{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:17:40Z","timestamp":1769638660089,"version":"3.49.0"},"reference-count":101,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T00:00:00Z","timestamp":1751932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Regional Collaborative Prevention and Control of Major Invasive Species: Technical System Design and Eco-Economic Evaluation","award":["2022YFC2601405"],"award-info":[{"award-number":["2022YFC2601405"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Zeugodacus cucuribitae (Coquillett) (Z. cucuribitae) is a global extremely invasive quarantine pest which has a wide host range of fruits and vegetables. At present, there are a few control measures for Z. cucuribitae, and deltamethrin and avermectin are commonly used. Among the hosts of Z. cucuribitae, Luffa acutangular, Luffa cylindrica, Sechium edule, Brassica oleracea var. botrytis, Musa nana, and Fragaria \u00d7 ananassa are non-favored hosts. However, it is still not clear why these hosts are non-favored and whether there are any repellent components of Z. cucuribitae in these hosts. In this study, the components of these six hosts were collected from the literature, and the genes of odor and chemical sensation were determined from the genome of Z. cucuribitae. After the potential relationships between these components and genes were determined by molecular docking methods, the KEGG and GO enrichment analysis of these genes was conducted, and a complex network of genes vs. components vs. Kegg pathway vs. GO terms was constructed and used to select the key components for experiments. The results show that oleanolic acid (1 mg\/mL, 0.1 mg\/mL, and 0.01 mg\/mL), rotenone (1 mg\/mL, 0.1 mg\/mL, and 0.01 mg\/mL), and beta-caryophyllene oxide (1 mg\/mL, 0.1 mg\/mL, and 0.01 mg\/mL) had a significant repellent effect on Z. cucuribitae, and three components, rotenone (1 mg\/mL and 0.1 mg\/mL), echinocystic acid (1 mg\/mL, 0.1 mg\/mL, and 0.01 mg\/mL), and beta-caryophyllene oxide (1 mg\/mL, and 0.1 mg\/mL) had significant stomach toxicity in Z. cucuribitae. Furthermore, a complex signaling pathway was built and used to predict the effect of these components on Z. cucuribitae. These components probably play roles in the neuroactive ligand\u2013receptor interaction (ko04080) and calcium signaling (ko04020) pathways. This study provides a reference for the prevention and control of Z. cucuribitae and a scientific reference for the rapid screening and development of new pest control drugs.<\/jats:p>","DOI":"10.3390\/ijms26146556","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T07:31:57Z","timestamp":1751959917000},"page":"6556","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Discovery of Potential Repellent Compounds for Zeugodacus cucuribitae (Coquillett) from Six Non-Favored Hosts"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3091-3361","authenticated-orcid":false,"given":"Yu","family":"Fu","sequence":"first","affiliation":[{"name":"School of Tropical Agriculture and Forestry, Hainan University, Haikou 570100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yupeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Systems Medicine and Health Sciences, Hong Kong Baptist University, Hong Kong SAR 999077, China"},{"name":"School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR 999077, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yani","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Tropical Agriculture and Forestry, Hainan University, Haikou 570100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Tropical Agriculture and Forestry, Hainan University, Haikou 570100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunda","family":"Jin","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Sanya Institute of Henan University, Sanya 572025, China"},{"name":"National Key Laboratory of Cotton Bio-Breeding and Integrated Utilization, Henan Joint International Laboratory for Crop Multi-Omics Research, School of Life Sciences, Henan University, Kaifeng 475000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Yi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Integrated Pest Management of Southwest Crops, Institute of Plant Protection, Sichuan Academy of Agricultural Sciences, Chengdu 610066, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Bai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Rice Biology and Breeding, Ministry of Agricultural and Rural Affairs Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Key Laboratory of Biology of Crop Pathogens and Insects of Zhejiang Province, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youqing","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Tropical Agriculture and Forestry, Hainan University, Haikou 570100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Miao","sequence":"additional","affiliation":[{"name":"School of Tropical Agriculture and Forestry, Hainan University, Haikou 570100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyu","family":"Geng","sequence":"additional","affiliation":[{"name":"School of Tropical Agriculture and Forestry, Hainan University, Haikou 570100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianli","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Tropical Agriculture and Forestry, Hainan University, Haikou 570100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rihui","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Tropical Agriculture and Forestry, Hainan University, Haikou 570100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongshi","family":"Zhou","sequence":"additional","affiliation":[{"name":"National Nanfan Research Institute, Chinese Academy of Agricultural Sciences, Sanya 572019, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengqin","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Tropical Agriculture and Forestry, Hainan University, Haikou 570100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/jis\/5.1.40","article-title":"The Melon Fruit Fly, Bactrocera Cucurbitae: A Re-view of Its Biology and Management","volume":"5","author":"Dhillon","year":"2005","journal-title":"J. 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