{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:02:08Z","timestamp":1792324928109,"version":"4.4.0"},"reference-count":120,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>The success of in vitro fertilization (IVF) and female reproductive capacity are significantly determined by oocyte quality. Increasing data highlights the significance of oxidative stress\u2014a state of imbalance between reactive oxygen species (ROS) and antioxidant defenses\u2014in regulating oocyte competence. Normal folliculogenesis and ovulation rely on optimal ROS levels; excessive oxidative stress (OS) can lead to DNA fragmentation, undermine meiotic spindle integrity, and trigger apoptosis in cumulus and granulosa cells. Molecular insults impair nuclear and cytoplasmic maturation, thereby impacting fertilization potential and embryonic development. Individuals with polycystic ovarian syndrome (PCOS), endometriosis, advanced maternal age, and metabolic disorders\u2014conditions associated with suboptimal IVF outcomes\u2014frequently exhibit redox imbalance. This narrative review examines significant oxidative markers in the follicular environment, exploring the molecular processes linking OS to diminished oocyte quality and discussing therapy techniques aimed at mitigating oxidative damage. Maintaining redox homeostasis in the ovarian milieu appears to be an effective strategy for enhancing oocyte competence and optimizing outcomes in assisted reproduction.<\/jats:p>","DOI":"10.3390\/ijms26136377","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T09:08:44Z","timestamp":1751447324000},"page":"6377","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Cracking the Code of Oocyte Quality: The Oxidative Stress Link to IVF Success"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9477-7619","authenticated-orcid":false,"given":"Charalampos","family":"Voros","sequence":"first","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diamantis","family":"Athanasiou","sequence":"additional","affiliation":[{"name":"IVF Athens Reproduction Center V. Athanasiou, 15123 Maroussi, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9723-5054","authenticated-orcid":false,"given":"Ioannis","family":"Papapanagiotou","sequence":"additional","affiliation":[{"name":"Athens Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1220-6594","authenticated-orcid":false,"given":"Despoina","family":"Mavrogianni","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8725-7103","authenticated-orcid":false,"given":"Antonia","family":"Varthaliti","sequence":"additional","affiliation":[{"name":"1st Department of Obstetrics and Gynecology, \u2018Alexandra\u2019 General Hospital, National and Kapodistrian University of Athens, 80 Vasilissis Sofias Avenue, 11528 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriakos","family":"Bananis","sequence":"additional","affiliation":[{"name":"King\u2019s College Hospitals NHS Foundation Trust, London SE5 9RS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia","family":"Athanasiou","sequence":"additional","affiliation":[{"name":"IVF Athens Reproduction Center V. 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Steril."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Fluks, M., Collier, R., Walewska, A., Bruce, A.W., and Ajduk, A. (2024). How great thou ART: Biomechanical properties of oocytes and embryos as indicators of quality in assisted reproductive technologies. Front. Cell Dev. Biol., 12.","DOI":"10.3389\/fcell.2024.1342905"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s11684-017-0575-y","article-title":"Oxidative stress in granulosa cells contributes to poor oocyte quality and IVF-ET outcomes in women with polycystic ovary syndrome","volume":"12","author":"Lai","year":"2018","journal-title":"Front. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.reprotox.2013.08.005","article-title":"Markers of oxidative stress in follicular fluid of women with endometriosis and tubal infertility undergoing IVF","volume":"42","author":"Singh","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"021","DOI":"10.1055\/s-0040-1721377","article-title":"The Role of Oocyte Quality in Explaining \u201cUnexplained\u201d Infertility","volume":"38","author":"Homer","year":"2020","journal-title":"Semin. Reprod. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3390\/oxygen2040030","article-title":"RONS and Oxidative Stress: An Overview of Basic Concepts","volume":"2","year":"2022","journal-title":"Oxygen"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/RD9.0000000000000100","article-title":"The impact of antioxidant supplements on oocytes and preimplantation embryos of humans and mammals, and their potential application for mitigating the consequences of oxidative stress in vitro: A review","volume":"8","author":"Guseva","year":"2024","journal-title":"Reprod. Dev. Med."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Agarwal, A., Gupta, S., and Sharma, R.K. (2005). Role of oxidative stress in female reproduction. Reprod. Biol. Endocrinol., 3.","DOI":"10.1186\/1477-7827-3-28"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Wang, H.Q., Zhang, W.D., Yuan, B., and Zhang, J.B. (2021). Advances in the Regulation of Mammalian Follicle-Stimulating Hormone Secretion. Animals, 11.","DOI":"10.3390\/ani11041134"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"R453\u201362","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS Function in Redox Signaling and Oxidative Stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Rodr\u00edguez-Varela, C., and Labarta, E. (2020). Clinical Application of Antioxidants to Improve Human Oocyte Mitochondrial Function: A Review. Antioxidants, 9.","DOI":"10.3390\/antiox9121197"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Sasaki, H., Hamatani, T., Kamijo, S., Iwai, M., Kobanawa, M., Ogawa, S., Miyado, K., and Tanaka, M. (2019). Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence. Front. Endocrinol., 10.","DOI":"10.3389\/fendo.2019.00811"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40035-023-00350-4","article-title":"Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases","volume":"12","author":"Shadfar","year":"2023","journal-title":"Transl. Neurodegener."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"R217","DOI":"10.1530\/REP-13-0111","article-title":"Oxidative stress and ageing of the post-ovulatory oocyte","volume":"146","author":"Lord","year":"2013","journal-title":"Reproduction"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2015.06.021","article-title":"Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease","volume":"88","author":"Tebay","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Yan, H., Wang, L., Zhang, G., Li, N., Zhao, Y., Liu, J., Jiang, M., Du, X., Zeng, Q., and Xiong, D. (2024). Oxidative stress and energy metabolism abnormalities in polycystic ovary syndrome: From mechanisms to therapeutic strategies. Reprod. Biol. Endocrinol., 22.","DOI":"10.1186\/s12958-024-01337-0"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/humupd\/dmab014","article-title":"Novel therapeutic targets to improve IVF outcomes in endometriosis patients: A review and future prospects","volume":"27","author":"Pellicer","year":"2021","journal-title":"Hum. Reprod. Update"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/CM9.0000000000001214","article-title":"NLRP3 inflammasome: A new therapeutic target for high-risk reproductive disorders?","volume":"134","author":"Zhou","year":"2021","journal-title":"Chin. Med. J."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Moustakli, E., Zikopoulos, A., Skentou, C., Bouba, I., Dafopoulos, K., and Georgiou, I. (2024). Evolution of Minimally Invasive and Non-Invasive Preimplantation Genetic Testing: An Overview. J. Clin. Med., 13.","DOI":"10.3390\/jcm13082160"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kobayashi, H., and Imanaka, S. (2024). Mitochondrial DNA Damage and Its Repair Mechanisms in Aging Oocytes. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252313144"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/rmb2.12229","article-title":"Evaluation of antioxidant status and oxidative stress markers in follicular fluid for human in vitro fertilization outcome","volume":"17","author":"Nishihara","year":"2018","journal-title":"Reprod. Med. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.21037\/atm-20-397","article-title":"Peroxiredoxin 4, a new oxidative stress marker in follicular fluid, may predict in vitro fertilization and embryo transfer outcomes","volume":"8","author":"Yi","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10815-020-02014-y","article-title":"Oxidative stress markers in the follicular fluid of patients with polycystic ovary syndrome correlate with a decrease in embryo quality","volume":"38","author":"Liu","year":"2021","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Artini, P.G., Scarf\u00f2, G., Marzi, I., Fusi, J., Obino, M.E., Franzoni, F., Zappelli, E., Chelucci, E., Martini, C., and Cela, V. (2022). Oxidative Stress-Related Signaling Pathways Predict Oocytes\u2019 Fertilization In Vitro and Embryo Quality. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113442"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3390\/futurepharmacol4030035","article-title":"Understanding the Impact of Oxidative Stress on Ovarian Cancer: Advances in Diagnosis and Treatment","volume":"4","author":"Meshkovska","year":"2024","journal-title":"Future Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2147\/JIR.S275595","article-title":"Reactive Oxygen Species: Drivers of Physiological and Pathological Processes","volume":"13","author":"Checa","year":"2020","journal-title":"J. Inflamm. Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Chen, Y., Yang, J., and Zhang, L. (2023). The Impact of Follicular Fluid Oxidative Stress Levels on the Outcomes of Assisted Reproductive Therapy. Antioxidants, 12.","DOI":"10.3390\/antiox12122117"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Averill-Bates, D. (2024). Reactive oxygen species and cell signaling. Rev. Biochim. Biophys. Acta (BBA) Mol. Cell Res., 1871.","DOI":"10.1016\/j.bbamcr.2023.119573"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1038\/sj.onc.1209255","article-title":"Regulation of cyclin D2 and the cyclin D2 promoter by protein kinase A and CREB in lymphocytes","volume":"25","author":"White","year":"2006","journal-title":"Oncogene"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e16848","DOI":"10.1016\/j.heliyon.2023.e16848","article-title":"Different types of bisphenols alter ovarian steroidogenesis: Special attention to BPA","volume":"9","author":"Shoorei","year":"2023","journal-title":"Heliyon"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Nowak, K., Jab\u0142o\u0144ska, E., and Ratajczak-Wrona, W. (2021). NF-\u03baB\u2014An Important Player in Xenoestrogen Signaling in Immune Cells. Cells, 10.","DOI":"10.3390\/cells10071799"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Fukai, T., and Ushio-Fukai, M. (2020). Cross-Talk between NADPH Oxidase and Mitochondria: Role in ROS Signaling and Angiogenesis. Cells, 9.","DOI":"10.3390\/cells9081849"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Pan, B., and Li, J. (2019). The art of oocyte meiotic arrest regulation. Reprod. Biol. Endocrinol., 17.","DOI":"10.1186\/s12958-018-0445-8"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Sasseville, M., C\u00f4t\u00e9, N., Guillemette, C., and Richard, F.J. (2006). New insight into the role of phosphodiesterase 3A in porcine oocyte maturation. BMC Dev. Biol., 6.","DOI":"10.1186\/1471-213X-6-47"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.cmet.2022.10.008","article-title":"Mitochondrial signal transduction","volume":"34","author":"Picard","year":"2022","journal-title":"Cell Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1080\/15476286.2020.1809186","article-title":"RNA-binding proteins in neurological development and disease","volume":"18","author":"Prashad","year":"2021","journal-title":"RNA Biol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"17208","DOI":"10.1074\/jbc.RA118.002579","article-title":"Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly","volume":"293","author":"Hinchy","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1080\/0886022X.2022.2126789","article-title":"Activation of AMPK-PGC-1\u03b1 pathway ameliorates peritoneal dialysis related peritoneal fibrosis in mice by enhancing mitochondrial biogenesis","volume":"44","author":"Wu","year":"2022","journal-title":"Ren. Fail."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1089\/ars.2008.2146","article-title":"Oxidative-Dependent Integration of Signal Transduction with Intercellular Gap Junctional Communication in the Control of Gene Expression","volume":"11","author":"Upham","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"13682","DOI":"10.1074\/jbc.M407762200","article-title":"Oxidative Activation of Protein Kinase C\u03b3 through the C1 Domain","volume":"280","author":"Lin","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Carbonell, T., and Gomes, A.V. (2020). MicroRNAs in the regulation of cellular redox status and its implications in myocardial ischemia-reperfusion injury. Redox Biol., 36.","DOI":"10.1016\/j.redox.2020.101607"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Nail, H.M., Chiu, C.C., Leung, C.H., Ahmed, M.M.M., and Wang, H.M.D. (2023). Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments. J. Biomed. Sci., 30.","DOI":"10.1186\/s12929-023-00964-w"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.cellsig.2013.04.010","article-title":"Multi-level control of actin dynamics by protein kinase D","volume":"25","author":"Olayioye","year":"2013","journal-title":"Cell. Signal."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"4123854","DOI":"10.1155\/2017\/4123854","article-title":"Reactive Oxygen Species Mediated Prostaglandin E2 Contributes to Acute Response of Epithelial Injury","volume":"2017","author":"Hu","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1152\/physiolgenomics.00041.2017","article-title":"Nrf2 at the heart of oxidative stress and cardiac protection","volume":"50","author":"Chen","year":"2018","journal-title":"Physiol. Genom."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcp.30613","article-title":"Role of autophagy in follicular development and maintenance of primordial follicular pool in the ovary","volume":"237","author":"Bhardwaj","year":"2022","journal-title":"J. Cell. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Guo, H., Ouyang, Y., Yin, H., Cui, H., Deng, H., Liu, H., Jian, Z., Fang, J., Zuo, Z., and Wang, X. (2022). Induction of autophagy via the ROS-dependent AMPK-mTOR pathway protects copper-induced spermatogenesis disorder. Redox Biol., 49.","DOI":"10.1016\/j.redox.2021.102227"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.theriogenology.2020.01.075","article-title":"Extracellular vesicle mediated molecular signaling in ovarian follicle: Implication for oocyte developmental competence","volume":"150","author":"Tesfaye","year":"2020","journal-title":"Theriogenology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3553617","DOI":"10.1155\/2022\/3553617","article-title":"Crosstalk between Oxidative Stress and Exosomes","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"14278","DOI":"10.1074\/jbc.M115.647545","article-title":"Thioredoxin Selectivity for Thiol-based Redox Regulation of Target Proteins in Chloroplasts","volume":"290","author":"Yoshida","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"8742","DOI":"10.3390\/molecules20058742","article-title":"Glutathione in Cellular Redox Homeostasis: Association with the Excitatory Amino Acid Carrier 1 (EAAC1)","volume":"20","author":"Aoyama","year":"2015","journal-title":"Molecules"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/s12276-024-01209-y","article-title":"Regulation of cargo selection in exosome biogenesis and its biomedical applications in cancer","volume":"56","author":"Lee","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Sunkar, R. (2024). Thiol Redox Proteomics for Identifying Redox-Sensitive Cysteine Residues Within the Protein of Interest During Stress. Plant Stress Tolerance, Springer.","DOI":"10.1007\/978-1-0716-3973-3"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Vitale, S.G., Fulghesu, A.M., Miku\u0161, M., Watrowski, R., D\u2019Alterio, M.N., Lin, L.T., Shah, M., Reyes-Mu\u00f1oz, E., Sathyapalan, T., and Angioni, S. (2022). The Translational Role of miRNA in Polycystic Ovary Syndrome: From Bench to Bedside\u2014A Systematic Literature Review. Biomedicines, 10.","DOI":"10.3390\/biomedicines10081816"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Andronico, F., Battaglia, R., Ragusa, M., Barbagallo, D., Purrello, M., and Di Pietro, C. (2019). Extracellular Vesicles in Human Oogenesis and Implantation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20092162"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.freeradbiomed.2021.01.009","article-title":"Expanding the link between circadian rhythms and redox metabolism of epigenetic control","volume":"170","author":"Sato","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejogrb.2020.06.021","article-title":"Effects of follicular fluid oxidative status on human mural granulosa cells, oocyte competency and ICSI parameters","volume":"252","author":"Karabulut","year":"2020","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Afzal, S., Abdul Manap, A.S., Attiq, A., Albokhadaim, I., Kandeel, M., and Alhojaily, S.M. (2023). From imbalance to impairment: The central role of reactive oxygen species in oxidative stress-induced disorders and therapeutic exploration. Front. Pharmacol., 14.","DOI":"10.3389\/fphar.2023.1269581"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1093\/biolre\/ioac024","article-title":"Oocyte mitochondria\u2014Key regulators of oocyte function and potential therapeutic targets for improving fertility","volume":"106","author":"Adhikari","year":"2022","journal-title":"Biol. Reprod."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/s41418-023-01187-0","article-title":"Identity, structure, and function of the mitochondrial permeability transition pore: Controversies, consensus, recent advances, and future directions","volume":"30","author":"Bernardi","year":"2023","journal-title":"Cell Death Differ."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Gorbacheva EYu Sventitskaya, M.A., Biryukov, N.S., and Ogneva, I.V. (2023). The Oxidative Phosphorylation and Cytoskeleton Proteins of Mouse Ovaries after 96 Hours of Hindlimb Suspension. Life, 13.","DOI":"10.3390\/life13122332"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/1873-3468.12956","article-title":"Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease","volume":"592","author":"Nissanka","year":"2018","journal-title":"FEBS Lett."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.molcel.2016.02.022","article-title":"Mitofusins, from Mitochondria to Metabolism","volume":"61","author":"Schrepfer","year":"2016","journal-title":"Mol. Cell"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Mustafa, M., Ahmad, R., Tantry, I.Q., Ahmad, W., Siddiqui, S., Alam, M., Abbas, K., Hassan, M.I., Habib, S., and Islam, S. (2024). Apoptosis: A Comprehensive Overview of Signaling Pathways, Morphological Changes, and Physiological Significance and Therapeutic Implications. Cells, 13.","DOI":"10.3390\/cells13221838"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1016\/j.devcel.2022.06.008","article-title":"A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase","volume":"57","author":"Kirova","year":"2022","journal-title":"Dev. Cell"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"13214","DOI":"10.1128\/JVI.77.24.13214-13224.2003","article-title":"Mechanisms Governing Maintenance of Cdk1\/Cyclin B1Kinase Activity in Cells Infected with HumanCytomegalovirus","volume":"77","author":"Sanchez","year":"2003","journal-title":"J. Virol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1242\/dev.144410","article-title":"A MAPK cascade couples maternal mRNA translation and degradation to meiotic cell cycle progression in mouse oocytes","volume":"144","author":"Sha","year":"2017","journal-title":"Development"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Patel, V., and Preedy, V. (2017). Guanine-Quadruplexes and Possible Role in Nutritional Epigenetics and Aging. Handbook of Nutrition, Diet, and Epigenetics, Springer International Publishing.","DOI":"10.1007\/978-3-319-31143-2"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"103027","DOI":"10.1016\/j.dnarep.2020.103027","article-title":"Towards a comprehensive view of 8-oxo-7,8-dihydro-2\u2032-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability","volume":"97","author":"Gorini","year":"2021","journal-title":"DNA Repair."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Spies, J., Polasek-Sedlackova, H., Lukas, J., and Somyajit, K. (2021). Homologous Recombination as a Fundamental Genome Surveillance Mechanism during DNA Replication. Genes, 12.","DOI":"10.3390\/genes12121960"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nature05978","article-title":"Base-excision repair of oxidative DNA damage","volume":"447","author":"David","year":"2007","journal-title":"Nature"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mrfmmm.2009.08.001","article-title":"Mechanism of elimination of phosphorylated histone H2AX from chromatin after repair of DNA double-strand breaks","volume":"685","author":"Svetlova","year":"2010","journal-title":"Mutat. Res. Fundam. Mol. Mech. Mutagen."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/ncb0504-386","article-title":"Fatal liaisons of p53 with Bax and Bak","volume":"6","author":"Perfettini","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/hed.20319","article-title":"p53 apoptotic response to DNA damage dependent on bcl2 but not bax in head and neck squamous cell carcinoma lines","volume":"28","author":"Crowe","year":"2006","journal-title":"Head Neck"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2008.03.036","article-title":"Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair","volume":"270","author":"Sallmyr","year":"2008","journal-title":"Cancer Lett."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.semcancer.2017.11.001","article-title":"Vitamin C\u2014A new player in regulation of the cancer epigenome","volume":"51","author":"Gillberg","year":"2018","journal-title":"Semin. Cancer Biol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Voros, C., Athanasiou, D., Mavrogianni, D., Varthaliti, A., Bananis, K., Athanasiou, A., Athanasiou, A., Papadimas, G., Gkirgkinoudis, A., and Papapanagiotou, I. (2025). Exosomal Communication Between Cumulus\u2013Oocyte Complexes and Granulosa Cells: A New Molecular Axis for Oocyte Competence in Human-Assisted Reproduction. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26115363"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1074\/jbc.M707224200","article-title":"Programmed Cell Death 4 (PDCD4) Is an Important Functional Target of the MicroRNA miR-21 in Breast Cancer Cells","volume":"283","author":"Frankel","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13048-015-0162-2","article-title":"MicroRNAs in ovarian function and disorders","volume":"8","author":"Li","year":"2015","journal-title":"J. Ovarian Res."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Ciesielska, S., Slezak-Prochazka, I., Bil, P., and Rzeszowska-Wolny, J. (2021). Micro RNAs in Regulation of Cellular Redox Homeostasis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22116022"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Gorre, N., Adhikari, D., Lindkvist, R., Br\u00e4nnstr\u00f6m, M., Liu, K., and Shen, Y. (2014). mTORC1 Signaling in Oocytes Is Dispensable for the Survival of Primordial Follicles and for Female Fertility. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0110491"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.molcel.2013.08.027","article-title":"The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs","volume":"52","author":"Kallen","year":"2013","journal-title":"Mol. Cell"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.celrep.2012.06.003","article-title":"The lncRNA Malat1 Is Dispensable for Mouse Development but Its Transcription Plays a cis-Regulatory Role in the Adult","volume":"2","author":"Zhang","year":"2012","journal-title":"Cell Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/sj.embor.7400645","article-title":"The role of glutathione in disulphide bond formation and endoplasmic-reticulum-generated oxidative stress","volume":"7","author":"Chakravarthi","year":"2006","journal-title":"EMBO Rep."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41420-024-02278-8","article-title":"Free radicals and their impact on health and antioxidant defenses: A review","volume":"11","author":"Chandimali","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1021\/cr300354g","article-title":"Bioanalysis of Eukaryotic Organelles","volume":"113","author":"Satori","year":"2013","journal-title":"Chem. Rev."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1093\/humrep\/dez161","article-title":"Mitochondria-targeted therapy rescues development and quality of embryos derived from oocytes matured under oxidative stress conditions: A bovine in vitro model","volume":"34","author":"Marei","year":"2019","journal-title":"Hum. Reprod."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"100273","DOI":"10.1016\/j.advnut.2024.100273","article-title":"Antioxidants and Fertility in Women with Ovarian Aging: A Systematic Review and Meta-Analysis","volume":"15","author":"Shang","year":"2024","journal-title":"Adv. Nutr."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Neyroud, A.S., Chiechio, R.M., Moulin, G., Ducarre, S., Heichette, C., Dupont, A., Budzynski, M., Even-Hernandez, P., Faro, M.J., and Yefimova, M. (2022). Diversity of Extracellular Vesicles in Human Follicular Fluid: Morphological Analysis and Quantification. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911676"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s43856-024-00460-8","article-title":"Small extracellular vesicles in follicular fluids for predicting reproductive outcomes in assisted reproductive technology","volume":"4","author":"Muraoka","year":"2024","journal-title":"Commun. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.fertnstert.2006.03.053","article-title":"Effect of sperm glutathione peroxidases 1 and 4 on embryo asymmetry and blastocyst quality in oocyte donation cycles","volume":"86","author":"Meseguer","year":"2006","journal-title":"Fertil. Steril."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"136","DOI":"10.5152\/jtgga.2013.53323","article-title":"Effect of Follicular Fluid NO, MDA and GSH Levels on in vitro Fertilization Outcomes","volume":"14","author":"Yalcinkaya","year":"2013","journal-title":"J. Turk. Ger. Gynecol. Assoc."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"430","DOI":"10.5468\/ogs.22170","article-title":"Can follicular fluid 8-oxo-2\u2032-deoxyguanosine predict the clinical outcomes in ICSI cycle among couples with normospermia male?","volume":"66","author":"Nori","year":"2023","journal-title":"Obs. Gynecol. Sci."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Ten\u00f3rio, M.C.D.S., Graciliano, N.G., Moura, F.A., Oliveira, A.C.M.D., and Goulart, M.O.F. (2021). N-Acetylcysteine (NAC): Impacts on Human Health. Antioxidants, 10.","DOI":"10.3390\/antiox10060967"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Song, C., Peng, W., Yin, S., Zhao, J., Fu, B., Zhang, J., Mao, T., Wu, H., and Zhang, Y. (2016). Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice. Sci. Rep., 6.","DOI":"10.1038\/srep35165"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"skac425","DOI":"10.1093\/jas\/skac425","article-title":"Glycine regulates lipid peroxidation promoting porcine oocyte maturation and early embryonic development","volume":"101","author":"Gao","year":"2023","journal-title":"J. Anim. Sci."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13048-022-01032-x","article-title":"The role of oxidative stress in ovarian aging: A review","volume":"15","author":"Yan","year":"2022","journal-title":"J. Ovarian Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.3390\/cimb45020083","article-title":"Oxidative Stress in Assisted Reproductive Techniques, with a Focus on an Underestimated Risk Factor","volume":"45","author":"Mauchart","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Fan, J., Chen, C., and Zhong, Y. (2024). A cohort study on IVF outcomes in infertile endometriosis patients: The effects of rapamycin treatment. Reprod. Biomed. Online, 48.","DOI":"10.1016\/j.rbmo.2023.103319"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"121224","DOI":"10.1016\/j.lfs.2022.121224","article-title":"Hyperandrogen-induced polyol pathway flux increase affects ovarian function in polycystic ovary syndrome via excessive oxidative stress","volume":"313","author":"Wang","year":"2023","journal-title":"Life Sci."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Khan, M.Z., Khan, A., Chen, W., Chai, W., and Wang, C. (2024). Advancements in Genetic Biomarkers and Exogenous Antioxidant Supplementation for Safeguarding Mammalian Cells against Heat-Induced Oxidative Stress and Apoptosis. Antioxidants, 13.","DOI":"10.3390\/antiox13030258"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Ngo, V., and Duennwald, M.L. (2022). Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease. Antioxidants, 11.","DOI":"10.3390\/antiox11122345"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.molmed.2019.09.007","article-title":"Nrf2: Redox and Metabolic Regulator of Stem Cell State and Function","volume":"26","author":"Dai","year":"2020","journal-title":"Trends Mol. Med."},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Savant, S., Sriramkumar, S., and O\u2019Hagan, H. (2018). The Role of Inflammation and Inflammatory Mediators in the Development, Progression, Metastasis, and Chemoresistance of Epithelial Ovarian Cancer. Cancers, 10.","DOI":"10.3390\/cancers10080251"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"27728","DOI":"10.1074\/jbc.M411657200","article-title":"Simultaneous Blockade of NF\u03baB, JNK, and p38 MAPK by a Kinase-inactive Mutant of the Protein Kinase TAK1 Sensitizes Cells to Apoptosis and Affects a Distinct Spectrum of Tumor Necrosis Target Genes","volume":"280","author":"Thiefes","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"12943","DOI":"10.18632\/aging.103378","article-title":"Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1","volume":"12","author":"Dong","year":"2020","journal-title":"Aging"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2017.04.001","article-title":"Effect of lipopolysaccharide on developmental competence of oocytes","volume":"71","author":"Magata","year":"2017","journal-title":"Reprod. Toxicol."},{"key":"ref_110","doi-asserted-by":"crossref","unstructured":"Yong, W., Ma, H., Na, M., Gao, T., Zhang, Y., Hao, L., Yu, H., Yang, H., and Deng, X. (2021). Roles of melatonin in the field of reproductive medicine. Biomed. Pharmacother., 144.","DOI":"10.1016\/j.biopha.2021.112001"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Kobyli\u0144ska, A., and Posmyk, M.M. (2021). Melatonin Protects Tobacco Suspension Cells against Pb-Induced Mitochondrial Dysfunction. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222413368"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Sun, T.C., Liu, X.C., Yang, S.H., Song, L.L., Zhou, S.J., Deng, S.L., Tian, L., and Cheng, L.Y. (2020). Melatonin Inhibits Oxidative Stress and Apoptosis in Cryopreserved Ovarian Tissues via Nrf2\/HO-1 Signaling Pathway. Front. Mol. Biosci., 7.","DOI":"10.3389\/fmolb.2020.00163"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"117642","DOI":"10.1016\/j.ecoenv.2024.117642","article-title":"Enhancing the efficacy of low doses of N-acetyl-L-cysteine in mitigating CCl4-induced hepatotoxicity in animal model using physical cold plasma","volume":"289","author":"Farhadi","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s13311-015-0404-4","article-title":"Neuronal Glutathione Content and Antioxidant Capacity can be Normalized In Situ by N-acetyl Cysteine Concentrations Attained in Human Cerebrospinal Fluid","volume":"13","author":"Reyes","year":"2016","journal-title":"Neurotherapeutics"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Jarmuszkiewicz, W., Dominiak, K., Budzinska, A., Wojcicki, K., and Galganski, L. (2023). Mitochondrial Coenzyme Q Redox Homeostasis and Reactive Oxygen Species Production. Front. Biosci. (Landmark Ed.), 28.","DOI":"10.31083\/j.fbl2803061"},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Mantle, D., Dewsbury, M., and Hargreaves, I.P. (2024). The Ubiquinone-Ubiquinol Redox Cycle and Its Clinical Consequences: An Overview. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25126765"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41392-024-02044-3","article-title":"Mitochondrial diseases: From molecular mechanisms to therapeutic advances","volume":"10","author":"Wen","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"36396","DOI":"10.1074\/jbc.M111.257071","article-title":"Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype","volume":"286","author":"Rodier","year":"2011","journal-title":"J. Biol. Chem."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Tang, L., Zhang, W., Liao, Y., Wang, W., Deng, X., Wang, C., and Shi, W. (2025). Autophagy: A double-edged sword in ischemia\u2013reperfusion injury. Cell Mol. Biol. Lett., 30.","DOI":"10.1186\/s11658-025-00713-x"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40001-023-01586-6","article-title":"Metabolomic profiling of exosomes reveals age-related changes in ovarian follicular fluid","volume":"29","author":"Gu","year":"2024","journal-title":"Eur. J. Med. Res."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/13\/6377\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:03:13Z","timestamp":1760032993000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/13\/6377"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":120,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["ijms26136377"],"URL":"https:\/\/doi.org\/10.3390\/ijms26136377","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]}}}