{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:06:50Z","timestamp":1790777210517,"version":"4.1.0"},"reference-count":87,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>In chronic kidney disease (CKD), various disorders occur that worsen with the progression of CKD. These include increased levels of hormones such as adiponectin, leptin, and prolactin, changes in feedback loops and metabolism, and decreased renal clearance, contributing to significant morbidity and mortality. We conducted a cross-sectional observational study on 157 randomly selected patients with various stages of chronic kidney disease, 29% of whom had diabetes. We recorded clinical and usual laboratory data. We determined muscle mass and adipose tissue mass using bioimpedance. In addition, we measured serum prolactin levels, tumor necrosis factor-alpha (TNF-\u03b1), Interleukin 6 (IL-6), and Interleukin-1 beta (IL-1\u03b2). N-terminal pro-B-type natriuretic peptide (NT-proBNP) was evaluated as a marker of cardiac function. We evaluated the relation between prolactin, TNF-\u03b1, IL-6, IL-1\u03b2, and NT-proBNP by bivariate and multivariate analysis. In bivariate analysis, we recorded associations of prolactin with inflammatory markers: TNF-\u03b1 (r = 0.65, p &lt; 0.001), IL-6 (r = 0.66, p &lt; 0.001), and IL-1\u03b2 (r = 0.25, p = 0.002). In multivariate analysis we observed that serum prolactin values are associated with IL-1\u03b2 [median (25th\u201375th percentile): [\u22120.001 (\u22120.001; \u22120.00003), p = 0.037], muscle mass [\u22120.03 (\u22120.04; \u22120.01), p = 0.003], and NT-proBNP [0.0001 (0.0001; 0.0001)] p &lt; 0.001 In conclusion, in chronic kidney disease, prolactin is associated with inflammatory markers (IL-1\u03b2, TNF-\u03b1, IL-6), and nutritional status. Additionally, prolactin has been linked to NT-ProBNP, a marker of cardiac function.<\/jats:p>","DOI":"10.3390\/ijms26136347","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T06:56:54Z","timestamp":1751353014000},"page":"6347","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Interplay of Prolactin with Inflammatory Nutritional Markers and NT-proBNP in Chronic Kidney Disease"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7708-9320","authenticated-orcid":false,"given":"Crina Claudia","family":"Rusu","sequence":"first","affiliation":[{"name":"Department of Nephrology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania"},{"name":"Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5463-5317","authenticated-orcid":false,"given":"Diana","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania"},{"name":"Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6995-2737","authenticated-orcid":false,"given":"Alina","family":"Potra","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania"},{"name":"Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dacian","family":"Tirinescu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania"},{"name":"Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3143-4701","authenticated-orcid":false,"given":"Maria","family":"Ticala","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania"},{"name":"Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriy","family":"Maslyennikov","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania"},{"name":"Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7176-8856","authenticated-orcid":false,"given":"Andrada","family":"Barar","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania"},{"name":"Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9928-8443","authenticated-orcid":false,"given":"Alexandra","family":"Urs","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania"},{"name":"Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6245-4188","authenticated-orcid":false,"given":"Cosmina Ioana","family":"Bondor","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj, 6 Pasteur Street, 400349 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2266-2916","authenticated-orcid":false,"given":"Ana","family":"Valea","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania"},{"name":"Endocrinology Clinic, County Emergency Clinical Hospital Cluj, 400347 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1167-9154","authenticated-orcid":false,"given":"Ina","family":"Kacso","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d Cluj, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania"},{"name":"Department of Nephrology, County Emergency Clinical Hospital Cluj, 3-5 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.semnephrol.2021.03.012","article-title":"The Interplay Between Nutrition, Metabolic, and Endocrine Disorders in Chronic Kidney Disease","volume":"41","author":"Mahmoud","year":"2021","journal-title":"Semin. 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