{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:24:56Z","timestamp":1760059496362,"version":"build-2065373602"},"reference-count":65,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Thymic epithelial tumors (TETs) display heterogeneous histology and often unpredictable clinical behavior. The Hippo signaling pathway has been implicated in tumorigenesis, but its role in TETs remains poorly characterized. We performed the first comprehensive immunohistochemical analysis of core and upstream Hippo pathway components\u2014YAP1, active YAP (AYAP), TAZ, LATS1, MOB1A, MST1, SAV1, and TEAD4\u2014in 77 TETs. Associations with clinicopathological parameters and survival were explored. We observed widespread expression of Hippo components in TETs with significant associations among molecules and differences in subcellular localization and expression in normal tissue. Early stage TETs showed higher nuclear YAP1 (p = 0.032) and AYAP (p = 0.007), while cytoplasmic MST1 (p = 0.002), LATS1 (p = 0.007), MOB1A (p = 0.033) and TEAD4 (p &lt; 0.001) correlated with advanced stage. Cytoplasmic MST1 (p = 0.014), LATS1 (p &lt; 0.001) and TEAD4 (p = 0.005) were associated with histological aggressiveness. Cytoplasmic TEAD4 overexpression was associated with poorer overall survival (log-rank, &lt;70% versus \u226570%, p = 0.003). Our findings provide novel insights into the differential regulation and compartmentalization of Hippo components in TETs. While indolent tumors show features that are consistent with partial Hippo inactivation, more aggressive phenotypes exhibit reduced nuclear YAP\/TAZ and altered TEAD4 compartmentalization, suggesting a context-dependent Hippo signaling state. Cytoplasmic TEAD4 emerges as a potential adverse prognosticator, indicating involvement in non-canonical or Hippo-independent mechanisms.<\/jats:p>","DOI":"10.3390\/ijms26135938","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T08:13:56Z","timestamp":1750407236000},"page":"5938","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hippo Pathway Dysregulation in Thymic Epithelial Tumors (TETs): Associations with Clinicopathological Features and Patients\u2019 Prognosis"],"prefix":"10.3390","volume":"26","author":[{"given":"Lisa","family":"Elm","sequence":"first","affiliation":[{"name":"Department of Pathology, Nuremberg Clinic, Paracelsus Medical University, 90419 Nuremberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadja","family":"Gerlitz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nuremberg Clinic, Paracelsus Medical University, 90419 Nuremberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Hochholzer","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nuremberg Clinic, Paracelsus Medical University, 90419 Nuremberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nuremberg Clinic, Paracelsus Medical University, 90419 Nuremberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1398-178X","authenticated-orcid":false,"given":"Georgia","family":"Levidou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Nuremberg Clinic, Paracelsus Medical University, 90419 Nuremberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Palamaris, K., Levidou, G., Kordali, K., Masaoutis, C., Rontogianni, D., and Theocharis, S. (2023). Searching for Novel Biomarkers in Thymic Epithelial Tumors: Immunohistochemical Evaluation of Hippo Pathway Components in a Cohort of Thymic Epithelial Tumors. Biomedicines, 11.","DOI":"10.3390\/biomedicines11071876"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4161\/cam.4.3.11789","article-title":"The thymus microenvironment in regulating thymocyte differentiation","volume":"4","author":"Gameiro","year":"2010","journal-title":"Cell Adh. Migr."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lin, X., Gao, Y., Ding, Y., and Zhao, B. (2023). Editorial: Revisiting the thymus: The origin of T cells. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1197066"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Dai, H., Lan, B., Li, S., Huang, Y., Jiang, G., and Tian, J. (2023). Prognostic CT features in patients with untreated thymic epithelial tumors. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-30041-z"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Sumi, A., and Fujimoto, K. (2018). Is there any consensus of long-term follow-up for incidental anterior mediastinal nodular lesions?. Shanghai Chest, 2.","DOI":"10.21037\/shc.2018.12.01"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Veraar, C., Janik, S., Thanner, J., Veraar, C., Mouhieddine, M., Schiefer, A.-I., M\u00fcllauer, L., Dworschak, M., Klepetko, W., and Ankersmit, H.J. (2019). Clinical prognostic scores for patients with thymic epithelial tumors. Sci. Rep., 9.","DOI":"10.1038\/s41598-019-54906-4"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Elm, L., and Levidou, G. (2024). The Molecular Landscape of Thymic Epithelial Tumors: A Comprehensive Review. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25031554"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/JTO.0000000000000154","article-title":"ITMIG consensus statement on the use of the WHO histological classification of thymoma and thymic carcinoma: Refined definitions, histological criteria, and reporting","volume":"9","author":"Marx","year":"2014","journal-title":"J. Thorac. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2214\/ajr.179.4.1790881","article-title":"Using the World Health Organization Classification of Thymic Epithelial Neoplasms to Describe CT Findings","volume":"179","author":"Tomiyama","year":"2002","journal-title":"Am. J. Roentgenol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Tassi, V., Vannucci, J., Ceccarelli, S., Gili, A., Matricardi, A., Avenia, N., and Puma, F. (2019). Stage-related outcome for thymic epithelial tumours. BMC Surg., 18.","DOI":"10.1186\/s12893-018-0434-z"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"901","DOI":"10.21037\/jtd.2016.03.53","article-title":"Prognostic stratification of thymic epithelial tumors based on both Masaoka-Koga stage and WHO classification systems","volume":"8","author":"Lee","year":"2016","journal-title":"J. Thorac. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Zhou, Q., Ke, X., Man, J., Zhang, B., Wang, F., and Zhou, J. (2021). Predicting Masaoka-Koga Clinical Stage of Thymic Epithelial Tumors Using Preoperative Spectral Computed Tomography Imaging. Front. Oncol., 11.","DOI":"10.3389\/fonc.2021.631649"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Liu, Q., Liu, X., and Song, G. (2021). The Hippo Pathway: A Master Regulatory Network Important in Cancer. Cells, 10.","DOI":"10.3390\/cells10061416"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"110586","DOI":"10.1016\/j.intimp.2023.110586","article-title":"Regulation of the tumor immune microenvironment by the Hippo Pathway: Implications for cancer immunotherapy","volume":"122","author":"Liu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"642","DOI":"10.15252\/embr.201438638","article-title":"The Hippo signaling pathway in stem cell biology and cancer","volume":"15","author":"Mo","year":"2014","journal-title":"EMBO Rep."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Moshe Oren, Y.A. (2013). The Hippo Signaling Pathway and Cancer, Springer.","DOI":"10.1007\/978-1-4614-6220-0"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/s41392-022-01191-9","article-title":"The Hippo signalling pathway and its implications in human health and diseases","volume":"7","author":"Fu","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/s41417-024-00761-z","article-title":"Hippo pathway in non-small cell lung cancer: Mechanisms, potential targets, and biomarkers","volume":"31","author":"Liang","year":"2024","journal-title":"Cancer Gene Ther."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1038\/onc.2015.342","article-title":"Increased TEAD4 expression and nuclear localization in colorectal cancer promote epithelial-mesenchymal transition and metastasis in a YAP-independent manner","volume":"35","author":"Liu","year":"2016","journal-title":"Oncogene"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Takeda, M., Yoshida, S., Inoue, T., Sekido, Y., Hata, T., Hamabe, A., Ogino, T., Miyoshi, N., Uemura, M., and Yamamoto, H. (2025). The Role of KRAS Mutations in Colorectal Cancer: Biological Insights, Clinical Implications, and Future Therapeutic Perspectives. Cancers, 17.","DOI":"10.3390\/cancers17030428"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bbrc.2016.04.089","article-title":"Hippo pathway effector YAP inhibition restores the sensitivity of EGFR-TKI in lung adenocarcinoma having primary or acquired EGFR-TKI resistance","volume":"474","author":"Lee","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41568-023-00579-1","article-title":"Insights into recent findings and clinical application of YAP and TAZ in cancer","volume":"23","author":"Franklin","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ccr.2009.09.026","article-title":"Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene","volume":"16","author":"Zhou","year":"2009","journal-title":"Cancer Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.humpath.2017.08.032","article-title":"Expression of YES-associated protein (YAP) and its clinical significance in breast cancer tissues","volume":"68","author":"Cao","year":"2017","journal-title":"Hum. Pathol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.2147\/OTT.S109540","article-title":"Prognostic significance of TAZ expression in various cancers: A meta-analysis","volume":"9","author":"Feng","year":"2016","journal-title":"OncoTargets Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"7362","DOI":"10.1073\/pnas.1201595109","article-title":"Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment","volume":"109","author":"Home","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1242\/dev.093799","article-title":"TEAD4 establishes the energy homeostasis essential for blastocoel formation","volume":"140","author":"Kaneko","year":"2013","journal-title":"Development"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1038\/sj.emboj.7601872","article-title":"The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1","volume":"26","author":"Cinar","year":"2007","journal-title":"EMBO J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"9865","DOI":"10.2147\/OTT.S266649","article-title":"Structural and Functional Overview of TEAD4 in Cancer Biology","volume":"13","author":"Chen","year":"2020","journal-title":"OncoTargets Ther."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Hsu, S.-C., Lin, C.-Y., Lin, Y.-Y., Collins, C.C., Chen, C.-L., and Kung, H.-J. (2022). TEAD4 as an Oncogene and a Mitochondrial Modulator. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.890419"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"ncomms11840","DOI":"10.1038\/ncomms11840","article-title":"A splicing isoform of TEAD4 attenuates the Hippo\u2013YAP signalling to inhibit tumour proliferation","volume":"7","author":"Qi","year":"2016","journal-title":"Nat. Commun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1158\/1541-7786.MCR-18-0910","article-title":"MST1 Suppresses Pancreatic Cancer Progression via ROS-Induced Pyroptosis","volume":"17","author":"Cui","year":"2019","journal-title":"Mol. Cancer Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3892\/mmr.2021.12022","article-title":"MST1 inhibits the progression of breast cancer by regulating the Hippo signaling pathway and may serve as a prognostic biomarker","volume":"23","author":"Jin","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1073\/pnas.0911409107","article-title":"Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression","volume":"107","author":"Song","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1038\/s41418-019-0321-x","article-title":"FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1\/2-dependent apoptosis","volume":"26","author":"Turunen","year":"2019","journal-title":"Cell Death Differ."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"10148","DOI":"10.1073\/pnas.181161698","article-title":"Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation","volume":"98","author":"Ura","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.3892\/ijo.2014.2687","article-title":"Methylation-associated inactivation of LATS1 and its effect on demethylation or overexpression on YAP and cell biological function in human renal cell carcinoma","volume":"45","author":"Chen","year":"2014","journal-title":"Int. J. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"16207","DOI":"10.1007\/s13277-016-5457-4","article-title":"Expression profile and prognostic value of SAV1 in patients with pancreatic ductal adenocarcinoma","volume":"37","author":"Wang","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1111\/1759-7714.13608","article-title":"Association of Mps one binder kinase activator 1 (MOB1) expression with poor disease-free survival in individuals with non-small cell lung cancer","volume":"11","author":"Ando","year":"2020","journal-title":"Thorac. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/gtc.12704","article-title":"MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner","volume":"24","author":"Kato","year":"2019","journal-title":"Genes Cells"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"10106","DOI":"10.1038\/s41467-024-54480-y","article-title":"Functional annotation of the Hippo pathway somatic mutations in human cancers","volume":"15","author":"Han","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1042\/CS20201474","article-title":"The Hippo pathway in cancer: YAP\/TAZ and TEAD as therapeutic targets in cancer","volume":"136","author":"Cunningham","year":"2022","journal-title":"Clin. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3892\/ol.2021.12574","article-title":"Hippo\/TEAD4 signaling pathway as a potential target for the treatment of breast cancer","volume":"21","author":"Wu","year":"2021","journal-title":"Oncol. Lett."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/s13046-022-02377-3","article-title":"TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K\/AKT pathway in bladder cancer","volume":"41","author":"Chi","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"937","DOI":"10.2147\/OTT.S290425","article-title":"TEAD4 as a Prognostic Marker Promotes Cell Migration and Invasion of Urinary Bladder Cancer via EMT","volume":"14","author":"Huang","year":"2021","journal-title":"OncoTargets Ther."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/PAI.0000000000001164","article-title":"High TEAD4 Expression is Associated With Aggressive Clear Cell Renal Cell Carcinoma, Regardless of YAP1 Expression","volume":"31","author":"Park","year":"2023","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Gong, X., Li, N., Sun, C., Li, Z., and Xie, H. (2022). A Four-Gene Prognostic Signature Based on the TEAD4 Differential Expression Predicts Overall Survival and Immune Microenvironment Estimation in Lung Adenocarcinoma. Front. Pharmacol., 13.","DOI":"10.3389\/fphar.2022.874780"},{"key":"ref_48","first-page":"4827","article-title":"Overexpression of TEAD4 correlates with poor prognosis of glioma and promotes cell invasion","volume":"11","author":"Xu","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"27534","DOI":"10.1074\/jbc.M804380200","article-title":"Mst2 and Lats Kinases Regulate Apoptotic Function of Yes Kinase-associated Protein (YAP)","volume":"283","author":"Oka","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/j.celrep.2018.10.001","article-title":"Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer","volume":"25","author":"Wang","year":"2018","journal-title":"Cell Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"F511","DOI":"10.1152\/ajprenal.00347.2023","article-title":"Guidelines on antibody use in physiology research","volume":"326","author":"Brooks","year":"2024","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e589","DOI":"10.1002\/cpz1.589","article-title":"Do more with Less: Improving High Parameter Cytometry Through Overnight Staining","volume":"2","author":"Whyte","year":"2022","journal-title":"Curr. Protoc."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"RP87253","DOI":"10.7554\/eLife.87253","article-title":"Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A","volume":"12","author":"Cacioppo","year":"2023","journal-title":"eLife"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"5029","DOI":"10.1038\/s41467-023-40271-4","article-title":"Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response","volume":"14","author":"Arora","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41698-025-00857-1","article-title":"Quantifying and interpreting biologically meaningful spatial signatures within tumor microenvironments","volume":"9","author":"Jing","year":"2025","journal-title":"NPJ Precis. Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Borreguero-Mu\u00f1oz, N., Fletcher, G.C., Aguilar-Aragon, M., Elbediwy, A., Vincent-Mistiaen, Z.I., and Thompson, B.J. (2019). The Hippo pathway integrates PI3K-Akt signals with mechanical and polarity cues to control tissue growth. PLoS Biol., 17.","DOI":"10.1371\/journal.pbio.3000509"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1097\/JTO.0000000000000493","article-title":"Hippo Pathway Gene Mutations in Malignant Mesothelioma: Revealed by RNA and Targeted Exon Sequencing","volume":"10","author":"Miyanaga","year":"2015","journal-title":"J. Thorac. Oncol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1586\/14737159.2015.1039516","article-title":"Whole-exome sequencing as a diagnostic tool: Current challenges and future opportunities","volume":"15","author":"Tetreault","year":"2015","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"12527","DOI":"10.3390\/cimb46110744","article-title":"From Genomic Exploration to Personalized Treatment: Next-Generation Sequencing in Oncology","volume":"46","author":"Vashisht","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e70438","DOI":"10.1096\/fj.202401895RR","article-title":"Pharmacological regulators of Hippo pathway: Advances and challenges of drug development","volume":"39","author":"Lao","year":"2025","journal-title":"FASEB J."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1016\/S0959-8049(22)00909-1","article-title":"Covalent pan-TEAD inhibitors for the treatment of cancers with Hippo pathway alterations","volume":"174","author":"Guo","year":"2022","journal-title":"Eur. J. Cancer"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/s43018-023-00577-0","article-title":"An allosteric pan-TEAD inhibitor blocks oncogenic YAP\/TAZ signaling and overcomes KRAS G12C inhibitor resistance","volume":"4","author":"Hagenbeek","year":"2023","journal-title":"Nat. Cancer"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1158\/0008-5472.CAN-23-2729","article-title":"Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy","volume":"83","author":"Mukhopadhyay","year":"2023","journal-title":"Cancer Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/s43018-024-00754-9","article-title":"Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers","volume":"5","author":"Chapeau","year":"2024","journal-title":"Nat. Cancer"},{"key":"ref_65","unstructured":"Elm, L., and Levidou, G. (2025, January 12\u201315). Deciphering Molecular Alterations of the Hippo Signaling Pathway in Thymic Epithelial Tumors Using Immunohistochemistry. Proceedings of the Oral presentation at the the 3rd International Electronic Conference on Biomedicines, Online."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/13\/5938\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:55:44Z","timestamp":1760032544000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/13\/5938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,20]]},"references-count":65,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["ijms26135938"],"URL":"https:\/\/doi.org\/10.3390\/ijms26135938","relation":{},"ISSN":["1422-0067"],"issn-type":[{"type":"electronic","value":"1422-0067"}],"subject":[],"published":{"date-parts":[[2025,6,20]]}}}