{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:16:25Z","timestamp":1780056985358,"version":"3.54.0"},"reference-count":43,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["24-45-00071"],"award-info":[{"award-number":["24-45-00071"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["82361138563"],"award-info":[{"award-number":["82361138563"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["24-45-00071"],"award-info":[{"award-number":["24-45-00071"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82361138563"],"award-info":[{"award-number":["82361138563"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>A series of new isatin hydrazones bearing phosphorus-containing moiety was synthesized through a simple, high-yield and easy work-up reaction of phosphine oxide (Phosenazide) or phosphinate (2-chloroethyl (4-(dimethylamino)phenyl)(2-hydrazinyl-2-oxoethyl)phosphinate, CAPAH) hydrazides with aryl-substituted isatins. The 31P NMR technique showed that, in most cases, out of 12 examples in solution, the ratio of the two spatial isomers varied from 1:1 to 1:3. Quantum chemical calculations confirmed the predominance of Z,syn form both in the gas phase and in solution. According to X-ray analysis data in crystals, they exist only in Z,syn form too. Most of the phosphine oxide derivatives and 5-methoxy- and 5-bromoaryl phosphinate analogs exhibit anti-aggregant activity at the level of acetylsalicylic acid but inhibit platelet activation processes more effectively. The 5-chloro type phosphinate derivative exhibits anti-aggregant properties more effectively than acetylsalicylic acid under the conditions of the tissue factor (TF)-activated thromboelastography (TEG) model, the ex vivo thrombosis model. Thus, all the obtained results can become the basis for future pharmaceutical developments to create effective anti-aggregation drugs with broad antithrombotic potential.<\/jats:p>","DOI":"10.3390\/ijms26136147","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T06:55:13Z","timestamp":1750920913000},"page":"6147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Phosphorus-Derived Isatin Hydrazones: Synthesis, Structure, Thromboelastography, Antiplatelet, and Anticoagulation Activity Evaluation"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9302-499X","authenticated-orcid":false,"given":"Aleksandr V.","family":"Samorodov","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Bashkir State Medical University, Lenin St. 3, Ufa 450008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Yi","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Hangzhou Normal University, Yuhangtan, 2318, Hangzhou 310030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry A.","family":"Kudlay","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Sechenov First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya St. 2, Building 4, Moscow 119435, Russia"},{"name":"Institute of Immunology FMBA of Russia, Kashirskoye Highway, Building 24, Moscow 115522, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2615-7167","authenticated-orcid":false,"given":"Elena A.","family":"Smolyarchuk","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Sechenov First Moscow State Medical University (Sechenov University), Bolshaya Pirogovskaya St. 2, Building 4, Moscow 119435, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4912-3699","authenticated-orcid":false,"given":"Alexey B.","family":"Dobrynin","sequence":"additional","affiliation":[{"name":"Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov St. 8, Kazan 420088, Russia"},{"name":"Department for Design and Techiques of Electronic Tools Manufacturing, Institute for Radio-Electronics and Telecommunications, Kazan National Research Technical University Named After A. N. Tupolev-KAI, Karl Marx St. 10, Kazan 420111, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2865-8619","authenticated-orcid":false,"given":"Ayrat R.","family":"Khamatgalimov","sequence":"additional","affiliation":[{"name":"Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov St. 8, Kazan 420088, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Shchebneva","sequence":"additional","affiliation":[{"name":"Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov St. 8, Kazan 420088, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Kadomtseva","sequence":"additional","affiliation":[{"name":"A.M. Butlerov Institute of Chemistry, Kazan Federal University, Kremlevskaya St. 29, Kazan 420008, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilbar","family":"Komunarova","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Kazan National Research Technological University, Sibirsky Trakt 12, Kazan 420029, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna G.","family":"Strelnik","sequence":"additional","affiliation":[{"name":"Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov St. 8, Kazan 420088, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei V.","family":"Bogdanov","sequence":"additional","affiliation":[{"name":"Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Akad. Arbuzov St. 8, Kazan 420088, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/eurheartj\/sun040","article-title":"Clinical implications of the results of recent atherothrombotic trials on patient management","volume":"10","author":"Betriu","year":"2008","journal-title":"Eur. 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