{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:28:49Z","timestamp":1783556929432,"version":"3.55.0"},"reference-count":58,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,22]],"date-time":"2025-06-22T00:00:00Z","timestamp":1750550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University (IMSIU)","award":["IMSIU-DDRSP2501"],"award-info":[{"award-number":["IMSIU-DDRSP2501"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Endometriosis is a complex gynecological disorder characterized by the presence of endometrial-like tissue outside the uterus, leading to chronic pain and infertility. Immunohistochemistry (IHC) serves as a vital technique for elucidating the molecular and cellular differences between ectopic endometriotic tissues and eutopic endometrium. IHC reveals significant variations in the expression of inflammatory markers, adhesion molecules, and cell cycle regulators. This literature review compiles findings from various studies that assess the role of key proteins, such as leukemia inhibitory factor (LIF), cyclooxygenase-2 (COX-2), and b-cell lymphoma 2 (BCL-2), across different menstrual phases and lesion types. Notably, elevated LIF levels and increased mast cell activity in ectopic tissues underscore the inflammatory landscape of endometriosis. Additionally, altered expression of adhesion molecules like integrins and cluster of differentiation 44 (CD44) suggests modified cellular interactions, while apoptotic markers reveal a survival advantage for ectopic cells. These insights enhance our understanding of endometriosis pathophysiology.<\/jats:p>","DOI":"10.3390\/ijms26135998","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T09:08:44Z","timestamp":1750669724000},"page":"5998","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pathophysiology of Endometriosis: Insights from Immunohistochemical Analysis of Ectopic and Eutopic Tissues"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4237-9464","authenticated-orcid":false,"given":"Fahad T.","family":"Alotaibi","sequence":"first","affiliation":[{"name":"Department of Anatomy and Physiology, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cano-Herrera, G., Salmun Nehmad, S., Ruiz de Ch\u00e1vez Gasc\u00f3n, J., M\u00e9ndez Vionet, A., van Tienhoven, X.A., Osorio Mart\u00ednez, M.F., Muleiro Alvarez, M., Vasco Rivero, M.X., L\u00f3pez Torres, M.F., and Barroso Valverde, M.J. (2024). Endometriosis: A Comprehensive Analysis of the Pathophysiology, Treatment, and Nutritional Aspects, and Its Repercussions on the Quality of Life of Patients. Biomedicines, 12.","DOI":"10.3390\/biomedicines12071476"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100049","DOI":"10.1016\/j.jeud.2023.100049","article-title":"Immune and endocrine regulation in endometriosis: What we know","volume":"4","author":"Zhang","year":"2023","journal-title":"J. Endometr. Uterine Disord."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ochoa Bernal, M.A., and Fazleabas, A.T. (2024). The Known, the Unknown and the Future of the Pathophysiology of Endometriosis. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25115815"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Zutautas, K.B., Sisnett, D.J., Miller, J.E., Lingegowda, H., Childs, T., Bougie, O., Lessey, B.A., and Tayade, C. (2023). The dysregulation of leukemia inhibitory factor and its implications for endometriosis pathophysiology. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1089098"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.fertnstert.2004.03.059","article-title":"Cyclooxygenase-2 expression in deep endometriosis and matched eutopic endometrium","volume":"82","author":"Matsuzaki","year":"2004","journal-title":"Fertil. Steril."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Vergetaki, A., Jeschke, U., Vrekoussis, T., Taliouri, E., Sabatini, L., Papakonstanti, E.A., and Makrigiannakis, A. (2013). Differential expression of CRH, UCN, CRHR1 and CRHR2 in eutopic and ectopic endometrium of women with endometriosis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062313"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0015-0282(97)81909-7","article-title":"Localization of laminin, fibronectin, E-cadherin, and integrins in endometrium and endometriosis","volume":"67","author":"Donnez","year":"1997","journal-title":"Fertil. Steril."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Sancakli Usta, C., Turan, G., Bulbul, C.B., Usta, A., and Adali, E. (2020). Differential expression of Oct-4, CD44, and E-cadherin in eutopic and ectopic endometrium in ovarian endometriomas and their correlations with clinicopathological variables. Reprod. Biol. Endocrinol., 18.","DOI":"10.1186\/s12958-020-00673-1"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.115.137158","article-title":"Protein Inhibitor of Activated STAT3 (PIAS3) Is Down-Regulated in Eutopic Endometrium of Women with Endometriosis","volume":"95","author":"Yoo","year":"2016","journal-title":"Biol. Reprod."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Alotaibi, F.T., Peng, B., Klausen, C., Lee, A.F., Abdelkareem, A.O., Orr, N.L., Noga, H., Bedaiwy, M.A., and Yong, P.J. (2019). Plasminogen activator inhibitor-1 (PAI-1) expression in endometriosis. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0219064"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.tjog.2021.09.017","article-title":"The deep infiltrating endometriosis tissue has lower T-cadherin, E-cadherin, progesterone receptor and oestrogen receptor than endometrioma tissue","volume":"60","author":"Biyik","year":"2021","journal-title":"Taiwan J. Obstet. Gynecol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Sommar, A., Bahat, P.Y., \u00d6zaydin, I.Y., Bixo, M., B\u00e4ckstr\u00f6m, T., Oral, E., and Turkmen, S. (2025). Influence of endometrial nerve fibers and hormones on pain in women with endometriosis. Eur. J. Obstet. Gynecol. Reprod. Biol., 310.","DOI":"10.1016\/j.ejogrb.2025.113950"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0015-0282(01)03211-3","article-title":"Potential involvement of hemoglobin and heme in the pathogenesis of peritoneal endometriosis","volume":"77","author":"Dolmans","year":"2002","journal-title":"Fertil. Steril."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Honda, H., Barrueto, F.F., Gogusev, J., Im, D.D., and Morin, P.J. (2008). Serial analysis of gene expression reveals differential expression between endometriosis and normal endometrium. Possible roles for AXL and SHC1 in the pathogenesis of endometriosis. Reprod. Biol. Endocrinol., 6.","DOI":"10.1186\/1477-7827-6-59"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chu, L.H., Liao, C.C., Liew, P.L., Chen, C.W., Su, P.H., Wen, K.C., Lai, H.C., Huang, R.L., and Chen, L.Y. (2022). Epigenomic Analysis Reveals the KCNK9 Potassium Channel as a Potential Therapeutic Target for Adenomyosis. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23115973"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1177\/1744806917705564","article-title":"Local upregulation of transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 ion channels in rectosigmoid deep infiltrating endometriosis","volume":"13","author":"Bohonyi","year":"2017","journal-title":"Mol. Pain"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1007\/s43032-021-00508-3","article-title":"Histomorphological and Functional Features of the Eutopic Endometrium in Patients with Ovarian Endometriosis After Surgery-a Clinical Study","volume":"28","author":"Mikhaleva","year":"2021","journal-title":"Reprod. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Coroleuc\u0103, C.A., Coroleuc\u0103, C.B., Coroleuc\u0103, R., Br\u0103til\u0103, P.C., Nodi\u021bi, A.R., Ro\u0219ca, I., Br\u00eendu\u0219e, L.A., Br\u0103til\u0103, E., and Bo\u021b, M. (2025). Molecular Profile (Estrogen Receptor, Progesterone Receptor, Bcl-2 and Ki-67) of the Ectopic Endometrium in Patients with Endometriosis. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26072983"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5507\/bp.2020.006","article-title":"Comparative immunohistochemical study of deep infiltrating endometriosis, lymph node endometriosis and atypical ovarian endometriosis including description of a perineural invasion","volume":"165","author":"Lenz","year":"2021","journal-title":"Biomed. Pap. Med. Fac. Palacky Univ. Olomouc"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.fertnstert.2003.11.048","article-title":"Reduction of apoptosis and proliferation in endometriosis","volume":"82","author":"Foidart","year":"2004","journal-title":"Fertil. Steril."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/humrep\/dez082","article-title":"Melatonin activity and receptor expression in endometrial tissue and endometriosis","volume":"34","author":"Mosher","year":"2019","journal-title":"Hum. Reprod."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Matasariu, D.R., Bausic, A.I.G., Mandici, C.E., Bujor, I.E., Cristofor, A.E., Bratila, E., Lozneanu, L., Boiculese, L.V., Grigore, M., and Ursache, A. (2023). Effects of Progestin on Modulation of the Expression of Biomarkers in Endometriosis. Biomedicines, 11.","DOI":"10.3390\/biomedicines11072036"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Trapero, C., Vidal, A., Fern\u00e1ndez-Montol\u00ed, M.E., Coroleu, B., Tresserra, F., Barri, P., De Aranda, I.G., S\u00e9vigny, J., Ponce, J., and Matias-Guiu, X. (2019). Impaired Expression of Ectonucleotidases in Ectopic and Eutopic Endometrial Tissue Is in Favor of ATP Accumulation in the Tissue Microenvironment in Endometriosis. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20225532"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0015-0282(01)01670-3","article-title":"Xanthine oxidase in eutopic and ectopic endometrium in endometriosis and adenomyosis","volume":"75","author":"Ota","year":"2001","journal-title":"Fertil. Steril."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"100077","DOI":"10.1016\/j.jeud.2024.100077","article-title":"Metabolomic biomarkers of endometriosis: A systematic review","volume":"7","author":"Adamyan","year":"2024","journal-title":"J. Endometr. Uterine Disord."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-018-0008-5","article-title":"Endometriosis","volume":"4","author":"Zondervan","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.fertnstert.2006.03.057","article-title":"Pain, mast cells, and nerves in peritoneal, ovarian, and deep infiltrating endometriosis","volume":"86","author":"Anaf","year":"2006","journal-title":"Fertil. Steril."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.47162\/RJME.63.1.14","article-title":"Hormonal, apoptotic, proliferative and inflammatory markers\u2019 expression in Desogestrel-treated women with ovarian endometriosis","volume":"63","author":"Matasariu","year":"2022","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"480","DOI":"10.17826\/cumj.1247227","article-title":"Levels of oxidative stress and apoptosis-related biomarkers in endometriosis","volume":"48","author":"BAKIR","year":"2023","journal-title":"Cukurova Med. J."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Azam, I.N.A., Wahab, N.A., Mokhtar, M.H., Shafiee, M.N., and Mokhtar, N.M. (2022). Roles of microRNAs in Regulating Apoptosis in the Pathogenesis of Endometriosis. Life, 12.","DOI":"10.3390\/life12091321"},{"key":"ref_31","first-page":"1301","article-title":"The assessment of immunohistochemical profile of endometriosis implants, a practical method to appreciate the aggressiveness and recurrence risk of endometriosis","volume":"56","author":"Berceanu","year":"2015","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s00192-022-05335-x","article-title":"Ectopic endometriosis in the pelvic cavity evokes bladder hypersensitivity via transient receptor potential ankyrin 1 hyperexpression in rats","volume":"34","author":"Hayashi","year":"2023","journal-title":"Int. Urogynecol. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1146\/annurev-pharmtox-010919-023238","article-title":"TRP Channel Cooperation for Nociception: Therapeutic Opportunities","volume":"61","author":"Bamps","year":"2021","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/humrep\/dey332","article-title":"Iatrogenic endometriosis harbors somatic cancer-driver mutations","volume":"34","author":"Lac","year":"2019","journal-title":"Hum. Reprod."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Yoo, J.N., Shin, H., Kim, T.H., Choi, W.S., Ferguson, S.D., Fazleabas, A.T., Young, S.L., Lessey, B.A., Ha, U.H., and Jeong, J.W. (2014). CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0100481"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Sarsenova, M., Lawarde, A., Pathare, A.D.S., Saare, M., Modhukur, V., Soplepmann, P., Terasmaa, A., K\u00e4\u00e4mbre, T., Gemzell-Danielsson, K., and Lalitkumar, P.G.L. (2024). Endometriotic lesions exhibit distinct metabolic signature compared to paired eutopic endometrium at the single-cell level. Commun. Biol., 7.","DOI":"10.1038\/s42003-024-06713-5"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1016\/j.jmig.2021.03.011","article-title":"Gene Expression Signature of Endometrial Samples from Women with and without Endometriosis","volume":"28","author":"Adamyan","year":"2021","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1620\/tjem.243.141","article-title":"The Expression of Cyclophilin A in Ovarian Endometrioma: Its Correlation with Recurrence and Vascularity","volume":"243","author":"Usta","year":"2017","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"110375","DOI":"10.1016\/j.cellsig.2022.110375","article-title":"In Vitro modeling of endometriosis and endometriotic microenvironment\u2014Challenges and recent advances","volume":"97","author":"Olejnik","year":"2022","journal-title":"Cell Signal"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"9972","DOI":"10.1111\/jcmm.16835","article-title":"Histone deacetylase HDAC2 silencing prevents endometriosis by activating the HNF4A\/ARID1A axis","volume":"25","author":"Mai","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.fertnstert.2011.11.011","article-title":"Endometriosis-associated nerve fibers, peritoneal fluid cytokine concentrations, and pain in endometriotic lesions from different locations","volume":"97","author":"McKinnon","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.xfss.2024.10.001","article-title":"Tertiary lymphoid structures in endometriosis","volume":"5","author":"Zutautas","year":"2024","journal-title":"F&S Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/RD9.0000000000000120","article-title":"C5aR1+ Macrophages are Involved in the Progression of Endometriosis","volume":"9","author":"Chen","year":"2024","journal-title":"Reprod. Dev. Med."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Istrate-Ofi\u0163eru, A.M., Berbecaru, E.I.A., Zoril\u0103, G.L., Ro\u015fu, G.C., D\u00eer\u0103, L.M., Com\u0103nescu, C.M., Dr\u0103gu\u015fin, R.C., Ruican, D., Nagy, R.D., and Iliescu, D.G. (2022). Specific Local Predictors That Reflect the Tropism of Endometriosis-A Multiple Immunohistochemistry Technique. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23105614"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1007\/s43032-023-01190-3","article-title":"A Pilot Study on the Co-existence of Diabetes and Endometriosis in Reproductive-Age Women: Potential for Endometriosis Progression","volume":"30","author":"Alhallak","year":"2023","journal-title":"Reprod. Sci."},{"key":"ref_46","first-page":"1601","article-title":"MiRNA Expression Profiles in an Ectopic Endometrium of Patients at Different Stage of Endometriosis","volume":"76","author":"Spasova","year":"2023","journal-title":"Proc. Bulg. Acad. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1159\/000488838","article-title":"NR4A1 is Involved in Fibrogenesis in Ovarian Endometriosis","volume":"46","author":"Zeng","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4323259","DOI":"10.1155\/2022\/4323259","article-title":"Detection of Cannabinoid Receptor Expression by Endometriotic Lesions in Women with Endometriosis as an Alternative to Opioid-Based Pain Medication","volume":"2022","author":"Allam","year":"2022","journal-title":"J. Immunol. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1507\/endocrj.EJ13-0027","article-title":"Possible involvement of nerve growth factor in dysmenorrhea and dyspareunia associated with endometriosis","volume":"60","author":"Kajitani","year":"2013","journal-title":"Endocr. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"100074","DOI":"10.1016\/j.clinsp.2022.100074","article-title":"Expression of ezrin protein and phosphorylated ezrin in pelvic endometriotic lesions","volume":"77","author":"Peloggia","year":"2022","journal-title":"Clinics"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.fertnstert.2020.01.036","article-title":"Estrogen receptor-\u03b1 immunoreactivity predicts symptom severity and pain recurrence in deep endometriosis","volume":"113","author":"Pluchino","year":"2020","journal-title":"Fertil. Steril."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.fertnstert.2022.04.016","article-title":"Identification of lesional attributes of dysmenorrhea severity and the serum antim\u00fcllerian hormone levels in women with ovarian endometriomas","volume":"118","author":"Nie","year":"2022","journal-title":"Fertil. Steril."},{"key":"ref_53","first-page":"399","article-title":"Dysmenorrhea: Risk factors in women with endometriosis","volume":"4","author":"Liu","year":"2008","journal-title":"Women\u2019s Health"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/humrep\/deh054","article-title":"Analysis of cyclooxygenase-2 (COX-2) expression in different sites of endometriosis and correlation with clinico-pathological parameters","volume":"19","author":"Fagotti","year":"2004","journal-title":"Hum. Reprod."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/humrep\/deaa017","article-title":"Role of interleukin-1\u03b2 in nerve growth factor expression, neurogenesis and deep dyspareunia in endometriosis","volume":"35","author":"Peng","year":"2020","journal-title":"Hum. Reprod."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1007\/s43032-023-01181-4","article-title":"Genome-Wide Gene Expression Profiling Reveals the Direct Effect of Dienogest on Ovarian Endometriotic Stromal Cells","volume":"30","author":"Honda","year":"2023","journal-title":"Reprod. Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1210\/jc.2018-01227","article-title":"Progesterone Receptor Status Predicts Response to Progestin Therapy in Endometriosis","volume":"103","author":"Flores","year":"2018","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Koninckx, P.R., Fernandes, R., Ussia, A., Schindler, L., Wattiez, A., Al-Suwaidi, S., Amro, B., Al-Maamari, B., Hakim, Z., and Tahlak, M. (2021). Pathogenesis Based Diagnosis and Treatment of Endometriosis. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.745548"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/13\/5998\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:56:44Z","timestamp":1760032604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/13\/5998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,22]]},"references-count":58,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["ijms26135998"],"URL":"https:\/\/doi.org\/10.3390\/ijms26135998","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,22]]}}}