{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T17:35:01Z","timestamp":1784396101646,"version":"3.55.0"},"reference-count":164,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science development fund of the Warsaw University of Life Sciences\u2014SGGW"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Duchenne muscular dystrophy (DMD) manifests as a hereditary condition that diminishes muscular strength through the progressive degeneration of structural muscle tissue, which is brought about by deficiencies in the dystrophin protein required for the integrity of muscle cells. DMD is among four different types of dystrophinopathy disorders. Current studies have established that long non-coding RNAs (lncRNAs) play a significant role in determining the trajectory and overall prognosis of chronic musculoskeletal conditions. LncRNAs are different in terms of their lengths, production mechanisms, and operational modes, but they do not produce proteins, as their primary activity is the regulation of gene expression. This research synthesizes current literature on the role of lncRNAs in the regulation of myogenesis with a specific focus on certain lncRNAs leading to DMD increments or suppressing muscle biological functions. LncRNAs modulate skeletal myogenesis gene expression, yet pathological lncRNA function is linked to various muscular diseases. Some lncRNAs directly control genes or indirectly control miRNAs with positive or negative effects on muscle cells or the development of DMD. The research findings have significantly advanced our knowledge about the regulatory function of lncRNAs on muscle growth and regeneration processes and DMD diseases.<\/jats:p>","DOI":"10.3390\/ijms26136032","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T06:49:38Z","timestamp":1750747778000},"page":"6032","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Exploring lncRNA-Mediated Mechanisms in Muscle Regulation and Their Implications for Duchenne Muscular Dystrophy"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6282-9103","authenticated-orcid":false,"given":"Abdolvahab Ebrahimpour","family":"Gorji","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-787 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3357-3126","authenticated-orcid":false,"given":"Zahra","family":"Roudbari","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Agriculture, University of Jiroft, Jiroft 78671-55311, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasra","family":"Ahmadian","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad 91779-48974, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8966-6081","authenticated-orcid":false,"given":"Vahid","family":"Razban","sequence":"additional","affiliation":[{"name":"Agri-Food and Biosciences Institute, Belfast BT9 5PX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5401-0541","authenticated-orcid":false,"given":"Masoud","family":"Shirali","sequence":"additional","affiliation":[{"name":"Agri-Food and Biosciences Institute, Belfast BT9 5PX, UK"},{"name":"School of Biological Sciences, Queen\u2019s University Belfast, Belfast BT9 5DL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Hasanpur","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Faculty of Agriculture, University of Tabriz, Tabriz 51666-16471, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9175-7110","authenticated-orcid":false,"given":"Tomasz","family":"Sadkowski","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, 02-787 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6244","DOI":"10.1038\/ncomms7244","article-title":"Multiplex CRISPR\/Cas9-Based Genome Editing for Correction of Dystrophin Mutations That Cause Duchenne Muscular Dystrophy","volume":"6","author":"Ousterout","year":"2015","journal-title":"Nat. Commun."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e5546843","DOI":"10.1155\/2021\/5546843","article-title":"Dietary Beta-Hydroxy Beta-Methyl Butyrate Supplementation Alleviates Liver Injury in Lipopolysaccharide-Challenged Piglets","volume":"2021","author":"Duan","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/S0140-6736(19)32910-1","article-title":"Muscular Dystrophies","volume":"394","author":"Mercuri","year":"2019","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/hgtb.2018.187","article-title":"Development of CRISPR-Mediated Systems in the Study of Duchenne Muscular Dystrophy","volume":"30","author":"Cai","year":"2019","journal-title":"Hum. Gene Ther. Methods"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s13023-020-01430-8","article-title":"Global Epidemiology of Duchenne Muscular Dystrophy: An Updated Systematic Review and Meta-Analysis","volume":"15","author":"Crisafulli","year":"2020","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/s41580-021-00389-z","article-title":"Molecular and Cellular Basis of Genetically Inherited Skeletal Muscle Disorders","volume":"22","author":"Dowling","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/j.1365-2796.2009.02158.x","article-title":"Skeletal Muscle Stem Cells in Developmental versus Regenerative Myogenesis","volume":"266","author":"Tajbakhsh","year":"2009","journal-title":"J. Intern. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.vph.2018.10.001","article-title":"Role of Flow-Sensitive microRNAs and Long Noncoding RNAs in Vascular Dysfunction and Atherosclerosis","volume":"114","author":"Kumar","year":"2019","journal-title":"Vasc. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/j.clnu.2017.09.011","article-title":"Potential Therapeutic Impact of Omega-3 Long Chain-Polyunsaturated Fatty Acids on Inflammation Markers in Duchenne Muscular Dystrophy: A Double-Blind, Controlled Randomized Trial","volume":"37","author":"Huicochea","year":"2018","journal-title":"Clin. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Cheng, J.-T., Wang, L., Wang, H., Tang, F.-R., Cai, W.-Q., Sethi, G., Xin, H.-W., and Ma, Z. (2019). Insights into Biological Role of LncRNAs in Epithelial-Mesenchymal Transition. Cells, 8.","DOI":"10.3390\/cells8101178"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Martone, J., Mariani, D., Desideri, F., and Ballarino, M. (2019). Non-Coding RNAs Shaping Muscle. Front. Cell Dev. Biol., 7.","DOI":"10.3389\/fcell.2019.00394"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrg3074","article-title":"Non-Coding RNAs in Human Disease","volume":"12","author":"Esteller","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"R17","DOI":"10.1093\/hmg\/ddl046","article-title":"Non-Coding RNA","volume":"15","author":"Mattick","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1101\/gr.132159.111","article-title":"The GENCODE v7 Catalog of Human Long Noncoding RNAs: Analysis of Their Gene Structure, Evolution, and Expression","volume":"22","author":"Derrien","year":"2012","journal-title":"Genome Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1113\/EP087564","article-title":"Regular Aerobic Exercise-Ameliorated Troponin I Carbonylation to Mitigate Aged Rat Soleus Muscle Functional Recession","volume":"104","author":"Liu","year":"2019","journal-title":"Exp. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"102232","DOI":"10.1016\/j.isci.2021.102232","article-title":"RNA Expression Profiles and Regulatory Networks in Human Right Ventricular Hypertrophy Due to High Pressure Load","volume":"24","author":"Chouvarine","year":"2021","journal-title":"iScience"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.molcel.2013.08.027","article-title":"The Imprinted H19 lncRNA Antagonizes Let-7 microRNAs","volume":"52","author":"Kallen","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.molcel.2013.07.022","article-title":"eRNAs Promote Transcription by Establishing Chromatin Accessibility at Defined Genomic Loci","volume":"51","author":"Mousavi","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"D135","DOI":"10.1093\/nar\/gky1031","article-title":"LNCipedia 5: Towards a Reference Set of Human Long Non-Coding RNAs","volume":"47","author":"Volders","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41419-020-2570-5","article-title":"The Micropeptide LEMP Plays an Evolutionarily Conserved Role in Myogenesis","volume":"11","author":"Wang","year":"2020","journal-title":"Cell Death Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5847","DOI":"10.1038\/s41467-020-19554-7","article-title":"Long Non-Coding RNA Gm15441 Attenuates Hepatic Inflammasome Activation in Response to PPARA Agonism and Fasting","volume":"11","author":"Brocker","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Xin, M., Guo, Q., Lu, Q., Lu, J., Wang, P.-S., Dong, Y., Li, T., Chen, Y., Gerhard, G.S., and Yang, X.-F. (2021). Identification of Gm15441, a Txnip Antisense lncRNA, as a Critical Regulator in Liver Metabolic Homeostasis. Cell Biosci., 11.","DOI":"10.1186\/s13578-021-00722-1"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.biocel.2018.08.013","article-title":"Dynamic Transcriptome Profile in Db\/Db Skeletal Muscle Reveal Critical Roles for Long Noncoding RNA Regulator","volume":"104","author":"Zhang","year":"2018","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Arvaniti, E., Moulos, P., Vakrakou, A., Chatziantoniou, C., Chadjichristos, C., Kavvadas, P., Charonis, A., and Politis, P.K. (2016). Whole-Transcriptome Analysis of UUO Mouse Model of Renal Fibrosis Reveals New Molecular Players in Kidney Diseases. Sci. Rep., 6.","DOI":"10.1038\/srep26235"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e13747","DOI":"10.1002\/jcsm.13747","article-title":"Functions and Therapeutic Potentials of Long Noncoding RNA in Skeletal Muscle Atrophy and Dystrophy","volume":"16","author":"Zhang","year":"2025","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Ling, Y., Zheng, Q., Sui, M., Zhu, L., Xu, L., Zhang, Y., Liu, Y., Fang, F., Chu, M., and Ma, Y. (2019). Comprehensive Analysis of LncRNA Reveals the Temporal-Specific Module of Goat Skeletal Muscle Development. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20163950"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1261\/rna.073692.119","article-title":"Ppp1r1b-lncRNA Inhibits PRC2 at Myogenic Regulatory Genes to Promote Cardiac and Skeletal Muscle Development in Mouse and Human","volume":"26","author":"Kang","year":"2020","journal-title":"Rna"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12986-021-00634-4","article-title":"The Role and Possible Mechanism of the Long Noncoding RNA LINC01260 in Nonalcoholic Fatty Liver Disease","volume":"19","author":"Ge","year":"2022","journal-title":"Nutr. Metab."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1172\/JCI32054","article-title":"A Foxo\/Notch Pathway Controls Myogenic Differentiation and Fiber Type Specification","volume":"117","author":"Kitamura","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.bone.2011.06.034","article-title":"FoxO1, the Transcriptional Chief of Staff of Energy Metabolism","volume":"50","author":"Kousteni","year":"2012","journal-title":"Bone"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00018-008-8465-8","article-title":"The Role of the ZEB Family of Transcription Factors in Development and Disease","volume":"66","author":"Vandewalle","year":"2009","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1097\/MPG.0b013e3181d98e85","article-title":"Effects of Zinc Exposure on Zinc Transporter Expression in Human Intestinal Cells of Varying Maturity","volume":"50","author":"Jou","year":"2010","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"109697","DOI":"10.1016\/j.cellsig.2020.109697","article-title":"Silence of lncRNA MIAT-Mediated Inhibition of DLG3 Promoter Methylation Suppresses Breast Cancer Progression via the Hippo Signaling Pathway","volume":"73","author":"Li","year":"2020","journal-title":"Cell. Signal."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.kint.2019.02.020","article-title":"Aberrant DNA Methylation of mTOR Pathway Genes Promotes Inflammatory Activation of Immune Cells in Diabetic Kidney Disease","volume":"96","author":"Chen","year":"2019","journal-title":"Kidney Int."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Yang, M., and Wang, L.I. (2021). MALAT1 Knockdown Protects from Bronchial\/Tracheal Smooth Muscle Cell Injury via Regulation of microRNA-133a\/Ryanodine Receptor 2 Axis. J. Biosci., 46.","DOI":"10.1007\/s12038-021-00149-3"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13619-022-00114-x","article-title":"Myogenesis Controlled by a Long Non-Coding RNA 1700113A16RIK and Post-Transcriptional Regulation","volume":"11","author":"Fu","year":"2022","journal-title":"Cell Regen."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.2527\/jas2016.1297","article-title":"LncRNA Profiling of Skeletal Muscles in Large White Pigs and Mashen Pigs during Development","volume":"95","author":"Gao","year":"2017","journal-title":"J. Anim. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1101\/gad.234419.113","article-title":"The H19 Long Noncoding RNA Gives Rise to microRNAs miR-675-3p and miR-675-5p to Promote Skeletal Muscle Differentiation and Regeneration","volume":"28","author":"Dey","year":"2014","journal-title":"Genes Dev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.2337\/db18-0370","article-title":"H19 lncRNA Promotes Skeletal Muscle Insulin Sensitivity in Part by Targeting AMPK","volume":"67","author":"Geng","year":"2018","journal-title":"Diabetes"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Padilla, C., Dom\u00ednguez, J.N., Ar\u00e1nega, A.E., and Franco, D. (2019). Differential Chamber-Specific Expression and Regulation of Long Non-Coding RNAs during Cardiac Development. Biochim. Biophys. Acta Gene Regul. Mech., 1862.","DOI":"10.1016\/j.bbagrm.2019.194435"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1038\/ng.2772","article-title":"BMP Signaling Controls Muscle Mass","volume":"45","author":"Sartori","year":"2013","journal-title":"Nat. Genet."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1083\/jcb.201211134","article-title":"The Bone Morphogenetic Protein Axis Is a Positive Regulator of Skeletal Muscle Mass","volume":"203","author":"Winbanks","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1083\/jcb.201612100","article-title":"lncRNA Chronos Is an Aging-Induced Inhibitor of Muscle Hypertrophy","volume":"216","author":"Neppl","year":"2017","journal-title":"J. Cell Biol."},{"key":"ref_44","first-page":"4038","article-title":"Dach2-Hdac9 Signaling Regulates Reinnervation of Muscle Endplates","volume":"142","author":"Macpherson","year":"2015","journal-title":"Development"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/jcsm.12281","article-title":"A Newly Identified lncRNA MAR1 Acts as a miR-487b Sponge to Promote Skeletal Muscle Differentiation and Regeneration","volume":"9","author":"Zhang","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1002\/jcsm.13012","article-title":"Conservative Analysis of Synaptopodin-2 Intron Sense-Overlapping lncRNA Reveals Its Novel Function in Promoting Muscle Atrophy","volume":"13","author":"Jin","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Zhang, P., Du, J., Guo, X., Wu, S., He, J., Li, X., Shen, L., Chen, L., Li, B., and Zhang, J. (2021). LncMyoD Promotes Skeletal Myogenesis and Regulates Skeletal Muscle Fiber-Type Composition by Sponging miR-370-3p. Genes, 12.","DOI":"10.3390\/genes12040589"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/cr.2015.21","article-title":"LncRNA Dum Interacts with Dnmts to Regulate Dppa2 Expression during Myogenic Differentiation and Muscle Regeneration","volume":"25","author":"Wang","year":"2015","journal-title":"Cell Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41420-021-00463-7","article-title":"LncRNA-FKBP1C Regulates Muscle Fiber Type Switching by Affecting the Stability of MYH1B","volume":"7","author":"Yu","year":"2021","journal-title":"Cell Death Discov."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Wang, S., Jin, J., Xu, Z., and Zuo, B. (2019). Functions and Regulatory Mechanisms of lncRNAs in Skeletal Myogenesis, Muscle Disease and Meat Production. Cells, 8.","DOI":"10.3390\/cells8091107"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2217\/epi-2017-0176","article-title":"Uncovering Novel Landscape of Cardiovascular Diseases and Therapeutic Targets for Cardioprotection via Long Noncoding RNA-miRNA-mRNA Axes","volume":"10","author":"He","year":"2018","journal-title":"Epigenomics"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"E9802","DOI":"10.1073\/pnas.1801471115","article-title":"Long Noncoding RNA SYISL Regulates Myogenesis by Interacting with Polycomb Repressive Complex 2","volume":"115","author":"Jin","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.devcel.2015.05.009","article-title":"A Long Non-Coding RNA, LncMyoD, Regulates Skeletal Muscle Differentiation by Blocking IMP2-Mediated mRNA Translation","volume":"34","author":"Gong","year":"2015","journal-title":"Dev. Cell"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.ymthe.2020.12.002","article-title":"Inhibition of lncRNA MAAT Controls Multiple Types of Muscle Atrophy by Cis- and Trans-Regulatory Actions","volume":"29","author":"Li","year":"2021","journal-title":"Mol. Ther. J. Am. Soc. Gene Ther."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.1007\/s00394-021-02598-w","article-title":"Magnesium Supplementation Alleviates Corticosteroid-Associated Muscle Atrophy in Rats","volume":"60","author":"Zheng","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrg2521","article-title":"Long Non-Coding RNAs: Insights into Functions","volume":"10","author":"Mercer","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e49485","DOI":"10.7554\/eLife.49485","article-title":"The Mammalian LINC Complex Component SUN1 Regulates Muscle Regeneration by Modulating Drosha Activity","volume":"8","author":"Loo","year":"2019","journal-title":"eLife"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.omtn.2020.09.037","article-title":"miR-324-5p Inhibits C2C12 Cell Differentiation and Promotes Intramuscular Lipid Deposition through lncDUM and PM20D1","volume":"22","author":"Liu","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.ajem.2018.06.008","article-title":"Circulating lncRNA NEAT1 Correlates with Increased Risk, Elevated Severity and Unfavorable Prognosis in Sepsis Patients","volume":"36","author":"Huang","year":"2018","journal-title":"Am. J. Emerg. Med."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Bovolenta, M., Erriquez, D., Valli, E., Brioschi, S., Scotton, C., Neri, M., Falzarano, M.S., Gherardi, S., Fabris, M., and Rimessi, P. (2012). The DMD Locus Harbours Multiple Long Non-Coding RNAs Which Orchestrate and Control Transcription of Muscle Dystrophin mRNA Isoforms. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0045328"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s12539-020-00388-2","article-title":"Comprehensive Analysis of Long Non-Coding RNA-Associated Competing Endogenous RNA Network in Duchenne Muscular Dystrophy","volume":"12","author":"Xu","year":"2020","journal-title":"Interdiscip. Sci. Comput. Life Sci."},{"key":"ref_62","first-page":"639","article-title":"Role of Dystrophin Isoforms and Associated Proteins in Muscular Dystrophy (Review)","volume":"2","author":"Culligan","year":"1998","journal-title":"Int. J. Mol. Med."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Gargaun, E., Falcone, S., Sol\u00e9, G., Durigneux, J., Urtizberea, A., Cuisset, J.M., Benkhelifa-Ziyyat, S., Julien, L., Boland, A., and Sandron, F. (2021). The lncRNA 44s2 Study Applicability to the Design of 45-55 Exon Skipping Therapeutic Strategy for DMD. Biomedicines, 9.","DOI":"10.3390\/biomedicines9020219"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Shen, Y., Kim, I.-M., Hamrick, M., and Tang, Y. (2023). Uncovering the Gene Regulatory Network of Endothelial Cells in Mouse Duchenne Muscular Dystrophy: Insights from Single-Nuclei RNA Sequencing Analysis. Biology, 12.","DOI":"10.3390\/biology12030422"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"5334","DOI":"10.18632\/aging.102105","article-title":"Down-Regulation of Long Non-Coding RNA MEG3 Suppresses Osteogenic Differentiation of Periodontal Ligament Stem Cells (PDLSCs) through miR-27a-3p\/IGF1 Axis in Periodontitis","volume":"11","author":"Liu","year":"2019","journal-title":"Aging"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1113\/expphysiol.2008.042838","article-title":"Insulin-like Growth Factor-I Analogue Protects Muscles of Dystrophic Mdx Mice from Contraction-Mediated Damage","volume":"93","author":"Gehrig","year":"2008","journal-title":"Exp. Physiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.7150\/ijbs.58910","article-title":"Long Non-Coding RNA MEG3 Promotes Cisplatin-Induced Nephrotoxicity through Regulating AKT\/TSC\/mTOR-Mediated Autophagy","volume":"17","author":"Jing","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1016\/j.yexcr.2006.04.024","article-title":"Hypertrophic Response of Duchenne and Limb-Girdle Muscular Dystrophies Is Associated with Activation of Akt Pathway","volume":"312","author":"Peter","year":"2006","journal-title":"Exp. Cell Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11010-019-03681-x","article-title":"LncRNA MEG3 Inhibits the Inflammatory Response of Ankylosing Spondylitis by Targeting miR-146a","volume":"466","author":"Li","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"ref_70","first-page":"16","article-title":"Activation of NF-kB Pathway in Duchenne Muscular Dystrophy: Relation to Age","volume":"30","author":"Messina","year":"2011","journal-title":"Acta Myol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.biopha.2017.02.041","article-title":"lncRNA MEG3 Had Anti-Cancer Effects to Suppress Pancreatic Cancer Activity","volume":"89","author":"Gu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"A997","DOI":"10.1016\/S0735-1097(15)60997-4","article-title":"Elevated St2 Serum Levels A Biomarker for Cardiomyopathy in Duchenne Muscular Dystrophy","volume":"65","author":"Anderson","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_73","first-page":"2337","article-title":"LncRNA MEG3 Overexpression Inhibits the Development of Diabetic Retinopathy by Regulating TGF-\u03921 and VEGF","volume":"16","author":"Zhang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1097\/00001756-200012180-00026","article-title":"Elevated Plasma Levels of Transforming Growth Factor \u03921 in Patients with Muscular Dystrophy","volume":"11","author":"Ishitobi","year":"2000","journal-title":"NeuroReport"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1530\/JME-12-0008","article-title":"MEG3 Noncoding RNA: A Tumor Suppressor","volume":"48","author":"Zhou","year":"2012","journal-title":"J. Mol. Endocrinol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.braindev.2008.09.008","article-title":"Serum Levels of Vascular Endothelial Growth Factor Elevated in Patients with Muscular Dystrophy","volume":"31","author":"Saito","year":"2009","journal-title":"Brain Dev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/jcb.25004","article-title":"Down-Regulated Long Non-Coding RNA MEG3 and Its Effect on Promoting Apoptosis and Suppressing Migration of Trophoblast Cells","volume":"116","author":"Zhang","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s11596-015-1467-5","article-title":"Long Non-Coding RNA MEG3 Induces Renal Cell Carcinoma Cells Apoptosis by Activating the Mitochondrial Pathway","volume":"35","author":"Wang","year":"2015","journal-title":"J. Huazhong Univ. Sci. Technol. Med. Sci."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"E10849","DOI":"10.1073\/pnas.1803377115","article-title":"microRNA-378 Promotes Autophagy and Inhibits Apoptosis in Skeletal Muscle","volume":"115","author":"Li","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbrc.2015.11.048","article-title":"Upregulation of lncRNA MEG3 Promotes Hepatic Insulin Resistance via Increasing FoxO1 Expression","volume":"469","author":"Zhu","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.placenta.2016.12.023","article-title":"dNK Derived IFN-\u03b3 Mediates VSMC Migration and Apoptosis via the Induction of LncRNA MEG3: A Role in Uterovascular Transformation","volume":"50","author":"Liu","year":"2017","journal-title":"Placenta"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00401-004-0941-0","article-title":"Increased mRNA Expression of Tissue Inhibitors of Metalloproteinase-1 and -2 in Duchenne Muscular Dystrophy","volume":"109","author":"Zwirner","year":"2005","journal-title":"Acta Neuropathol."},{"key":"ref_83","first-page":"1091","article-title":"Crosstalk between Meg3 and miR-1297 Regulates Growth of Testicular Germ Cell Tumor through PTEN\/PI3K\/AKT Pathway","volume":"8","author":"Yang","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ymthe.2020.09.029","article-title":"PTEN Inhibition Ameliorates Muscle Degeneration and Improves Muscle Function in a Mouse Model of Duchenne Muscular Dystrophy","volume":"29","author":"Yue","year":"2021","journal-title":"Mol. Ther."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"11200","DOI":"10.1002\/jcp.27770","article-title":"Long Noncoding RNA NEAT1 Accelerates the Proliferation and Fibrosis in Diabetic Nephropathy through Activating Akt\/mTOR Signaling Pathway","volume":"234","author":"Huang","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"15585","DOI":"10.1002\/jcb.28825","article-title":"NEAT1 Promotes Retinoblastoma Progression via Modulating miR-124","volume":"120","author":"Wang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_87","first-page":"8483","article-title":"LncRNA NEAT1 Regulates Pulmonary Fibrosis through miR-9-5p and TGF-\u03b2 Signaling Pathway","volume":"24","author":"Zhang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1083\/jcb.151.6.1321","article-title":"Expression Profiling in the Muscular Dystrophies","volume":"151","author":"Chen","year":"2000","journal-title":"J. Cell Biol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cbi.2019.04.017","article-title":"Long Non-Coding RNA-P21 Regulates MPP+-Induced Neuronal Injury by Targeting miR-625 and Derepressing TRPM2 in SH-SY5Y Cells","volume":"307","author":"Ding","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.atherosclerosis.2018.08.031","article-title":"Long Non-Coding RNA Nuclear-Enriched Abundant Transcript 1 Inhibition Blunts Myocardial Ischemia Reperfusion Injury via Autophagic Flux Arrest and Apoptosis in Streptozotocin-Induced Diabetic Rats","volume":"277","author":"Ma","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1530\/JME-18-0098","article-title":"LncRNA NEAT1 Promotes Inflammatory Response and Induces Corneal Neovascularization","volume":"61","author":"Bai","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/s41467-019-09482-6","article-title":"The lncRNA Neat1 Promotes Activation of Inflammasomes in Macrophages","volume":"10","author":"Zhang","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"8578","DOI":"10.1002\/jcp.26524","article-title":"NEAT1 Upregulates TGF-\u03921 to Induce Hepatocellular Carcinoma Progression by Sponging Hsa-Mir-139-5p","volume":"233","author":"Tu","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Chang, S., Chen, B., Wang, X., Wu, K., and Sun, Y. (2017). Long Non-Coding RNA XIST Regulates PTEN Expression by Sponging miR-181a and Promotes Hepatocellular Carcinoma Progression. BMC Cancer, 17.","DOI":"10.1186\/s12885-017-3216-6"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"F1350","DOI":"10.1152\/ajprenal.00254.2019","article-title":"Silencing of Long Noncoding RNA XIST Protects against Renal Interstitial Fibrosis in Diabetic Nephropathy via microRNA-93-5p-Mediated Inhibition of CDKN1A","volume":"317","author":"Yang","year":"2019","journal-title":"Am. J. Physiol.-Ren. Physiol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Sun, J., and Zhang, Y. (2019). LncRNA XIST Enhanced TGF-\u03922 Expression by Targeting miR-141-3p to Promote Pancreatic Cancer Cells Invasion. Biosci. Rep., 39.","DOI":"10.1042\/BSR20190332"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/(SICI)1097-0177(199702)208:2<278::AID-AJA14>3.0.CO;2-#","article-title":"Cellular Localisation of Transforming Growth Factor-Beta 2 and -Beta 3 (TGF-Beta2, TGF-Beta3) in Damaged and Regenerating Skeletal Muscles","volume":"208","author":"McLennan","year":"1997","journal-title":"Dev. Dyn."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"17584","DOI":"10.1002\/jcb.29025","article-title":"Overexpression of Long Noncoding RNA Malat1 Ameliorates Traumatic Brain Injury Induced Brain Edema by Inhibiting AQP4 and the NF-\u03baB\/IL-6 Pathway","volume":"120","author":"Zhang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.prp.2004.01.011","article-title":"Reduced Expression of Aquaporin 4 in Human Muscles with Amyotrophic Lateral Sclerosis and Other Neurogenic Atrophies","volume":"200","author":"Jimi","year":"2004","journal-title":"Pathol. Res. Pract."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"e2123","DOI":"10.1038\/cddis.2015.407","article-title":"Tumor-Suppressive Function of Long Noncoding RNA MALAT1 in Glioma Cells by Downregulation of MMP2 and Inactivation of ERK\/MAPK Signaling","volume":"7","author":"Han","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.3892\/ijmm.2016.2755","article-title":"Quercetin Promotes the Apoptosis of Fibroblast-like Synoviocytes in Rheumatoid Arthritis by Upregulating lncRNA MALAT1","volume":"38","author":"Pan","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"806","DOI":"10.4161\/cbt.28584","article-title":"MALAT1 Promotes the Proliferation and Metastasis of Gallbladder Cancer Cells by Activating the ERK\/MAPK Pathway","volume":"15","author":"Wu","year":"2014","journal-title":"Cancer Biol. Ther."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1080\/15384101.2020.1829799","article-title":"LncRNA MALAT1 Facilitates BM-MSCs Differentiation into Endothelial Cells via Targeting miR-206\/VEGFA Axis","volume":"19","author":"Sun","year":"2020","journal-title":"Cell Cycle"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1161\/01.ATV.0000118683.99628.42","article-title":"Absence of Dystrophin in Mice Reduces NO-Dependent Vascular Function and Vascular Density: Total Recovery after a Treatment with the Aminoglycoside Gentamicin","volume":"24","author":"Loufrani","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bbrc.2018.04.116","article-title":"Inhibition of MALAT1 Sensitizes Liver Cancer Cells to 5-Flurouracil by Regulating Apoptosis through IKK\u03b1\/NF-\u03baB Pathway","volume":"501","author":"Ji","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1016\/j.neurobiolaging.2010.01.008","article-title":"Telomere Shortening Is Associated to TRF1 and PARP1 Overexpression in Duchenne Muscular Dystrophy","volume":"32","author":"Aguennouz","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"ref_107","first-page":"221","article-title":"MIR31HG Promotes Cell Proliferation and Invasion by Activating the Wnt\/\u03b2-Catenin Signaling Pathway in Non-Small Cell Lung Cancer","volume":"17","author":"Zheng","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.2353\/ajpath.2009.080460","article-title":"PTEN Contributes to Profound PI3K\/Akt Signaling Pathway Deregulation in Dystrophin-Deficient Dog Muscle","volume":"174","author":"Feron","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"24071","DOI":"10.18632\/aging.203644","article-title":"LncRNA MIR31HG Is Induced by Tocilizumab and Ameliorates Rheumatoid Arthritis Fibroblast-like Synoviocyte-Mediated Inflammation via miR-214-PTEN-AKT Signaling Pathway","volume":"13","author":"Cao","year":"2021","journal-title":"Aging"},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Wu, Y., Jiang, Y., Liu, Q., and Liu, C.-Z. (2019). lncRNA H19 Promotes Matrix Mineralization through Up-Regulating IGF1 by Sponging miR-185-5p in Osteoblasts. BMC Mol. Cell Biol., 20.","DOI":"10.1186\/s12860-019-0230-3"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2147\/JAA.S316250","article-title":"Muc5ac Production Inhibited by Decreased lncRNA H19 via PI3K\/Akt\/NF-kB in Asthma","volume":"14","author":"Chen","year":"2021","journal-title":"J. Asthma Allergy"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"106470","DOI":"10.1016\/j.intimp.2020.106470","article-title":"LncRNA-H19 Induces Hepatic Stellate Cell Activation via Upregulating Alcohol Dehydrogenase III-Mediated Retinoic Acid Signals","volume":"84","author":"Wang","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13287-018-0861-x","article-title":"Long Noncoding RNA H19 Upregulates Vascular Endothelial Growth Factor A to Enhance Mesenchymal Stem Cells Survival and Angiogenic Capacity by Inhibiting miR-199a-5p","volume":"9","author":"Hou","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3892\/mmr.2021.12512","article-title":"Knockdown of lncRNA MEG8 Inhibits Cell Proliferation and Invasion, but Promotes Cell Apoptosis in Hemangioma, via miR-203-induced Mediation of the Notch Signaling Pathway","volume":"24","author":"Hu","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2015.10.049","article-title":"Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype","volume":"163","author":"Vieira","year":"2015","journal-title":"Cell"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s10571-020-00904-4","article-title":"LncRNA MEG8 Attenuates Cerebral Ischemia After Ischemic Stroke Through Targeting miR-130a-5p\/VEGFA Signaling","volume":"41","author":"Sui","year":"2021","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.cell.2012.03.035","article-title":"A Long ncRNA Links Copy Number Variation to a Polycomb\/Trithorax Epigenetic Switch in FSHD Muscular Dystrophy","volume":"149","author":"Cabianca","year":"2012","journal-title":"Cell"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"5026","DOI":"10.1038\/s41467-018-07313-8","article-title":"The Trithorax Protein Ash1L Promotes Myoblast Fusion by Activating Cdon Expression","volume":"9","author":"Castiglioni","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.celrep.2018.03.101","article-title":"The Long Non-Coding RNA Lnc-31 Interacts with Rock1 mRNA and Mediates Its YB-1-Dependent Translation","volume":"23","author":"Dimartino","year":"2018","journal-title":"Cell Rep."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s13073-021-00937-4","article-title":"Functional Significance of Gain-of-Function H19 lncRNA in Skeletal Muscle Differentiation and Anti-Obesity Effects","volume":"13","author":"Li","year":"2021","journal-title":"Genome Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/jhg.2012.131","article-title":"Molecular Characterization of an X(P21.2;Q28) Chromosomal Inversion in a Duchenne Muscular Dystrophy Patient with Mental Retardation Reveals a Novel Long Non-Coding Gene on Xq28","volume":"58","author":"Tran","year":"2013","journal-title":"J. Hum. Genet."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41419-021-03831-4","article-title":"Long Non-Coding RNA Xist Regulates Oocyte Loss via Suppressing miR-23b-3p\/miR-29a-3p Maturation and Upregulating STX17 in Perinatal Mouse Ovaries","volume":"12","author":"Zhou","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/jcp.25175","article-title":"Downregulation of Long Noncoding RNA Meg3 Affects Insulin Synthesis and Secretion in Mouse Pancreatic Beta Cells","volume":"231","author":"You","year":"2016","journal-title":"J. Cell. Physiol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.biocel.2018.03.016","article-title":"Expression Patterns of Regulatory RNAs, Including lncRNAs and tRNAs, during Postnatal Growth of Normal and Dystrophic (Mdx) Mouse Muscles, and Their Response to Taurine Treatment","volume":"99","author":"Butchart","year":"2018","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biomaterials.2018.04.055","article-title":"Placenta-Derived Mesenchymal Stromal Cells and Their Exosomes Exert Therapeutic Effects in Duchenne Muscular Dystrophy","volume":"174","author":"Bier","year":"2018","journal-title":"Biomaterials"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"23004","DOI":"10.18632\/aging.203592","article-title":"lncRNA MEG3 Aggravated Neuropathic Pain and Astrocyte Overaction through Mediating miR-130a-5p\/CXCL12\/CXCR4 Axis","volume":"13","author":"Dong","year":"2021","journal-title":"Aging"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.ajpath.2020.05.008","article-title":"Long Noncoding RNA MEG3 Inhibits Apoptosis of Retinal Pigment Epithelium Cells Induced by High Glucose via the miR-93\/Nrf2 Axis","volume":"190","author":"Luo","year":"2020","journal-title":"Am. J. Pathol."},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Xiao, F., Li, L., Fu, J.-S., Hu, Y.-X., and Luo, R. (2020). Regulation of the miR-19b-Mediated SOCS6-JAK2\/STAT3 Pathway by lncRNA MEG3 Is Involved in High Glucose-Induced Apoptosis in hRMECs. Biosci. Rep., 40.","DOI":"10.1042\/BSR20194370"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.bbi.2017.05.001","article-title":"The Long Non-Coding RNA Neat1 Is an Important Mediator of the Therapeutic Effect of Bexarotene on Traumatic Brain Injury in Mice","volume":"65","author":"Zhong","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.omtn.2019.10.028","article-title":"lncRNA MALAT1 Accelerates Skeletal Muscle Cell Apoptosis and Inflammatory Response in Sepsis by Decreasing BRCA1 Expression by Recruiting EZH2","volume":"19","author":"Yong","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s13577-021-00629-6","article-title":"Long Noncoding RNA XIST Modulates microRNA-135\/CREB1 Axis to Influence Osteogenic Differentiation of Osteoblast-like Cells in Mice with Tibial Fracture Healing","volume":"35","author":"Zhang","year":"2022","journal-title":"Hum. Cell"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/FJC.0000000000000835","article-title":"Long Noncoding RNA XIST\/miR-17\/PTEN Axis Modulates the Proliferation and Apoptosis of Vascular Smooth Muscle Cells to Affect Stanford Type A Aortic Dissection","volume":"76","author":"Zhang","year":"2020","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00441-015-2343-0","article-title":"Connective Tissue Cells Expressing Fibro\/Adipogenic Progenitor Markers Increase under Chronic Damage: Relevance in Fibroblast-Myofibroblast Differentiation and Skeletal Muscle Fibrosis","volume":"364","author":"Contreras","year":"2016","journal-title":"Cell Tissue Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1002\/jcb.26447","article-title":"XIST Promotes Gastric Cancer (GC) Progression through TGF-\u03921 via Targeting miR-185","volume":"119","author":"Zhang","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s13046-018-0831-2","article-title":"LINC01287\/miR-298\/STAT3 Feedback Loop Regulates Growth and the Epithelial-to-Mesenchymal Transition Phenotype in Hepatocellular Carcinoma Cells","volume":"37","author":"Mo","year":"2018","journal-title":"J. Exp. Clin. Cancer Res. CR"},{"key":"ref_136","first-page":"dev194027","article-title":"The Long Noncoding RNA Meg3 Regulates Myoblast Plasticity and Muscle Regeneration through Epithelial-Mesenchymal Transition","volume":"148","author":"Dill","year":"2021","journal-title":"Development"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3892\/mmr.2021.11830","article-title":"Long Non-coding RNA MEG3 Inhibits Cell Migration and Invasion of Non-small Cell Lung Cancer Cells by Regulating the miR-21-5p\/PTEN Axis","volume":"23","author":"Lv","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_138","first-page":"e924781","article-title":"Long Non-Coding RNA (lncRNA) NEAT1 Aggravates Cerebral Ischemia-Reperfusion Injury by Suppressing the Inhibitory Effect of miR-214 on PTEN","volume":"26","author":"Shen","year":"2020","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.ebiom.2015.03.018","article-title":"IL-6 Blockade as a Therapeutic Approach for Duchenne Muscular Dystrophy","volume":"2","author":"Mammen","year":"2015","journal-title":"EBioMedicine"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"12537","DOI":"10.18632\/aging.202927","article-title":"Silencing Long Noncoding RNA NEAT1 Alleviates Acute Liver Failure via the EZH2-Mediated microRNA-139\/PUMA Axis","volume":"13","author":"Wang","year":"2021","journal-title":"Aging"},{"key":"ref_141","first-page":"851","article-title":"LncRNA NEAT1 Promotes the Progression of Sepsis-Induced Myocardial Cell Injury by Sponging miR-144-3p","volume":"24","author":"Wei","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.yjmcc.2019.04.004","article-title":"LncRNA H19 Promotes Vascular Inflammation and Abdominal Aortic Aneurysm Formation by Functioning as a Competing Endogenous RNA","volume":"131","author":"Sun","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_143","first-page":"3000","article-title":"Long Non-Coding RNA LncHIFCAR Promotes Osteoarthritis Development via Positively Regulating HIF-1\u03b1 and Activating the PI3K\/AKT\/mTOR Pathway","volume":"11","author":"Sun","year":"2018","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1074\/mcp.M112.023127","article-title":"Identification of Disease Specific Pathways Using in Vivo SILAC Proteomics in Dystrophin Deficient Mdx Mouse","volume":"12","author":"Rayavarapu","year":"2013","journal-title":"Mol. Cell. Proteomics MCP"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1038\/s41418-022-00979-0","article-title":"Upregulation of Wilms\u2019 Tumor 1 in Epicardial Cells Increases Cardiac Fibrosis in Dystrophic Mice","volume":"29","author":"Guo","year":"2022","journal-title":"Cell Death Differ."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1007\/s00253-019-09837-5","article-title":"LncRNAs with miRNAs in Regulation of Gastric, Liver, and Colorectal Cancers: Updates in Recent Years","volume":"103","author":"Tam","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_147","first-page":"gmr16019269","article-title":"Effects of miRNA-143 and the Non-Coding RNA MALAT1 on the Pathogenesis and Metastasis of HeLa Cells","volume":"16","author":"Zhang","year":"2017","journal-title":"Genet. Mol. Res. GMR"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Li, C., Zhou, L., He, J., Fang, X.-Q., Zhu, S.-W., and Xiong, M.-M. (2016). Increased Long Noncoding RNA SNHG20 Predicts Poor Prognosis in Colorectal Cancer. BMC Cancer, 16.","DOI":"10.1186\/s12885-016-2719-x"},{"key":"ref_149","first-page":"2685","article-title":"Long Non-coding RNA MEG-3 Suppresses Gastric Carcinoma Cell Growth, Invasion and Migration via EMT Regulation","volume":"20","author":"Jiao","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1172\/JCI73579","article-title":"MicroRNA-486\u2013Dependent Modulation of DOCK3\/PTEN\/AKT Signaling Pathways Improves Muscular Dystrophy\u2013Associated Symptoms","volume":"124","author":"Alexander","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.cmet.2010.07.008","article-title":"MicroRNAs Involved in Molecular Circuitries Relevant for the Duchenne Muscular Dystrophy Pathogenesis Are Controlled by the Dystrophin\/nNOS Pathway","volume":"12","author":"Cacchiarelli","year":"2010","journal-title":"Cell Metab."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/CAD.0000000000000650","article-title":"LncRNA MALAT1 Promotes Migration and Invasion of Non-Small-Cell Lung Cancer by Targeting miR-206 and Activating Akt\/mTOR Signaling","volume":"29","author":"Tang","year":"2018","journal-title":"Anticancer Drugs"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1172\/JCI62656","article-title":"microRNA-206 Promotes Skeletal Muscle Regeneration and Delays Progression of Duchenne Muscular Dystrophy in Mice","volume":"122","author":"Liu","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"7383","DOI":"10.1007\/s13277-015-4605-6","article-title":"Reciprocal Regulation of Hsa-miR-1 and Long Noncoding RNA MALAT1 Promotes Triple-Negative Breast Cancer Development","volume":"37","author":"Jin","year":"2016","journal-title":"Tumour Biol."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41417-021-00381-x","article-title":"KRAS-Related Long Noncoding RNAs in Human Cancers","volume":"29","author":"Saliani","year":"2022","journal-title":"Cancer Gene Ther."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1038\/mtna.2014.29","article-title":"Circulating Muscle-Specific miRNAs in Duchenne Muscular Dystrophy Patients","volume":"3","author":"Li","year":"2014","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/jnc.12662","article-title":"Serum miR-206 and Other Muscle-Specific microRNAs as Non-Invasive Biomarkers for Duchenne Muscular Dystrophy","volume":"129","author":"Hu","year":"2014","journal-title":"J. Neurochem."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.gene.2017.07.066","article-title":"Lnc133b, a Novel, Long Non-Coding RNA, Regulates Bovine Skeletal Muscle Satellite Cell Proliferation and Differentiation by Mediating miR-133b","volume":"630","author":"Jin","year":"2017","journal-title":"Gene"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s12012-022-09742-w","article-title":"Evaluating the Role of lncRNAs in the Incidence of Cardiovascular Diseases in Androgenetic Alopecia Patients","volume":"22","author":"Roohaninasab","year":"2022","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"37857","DOI":"10.18632\/oncotarget.9347","article-title":"Long Non-Coding RNA Malat1 Promotes Gallbladder Cancer Development by Acting as a Molecular Sponge to Regulate miR-206","volume":"7","author":"Wang","year":"2016","journal-title":"Oncotarget"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Dong, Y., Wan, G., Peng, G., Yan, P., Qian, C., and Li, F. (2020). Long Non-Coding RNA XIST Regulates Hyperglycemia-Associated Apoptosis and Migration in Human Retinal Pigment Epithelial Cells. Biomed. Pharmacother., 125.","DOI":"10.1016\/j.biopha.2020.109959"},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Hu, Y., Yang, Q., Wang, L., Wang, S., Sun, F., Xu, D., and Jiang, J. (2018). Knockdown of the Oncogene lncRNA NEAT1 Restores the Availability of miR-34c and Improves the Sensitivity to Cisplatin in Osteosarcoma. Biosci. Rep., 38.","DOI":"10.1042\/BSR20180375"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s10528-021-10138-8","article-title":"The Role of Long Non-Coding RNA, Nuclear Enriched Abundant Transcript 1 (NEAT1) in Cancer and Other Pathologies","volume":"60","author":"Zhang","year":"2022","journal-title":"Biochem. Genet."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.18632\/aging.203949","article-title":"Manual Therapy Regulates Oxidative Stress in Aging Rat Lumbar Intervertebral Discs through the SIRT1\/FOXO1 Pathway","volume":"14","author":"Yao","year":"2022","journal-title":"Aging"}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/13\/6032\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:57:25Z","timestamp":1760032645000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/13\/6032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,24]]},"references-count":164,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["ijms26136032"],"URL":"https:\/\/doi.org\/10.3390\/ijms26136032","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,24]]}}}