2016","journal-title":"ChemBioChem"},{"key":"ref_285","doi-asserted-by":"crossref","first-page":"16416","DOI":"10.1074\/jbc.M110.109488","article-title":"The role of hepatocyte hemojuvelin in the regulation of bone morphogenic protein-6 and hepcidin expression in vivo","volume":"285","author":"Zhang","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_286","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/bcp.13877","article-title":"Targeting the hepcidin-ferroportin pathway in anaemia of chronic kidney disease","volume":"85","author":"Sheetz","year":"2019","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_287","doi-asserted-by":"crossref","first-page":"111583","DOI":"10.1016\/j.cellsig.2024.111583","article-title":"HDAC inhibitor enhances ferroptosis susceptibility of AML cells by stimulating iron metabolism","volume":"127","author":"Bian","year":"2025","journal-title":"Cell. Signal."},{"key":"ref_288","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1182\/blood-2013-04-491944","article-title":"Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling","volume":"122","author":"Hole","year":"2013","journal-title":"Blood"},{"key":"ref_289","doi-asserted-by":"crossref","first-page":"e2300736","DOI":"10.1002\/smll.202300736","article-title":"A Selective Nano Cell Cycle Checkpoint Inhibitor Overcomes Leukemia Chemoresistance","volume":"19","author":"Sun","year":"2023","journal-title":"Small"},{"key":"ref_290","doi-asserted-by":"crossref","unstructured":"Zhang, S., Lou, S., Bian, W., Liu, J., Wang, R., Wang, Y., Zhao, Y., Zou, X., Jin, D., and Liang, Y. (2024). Selective eradication of venetoclax-resistant monocytic acute myeloid leukemia with iron oxide nanozymes. Biochem. Biophys. Res. Commun., 719.","DOI":"10.1016\/j.bbrc.2024.150117"},{"key":"ref_291","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3892\/ol.2024.14707","article-title":"Ferroptosis: Potential therapeutic targets and prognostic predictions for acute myeloid leukemia (Review)","volume":"28","author":"Zhang","year":"2024","journal-title":"Oncol. Lett."},{"key":"ref_292","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41418-019-0352-3","article-title":"Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis","volume":"27","author":"Chen","year":"2020","journal-title":"Cell Death Differ."},{"key":"ref_293","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.freeradbiomed.2018.12.011","article-title":"DHA inhibits proliferation and induces ferroptosis of leukemia cells through autophagy dependent degradation of ferritin","volume":"131","author":"Du","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"ref_294","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.bbrc.2019.06.070","article-title":"Typhaneoside prevents acute myeloid leukemia (AML) through suppressing proliferation and inducing ferroptosis associated with autophagy","volume":"516","author":"Zhu","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_295","doi-asserted-by":"crossref","first-page":"144889","DOI":"10.1016\/j.gene.2020.144889","article-title":"Targeting ferroptosis contributes to ATPR-induced AML differentiation via ROS-autophagy-lysosomal pathway","volume":"755","author":"Du","year":"2020","journal-title":"Gene"},{"key":"ref_296","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1182\/blood-2012-04-422121","article-title":"The high Nrf2 expression in human acute myeloid leukemia is driven by NF-\u03baB and underlies its chemo-resistance","volume":"120","author":"Rushworth","year":"2012","journal-title":"Blood"},{"key":"ref_297","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1038\/s41417-022-00501-1","article-title":"Nrf2 overexpression increases the resistance of acute myeloid leukemia to cytarabine by inhibiting replication factor C4","volume":"29","author":"Hu","year":"2022","journal-title":"Cancer Gene Ther."},{"key":"ref_298","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41420-024-01800-2","article-title":"Inhibition of NRF2 enhances the acute myeloid leukemia cell death induced by venetoclax via the ferroptosis pathway","volume":"10","author":"Yu","year":"2024","journal-title":"Cell Death Discov."},{"key":"ref_299","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40164-023-00411-4","article-title":"Targeting NRF2 uncovered an intrinsic susceptibility of acute myeloid leukemia cells to ferroptosis","volume":"12","author":"Liu","year":"2023","journal-title":"Exp. Hematol. Oncol."},{"key":"ref_300","doi-asserted-by":"crossref","unstructured":"Di Francesco, B., Verzella, D., Capece, D., Vecchiotti, D., Di Vito Nolfi, M., Flati, I., Cornice, J., Di Padova, M., Angelucci, A., and Alesse, E. (2022). NF-\u03baB: A Druggable Target in Acute Myeloid Leukemia. Cancers, 14.","DOI":"10.3390\/cancers14143557"},{"key":"ref_301","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1111\/febs.16382","article-title":"Ferroptosis: Regulation by competition between NRF2 and BACH1 and propagation of the death signal","volume":"290","author":"Nishizawa","year":"2023","journal-title":"FEBS J."},{"key":"ref_302","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.1111\/jcmm.15353","article-title":"ATPR triggers acute myeloid leukaemia cells differentiation and cycle arrest via the RAR\u03b1\/LDHB\/ERK-glycolysis signalling axis","volume":"24","author":"Du","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_303","doi-asserted-by":"crossref","first-page":"102227","DOI":"10.1016\/j.tranon.2024.102227","article-title":"Exogenous dihomo-\u03b3-linolenic acid triggers ferroptosis via ACSL4-mediated lipid metabolic reprogramming in acute myeloid leukemia cells","volume":"52","author":"Jiang","year":"2025","journal-title":"Transl. Oncol."},{"key":"ref_304","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s43018-023-00653-5","article-title":"Imetelstat-mediated alterations in fatty acid metabolism to induce ferroptosis as a therapeutic strategy for acute myeloid leukemia","volume":"5","author":"Bruedigam","year":"2024","journal-title":"Nat. Cancer"},{"key":"ref_305","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1021\/acsnano.2c06313","article-title":"A Ferroptosis-Inducing and Leukemic Cell-Targeting Drug Nanocarrier Formed by Redox-Responsive Cysteine Polymer for Acute Myeloid Leukemia Therapy","volume":"17","author":"Yu","year":"2023","journal-title":"ACS Nano"},{"key":"ref_306","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/s41375-023-02117-2","article-title":"Mitochondrial regulation of GPX4 inhibition-mediated ferroptosis in acute myeloid leukemia","volume":"38","author":"Akiyama","year":"2024","journal-title":"Leukemia"},{"key":"ref_307","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.bbrc.2019.01.090","article-title":"The release and activity of HMGB1 in ferroptosis","volume":"510","author":"Wen","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_308","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.2174\/0929867325666180117105522","article-title":"The Role of AMPK\/mTOR Modulators in the Therapy of Acute Myeloid Leukemia","volume":"26","author":"Visnjic","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"ref_309","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1080\/15548627.2020.1822628","article-title":"The role of autophagy in targeted therapy for acute myeloid leukemia","volume":"17","author":"Du","year":"2021","journal-title":"Autophagy"},{"key":"ref_310","doi-asserted-by":"crossref","unstructured":"Lai, X., Sun, Y., Zhang, X., Wang, D., Wang, J., Wang, H., Zhao, Y., Liu, X., Xu, X., and Song, H. (2022). Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.897791"},{"key":"ref_311","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/jcb.24967","article-title":"Honokiol induces cell cycle arrest and apoptosis via inhibiting class I histone deacetylases in acute myeloid leukemia","volume":"116","author":"Li","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"ref_312","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.bcp.2016.12.022","article-title":"Honokiol induces proteasomal degradation of AML1-ETO oncoprotein via increasing ubiquitin conjugase UbcH8 expression in leukemia","volume":"128","author":"Zhou","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"ref_313","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1620\/tjem.237.163","article-title":"Honokiol Inhibits Constitutive and Inducible STAT3 Signaling via PU.1-Induced SHP1 Expression in Acute Myeloid Leukemia Cells","volume":"237","author":"Bi","year":"2015","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_314","doi-asserted-by":"crossref","first-page":"123297","DOI":"10.1016\/j.lfs.2024.123297","article-title":"M2 macrophages secrete CCL20 to regulate iron metabolism and promote daunorubicin resistance in AML cells","volume":"361","author":"Chen","year":"2025","journal-title":"Life Sci."},{"key":"ref_315","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3324\/haematol.10148","article-title":"Subclassification of patients with acute myelogenous leukemia based on chemokine responsiveness and constitutive chemokine release by their leukemic cells","volume":"92","author":"Bruserud","year":"2007","journal-title":"Haematologica"},{"key":"ref_316","doi-asserted-by":"crossref","unstructured":"Pourcelot, E., El Samra, G., Mossuz, P., and Moulis, J.M. (2023). Molecular Insight into Iron Homeostasis of Acute Myeloid Leukemia Blasts. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241814307"},{"key":"ref_317","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41392-019-0050-0","article-title":"Effects of insulin and pathway inhibitors on the PI3K-Akt-mTOR phosphorylation profile in acute myeloid leukemia cells","volume":"4","author":"Nepstad","year":"2019","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_318","doi-asserted-by":"crossref","unstructured":"Bruserud, \u00d8., Tsykunova, G., Hernandez-Valladares, M., Reikvam, H., and Tvedt, T.H.A. (2021). Therapeutic Use of Valproic Acid and All-Trans Retinoic Acid in Acute Myeloid Leukemia-Literature Review and Discussion of Possible Use in Relapse after Allogeneic Stem Cell Transplantation. Pharmaceuticals, 14.","DOI":"10.3390\/ph14050423"},{"key":"ref_319","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1158\/1078-0432.CCR-19-0171","article-title":"Histone Deacetylase Inhibition with Panobinostat Combined with Intensive Induction Chemotherapy in Older Patients with Acute Myeloid Leukemia: Phase I Study Results","volume":"25","author":"Wieduwilt","year":"2019","journal-title":"Clin. Cancer Res."},{"key":"ref_320","doi-asserted-by":"crossref","first-page":"eadk1731","DOI":"10.1126\/scitranslmed.adk1731","article-title":"Targeting ferritinophagy impairs quiescent cancer stem cells in acute myeloid leukemia in vitro and in vivo models","volume":"16","author":"Larrue","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"ref_321","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.blre.2008.08.001","article-title":"Ferritin for the clinician","volume":"23","author":"Knovich","year":"2009","journal-title":"Blood Rev."},{"key":"ref_322","doi-asserted-by":"crossref","unstructured":"Sandnes, M., Ulvik, R.J., Vorland, M., and Reikvam, H. (2021). Hyperferritinemia-A Clinical Overview. J. Clin. Med., 10.","DOI":"10.3390\/jcm10092008"},{"key":"ref_323","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00277-003-0741-y","article-title":"Spontaneous remission in adult acute myeloid leukemia in association with systemic bacterial infection-case report and review of the literature","volume":"83","author":"Maywald","year":"2004","journal-title":"Ann. Hematol."},{"key":"ref_324","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.2169\/internalmedicine.52.9505","article-title":"Spontaneous remission in patients with acute myeloid leukemia with t(8;21) or cutaneous myeloid sarcoma: Two case reports and a review of the literature","volume":"52","author":"Zeng","year":"2013","journal-title":"Intern. Med."},{"key":"ref_325","doi-asserted-by":"crossref","unstructured":"Imataki, O., Ishida, T., Kida, J.I., Uemura, M., Fujita, H., and Kadowaki, N. (2023). Repeated spontaneous remission of acute myeloid leukemia in response to various infections: A case report. BMC Infect. Dis., 23.","DOI":"10.1186\/s12879-023-08108-z"},{"key":"ref_326","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/1744666X.2024.2441246","article-title":"Future biomarkers for acute graft-versus-host disease: Potential roles of nucleic acids, metabolites, and immune cell markers","volume":"21","author":"Reikvam","year":"2024","journal-title":"Expert Rev. Clin. Immunol."},{"key":"ref_327","doi-asserted-by":"crossref","first-page":"126801","DOI":"10.1016\/j.talanta.2024.126801","article-title":"A novel prognosis evaluation indicator of patients with sepsis created by integrating six microfluidic-based neutrophil chemotactic migration parameters","volume":"281","author":"Yang","year":"2025","journal-title":"Talanta"},{"key":"ref_328","doi-asserted-by":"crossref","unstructured":"Moreno-Casta\u00f1o, A.B., Salas, M.Q., Palomo, M., Martinez-Sanchez, J., Rovira, M., Fern\u00e1ndez-Avil\u00e9s, F., Mart\u00ednez, C., Cid, J., Castro, P., and Escolar, G. (2022). Early vascular endothelial complications after hematopoietic cell transplantation: Role of the endotheliopathy in biomarkers and target therapies development. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.1050994"},{"key":"ref_329","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1080\/17474086.2021.1968823","article-title":"Endothelial dysfunction and vascular complications after allogeneic hematopoietic cell transplantation: An expert analysis","volume":"14","author":"Eftychidis","year":"2021","journal-title":"Expert Rev. Hematol."},{"key":"ref_330","doi-asserted-by":"crossref","unstructured":"Grishina, O., Schmoor, C., D\u00f6hner, K., Hackanson, B., Lubrich, B., May, A.M., Cieslik, C., M\u00fcller, M.J., and L\u00fcbbert, M. (2015). DECIDER: Prospective randomized multicenter phase II trial of low-dose decitabine (DAC) administered alone or in combination with the histone deacetylase inhibitor valproic acid (VPA) and all-trans retinoic acid (ATRA) in patients > 60 years with acute myeloid leukemia who are ineligible for induction chemotherapy. BMC Cancer, 15.","DOI":"10.1186\/s12885-015-1432-5"},{"key":"ref_331","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/ejh.14304","article-title":"Impact of TP53 Mutation Status in Elderly AML Patients When Adding All-Trans Retinoic Acid or Valproic Acid to Decitabine","volume":"114","author":"Bresser","year":"2025","journal-title":"Eur. J. Haematol."},{"key":"ref_332","doi-asserted-by":"crossref","unstructured":"Khorasani, A.B.S., Hafezi, N., Sanaei, M.J., Jafari-Raddani, F., Pourbagheri-Sigaroodi, A., and Bashash, D. (2024). The PI3K\/AKT\/mTOR signaling pathway in breast cancer: Review of clinical trials and latest advances. Cell Biochem. Funct., 42.","DOI":"10.1002\/cbf.3998"},{"key":"ref_333","doi-asserted-by":"crossref","first-page":"113892","DOI":"10.1016\/j.addr.2021.113892","article-title":"Ferritin nanocage: A promising and designable multi-module platform for constructing dynamic nanoassembly-based drug nanocarrier","volume":"176","author":"Zhang","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_334","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/wnan.1221","article-title":"Human ferritin for tumor detection and therapy","volume":"5","author":"Fan","year":"2013","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"ref_335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2016.05.006","article-title":"Comparison of two endogenous delivery agents in cancer therapy: Exosomes and ferritin","volume":"110","author":"Li","year":"2016","journal-title":"Pharmacol. Res."},{"key":"ref_336","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jconrel.2019.12.051","article-title":"L-ferritin: A theranostic agent of natural origin for MRI visualization and treatment of breast cancer","volume":"319","author":"Bitonto","year":"2020","journal-title":"J. Control Release"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/12\/5744\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:52:26Z","timestamp":1760032346000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/12\/5744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,15]]},"references-count":336,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["ijms26125744"],"URL":"https:\/\/doi.org\/10.3390\/ijms26125744","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,15]]}}}