{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:09:11Z","timestamp":1760123351164,"version":"build-2065373602"},"reference-count":84,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019278","name":"Institute of Atomic Physics","doi-asserted-by":"publisher","award":["ELI-RO\/RDI\/2024_022","PN-IV-P2-2.1-TE-2023-1686","PN-IV-P7.1-PED-2024-1995","30N\/2023"],"award-info":[{"award-number":["ELI-RO\/RDI\/2024_022","PN-IV-P2-2.1-TE-2023-1686","PN-IV-P7.1-PED-2024-1995","30N\/2023"]}],"id":[{"id":"10.13039\/501100019278","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Romanian Ministry of Education and Research","award":["ELI-RO\/RDI\/2024_022","PN-IV-P2-2.1-TE-2023-1686","PN-IV-P7.1-PED-2024-1995","30N\/2023"],"award-info":[{"award-number":["ELI-RO\/RDI\/2024_022","PN-IV-P2-2.1-TE-2023-1686","PN-IV-P7.1-PED-2024-1995","30N\/2023"]}]},{"name":"Romanian National Nucleu Programme LAPLAS VII","award":["ELI-RO\/RDI\/2024_022","PN-IV-P2-2.1-TE-2023-1686","PN-IV-P7.1-PED-2024-1995","30N\/2023"],"award-info":[{"award-number":["ELI-RO\/RDI\/2024_022","PN-IV-P2-2.1-TE-2023-1686","PN-IV-P7.1-PED-2024-1995","30N\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Breast cancer treatments, such as chemotherapy, radiation, and surgery, often face significant limitations, highlighting the need for more effective and targeted therapies. Here, we investigate the potential of 266 nm laser irradiation of chlorpromazine as a novel approach to develop new antitumoral compounds. We identify six chlorpromazine photocompounds with masses in the range of 178\u2013334 u, along with several dimeric compounds with masses between 566 and 600 u, using an HPLC-MS. In silico approaches assess their pharmacokinetic and pharmacodynamic properties while comparing their toxicity with the parent compound. Molecular docking simulations indicate that some photoproducts have a low estimated free energy of binding to cancer-related targets, suggesting enhanced therapeutic potential compared to chlorpromazine. Additionally, ADME-Tox predictions indicate that these photoproducts may have pharmacokinetic and toxicity profiles similar to chlorpromazine. Overall, this study highlights that laser-generated chlorpromazine photoproducts exhibit enhanced biological activity to breast cancer-related targets compared to chlorpromazine while maintaining a similar ADME-Tox profile.<\/jats:p>","DOI":"10.3390\/ijms26146668","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T13:44:19Z","timestamp":1752241459000},"page":"6668","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Laser-Induced Dimeric Photoproducts of Chlorpromazine: LC-MS Identification and Molecular Docking Evidence of Enhanced Anticancer Potential"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7659-7435","authenticated-orcid":false,"given":"Ana-Maria","family":"Udrea","sequence":"first","affiliation":[{"name":"National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor Str., 077125 Magurele, Romania"},{"name":"Department of Anatomy, Animal Biology, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, 91-95 Independentei Sp., 050095 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3136-905X","authenticated-orcid":false,"given":"Florin","family":"Bilea","sequence":"additional","affiliation":[{"name":"National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor Str., 077125 Magurele, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Speranta","family":"Avram","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Animal Biology, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, 91-95 Independentei Sp., 050095 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-0314","authenticated-orcid":false,"given":"Angela","family":"Staicu","sequence":"additional","affiliation":[{"name":"National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor Str., 077125 Magurele, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3390\/immuno3020013","article-title":"Current Advancements and Future Perspectives of Immunotherapy in Breast Cancer Treatment","volume":"3","author":"Vasileiou","year":"2023","journal-title":"Immuno"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12943-023-01805-y","article-title":"Advancements in Clinical Aspects of Targeted Therapy and Immunotherapy in Breast Cancer","volume":"22","author":"Ye","year":"2023","journal-title":"Mol. 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