{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:42:33Z","timestamp":1788392553571,"version":"build-2803163510"},"reference-count":28,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T00:00:00Z","timestamp":1751760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology (Taiwan)","award":["MOST 109-2628-B-303-002-"],"award-info":[{"award-number":["MOST 109-2628-B-303-002-"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Oxidative stress and hypoxia-induced inflammation contribute to benign prostatic hyperplasia (BPH) progression. This study investigated the roles of urinary inflammatory and oxidative stress biomarkers in BPH patients. This prospective study enrolled 62 clinical BPH patients (33 treated medically, 29 surgically) and 20 controls. Symptom scores, uroflowmetry, and urinary biomarker levels were assessed at baseline and three months post-treatment. Before treatment, BPH patients exhibited elevated urinary levels of total antioxidant capacity (TAC), PGE2, IL-1\u03b2, and IL-6. Post-treatment, successful outcomes were reported in 63.6% of the medical treatment group and 86.2% of the surgical treatment group, with improvements in symptom scores and urinary flow rate, along with reductions in urinary 8-isoprostane, TAC, and IL-1\u03b2. Prior to treatment, voiding efficiency (VE) was negatively correlated with urinary IL-1\u03b2, IL-6, and IL-8 levels, while bladder wall thickness was positively correlated with TAC. After treatment, changes in VE were negatively correlated with changes in IL-1\u03b2, and changes in post-void residual urine were positively correlated with changes in IL-1\u03b2, IL-6, IL-8, and TNF-\u03b1. Urinary inflammatory and oxidative stress biomarkers may serve as non-invasive indicators of disease severity and treatment response in clinical BPH. Their significant correlations with clinical improvements underscore their potential utility in monitoring treatment efficacy.<\/jats:p>","DOI":"10.3390\/ijms26136516","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T08:58:23Z","timestamp":1751878703000},"page":"6516","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Urinary Inflammatory and Oxidative Stress Biomarkers as Indicators for the Clinical Management of Benign Prostatic Hyperplasia"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7870-1574","authenticated-orcid":false,"given":"Yuan-Hong","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan"},{"name":"Department of Urology, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei 10051, Taiwan"},{"name":"Pathology Department, National Taiwan University Hospital, Taipei 10051, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-4771","authenticated-orcid":false,"given":"Hann-Chorng","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan"},{"name":"Department of Urology, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Hui","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jfma.2018.03.006","article-title":"The prevalence and bother of lower urinary tract symptoms in men and women aged 40 years or over in Taiwan","volume":"118","author":"Liu","year":"2019","journal-title":"J. Formos. Med. Assoc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s00345-019-02691-0","article-title":"What is a disease? What is the disease clinical benign prostatic hyperplasia (BPH)?","volume":"37","author":"Foo","year":"2019","journal-title":"World J. Urol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.urols.2015.07.002","article-title":"Videourodynamic analysis in men with lower urinary tract symptoms: Correlation between age and prostate size with lower urinary tract dysfunction","volume":"27","author":"Lee","year":"2016","journal-title":"Urol. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.eururo.2006.07.050","article-title":"The detrusor muscle: An innocent victim of bladder outlet obstruction","volume":"51","author":"Mirone","year":"2007","journal-title":"Eur. Urol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Fusco, F., Creta, M., De Nunzio, C., Iacovelli, V., Mangiapia, F., Li Marzi, V., and Finazzi Agro, E. (2018). Progressive bladder remodeling due to bladder outlet obstruction: A systematic review of morphological and molecular evidences in humans. BMC Urol., 18.","DOI":"10.1186\/s12894-018-0329-4"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Miyata, Y., Matsuo, T., Mitsunari, K., Asai, A., Ohba, K., and Sakai, H. (2019). A Review of Oxidative Stress and Urinary Dysfunction Caused by Bladder Outlet Obstruction and Treatments Using Antioxidants. Antioxidants, 8.","DOI":"10.3390\/antiox8050132"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/MOU.0b013e32835abd4a","article-title":"Correlation between benign prostatic hyperplasia and inflammation","volume":"23","author":"Bostanci","year":"2013","journal-title":"Curr. Opin. Urol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/iju.15518","article-title":"Chronic inflammation in benign prostatic hyperplasia: Pathophysiology and treatment options","volume":"31","author":"Inamura","year":"2024","journal-title":"Int. J. Urol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Kaltsas, A., Giannakas, T., Stavropoulos, M., Kratiras, Z., and Chrisofos, M. (2025). Oxidative Stress in Benign Prostatic Hyperplasia: Mechanisms, Clinical Relevance and Therapeutic Perspectives. Diseases, 13.","DOI":"10.3390\/diseases13020053"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11884-019-00504-z","article-title":"Urinary Biomarkers and Benign Prostatic Hyperplasia","volume":"14","author":"Tyagi","year":"2019","journal-title":"Curr. Bladder Dysfunct. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Malkov, M.I., Lee, C.T., and Taylor, C.T. (2021). Regulation of the Hypoxia-Inducible Factor (HIF) by Pro-Inflammatory Cytokines. Cells, 10.","DOI":"10.3390\/cells10092340"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Yu, W.R., Jiang, Y.H., Jhang, J.F., and Kuo, H.C. (2023). Use of Urinary Biomarkers in Discriminating Interstitial Cystitis\/Bladder Pain Syndrome from Male Lower Urinary Tract Dysfunctions. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241512055"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/pros.23439","article-title":"Molecular correlates in urine for the obesity and prostatic inflammation of BPH\/LUTS patients","volume":"78","author":"Tyagi","year":"2018","journal-title":"Prostate"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s11255-015-0992-2","article-title":"Urine chemokines indicate pathogenic association of obesity with BPH\/LUTS","volume":"47","author":"Tyagi","year":"2015","journal-title":"Int. Urol. Nephrol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"E524","DOI":"10.5489\/cuaj.1636","article-title":"Obstruction-induced alterations within the urinary bladder and their role in the pathophysiology of lower urinary tract symptomatology","volume":"8","author":"Komninos","year":"2014","journal-title":"Can. Urol. Assoc. J."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Akshay, A., Gheinani, A.H., Besic, M., Braga, S., Uldry, A.C., Heller, M., Rehrauer, H., Fournier, C.A., Burkhard, F.C., and Monastyrskaya, K. (2024). De-obstruction of bladder outlet in humans reverses organ remodelling by normalizing the expression of key transcription factors. BMC Urol., 24.","DOI":"10.1186\/s12894-024-01417-8"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1002\/nau.23136","article-title":"The relevance of immune responses to partial bladder outlet obstruction and reversal","volume":"36","author":"Lin","year":"2017","journal-title":"Neurourol. Urodyn."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/j.1464-410X.2012.11185.x","article-title":"Reversing bladder outlet obstruction attenuates systemic and tissue oxidative stress","volume":"110","author":"Lin","year":"2012","journal-title":"BJU Int."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Di Minno, A., Aveta, A., Gelzo, M., Tripodi, L., Pandolfo, S.D., Crocetto, F., Imbimbo, C., and Castaldo, G. (2022). 8-Hydroxy-2-Deoxyguanosine and 8-Iso-Prostaglandin F2alpha: Putative Biomarkers to assess Oxidative Stress Damage Following Robot-Assisted Radical Prostatectomy (RARP). J. Clin. Med., 11.","DOI":"10.3390\/jcm11206102"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/ptr.2909","article-title":"Eviprostat suppresses urinary oxidative stress in a rabbit model of partial bladder outlet obstruction and in patients with benign prostatic hyperplasia","volume":"24","author":"Matsumoto","year":"2010","journal-title":"Phytother. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/pros.23257","article-title":"Intraprostatic Reflux of Urine Induces Inflammation in a Rat","volume":"77","author":"Funahashi","year":"2017","journal-title":"Prostate"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.juro.2018.03.130","article-title":"Nerve Growth Factor Levels are Associated with Overactive Bladder Symptoms and Long-Term Treatment Outcome after Transurethral Resection of the Prostate in Patients with Benign Prostatic Hyperplasia","volume":"200","author":"Hu","year":"2018","journal-title":"J. Urol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0022-5347(01)63723-6","article-title":"The diagnosis of bladder outlet obstruction in men by ultrasound measurement of bladder wall thickness","volume":"159","author":"Manieri","year":"1998","journal-title":"J. Urol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.juro.2011.03.028","article-title":"Silodosin for men with chronic prostatitis\/chronic pelvic pain syndrome: Results of a phase II multicenter, double-blind, placebo controlled study","volume":"186","author":"Nickel","year":"2011","journal-title":"J. Urol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Jiang, Y.H., Jhang, J.F., Ho, H.C., Hsu, Y.H., and Kuo, H.C. (2022). Diagnostic and prognostic value of urine biomarkers among women with dysfunctional voiding. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-10696-w"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"F1391","DOI":"10.1152\/ajprenal.00051.2020","article-title":"Urine cytokines as biomarkers for diagnosing interstitial cystitis\/bladder pain syndrome and mapping its clinical characteristics","volume":"318","author":"Jiang","year":"2020","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1007\/s11255-017-1666-z","article-title":"Urinary biomarkers in patients with detrusor underactivity with and without bladder function recovery","volume":"49","author":"Chen","year":"2017","journal-title":"Int. Urol. Nephrol."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/13\/6516\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:05:32Z","timestamp":1760033132000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/13\/6516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,6]]},"references-count":28,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["ijms26136516"],"URL":"https:\/\/doi.org\/10.3390\/ijms26136516","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,6]]}}}