{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:29:55Z","timestamp":1791228595377,"version":"4.1.0"},"reference-count":86,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"OOO \u201cNPF \u201cMATERIA MEDICA HOLDING\u201d, Moscow, Russia","award":["39\/23\/HAK"],"award-info":[{"award-number":["39\/23\/HAK"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Aqueous solutions are not homogeneous and could be considered supramolecular systems. They can emit electromagnetic waves. Electromagnetic emission from one supramolecular system (\u201csource\u201d) can be received by another supramolecular system (\u201creceiver\u201d) without direct contact (distantly). This process represents a transfer of a \u201cmolecular signal\u201d and causes changes in conformation and symmetry of the \u201creceiver\u201d. The aim of the current work is to theoretically describe such changes primarily using a solution of the chiral protein interferon-gamma (IFN\u03b3) as an example. We provide theoretical evidence that supramolecular systems of highly diluted (HD) aqueous solutions formed by self-assembly after mechanical activation generate a stronger molecular signal compared to non-activated solutions, due to their higher energy-saturated state. Additionally, molecular signals cause supramolecular systems with complex (including chiral) structures to undergo easier changes in conformation and symmetry compared to simpler systems, enhancing their biological activity. Using statistical physics, we obtained the parameter Ic, characterizing the magnitude of conformational and symmetry changes in supramolecular (including chiral) systems caused by molecular signals. In quantum information science, there is an analogue of the parameter Ic, which characterizes the entanglement depth of quantum systems. This study contributes to the understanding of the physico-chemical basis of distant molecular interactions and opens up new possibilities for controlling the properties of complex biological and chemical systems.<\/jats:p>","DOI":"10.3390\/ijms26136411","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T06:54:16Z","timestamp":1751525656000},"page":"6411","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Theoretical Description of Changes in Conformation and Symmetry of Supramolecular Systems During the Reception of a Molecular Signal"],"prefix":"10.3390","volume":"26","author":[{"given":"Yuriy","family":"Gorovoy","sequence":"first","affiliation":[{"name":"Faculty of Digital Systems, Yaroslavl State Technical University, Yaroslavl 150023, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6487-8205","authenticated-orcid":false,"given":"Natalia","family":"Rodionova","sequence":"additional","affiliation":[{"name":"OOO \u201cNPF \u201cMATERIA MEDICA HOLDING\u201d, Moscow 129272, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"German","family":"Stepanov","sequence":"additional","affiliation":[{"name":"OOO \u201cNPF \u201cMATERIA MEDICA HOLDING\u201d, Moscow 129272, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6625-9061","authenticated-orcid":false,"given":"Anastasia","family":"Petrova","sequence":"additional","affiliation":[{"name":"OOO \u201cNPF \u201cMATERIA MEDICA HOLDING\u201d, Moscow 129272, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezda","family":"Penkova","sequence":"additional","affiliation":[{"name":"Institute of Cell Biophysics, Federal Research Center \u201cPushchino Scientific Center for Biological Research of the Russian Academy of Sciences\u201d, Pushchino 142290, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2212-5640","authenticated-orcid":false,"given":"Nikita","family":"Penkov","sequence":"additional","affiliation":[{"name":"Institute of Cell Biophysics, Federal Research Center \u201cPushchino Scientific Center for Biological Research of the Russian Academy of Sciences\u201d, Pushchino 142290, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3390\/sym6030677","article-title":"Supramolecular Chirality: Solvent Chirality Transfer in Molecular Chemistry and Polymer Chemistry","volume":"6","author":"Fujiki","year":"2014","journal-title":"Symmetry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3390\/sym6020444","article-title":"Chiral Liquid Crystals: Structures, Phases, Effects","volume":"6","author":"Dierking","year":"2014","journal-title":"Symmetry"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3390\/sym6020256","article-title":"Supramolecular Chirality in Porphyrin Chemistry","volume":"6","author":"Borovkov","year":"2014","journal-title":"Symmetry"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3103\/S1063455X17060029","article-title":"On the Possibility of Chiral Structure-Density Submillimeter Inhomogeneities Existing in Water","volume":"39","author":"Goncharuk","year":"2017","journal-title":"J. Water Chem. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Tverdislov, V.A., and Malyshko, E.V. (2020). Chiral Dualism as an Instrument of Hierarchical Structure Formation in Molecular Biology. Symmetry, 12.","DOI":"10.3390\/sym12040587"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Stefanelli, M., Magna, G., Di Natale, C., Paolesse, R., and Monti, D. (2022). Stereospecific Self-Assembly Processes of Porphyrin-Proline Conjugates: From the Effect of Structural Features and Bulk Solvent Properties to the Application in Stereoselective Sensor Systems. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232415587"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"\u0160akara\u0161vili, M., Ustrnul, L., Suut, E., Nallaparaju, J.V., Mishra, K.A., Konrad, N., Adamson, J., Borovkov, V., and Aav, R. (2022). Self-Assembly of Chiral Cyclohexanohemicucurbit[n]Urils with Bis(Zn Porphyrin): Size, Shape, and Time-Dependent Binding. Molecules, 27.","DOI":"10.3390\/molecules27030937"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Gaeta, M., D\u2019Urso, A., and Purrello, R. (2023). Chirogenesis in Molecular Aggregates. Chirogenesis in Chemical Science, World Scientific.","DOI":"10.1142\/9789811259227_0003"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e23695","DOI":"10.1002\/chir.23695","article-title":"Self-Assembled Chiral Film Based on Melanin Polymers","volume":"36","author":"Gaeta","year":"2024","journal-title":"Chirality"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ustrnul, L., Borovkov, V., and Aav, R. (2023). Chirogenesis in Supramolecular Systems. 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Sci., 12.","DOI":"10.3390\/app122110909"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"8993","DOI":"10.1038\/s41467-024-53161-0","article-title":"Ligand-Induced Conformational Changes in the \u03921-Adrenergic Receptor Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry","volume":"15","author":"Toporowska","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"RP99854","DOI":"10.7554\/eLife.99854.3","article-title":"Ligand-Coupled Conformational Changes in a Cyclic Nucleotide-Gated Ion Channel Revealed by Time-Resolved Transition Metal Ion FRET","volume":"13","author":"Eggan","year":"2024","journal-title":"Elife"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Narayanan, C., Bernard, D.N., Bafna, K., Gagn\u00e9, D., Agarwal, P.K., and Doucet, N. (2018). Ligand-Induced Variations in Structural and Dynamical Properties Within an Enzyme Superfamily. Front. Mol. Biosci., 5.","DOI":"10.3389\/fmolb.2018.00054"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1021\/acs.biochem.2c00178","article-title":"Enabling Role of Ligand-Driven Conformational Changes in Enzyme Evolution","volume":"61","author":"Richard","year":"2022","journal-title":"Biochemistry"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF00124323","article-title":"Hydration in Drug Design. 3. Conserved Water Molecules at the Ligand-Binding Sites of Homologous Proteins","volume":"9","author":"Poornima","year":"1995","journal-title":"J. Comput. Aided Mol. Des."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Singh, D.B., and Tripathi, T. (2020). Synergistic Effects of Hydration Sites in Protein Stability: A Theoretical Water Thermodynamics Approach. Frontiers in Protein Structure, Function, and Dynamics, Springer.","DOI":"10.1007\/978-981-15-5530-5"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1039\/D2CP04584B","article-title":"Uncovering Water Effects in Protein\u2013Ligand Recognition: Importance in the Second Hydration Shell and Binding Kinetics","volume":"25","author":"Chen","year":"2023","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1021\/acs.jctc.2c00776","article-title":"Heterogeneous and Allosteric Role of Surface Hydration for Protein\u2013Ligand Binding","volume":"19","author":"Shi","year":"2023","journal-title":"J. Chem. Theory Comput."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Penkov, N., and Penkova, N. (2020). Analysis of Emission Infrared Spectra of Protein Solutions in Low Concentrations. Front. Phys., 8.","DOI":"10.3389\/fphy.2020.624779"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Penkov, N. (2021). Antibodies Processed Using High Dilution Technology Distantly Change Structural Properties of IFN\u03b3 Aqueous Solution. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13111864"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Novikov, V.V., and Yablokova, E.V. (2022). Interaction between Highly Diluted Samples, Protein Solutions and Water in a Controlled Magnetic Field. Appl. Sci., 12.","DOI":"10.3390\/app12105185"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Penkov, N.V. (2023). Influence of the Combined Magnetic Field and High Dilution Technology on the Intrinsic Emission of Aqueous Solutions. Water, 15.","DOI":"10.3390\/w15030599"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10517-023-05862-7","article-title":"Modifying Distant Effect of High Dilutions of Inorganic and Biological Substances","volume":"175","author":"Alinkina","year":"2023","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Jerman, I., Ogrizek, L., Peri\u010dek Krape\u017e, V., and Jan, L. (2023). Physicochemical Study of the Molecular Signal Transfer of Ultra-High Diluted Antibodies to Interferon-Gamma. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241511961"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Jerman, I., Ogrizek, L., Krape\u017e, V.P., and Jan, L. (2024). Molecular Signal Transfer of Highly Diluted Antibodies to Interferon-Gamma Regarding Kind, Time, and Distance of Exposition. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25010656"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Novikov, V.V., Yablokova, E.V., Stepanov, G.O., Rodionova, N.N., Tarasov, S.A., Buravleva, E.V., Yablonskaya, O.I., and Voeikov, V.L. (2024). Non-Contact Interaction Between Phorbol Myristate Acetate and Aqueous Alcohol Solutions Under Combined Magnetic Fields. Molecules, 29.","DOI":"10.3390\/molecules29235814"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/15368378.2016.1194293","article-title":"Electromagnetic Homeostasis and the Role of Low-Amplitude Electromagnetic Fields on Life Organization","volume":"36","author":"Pregnolato","year":"2017","journal-title":"Electromagn. Biol. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/15368378.2017.1347882","article-title":"Electromagnetic Information Transfer through Aqueous System","volume":"36","author":"Foletti","year":"2017","journal-title":"Electromagn. Biol. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/15368378.2018.1558064","article-title":"Rate Limiting Factors for DNA Transduction Induced by Weak Electromagnetic Field","volume":"38","author":"Tang","year":"2019","journal-title":"Electromagn. Biol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s10973-011-1484-y","article-title":"Aqueous Nanostructures in Water Induced by Electromagnetic Fields Emitted by EDS: A Conductometric Study of Fullerene and Carbon Nanotube EDS","volume":"107","author":"Elia","year":"2012","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3103\/S1541308X24010084","article-title":"The Effect of Aqueous Solutions Processed Using Gradual Technology on the Emission of a Carbohydrate (Lactose) in the RF Range","volume":"32","author":"Stepanov","year":"2024","journal-title":"Phys. Wave Phen."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Epstein, O. (2023). The Supramolecular Matrix Concept. Symmetry, 15.","DOI":"10.3390\/sym15101914"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Epstein, O. (2018). The Spatial Homeostasis Hypothesis. Symmetry, 10.","DOI":"10.3390\/sym10040103"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3367\/UFNe.2016.05.037796","article-title":"Bubston Structure of Water and Electrolyte Aqueous Solutions","volume":"59","author":"Bunkin","year":"2016","journal-title":"Phys. Uspekhi"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3103\/S1541308X20020156","article-title":"Specific Features of the Concentration Dependences of Impurities in Condensed Media","volume":"28","author":"Shcherbakov","year":"2020","journal-title":"Phys. Wave Phen."},{"key":"ref_39","unstructured":"Lobyshev, V.I. (2022). Non-Monotonous Impedance Patterns of Diclofenac Centesimal Potentiated Solutions and Their Evolution-Summary. Water."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1134\/S0016702914130072","article-title":"Highly Diluted Aqueous Solutions: Formation of Nano-Sized Molecular Assemblies (Nanoassociates)","volume":"52","author":"Konovalov","year":"2014","journal-title":"Geochem. Int."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1134\/S0012501615070040","article-title":"Effect of Weak Electromagnetic Fields on Self-Organization of Highly Diluted Solutions of Alkylated p-Sulfonatocalix[6] Arene","volume":"463","author":"Konovalov","year":"2015","journal-title":"Dokl. Phys. Chem."},{"key":"ref_42","first-page":"54","article-title":"The Phenomenon of Release Activity and the Hypothesis of \u201cSpatial\u201d Homeostasis","volume":"44","author":"Epstein","year":"2023","journal-title":"Uspekhi Fiziol. Nauk."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.4049\/jimmunol.2000098","article-title":"Insights into the Mechanism of Action of Highly Diluted Biologics","volume":"205","author":"Tarasov","year":"2020","journal-title":"J. Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Odintsov, S.D., and Oikonomou, V.K. (2024). Towards Modelling Mechanical Shaking Using Potential Energy Surfaces: A Toy Model Analysis. Symmetry, 16.","DOI":"10.3390\/sym16050572"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Syroeshkin, A.V., Petrov, G.V., Taranov, V.V., Pleteneva, T.V., Koldina, A.M., Gaydashev, I.A., Kolyabina, E.S., Galkina, D.A., Sorokina, E.V., and Uspenskaya, E.V. (2023). Radiothermal Emission of Nanoparticles with a Complex Shape as a Tool for the Quality Control of Pharmaceuticals Containing Biologically Active Nanoparticles. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15030966"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Gudkov, S.V., Penkov, N.V., Baimler, I.V., Lyakhov, G.A., Pustovoy, V.I., Simakin, A.V., Sarimov, R.M., and Scherbakov, I.A. (2020). Effect of Mechanical Shaking on the Physicochemical Properties of Aqueous Solutions. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218033"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"012007","DOI":"10.1088\/1742-6596\/306\/1\/012007","article-title":"DNA Waves and Water","volume":"306","author":"Montagnier","year":"2011","journal-title":"J. Phys. Conf. Ser."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3109\/15368378.2015.1036072","article-title":"Transduction of DNA Information through Water and Electromagnetic Waves","volume":"34","author":"Montagnier","year":"2015","journal-title":"Electromagn. Biol. Med."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Penkov, N., and Penkova, N. (2020). Measurement of the Emission Spectra of Protein Solutions in the Infrared Range. Description of the Method and Testing Using Solution of Human Interferon Gamma as an Example. Front. Phys., 8.","DOI":"10.3389\/fphy.2020.615917"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3103\/S1541308X23030020","article-title":"Influence of the Vibration Impact Mode on the Spontaneous Chemiluminescence of Aqueous Protein Solutions","volume":"31","author":"Astashev","year":"2023","journal-title":"Phys. Wave Phen."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"A43","DOI":"10.1364\/JOSAB.446095","article-title":"Progress, Challenges, and Opportunities of Terahertz Emission from Liquids","volume":"39","author":"Yiwen","year":"2022","journal-title":"J. Opt. Soc. Am. B"},{"key":"ref_52","first-page":"115","article-title":"Liquids Prepared by Serially Diluting and Vigorously Shaking of Aqueous Solutions: Unveiling Effects of the Solute on Their Properties","volume":"10","author":"Yinnon","year":"2020","journal-title":"Water"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Sarimov, R.M., Serov, D.A., and Gudkov, S.V. (2023). Biological Effects of Magnetic Storms and ELF Magnetic Fields. Biology, 12.","DOI":"10.3390\/biology12121506"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Sarimov, R.M., Serov, D.A., and Gudkov, S.V. (2023). Hypomagnetic Conditions and Their Biological Action (Review). Biology, 12.","DOI":"10.3390\/biology12121513"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1096\/fj.04-2695fje","article-title":"Turning on Stem Cell Cardiogenesis with Extremely Low Frequency Magnetic Fields","volume":"19","author":"Ventura","year":"2005","journal-title":"FASEB J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1134\/S0030400X20060041","article-title":"Effects of Terahertz Radiation on Living Cells: A Review","volume":"128","author":"Cherkasova","year":"2020","journal-title":"Opt. Spectrosc."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1023\/A:1024801304083","article-title":"Dynamic Effects of Submillimeter Wave Radiation on Biological Objects of Various Levels of Organization","volume":"24","author":"Fedorov","year":"2003","journal-title":"Int. J. Infrared Millim. Waves"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zhong, Z., Wang, X., Yin, X., Tian, J., and Komatsu, S. (2021). Morphophysiological and Proteomic Responses on Plants of Irradiation with Electromagnetic Waves. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222212239"},{"key":"ref_59","unstructured":"Panchenko, V., Mourou, G., and Zheltikov, A.M. (2010). Protein Conformation Change Induced by THz Laser Radiation, LAT."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Cherkasova, O.P., Fedorov, V.I., Nemova, E.F., Popova, S.S., Pogodin, A.S., and Khamoyan, A.G. (2007). Terahertz radiation influence on peptide conformation. ICONO 2007: Nonlinear Laser Spectroscopy and High-Precision Measurements; and Fundamentals of Laser Chemistry and Biophotonics, SPIE.","DOI":"10.1117\/12.752431"},{"key":"ref_61","first-page":"1437","article-title":"Study on the membrane protein conformational changes and mechanisms of myocardial cell irradiated by pulse microwave","volume":"26","author":"Deng","year":"2006","journal-title":"Guang Pu Xue Yu Guang Pu Fen. Xi"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.3727\/096368911X600966","article-title":"Radiofrequency Energy Loop Primes Cardiac, Neuronal, and Skeletal Muscle Differentiation in Mouse Embryonic Stem Cells: A New Tool for Improving Tissue Regeneration","volume":"21","author":"Maioli","year":"2012","journal-title":"Cell Transplant."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2205988","DOI":"10.1002\/advs.202205988","article-title":"Effects of Nonthermal Radiofrequency Stimulation on Neuronal Activity and Neural Circuit in Mice","volume":"10","author":"Hao","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Barnes, F., and Freeman, J.E.R. (2022). Some Thoughts on the Possible Health Effects of Electric and Magnetic Fields and Exposure Guidelines. Front. Public Health, 10.","DOI":"10.3389\/fpubh.2022.994758"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF02111053","article-title":"Die Natur des spezifischen Erregers der Zellteilung","volume":"100","author":"Gurwitsch","year":"1923","journal-title":"Arch. F\u00fcr Mikrosk. Anat. Und Entwicklungsmechanik"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1134\/S0006350921050158","article-title":"Methods of Studying Ultraweak Photon Emission from Biological Objects: I. History, Types and Properties, Fundamental and Application Significance","volume":"66","author":"Naumova","year":"2021","journal-title":"Biophysics"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1134\/S000635092106021X","article-title":"Methods of Studying Ultraweak Photon Emissions from Biological Objects. II. Methods Based on Biological Detection","volume":"66","author":"Volodyaev","year":"2021","journal-title":"Biophysics"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1134\/S0006350922010109","article-title":"Methods of Studying Ultraweak Photon Emission from Biological Objects: III. Physical Methods","volume":"67","author":"Naumova","year":"2022","journal-title":"Biophysics"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1054\/mehy.1999.0891","article-title":"Activation of Human Neutrophils by Electronically Transmitted Phorbol\u2013Myristate Acetate","volume":"54","author":"Thomas","year":"2000","journal-title":"Med. Hypotheses"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.semcancer.2011.04.003","article-title":"New Perspectives in Cell Communication: Bioelectromagnetic Interactions","volume":"21","author":"Rossi","year":"2011","journal-title":"Semin. Cancer Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10517-023-05861-8","article-title":"Study of the Effects of Highly Diluted Sodium Sulfate and Interferon-Gamma","volume":"175","author":"Molodtsova","year":"2023","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Steed, J.W., and Atwood, J.L. (2009). Supramolecular Chemistry, Wiley. [1st ed.].","DOI":"10.1002\/9780470740880"},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Gorovoy, Y. (2022). The Relationship between Symmetry and Specific Properties of Supramolecular Systems. Symmetry, 14.","DOI":"10.3390\/sym14102070"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1038\/nutd.2015.20","article-title":"Subetta Increases Phosphorylation of Insulin Receptor \u03b2-Subunit Alone and in the Presence of Insulin","volume":"5","author":"Gorbunov","year":"2015","journal-title":"Nutr. Diabetes"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Gibbs, J.W. (2010). Elementary Principles in Statistical Mechanics: Developed with Especial Reference to the Rational Foundation of Thermodynamics, Cambridge University Press. [1st ed.].","DOI":"10.1017\/CBO9780511686948"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1070\/PU1986v029n12ABEH003626","article-title":"Low-Temperature Heat Capacity of DNA","volume":"29","author":"Andronikashvili","year":"1986","journal-title":"Sov. Phys. Uspekhi"},{"key":"ref_77","unstructured":"Landau, L.D., and Lifshits, E.M. (1960). Mechanics, Pergamon Press."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Landau, L., and Lifshitz, E. (1980). Statistical Physics, Part 1, Butterworth-Heinemann. Course of Theoretical Physics.","DOI":"10.1016\/B978-0-08-023039-9.50007-X"},{"key":"ref_79","first-page":"554","article-title":"Drugs at Ultra High Dilution Induce Changes in Enthalpy Associated with the Loss of Water of Crystallization in Lactose","volume":"35","author":"Konar","year":"2017","journal-title":"Environ. Ecol."},{"key":"ref_80","unstructured":"Prigogine, I. (2017). Non-Equilibrium Statistical Mechanics, Dover Publications."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Nielsen, M.A., and Chuang, I.L. (2012). Quantum Computation and Quantum Information: 10th Anniversary Edition, Cambridge University Press. [1st ed.].","DOI":"10.1017\/CBO9780511976667"},{"key":"ref_82","unstructured":"Preskill, J. (1998). Quantum Information and Quantum Computing, California Institute of Technology."},{"key":"ref_83","unstructured":"Landau, L.D. (1977). Quantum Mechanics: Non-Relativistic Theory, Pergamon Press. [3rd ed.]. Their Course of theoretical physics."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Woods, K.N., Pfeffer, J., Dutta, A., and Klein-Seetharaman, J. (2016). Vibrational Resonance, Allostery, and Activation in Rhodopsin-like G Protein-Coupled Receptors. Sci. Rep., 6.","DOI":"10.1038\/srep37290"},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Woods, K.N. (2023). Modeling of Protein Hydration Dynamics Is Supported by THz Spectroscopy of Highly Diluted Solutions. Front. Chem., 11.","DOI":"10.3389\/fchem.2023.1131935"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3103\/S1541308X21020102","article-title":"Infrared Emission Spectroscopy for Investigation of Biological Molecules in Aqueous Solutions","volume":"29","author":"Penkov","year":"2021","journal-title":"Phys. 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