{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T01:17:56Z","timestamp":1788484676023,"version":"build-2803163510"},"reference-count":108,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T00:00:00Z","timestamp":1750636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sichuan Science and Technology Program","award":["2025HJRC0035"],"award-info":[{"award-number":["2025HJRC0035"]}]},{"name":"Sichuan Science and Technology Program","award":["2024NSFC0709"],"award-info":[{"award-number":["2024NSFC0709"]}]},{"name":"Sichuan Science and Technology Program","award":["s202410632129"],"award-info":[{"award-number":["s202410632129"]}]},{"name":"Sichuan Science and Technology Program","award":["2024LZXNYD021"],"award-info":[{"award-number":["2024LZXNYD021"]}]},{"name":"Sichuan Science and Technology Program","award":["2024LZXNYD014"],"award-info":[{"award-number":["2024LZXNYD014"]}]},{"name":"College Students\u2019 Innovation and Entrepreneurship Project of Sichuan Province","award":["2025HJRC0035"],"award-info":[{"award-number":["2025HJRC0035"]}]},{"name":"College Students\u2019 Innovation and Entrepreneurship Project of Sichuan Province","award":["2024NSFC0709"],"award-info":[{"award-number":["2024NSFC0709"]}]},{"name":"College Students\u2019 Innovation and Entrepreneurship Project of Sichuan Province","award":["s202410632129"],"award-info":[{"award-number":["s202410632129"]}]},{"name":"College Students\u2019 Innovation and Entrepreneurship Project of Sichuan Province","award":["2024LZXNYD021"],"award-info":[{"award-number":["2024LZXNYD021"]}]},{"name":"College Students\u2019 Innovation and Entrepreneurship Project of Sichuan Province","award":["2024LZXNYD014"],"award-info":[{"award-number":["2024LZXNYD014"]}]},{"name":"Science and Technology Strategic Cooperation Programs of Luzhou Municipal People\u2019s Government and Southwest Medical University","award":["2025HJRC0035"],"award-info":[{"award-number":["2025HJRC0035"]}]},{"name":"Science and Technology Strategic Cooperation Programs of Luzhou Municipal People\u2019s Government and Southwest Medical University","award":["2024NSFC0709"],"award-info":[{"award-number":["2024NSFC0709"]}]},{"name":"Science and Technology Strategic Cooperation Programs of Luzhou Municipal People\u2019s Government and Southwest Medical University","award":["s202410632129"],"award-info":[{"award-number":["s202410632129"]}]},{"name":"Science and Technology Strategic Cooperation Programs of Luzhou Municipal People\u2019s Government and Southwest Medical University","award":["2024LZXNYD021"],"award-info":[{"award-number":["2024LZXNYD021"]}]},{"name":"Science and Technology Strategic Cooperation Programs of Luzhou Municipal People\u2019s Government and Southwest Medical University","award":["2024LZXNYD014"],"award-info":[{"award-number":["2024LZXNYD014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Growing evidence underscores the pivotal roles of both in situ-resident and -non-resident cardiac cells in the repair mechanisms following myocardial infarction (MI). MI continues to be a predominant cause of death and disability, posing a significant threat to global health and well-being. Despite advances in medical care, current therapies remain insufficient in preventing ventricular remodeling and heart failure post-MI. We seek to clarify the underlying regenerative mechanisms by which distinct cell types contribute to the repair of MI injury and to systematically assess the translational potential and therapeutic efficacy of these cell-based approaches in clinical applications. This review conducts a comprehensive analysis of recent research progress on the roles of non-cardiac stem cells in situ and cardiac cells derived from explants in MI repair. These cells contribute to the repair process through multiple mechanisms, including cell proliferation and differentiation, angiogenesis, paracrine signaling, immune regulation and fibrosis modulation. Our analysis reveals the intricate mechanisms of MI repair and highlights the necessity for developing age-specific therapeutic strategies for certain cell types. This review offers novel insights into cell-based treatment for MI and provides a scientific foundation for future clinical trials of cardiac regenerative medicine.<\/jats:p>","DOI":"10.3390\/ijms26136002","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T09:08:44Z","timestamp":1750669724000},"page":"6002","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unraveling the Complex Cellular Repair Mechanisms Following Myocardial Infarction"],"prefix":"10.3390","volume":"26","author":[{"given":"Ruiling","family":"Chen","sequence":"first","affiliation":[{"name":"The Key Laboratory of Medical Electrophysiology of Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China"},{"name":"Clinical Medical College, Southwest Medical University, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalin","family":"Fu","sequence":"additional","affiliation":[{"name":"Clinical Medical College, Southwest Medical University, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Hu","sequence":"additional","affiliation":[{"name":"Clinical Medical College, Southwest Medical University, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Public Health, Southwest Medical University, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5757-2956","authenticated-orcid":false,"given":"Pengyun","family":"Li","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Medical Electrophysiology of Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou 646000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Global Cardiovascular Risk Consortium (2023). 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