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Grant","award":["W81XWH2210689"],"award-info":[{"award-number":["W81XWH2210689"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Chitosan is increasingly utilized in combination with melatonin in novel formulations for a wide range of therapeutic applications. As a biocompatible and biodegradable polymer, chitosan exhibits notable properties, including antioxidant, antimicrobial, moisturizing, and absorption capabilities, in addition to a high potential for chemical modification due to its functional groups. These characteristics make it a valuable material in biomedical, pharmaceutical, cosmetic, food packaging, and environmental applications. Melatonin, an indoleamine primarily synthesized in the pineal gland but also found in various peripheral organs and in diverse organisms\u2014including plants, bacteria, and fungi\u2014has been extensively investigated for its antioxidant, anti-apoptotic, and anti-inflammatory activities, as well as its roles in immunomodulation, mitochondrial function, and melanin biosynthesis. This review summarizes recent advances in the combined use of chitosan and melatonin, with emphasis on their synergistic effects in wound healing, anti-cancer therapies, tissue engineering (i.e., skin and bone regeneration), and drug delivery systems. Additional potential applications are discussed in the context of cosmetology, aesthetic medicine, and veterinary practice.<\/jats:p>","DOI":"10.3390\/ijms26135918","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T03:05:27Z","timestamp":1750388727000},"page":"5918","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Melatonin\/Chitosan Biomaterials for Wound Healing and Beyond: A Multifunctional Therapeutic Approach"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0825-1774","authenticated-orcid":false,"given":"Karolina","family":"Kulka-Kami\u0144ska","sequence":"first","affiliation":[{"name":"Laboratory for Biomaterials and Cosmetics, Nicolaus Copernicus University in Toru\u0144, Gagarin Str. 7, 87-100 Toru\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrycja","family":"Brudzy\u0144ska","sequence":"additional","affiliation":[{"name":"Laboratory for Biomaterials and Cosmetics, Nicolaus Copernicus University in Toru\u0144, Gagarin Str. 7, 87-100 Toru\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuko","family":"Okura","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuyuki","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5720-6487","authenticated-orcid":false,"given":"Marco","family":"Skala","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of M\u00fcnster, Von-Esmarch-Str. 58, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6763-4225","authenticated-orcid":false,"given":"Russel J.","family":"Reiter","sequence":"additional","affiliation":[{"name":"Department of Cell Systems and Anatomy, Long School of Medicine, UT Health, San Antonio, TX 78229, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8963-3995","authenticated-orcid":false,"given":"Andrzej T.","family":"Slominski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Comprehensive Cancer Center, Cancer Chemoprevention Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA"},{"name":"VA Medical Center, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-9828","authenticated-orcid":false,"given":"Kazuo","family":"Kishi","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0500-2158","authenticated-orcid":false,"given":"Kerstin","family":"Steinbrink","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of M\u00fcnster, Von-Esmarch-Str. 58, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1551-2725","authenticated-orcid":false,"given":"Alina","family":"Sionkowska","sequence":"additional","affiliation":[{"name":"Laboratory for Biomaterials and Cosmetics, Nicolaus Copernicus University in Toru\u0144, Gagarin Str. 7, 87-100 Toru\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1311-263X","authenticated-orcid":false,"given":"Konrad","family":"Kleszczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of M\u00fcnster, Von-Esmarch-Str. 58, 48149 M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.21323\/2618-9771-2020-3-1-10-15","article-title":"Chitosan application in food technology: A review of recent advances","volume":"3","author":"Kabanov","year":"2020","journal-title":"Food Syst."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Kulka, K., and Sionkowska, A. 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