{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:48:11Z","timestamp":1791204491925,"version":"4.2.0"},"reference-count":84,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Jilin Province Science and Technology Development Plan Project","award":["20230204040YY"],"award-info":[{"award-number":["20230204040YY"]}]},{"name":"Jilin Province Science and Technology Development Plan Project","award":["21875085"],"award-info":[{"award-number":["21875085"]}]},{"name":"project of NSFC","award":["20230204040YY"],"award-info":[{"award-number":["20230204040YY"]}]},{"name":"project of NSFC","award":["21875085"],"award-info":[{"award-number":["21875085"]}]},{"name":"Innovation &amp; Opening Program of the State Key Laboratory of Supramolecular Structure and Materials, Jilin University","award":["20230204040YY"],"award-info":[{"award-number":["20230204040YY"]}]},{"name":"Innovation &amp; Opening Program of the State Key Laboratory of Supramolecular Structure and Materials, Jilin University","award":["21875085"],"award-info":[{"award-number":["21875085"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The HIV-1 capsid has emerged as a highly attractive drug target due to its highly conserved sequence and critical role in the viral life cycle. By disrupting interactions between capsid proteins and impairing the proper assembly or disassembly of the capsid, the inhibitors can effectively suppress HIV-1 replication and infection. Based on this mechanism, numerous small-molecule agents targeting the HIV-1 capsid protein have been developed to date. In this review, we report the latest advances in such inhibitors and delve into their molecular mechanisms of action. We find a focus on small molecules modulating capsid stability and their assembly\/disassembly. Hopefully this study will further enhance the understanding of HIV-1 inhibition mechanisms, facilitating the future exploration of novel capsid inhibitors.<\/jats:p>","DOI":"10.3390\/ijms26125819","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T11:53:14Z","timestamp":1750161194000},"page":"5819","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["New Advances in Anti-HIV-1 Strategies Targeting the Assembly and Stability of Capsid Protein"],"prefix":"10.3390","volume":"26","author":[{"given":"Chengfeng","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory for Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun 130012, China"},{"name":"Institute of Theoretical Chemistry, College of Chemistry, Jilin University, No. 2 Liutiao Road, Changchun 130023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benteng","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun 130012, China"},{"name":"Institute of Theoretical Chemistry, College of Chemistry, Jilin University, No. 2 Liutiao Road, Changchun 130023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamei","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun 130012, China"},{"name":"Institute of Theoretical Chemistry, College of Chemistry, Jilin University, No. 2 Liutiao Road, Changchun 130023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3074-1817","authenticated-orcid":false,"given":"Haihong","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, No. 2699 Qianjin Street, Changchun 130012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4883-5982","authenticated-orcid":false,"given":"Yuqing","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Supramolecular Structure and Materials, College of Chemistry, Jilin University, No. 2699 Qianjin Street, Changchun 130012, China"},{"name":"Institute of Theoretical Chemistry, College of Chemistry, Jilin University, No. 2 Liutiao Road, Changchun 130023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"ref_1","unstructured":"(2025, May 18). 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