{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:47:45Z","timestamp":1776185265337,"version":"3.50.1"},"reference-count":37,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the University of Medicine and Pharmacy \u201cCarol Davila\u201d through the institutional program \u201cPublish not Perish\u201d"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Lung involvement is the most common extraglandular manifestation of primary Sj\u00f6gren\u2019s Disease (pSjD). There is an increasing interest in finding the clinical\/serological risk predictors of this feature. A cross-sectional study evaluating anti-SSA\/Ro antibodies, anti-SSB\/La antibodies, rheumatoid factor, antinuclear antibodies, and the diffusing capacity of the lungs for carbon monoxide (DLCO) in 26 pSjD patients who presented interstitial changes on the chest CT scan was performed. The titres and positivity rates for anti-SSA\/Ro (p = 0.02, p = 0.02) and anti-SSB\/La antibodies (p = 0.01, p = 0.001) proved to be significantly increased in patients with abnormal DLCO. Anti-SSB\/La antibodies\u2019 titres seemed to be the best predictor for decreased DLCO\u2013AUC 0.791 (0.587\u20130.994), p = 0.016. A close-to-significance decrease was found in the titres (p = 0.07) and positivity rates\u2014p = 0.09 and OR of 0.15 (0.01\u20131.63)\u2014of anti-SSB\/La antibodies in patients with usual interstitial pneumonia (UIP), indicating their possible protective role against UIP. The lymphocytic interstitial pneumonitis (LIP) pattern on lung CT scan was significantly associated with the simultaneous positivity of the four examined serological markers (p = 0.03). The increase in anti-SSB\/La antibody positivity rate in patients with LIP patterns was situated close to the significance level (p = 0.09). Quadruple positivity, as well as isolated anti-SSB\/La positivity, could be risk factors for developing LIP in pSjD patients. Thus, anti-SSB\/La antibodies might represent a marker of lung involvement in pSjD patients.<\/jats:p>","DOI":"10.3390\/ijms26125867","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T06:11:07Z","timestamp":1750313467000},"page":"5867","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Role of Anti-SSB\/La Antibodies as Predictors of Decreased Diffusing Capacity of the Lungs for Carbon Monoxide (DLCO) in Primary Sj\u00f6gren Disease"],"prefix":"10.3390","volume":"26","author":[{"given":"Simona","family":"Caraiola","sequence":"first","affiliation":[{"name":"Fifth Department-Internal Medicine (Cardiology, Gastroenterology, Hepatology, Rheumatology, Geriatrics), Family Medicine, Occupational Medicine, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Internal Medicine Department, Colentina Clinical Hospital, 020125 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Voicu","sequence":"additional","affiliation":[{"name":"\u201cProf. Dr. C.C. Iliescu\u201d Emergency Institute for Cardiovascular Diseases, 022328 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3883-9672","authenticated-orcid":false,"given":"Daniela","family":"Opri\u0219-Belinski","sequence":"additional","affiliation":[{"name":"Fifth Department-Internal Medicine (Cardiology, Gastroenterology, Hepatology, Rheumatology, Geriatrics), Family Medicine, Occupational Medicine, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Rheumatology and Internal Medicine, Sf\u00e2nta Maria Clinical Hospital, 011172 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Oana","family":"Cobilinschi","sequence":"additional","affiliation":[{"name":"Fifth Department-Internal Medicine (Cardiology, Gastroenterology, Hepatology, Rheumatology, Geriatrics), Family Medicine, Occupational Medicine, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Rheumatology and Internal Medicine, Sf\u00e2nta Maria Clinical Hospital, 011172 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda Ileana","family":"P\u00e2rvu","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Colentina Clinical Hospital, 020125 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ion Andrei","family":"Ion","sequence":"additional","affiliation":[{"name":"Pneumology Department, Colentina Clinical Hospital, 020125 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela \u0218tefana","family":"Gologanu","sequence":"additional","affiliation":[{"name":"Pneumology Department, Colentina Clinical Hospital, 020125 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u0103zvan Adrian","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Fifth Department-Internal Medicine (Cardiology, Gastroenterology, Hepatology, Rheumatology, Geriatrics), Family Medicine, Occupational Medicine, Faculty of Medicine, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Internal Medicine Department, Colentina Clinical Hospital, 020125 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jaut.2012.01.002","article-title":"Pathogenesis of Sj\u00f6gren\u2019s syndrome: What we know and what we should learn","volume":"39","author":"Tzioufas","year":"2012","journal-title":"J. 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