{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T06:07:52Z","timestamp":1793858872864,"version":"4.6.1"},"reference-count":173,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Hong Kong Polytechnic University","award":["HTI: 1-WZ6T"],"award-info":[{"award-number":["HTI: 1-WZ6T"]}],"id":[{"id":"https:\/\/ror.org\/0030zas98","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Hong Kong Polytechnic University","award":["RiFood: 1-CD55"],"award-info":[{"award-number":["RiFood: 1-CD55"]}],"id":[{"id":"https:\/\/ror.org\/0030zas98","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Hong Kong Polytechnic University","award":["COVID1903007"],"award-info":[{"award-number":["COVID1903007"]}],"id":[{"id":"https:\/\/ror.org\/0030zas98","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Health and Medical Research Fund Commissioned Research on COVID-19","award":["HTI: 1-WZ6T"],"award-info":[{"award-number":["HTI: 1-WZ6T"]}]},{"name":"Health and Medical Research Fund Commissioned Research on COVID-19","award":["RiFood: 1-CD55"],"award-info":[{"award-number":["RiFood: 1-CD55"]}]},{"name":"Health and Medical Research Fund Commissioned Research on COVID-19","award":["COVID1903007"],"award-info":[{"award-number":["COVID1903007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Sepsis remains a critical global health challenge characterized by life-threatening organ dysfunction arising from a dysregulated host response to infection. Immunothrombosis refers to the intersection of immune activation and coagulation pathways, particularly relevant in the context of sepsis. A growing body of evidence identifies immunothrombosis, a tightly interwoven process between innate immunity and coagulation. While immunothrombosis serves as a host defense mechanism under physiological conditions, its aberrant activation in sepsis precipitates microvascular thrombosis, organ ischemia, and progression toward disseminated intravascular coagulation (DIC). This review provides a comprehensive overview of the cellular contributors to immunothrombosis, including neutrophils, monocytes, platelets, and endothelial cells, and elucidates the signaling cascades, such as nuclear factor kappa B (NF-\u03baB), mitogen-activated protein kinase (MAPK), and inflammasome activation, that govern their interplay. We further highlight emerging molecular mediators, including extracellular traps, tissue factor expression, and cytokine amplification loops, that collectively promote pathological thromboinflammation. A deeper understanding of these interconnected pathways offers critical insights into the pathogenesis of sepsis and unveils potential targets for timely intervention. Ultimately, this review aims to bridge immunological and hematological perspectives to inform the development of novel therapeutic strategies against sepsis-induced coagulopathy.<\/jats:p>","DOI":"10.3390\/ijms26136114","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T06:55:13Z","timestamp":1750920913000},"page":"6114","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Immunothrombosis in Sepsis: Cellular Crosstalk, Molecular Triggers, and Therapeutic Opportunities\u2014A Review"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8289-5861","authenticated-orcid":false,"given":"Addis","family":"Aklilu","sequence":"first","affiliation":[{"name":"Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Siu-Lun","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-8185","authenticated-orcid":false,"given":"Shea Ping","family":"Yip","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6396-5649","authenticated-orcid":false,"given":"Chien-Ling","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.2147\/JIR.S504184","article-title":"The Mechanisms of Sepsis Induced Coagulation Dysfunction and Its Treatment","volume":"18","author":"Zhu","year":"2025","journal-title":"J. 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