{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:10:16Z","timestamp":1790604616038,"version":"4.1.0"},"reference-count":85,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidad Aut\u00f3noma de Guadalajara"},{"name":"McGill University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is one of the primary dementia causes worldwide. For this reason, there is a need for plasma-based diagnostic biomarkers to facilitate the timely diagnosis of AD. This work synthesizes the current evidence concerning the tau protein p-tau phosphorylated at threonine 217 (p-tau217) as an emerging biomarker, emphasizing its utility in preclinical phases and its potential application in Latin American populations. The findings indicate that p-tau217 has superior sensitivity and specificity compared to classical biomarkers such as p-tau181 and A\u03b242. Likewise, its plasma concentration regulates neuropathological progression, as studies by Braak have shown, enabling it to identify alterations from the early stages. In Latin America, studies in Peru, Colombia, and Brazil have shown promising results, albeit with methodological limitations. Some of them have small sample sizes or lack neuroimaging confirmation. Additionally, clinical factors common in the region, such as hypertension, diabetes, or chronic kidney disease, may alter the clinical interpretation. In short, p-tau217 represents a potential non-invasive diagnostic resource. More diverse cohorts are needed to confirm its validity in daily clinical practice.<\/jats:p>","DOI":"10.3390\/ijms26146633","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T12:46:33Z","timestamp":1752237993000},"page":"6633","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["P-tau217 as a Biomarker in Alzheimer\u2019s Disease: Applications in Latin American Populations"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8397-2853","authenticated-orcid":false,"given":"Christian Alexis","family":"Varela-Vidales","sequence":"first","affiliation":[{"name":"Departamento Acad\u00e9mico de Formaci\u00f3n Universitaria, Ciencias de la Salud, Universidad Aut\u00f3noma de Guadalajara, Zapopan 45129, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Mart\u00ednez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Departamento Acad\u00e9mico de Formaci\u00f3n Universitaria, Ciencias de la Salud, Universidad Aut\u00f3noma de Guadalajara, Zapopan 45129, Jalisco, Mexico"},{"name":"Unidad-321 Zacatecas, Universidad Pedag\u00f3gica Nacional, Guadalupe 98615, Zacatecas, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0918-6588","authenticated-orcid":false,"given":"Elizabeth","family":"Hern\u00e1ndez-Castellanos","sequence":"additional","affiliation":[{"name":"School of Dietetics and Human Nutrition, McGill University, Montreal, Sainte-Anne-de-Bellevue, Qu\u00e9bec, QC H9X 3V9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1968-4815","authenticated-orcid":false,"given":"Daniela L. C.","family":"Delgado-Lara","sequence":"additional","affiliation":[{"name":"Departamento Acad\u00e9mico de Formaci\u00f3n Universitaria, Ciencias de la Salud, Universidad Aut\u00f3noma de Guadalajara, Zapopan 45129, Jalisco, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: Toward a Biological Definition of Alzheimer\u2019s Disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jalz.2012.11.007","article-title":"The Global Prevalence of Dementia: A Systematic Review and Metaanalysis","volume":"9","author":"Prince","year":"2013","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/alz.12757","article-title":"Biomarkers for Dementia in Latin American Countries: Gaps and Opportunities","volume":"19","author":"Parra","year":"2022","journal-title":"Alzheimer\u2019s Dement."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/joim.12816","article-title":"Biomarkers for Alzheimer\u2019s Disease: Current Status and Prospects for the Future","volume":"284","author":"Blennow","year":"2018","journal-title":"J. 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