{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:04:43Z","timestamp":1792789483317,"version":"4.5.0"},"reference-count":140,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for Science and Technology (FCT\/MCTES)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Uncaria tomentosa (Ut) is a Rubiaceae widely used in Peru\u2019s traditional medicine. It is mainly known by the vernacular name of Cat\u2019s claw due to its morphological aspects and is found in tropical low mountain forests of Central and South America. A decoction of Ut bark, root and leaves is used traditionally for different health problems, including arthritis, weakness, viral infections, skin disorders, abscesses, allergies, asthma, cancer, fevers, gastric ulcers, haemorrhages, inflammations, menstrual irregularity, rheumatism, urinary tract inflammation and wounds, among others, which gave rise to scientific and commercial interest. The present paper reviews research progress relating to the ethnobotany, phytochemistry and pharmacology of Ut, and some promising research routes are also discussed. We highlight the centrality of its different biological activities, such as antioxidant, anti-inflammatory, antiproliferative, antiviral, and antinociceptive, among others. Recently, studies of the health effects of this plant suggest that novel nutraceuticals can be obtained from it and applied as a preventive or prophylaxis strategy before the start of conventional drug therapy, especially for patients who are not prone to conventional pharmacological approaches to diseases. The present work emphasizes the current pharmacological properties of Uncaria tomentosa, evidencing its therapeutic benefits and encouraging further research on this medicinal plant.<\/jats:p>","DOI":"10.3390\/ijms26146758","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T09:45:52Z","timestamp":1752572752000},"page":"6758","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Uncaria tomentosa as a Promising Natural Source of Molecules with Multiple Activities: Review of Its Ethnomedicinal Uses, Phytochemistry and Pharmacology"],"prefix":"10.3390","volume":"26","author":[{"given":"Olinda","family":"Marques","sequence":"first","affiliation":[{"name":"University of Coimbra, Faculty of Pharmacy, 3000-548 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3064-5718","authenticated-orcid":false,"given":"Artur","family":"Figueirinha","sequence":"additional","affiliation":[{"name":"University of Coimbra, Faculty of Pharmacy, 3000-548 Coimbra, Portugal"},{"name":"Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE), University of Coimbra, 3000-548 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0189-1370","authenticated-orcid":false,"given":"Maria Eug\u00e9nia","family":"Pina","sequence":"additional","affiliation":[{"name":"University of Coimbra, Faculty of Pharmacy, 3000-548 Coimbra, Portugal"},{"name":"Chemical Engineering and Renewable Resources for Sustainability (CERES), Department of Chemical Engineering, University of Coimbra, 3030-790 Coimbra, Portugal"},{"name":"Research Institute for Medicine (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-004 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4183-6202","authenticated-orcid":false,"given":"Maria Teresa","family":"Batista","sequence":"additional","affiliation":[{"name":"University of Coimbra, Faculty of Pharmacy, 3000-548 Coimbra, Portugal"},{"name":"Chemical Engineering and Renewable Resources for Sustainability (CERES), Department of Chemical Engineering, University of Coimbra, 3030-790 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"ref_1","unstructured":"Cunha, A.P., Silva, A.R., and Rodrigues, O. (2012). Plantas e Produtos Vegetais Em Fitoterapia, Funda\u00e7\u00e3o Calouste Gulbenkian."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jep.2005.08.046","article-title":"Antioxidant Activity of Ethanolic and Aqueous Extracts of Uncaria tomentosa (Willd.) DC","volume":"104","author":"Pilarski","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1055\/s-2001-15824","article-title":"Improved Method for the Determination of Oxindole Alkaloids in Uncaria tomentosa by High Performance Liquid Chromatography","volume":"67","author":"Ganzera","year":"2001","journal-title":"Planta Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.phytochem.2004.10.025","article-title":"Antioxidant Properties of Proanthocyanidins of Uncaria tomentosa Bark Decoction: A Mechanism for Anti-Inflammatory Activity","volume":"66","author":"Dinis","year":"2005","journal-title":"Phytochemistry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0031-9422(96)00716-9","article-title":"Triterpenes and Quinovic Acid Glycosides from Uncaria tomentosa","volume":"45","author":"Aquino","year":"1997","journal-title":"Phytochemistry"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1021\/np50064a002","article-title":"Plant Metabolites. Structure and in Vitro Antiviral Activity of Quinovic Acid Glycosides from Uncaria tomentosa and Guettarda platypoda","volume":"52","author":"Aquino","year":"1989","journal-title":"J. Nat. Prod."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1021\/np50069a004","article-title":"New Polyhydroxylated Triterpenes from Uncaria tomentosa","volume":"53","author":"Aquino","year":"1990","journal-title":"J. Nat. Prod."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1021\/np50074a016","article-title":"Plant Metabolites. New Compounds and Antiinflammatory Activity of Uncaria tomentosa","volume":"54","author":"Aquino","year":"1991","journal-title":"J. Nat. Prod."},{"key":"ref_9","unstructured":"USP (2016). Cat\u2019s Claw. United States Pharmacopeia, United States Pharmacopeial Convention. Available online: https:\/\/www.uspnf.com\/sites\/default\/files\/usp_pdf\/EN\/USPNF\/revisions\/revUSP31nf26pg04.pdf."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1211\/0022357001777612","article-title":"Effects of Uncaria tomentosa Total Alkaloid and Its Components on Experimental Amnesia in Mice: Elucidation Using the Passive Avoidance Test","volume":"52","author":"Matsumoto","year":"2000","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_11","first-page":"3363","article-title":"Induction of Apoptosis and Inhibition of Proliferation in Human Tumor Cells Treated with Extracts of Uncaria tomentosa","volume":"18","author":"Sheng","year":"1998","journal-title":"Anticancer Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1046\/j.1365-2036.1998.00424.x","article-title":"Antiinflammatory Actions of Cat\u2019s Claw: The Role of NF-\u039aB","volume":"12","author":"Thompson","year":"1998","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0378-8741(93)90080-O","article-title":"Mutagenic and Antimutagenic Activities of Uncaria tomentosa and Its Extracts","volume":"38","author":"Rizzi","year":"1993","journal-title":"J. Ethnopharmacol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.phymed.2006.12.023","article-title":"Antiproliferative Effects of Mitraphylline, a Pentacyclic Oxindole Alkaloid of Uncaria tomentosa on Human Glioma and Neuroblastoma Cell Lines","volume":"14","year":"2007","journal-title":"Phytomedicine"},{"key":"ref_15","first-page":"4519","article-title":"Antiproliferative and Pro-Apoptotic Effects of Uncaria tomentosa in Human Medullary Thyroid Carcinoma Cells","volume":"29","author":"Rinner","year":"2009","journal-title":"Anticancer Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4932572","DOI":"10.1155\/2020\/4932572","article-title":"Investigating Potential Inhibitory Effect of Uncaria tomentosa (Cat\u2019s Claw) against the Main Protease 3CLproof SARS-CoV-2 by Molecular Modeling","volume":"2020","year":"2020","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1590\/S1806-83242007000100008","article-title":"Antimicrobial Activity of Uncaria tomentosa against Oral Human Pathogens","volume":"21","year":"2007","journal-title":"Braz. Oral Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"473","DOI":"10.2334\/josnusd.52.473","article-title":"In Vitro Antimicrobial Activity of Phytotherapic Uncaria tomentosa against Endodontic Pathogens","volume":"52","author":"Herrera","year":"2010","journal-title":"J. Oral Sci."},{"key":"ref_19","first-page":"123","article-title":"Depletion of Specific Binding Sites for Estrogen Receptor by Uncaria tomentosa","volume":"41","author":"Salazar","year":"1998","journal-title":"Proc. West. Pharmacol. Soc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/ptr.1827","article-title":"A Water Soluble Extract from Uncaria tomentosa (Cat\u2019s Claw) Is a Potent Enhancer of DNA Repair in Primary Organ Cultures of Human Skin","volume":"20","author":"Mammone","year":"2006","journal-title":"Phyther. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2165\/00139709-200524010-00002","article-title":"Toxicological Aspects of the South American Herbs Cat\u2019s Claw (Uncaria tomentosa) and Maca (Lepidium meyenii): A Critical Synopsis","volume":"24","author":"Valerio","year":"2005","journal-title":"Toxicol. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-8741(98)00096-8","article-title":"Uncaria tomentosa (Willd.) DC.\u2014Ethnomedicinal Use and New Pharmacological, Toxicological and Botanical Results","volume":"64","author":"Keplinger","year":"1998","journal-title":"J. Ethnopharmacol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1016\/j.fct.2007.05.016","article-title":"Induction of Apoptosis by Uncaria tomentosa through Reactive Oxygen Species Production, Cytochrome c Release, and Caspases Activation in Human Leukemia Cells","volume":"45","author":"Cheng","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1089\/acm.1999.5.143","article-title":"Uncaria tomentosa (Willd.) D.C.: Cat\u2019s Claw, Una de Gato, or Saventaro","volume":"5","author":"Reinhard","year":"1999","journal-title":"J. Altern. Complement. Med."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Castilhos, L.G., Rezer, J.P., Ruchel, J.B., Thorstenberg, M.L.M.L., Jaques, J.A.D.S., Schlemmer, J.B., Doleski, P.H., Rossato, M.F., da Silva, M.A., and Casalli, E.A. (2015). Effect of Uncaria tomentosa Extract on Purinergic Enzyme Activities in Lymphocytes of Rats Submitted to Experimental Adjuvant Arthritis Model. BMC Complement. Altern. Med., 15.","DOI":"10.1186\/s12906-015-0694-4"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jep.2015.06.011","article-title":"Medicinal Uses, Phytochemistry and Pharmacology of the Genus Uncaria","volume":"173","author":"Zhang","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"ref_27","first-page":"678","article-title":"Randomized Double Blind Trial of an Extract from the Pentacyclic Alkaloid-Chemotype of Uncaria tomentosa for the Treatment of Rheumatoid Arthritis","volume":"29","author":"Mur","year":"2002","journal-title":"J. Rheumatol."},{"key":"ref_28","first-page":"881","article-title":"Stability Testing on Typical Flavonoid Containing Herbal Drugs","volume":"58","author":"Heigl","year":"2003","journal-title":"Pharmazie"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0891-5849(00)00327-0","article-title":"Cat\u2019s Claw Inhibits TNF\u03b1 Production and Scavenges Free Radicals: Role in Cytoprotection","volume":"29","author":"Sandoval","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1078\/0944-7113-00045","article-title":"DNA Repair Enhancement of Aqueous Extracts of Uncaria tomentosa in a Human Volunteer Study","volume":"8","author":"Sheng","year":"2001","journal-title":"Phytomedicine"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0031-9422(97)00061-7","article-title":"Alkaloids of Peruvian Uncaria tomentosa","volume":"45","author":"Laus","year":"1997","journal-title":"Phytochemistry"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/ptr.1469","article-title":"Advances in Chemistry and Bioactivity of the Genus Uncaria","volume":"18","author":"Laus","year":"2004","journal-title":"Phyther. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1248\/cpb.50.1376","article-title":"Synthesis and Absolute Configuration of a New 3,4-Dihydro-\u03b2-Carboline- Type Alkaloid, 3,4-Dehydro-5(S)-5-Carboxystrictosidine, Isolated from Peruvian U\u00f1a de Gato (Uncaria tomentosa)","volume":"50","author":"Kitajima","year":"2002","journal-title":"Chem. Pharm. Bull."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s10529-012-1128-8","article-title":"Differential Alkaloid Profile in Uncaria tomentosa Micropropagated Plantlets and Root Cultures","volume":"35","year":"2013","journal-title":"Biotechnol. Lett."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1078\/0944-7113-00117","article-title":"Anti-Inflammatory and Antioxidant Activities of Cat\u2019s Claw (Uncaria tomentosa and Uncaria guianensis) Are Independent of Their Alkaloid Content","volume":"9","author":"Sandoval","year":"2002","journal-title":"Phytomedicine"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s11101-024-09949-5","article-title":"Unlocking the Therapeutic Potential of Cinchonains: A Comprehensive Review","volume":"24","author":"Fahsi","year":"2024","journal-title":"Phytochem. Rev."},{"key":"ref_37","first-page":"565","article-title":"Antiproliferative Activity of Various Uncaria tomentosa Preparations on HL-60 Promyelocytic Leukemia Cells","volume":"59","author":"Pilarski","year":"2007","journal-title":"Pharmacol. Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.phytochem.2004.10.022","article-title":"Ethnobotany, Phytochemistry and Pharmacology of Uncaria (Rubiaceae)","volume":"66","author":"Heitzman","year":"2005","journal-title":"Phytochemistry"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.jpba.2011.12.031","article-title":"HPLC-PDA Method for Quinovic Acid Glycosides Assay in Cat\u2019s Claw (Uncaria tomentosa) Associated with UPLC\/Q-TOF\u2013MS Analysis","volume":"62","author":"Pavei","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0040-4020(99)01048-0","article-title":"Two New 19-Hydroxyursolic Acid-Type Triterpenes from Peruvian \u201cUna de Gato\u201d (Uncaria tomentosa)","volume":"56","author":"Kitajima","year":"2000","journal-title":"Tetrahedron"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1021\/np0203741","article-title":"Two New Nor-Triterpene Glycosides from Peruvian \u201cU\u00f1a de Gato\u201d (Uncaria tomentosa)","volume":"66","author":"Kitajima","year":"2003","journal-title":"J. Nat. Prod."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1248\/cpb.52.1258","article-title":"New Oleanan-Type Triterpene and Cincholic Acid Glycosides from Peruvian \u201cU\u00f1a de Gato\u201d (Uncaria tomentosa)","volume":"52","author":"Kitajima","year":"2004","journal-title":"Chem. Pharm. Bull."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0031-9422(01)00043-7","article-title":"Investigation of U\u00f1a de Gato I. 7-Deoxyloganic Acid and 15N NMR Spectroscopic Studies on Pentacyclic Oxindole Alkaloids from Uncaria tomentosa","volume":"57","author":"Muhammad","year":"2001","journal-title":"Phytochemistry"},{"key":"ref_44","first-page":"517","article-title":"Phytochemical and Biological Study of Uncaria tomentosa","volume":"65","author":"Senatore","year":"1989","journal-title":"Boll. Soc. Ital. Biol. Sper."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jep.2004.10.002","article-title":"An Active Ingredient of Cat\u2019s Claw Water Extracts: Identification and Efficacy of Quinic Acid","volume":"96","author":"Sheng","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.intimp.2004.09.028","article-title":"Quinic Acid Is a Biologically Active Component of the Uncaria tomentosa Extract C-Med 100\u00ae","volume":"5","author":"Lindgren","year":"2005","journal-title":"Int. Immunopharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jep.2008.10.023","article-title":"Effect of Alkaloid-Free and Alkaloid-Rich Preparations from Uncaria tomentosa Bark on Mitotic Activity and Chromosome Morphology Evaluated by Allium Test","volume":"121","author":"Pilarski","year":"2009","journal-title":"J. Ethnopharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0300-483X(00)00210-9","article-title":"Free Radicals and Grape Seed Proanthocyanidin Extract: Importance in Human Health and Disease Prevention","volume":"148","author":"Bagchi","year":"2000","journal-title":"Toxicology"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1177\/1082013205054498","article-title":"Review: Health Effects of Cocoa Flavonoids","volume":"11","author":"Tornero","year":"2005","journal-title":"Food Sci. Technol. Int."},{"key":"ref_50","first-page":"567","article-title":"Review of Antiviral and Immunomodulating Properties of Plants of the Peruvian Rainforest with a Particular Emphasis on U\u00f1a de Gato and Sangre de Grado","volume":"6","author":"Williams","year":"2001","journal-title":"Altern. Med. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1016\/j.fct.2011.06.013","article-title":"Protective Activity of the Uncaria tomentosa Extracts on Human Erythrocytes in Oxidative Stress Induced by 2,4-Dichlorophenol (2,4-DCP) and Catechol","volume":"49","author":"Bors","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"ref_52","first-page":"50","article-title":"Uncaria tomentosa: An Approach to the Bioavailability of the Compounds with Antioxidant Activity","volume":"2","author":"Marques","year":"2008","journal-title":"Exp. Pathol. Heal. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Navarro-Hoyos, M., Alvarado-Corella, D., Moreira-Gonzalez, I., Arnaez-Serrano, E., and Monagas-Juan, M. (2018). Polyphenolic Composition and Antioxidant Activity of Aqueous and Ethanolic Extracts from Uncaria tomentosa Bark and Leaves. Antioxidants, 7.","DOI":"10.3390\/antiox7050065"},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Duchnowicz, P., Pilarski, R., Micha\u0142owicz, J., and Bukowska, B. (2021). Changes in Human Erythrocyte Membrane Exposed to Aqueous and Ethanolic Extracts from Uncaria tomentosa. Molecules, 26.","DOI":"10.3390\/molecules26113189"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jep.2006.07.039","article-title":"Treatment of THP-1 Cells with Uncaria tomentosa Extracts Differentially Regulates the Expression If IL-1\u03b2 and TNF-\u03b1","volume":"109","author":"Cano","year":"2007","journal-title":"J. Ethnopharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jep.2009.12.004","article-title":"Uncaria tomentosa Acts as a Potent TNF-\u03b1 Inhibitor through NF-\u039aB","volume":"127","author":"Arnason","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"ref_57","first-page":"633","article-title":"Lymphocyte Subsets, Dendritic Cells and Cytokine Profiles in Mice with Melanoma Treated with Uncaria tomentosa","volume":"32","author":"Kahn","year":"2015","journal-title":"Rev. Peru. Med. Exp. Salud Publica"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0378-8741(02)00093-4","article-title":"Anti-Inflammatory Activity of Two Different Extracts of Uncaria tomentosa (Rubiaceae)","volume":"81","author":"Aguilar","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jep.2004.06.039","article-title":"An Uncaria tomentosa (Cat\u2019s Claw) Extract Protects Mice against Ozone-Induced Lung Inflammation","volume":"96","author":"Cisneros","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Dietrich, F., Martins, J.P., Kaiser, S., Silva, R.B.M., Rockenbach, L., Edelweiss, M.I.A., Ortega, G.G., Morrone, F.B., Campos, M.M., and Battastini, A.M.O. (2015). The Quinovic Acid Glycosides Purified Fraction from Uncaria tomentosa Protects against Hemorrhagic Cystitis Induced by Cyclophosphamide in Mice. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0131882"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"PF94","DOI":"10.1055\/s-0032-1320641","article-title":"Anti-Inflammatory Effect of Uncaria tomentosa in an Experimental Model of Cyclophosphamide-Induced Hemorrhagic Cystitis","volume":"78","author":"Figueiredo","year":"2012","journal-title":"Planta Med."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Navarro-Hoyos, M., Lebr\u00f3n-Aguilar, R., Quintanilla-L\u00f3pez, J.E., Cueva, C., Hevia, D., Quesada, S., Azofeifa, G., Moreno-Arribas, M.V., Monagas, M., and Bartolom\u00e9, B. (2017). Proanthocyanidin Characterization and Bioactivity of Extracts from Different Parts of Uncaria tomentosa L. (Cat\u2019s Claw). Antioxidants, 6.","DOI":"10.3390\/antiox6010012"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"153327","DOI":"10.1016\/j.phymed.2020.153327","article-title":"Uncaria tomentosa Reduces Osteoclastic Bone Loss in Vivo","volume":"79","author":"Lima","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Zebeaman, M., Tadesse, M.G., Bachheti, R.K., Bachheti, A., Gebeyhu, R., and Chaubey, K.K. (2023). Plants and Plant-Derived Molecules as Natural Immunomodulators. BioMed Res. Int., 2023.","DOI":"10.1155\/2023\/7711297"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1055\/s-2007-969537","article-title":"Die Alkaloide von Uncaria tomentosa Und Ihre Phagozytose-Steigernde Wirkung","volume":"51","author":"Wagner","year":"1985","journal-title":"Planta Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-8741(98)00113-5","article-title":"Stimulation of Interleukin-1 and -6 Production in Alveolar Macrophages by the Neotropical Liana, Uncaria tomentosa (Una de Gato)","volume":"64","author":"Lemaire","year":"1999","journal-title":"J. Ethnopharmacol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1078\/0944-7113-00046","article-title":"Persistent Response to Pneumococcal Vaccine in Individuals Supplemented with a Novel Water Soluble Extract of Uncaria tomentosa, C-Med-100\u00ae","volume":"8","author":"Lamm","year":"2001","journal-title":"Phytomedicine"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1078\/094471103321648629","article-title":"C-Med 100\u00ae, a Hot Water Extract of Uncaria tomentosa, Prolongs Lymphocyte Survival in Vivo","volume":"10","author":"Pero","year":"2003","journal-title":"Phytomedicine"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.intimp.2005.03.001","article-title":"Uncaria tomentosa Extract Increases the Number of Myeloid Progenitor Cells in the Bone Marrow of Mice Infected with Listeria Monocytogenes","volume":"5","author":"Eberlin","year":"2005","journal-title":"Int. Immunopharmacol."},{"key":"ref_70","first-page":"667","article-title":"Immune Responses Induced in Hens after Oral Administration of Bovine Serum Albumin in Combination with an Extract of Uncaria tomentosa","volume":"52","author":"Jonauskiene","year":"2008","journal-title":"Bull. Vet. Inst. Pulawy"},{"key":"ref_71","unstructured":"Lozada-Requena, I., N\u00fa\u00f1ez, C., \u00c1lvarez, Y., and Luis Aguilar, J. (2025, April 18). Efecto de Um Extrato Hidroalcoh\u00f3lico de Uncaria tomentosa (U\u00f1a de Gato) Sobre La Poblaci\u00f3n de C\u00e9lulas Dendr\u00edticas y Sus Moleculas HLA-DR y CD 86 Ante El Est\u00edmulo Con Lipopolisac\u00e1ridos; Instituto Nacional de Salud, 2009; Volume 26. Available online: http:\/\/www.scielo.org.pe\/scielo.php?script=sci_arttext&pid=S1726-46342009000200006&lng=es&nrm=iso&tlng=es."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"PD9","DOI":"10.1055\/s-0032-1320367","article-title":"Immunostimulant Activity of Uncaria tomentosa and Its Tannins","volume":"78","author":"Francisco","year":"2012","journal-title":"Planta Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jep.2011.06.021","article-title":"Prevention of Experimental Diabetes by Uncaria tomentosa Extract: Th2 Polarization, Regulatory T Cell Preservation or Both?","volume":"137","author":"Domingues","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"ref_74","first-page":"92","article-title":"Plantas Medicinales Que Act\u00faan Sobre El Sistema Inmune Medicinal Plants That Act on the Immune System","volume":"63","author":"Del","year":"2022","journal-title":"Ars Pharma"},{"key":"ref_75","first-page":"97","article-title":"Pharmacological Actions of Uncaria Alkaloids, Rhynchophylline and Isorhynchophylline","volume":"24","author":"Shi","year":"2003","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1007\/s00210-003-0854-9","article-title":"In Vitro Vasodilator Mechanisms of the Indole Alkaloids Rhynchophylline and Isorhynchophylline, Isolated from the Hook of Uncaria rhynchophylla (Miquel)","volume":"369","author":"Zhang","year":"2004","journal-title":"Naunyn. Schmiedebergs. Arch. Pharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1254\/fpj.94.17","article-title":"Pharmacological Studies of Indole Alkaloids Obtained from Domestic Plants, Uncaria rhynchophylla MIQ. and Amsonia elliptica Roem. et Schult","volume":"94","author":"Ozaki","year":"1989","journal-title":"Folia Pharmacol. Jpn."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Geetha, R.G., and Ramachandran, S. (2021). Recent Advances in the Anti-Inflammatory Activity of Plant-Derived Alkaloid Rhynchophylline in Neurological and Cardiovascular Diseases. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13081170"},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Bhuia, M.S., Wilairatana, P., Ferdous, J., Chowdhury, R., Bappi, M.H., Rahman, M.A., Mubarak, M.S., and Islam, M.T. (2023). Hirsutine, an Emerging Natural Product with Promising Therapeutic Benefits: A Systematic Review. Molecules, 28.","DOI":"10.3390\/molecules28166141"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"298S","DOI":"10.1093\/ajcn\/81.1.298S","article-title":"Cocoa Antioxidants and Cardiovascular Health","volume":"81","author":"Keen","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"113494","DOI":"10.1016\/j.jep.2020.113494","article-title":"Extracts from Uncaria tomentosa as Antiplatelet Agents and Thrombin Inhibitors\u2014The in Vitro and in Silico Study","volume":"267","author":"Ponczek","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.preghy.2021.10.013","article-title":"Uncaria tomentosa Extract (AC-11) Improves Pregnancy Hypertension Together with Suppression of SFlt-1 and SEng","volume":"26","author":"Oogaki","year":"2021","journal-title":"Pregnancy Hypertens."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.pbb.2005.04.004","article-title":"Involvement of 5-HT2 Receptors in the Antinociceptive Effect of Uncaria tomentosa","volume":"81","author":"Angers","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"ref_84","first-page":"445","article-title":"Effect of Rhynchophylline on Apoptosis Induced by Dopamine in NT2 Cells","volume":"23","author":"Shi","year":"2002","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.lfs.2004.08.012","article-title":"Protective Effect of Rhynchophylline and Isorhynchophylline on in Vitro Ischemia-Induced Neuronal Damage in the Hippocampus: Putative Neurotransmitter Receptors Involved in Their Action","volume":"76","author":"Kang","year":"2004","journal-title":"Life Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ejphar.2005.05.015","article-title":"Suppressive Effects of Isorhynchophylline on 5-HT2A Receptor Function in the Brain: Behavioural and Electrophysiological Studies","volume":"517","author":"Matsumoto","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4172\/2161-119X.1000131","article-title":"Reduced Phosphorylation of Histone Variant H2Ax in the Organ of Corti Is Associated with Otoprotection from Noise Injury","volume":"3","author":"Guthrie","year":"2013","journal-title":"Otolaryngology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/WNF.0b013e31815a5eef","article-title":"Reversible Worsening of Parkinson Disease Motor Symptoms after Oral Intake of Uncaria tomentosa (Cat\u2019s Claw)","volume":"31","author":"Cosentino","year":"2008","journal-title":"Clin. Neuropharmacol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.neuint.2013.03.001","article-title":"Neuroprotective Effects of Aqueous Extracts of Uncaria tomentosa: Insights from 6-OHDA Induced Cell Damage and Transgenic Caenorhabditis Elegans Model","volume":"62","author":"Shi","year":"2013","journal-title":"Neurochem. Int."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"111016","DOI":"10.1016\/j.exger.2020.111016","article-title":"Uncaria tomentosa Improves Cognition, Memory and Learning in Middle-Aged Rats","volume":"138","author":"Castilhos","year":"2020","journal-title":"Exp. Gerontol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s13020-021-00514-2","article-title":"Comparison of the Chemical Constituents and Anti-Alzheimer\u2019s Disease Effects of Uncaria rhynchophylla and Uncaria tomentosa","volume":"16","author":"Xu","year":"2021","journal-title":"Chin. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural Products as Sources of New Drugs over the Nearly Four Decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. Nat. Prod."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.phymed.2010.04.013","article-title":"Anticancer Activity of the Uncaria tomentosa (Willd.) DC. Preparations with Different Oxindole Alkaloid Composition","volume":"17","author":"Pilarski","year":"2010","journal-title":"Phytomedicine"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.hermed.2013.04.002","article-title":"Enhanced Proapoptotic Response of the Promyelocytic Leukemia HL-60 Cells Treated with an Uncaria tomentosa Alkaloid Preparation","volume":"3","author":"Pilarski","year":"2013","journal-title":"J. Herb. Med."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Dreifuss, A.A., Bastos-Pereira, A.L., Fabossi, I.A., L\u00edvero, F.A.D.R., Stolf, A.M., Alves de Souza, C.E., de Gomes, L.O., Constantin, R.P., Furman, A.E.F., and Strapasson, R.L.B. (2013). Uncaria tomentosa Exerts Extensive Anti-Neoplastic Effects against the Walker-256 Tumour by Modulating Oxidative Stress and Not by Alkaloid Activity. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0054618"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00706-014-1212-y","article-title":"Insights into Mechanism of Anticancer Activity of Pentacyclic Oxindole Alkaloids of Uncaria tomentosa by Means of a Computational Reverse Virtual Screening and Molecular Docking Approach","volume":"145","author":"Kozielewicz","year":"2014","journal-title":"Monatshefte Chem."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jep.2016.05.026","article-title":"Genotoxicity and Cytotoxicity of Oxindole Alkaloids from Uncaria tomentosa (Cat\u2019s Claw): Chemotype Relevance","volume":"189","author":"Kaiser","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_98","first-page":"2457","article-title":"The Antiproliferative Effects of Uncaria tomentosa Extracts and Fractions on the Growth of Breast Cancer Cell Line","volume":"21","author":"Riva","year":"2001","journal-title":"Anticancer Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jep.2006.02.013","article-title":"Proapoptotic Effect of Uncaria tomentosa Extracts","volume":"107","author":"Martinot","year":"2006","journal-title":"J. Ethnopharmacol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0944-7113(00)80086-0","article-title":"Treatment of Chemotherapy-Induced Leukopenia in a Rat Model with Aqueous Extract from Uncaria tomentosa","volume":"7","author":"Sheng","year":"2000","journal-title":"Phytomedicine"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jep.2011.07.011","article-title":"Uncaria tomentosa Stimulates the Proliferation of Myeloid Progenitor Cells","volume":"137","author":"Farias","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"892182","DOI":"10.1155\/2012\/892182","article-title":"Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial","volume":"2012","author":"Farias","year":"2012","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_103","first-page":"340","article-title":"Uncaria tomentosa Reduces Lipid Peroxidation and DNA-Damage from Chemotherapy","volume":"32","author":"Farias","year":"2013","journal-title":"Lat. Am. J. Pharm."},{"key":"ref_104","first-page":"676984","article-title":"Uncaria tomentosa\u2014Adjuvant Treatment for Breast Cancer: Clinical Trial","volume":"2012","author":"Farias","year":"2012","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"274786","DOI":"10.1155\/2014\/274786","article-title":"Effect of Uncaria tomentosa Extract on Apoptosis Triggered by Oxaliplatin Exposure on HT29 Cells","volume":"2014","author":"Farias","year":"2014","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"101900","DOI":"10.1016\/j.toxrep.2025.101900","article-title":"Recent Developments on Ursolic Acid and Its Potential Biological Applications","volume":"14","author":"Arulnangai","year":"2025","journal-title":"Toxicol. Rep."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1186\/s12935-022-02804-7","article-title":"Ursolic Acid: A Natural Modulator of Signaling Networks in Different Cancers","volume":"22","author":"Zafar","year":"2022","journal-title":"Cancer Cell Int."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.phymed.2010.11.002","article-title":"Inhibitory Mechanisms of Two Uncaria tomentosa Extracts Affecting the Wnt-Signaling Pathway","volume":"18","author":"Gulewicz","year":"2011","journal-title":"Phytomedicine"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jep.2016.08.051","article-title":"Uncaria tomentosa Extract Alters the Catabolism of Adenine Nucleotides and Expression of Ecto-5\u2032-Nucleotidase\/CD73 and P2X7 and A1 Receptors in the MDA-MB-231 Cell Line","volume":"194","author":"Santos","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"gmr16039782","DOI":"10.4238\/gmr16039782","article-title":"Chemotherapeutical Effects of the Herbal Medicine Uncaria tomentosa (Willd.) DC","volume":"16","author":"Almeida","year":"2017","journal-title":"Genet. Mol. Res."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Zari, A., Alfarteesh, H., Buckner, C., and Lafrenie, R. (2021). Treatment with Uncaria tomentosa Promotes Apoptosis in B16-Bl6 Mouse Melanoma Cells and Inhibits the Growth of B16-Bl6 Tumours. Molecules, 26.","DOI":"10.3390\/molecules26041066"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s00109-021-02041-x","article-title":"P2X7 Receptor: A Critical Regulator and Potential Target for Breast Cancer","volume":"99","author":"Zhu","year":"2021","journal-title":"J. Mol. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jep.2005.01.062","article-title":"Antibacterial Screening of Some Peruvian Medicinal Plants Used in Caller\u00eda District","volume":"99","author":"Kloucek","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"ref_114","first-page":"69","article-title":"The in Vitro Effect of Uncaria tomentosa Water and Ethanol Extract on the Metabolic Activity of Blood Granulocytes in Mice","volume":"35","author":"Nowakowska","year":"2010","journal-title":"Cent. J. Immunol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/jopr.12248","article-title":"Uncaria tomentosa Gel against Denture Stomatitis: Clinical Report","volume":"24","author":"Tay","year":"2015","journal-title":"J. Prosthodont."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1590\/1807-3107BOR-2016.vol30.0061","article-title":"Antimicrobial Activity and Substantivity of Uncaria tomentosa in Infected Root Canal Dentin","volume":"30","author":"Herrera","year":"2016","journal-title":"Braz. Oral Res."},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"Dioguardi, M., Spirito, F., Sovereto, D., Ballini, A., Alovisi, M., and Lo Muzio, L. (2022). Application of the Extracts of Uncaria tomentosa in Endodontics and Oral Medicine: Scoping Review. J. Clin. Med., 11.","DOI":"10.3390\/jcm11175024"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/appliedchem2010001","article-title":"Comprehensive Review of the Components in Cat\u2019s Claw (Uncaria tomentosa) and Their Antibacterial Activity","volume":"2","author":"Blanck","year":"2022","journal-title":"AppliedChem"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.intimp.2007.11.010","article-title":"Immunomodulating and Antiviral Activities of Uncaria tomentosa on Human Monocytes Infected with Dengue Virus-2","volume":"8","author":"Reis","year":"2008","journal-title":"Int. Immunopharmacol."},{"key":"ref_120","first-page":"1547","article-title":"Uncaria tomentosa Alkaloidal Fraction Reduces Paracellular Permeability, Il-8 and Ns1 Production on Human Microvascular Endothelial Cells Infected with Dengue Virus","volume":"8","author":"Kubelka","year":"2013","journal-title":"Nat. Prod. Commun."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.fct.2014.01.013","article-title":"Antimutagenic and Antiherpetic Activities of Different Preparations from Uncaria tomentosa (Cat\u2019s Claw)","volume":"66","author":"Caon","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/jwas.12483","article-title":"Survival of White Spot Syndrome Virus\u2013Infected Litopenaeus vannamei Fed with Ethanol Extract of Uncaria tomentosa","volume":"49","author":"Kuhn","year":"2018","journal-title":"J. World Aquac. Soc."},{"key":"ref_123","first-page":"6679761","article-title":"The Hydroalcoholic Extract of Uncaria tomentosa (Cat\u2019s Claw) Inhibits the Infection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Vitro","volume":"2021","author":"Oliveros","year":"2021","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_124","first-page":"2227","article-title":"Uncaria tomentosa (Cat\u2019s Claw): A Promising Herbal Medicine against SARS-CoV-2\/ACE-2 Junction and SARS-CoV-2 Spike Protein Based on Molecular Modeling","volume":"40","year":"2020","journal-title":"J. Biomol. Struct. Dyn."},{"key":"ref_125","first-page":"8539918","article-title":"Computational Study of the Phytochemical Constituents from Uncaria tomentosa Stem Bark against SARS-CoV-2 Omicron Spike Protein","volume":"2022","author":"Saleh","year":"2022","journal-title":"J. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1590\/S0102-86502011000800004","article-title":"Contraceptive Effect of Uncaria tomentosa (Cat\u2019s Claw) in Rats with Experimental Endometriosis","volume":"26","author":"Cavalcante","year":"2011","journal-title":"Acta Cir. Bras."},{"key":"ref_127","first-page":"431","article-title":"Poly \u03b5-Caprolactone Nanoparticles Loaded with Uncaria tomentosa Extract: Preparation, Characterization, and Optimization Using the Box-Behnken Design","volume":"8","author":"Ribeiro","year":"2013","journal-title":"Int. J. Nanomed."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11051-015-2883-y","article-title":"Design of Experiments for the Development of Poly(d,l-Lactide-Co-Glycolide) Nanoparticles Loaded with Uncaria tomentosa","volume":"17","author":"Ribeiro","year":"2015","journal-title":"J. Nanoparticle Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"e20190336","DOI":"10.1590\/0001-3765202020190336","article-title":"Characterization and in Vitro Antitumor Activity of Polymeric Nanoparticles Loaded with Uncaria tomentosa Extract","volume":"92","author":"Ribeiro","year":"2020","journal-title":"An. Acad. Bras. Cienc."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"11949","DOI":"10.1007\/s10973-022-11428-y","article-title":"Preparation and Characterization of Microcapsules Loaded with Polyphenols-Enriched Uncaria tomentosa Extract Using Spray-Dryer Technique","volume":"147","author":"Borges","year":"2022","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Araya-Sibaja, A.M., Wilhelm-Romero, K., Vargas-Huertas, F., Quir\u00f3s-Fallas, M.I., Alvarado-Corella, D., Mora-Rom\u00e1n, J.J., Vega-Baudrit, J.R., S\u00e1nchez-Kopper, A., and Navarro-Hoyos, M. (2022). Hybrid Nanoparticles of Proanthocyanidins from Uncaria tomentosa Leaves: QTOF-ESI MS Characterization, Antioxidant Activity and Immune Cellular Response. Plants, 11.","DOI":"10.3390\/plants11131737"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"e38813","DOI":"10.1016\/j.heliyon.2024.e38813","article-title":"Preclinical Approaches to Evaluate Uncaria tomentosa Bark Extract Loaded FDOFs Using Osteoarthritis Models","volume":"10","author":"Sowjanya","year":"2024","journal-title":"Heliyon"},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Arado, G.M., Amatto, P.d.P.G., Marins, M., Rizzi, E.S., Fran\u00e7a, S.d.C., Coppede, J.d.S., Carmona, F., and Pereira, A.M.S. (2024). Anti-Inflammatory and\/or Immunomodulatory Activities of Uncaria tomentosa (Cat\u2019s Claw) Extracts: A Systematic Review and Meta-Analysis of in Vivo Studies. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1378408"},{"key":"ref_134","first-page":"289","article-title":"Analysis of Phenotype and Functions of Peripheral Blood Leukocytes in Cellular Immunity of Calves Treated with Uncaria tomentosa","volume":"48","author":"Bednarek","year":"2004","journal-title":"Bull. Vet. Inst. Pulawy"},{"key":"ref_135","first-page":"412437","article-title":"Acute Toxicity and Determination of the Active Constituents of Aqueous Extract of Uncaria tomentosa Bark in Hyphessobrycon Eques","volume":"2014","author":"Claudiano","year":"2014","journal-title":"J. Toxicol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1590\/S0100-879X2007000100010","article-title":"Effect of Oral Ingestion of an Extract of the Herb Uncaria tomentosa on the Biodistribution of Sodium Pertechnetate in Rats","volume":"40","author":"Moreno","year":"2007","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3409\/fb57_3-4.207-212","article-title":"Evaluation of Biological Activity of Uncaria tomentosa (Willd.) DC. Using the Chicken Embryo Model","volume":"57","author":"Pilarski","year":"2009","journal-title":"Folia Biol."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ptr.3593","article-title":"Uncaria tomentosa (Willd. Ex. Roem. & Schult.) DC. and Eucalyptus Globulus Labill. Interactions When Administered with Diazepam","volume":"26","author":"Saenz","year":"2012","journal-title":"Phyther. Res."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"11703","DOI":"10.1007\/s11356-018-1350-6","article-title":"Protective Effect of Uncaria tomentosa Extract against Oxidative Stress and Genotoxicity Induced by Glyphosate-Roundup\u00ae Using Zebrafish (Danio Rerio) as a Model","volume":"25","author":"Santo","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.mrgentox.2005.05.004","article-title":"Genotoxicity and Anti-Genotoxicity of Some Traditional Medicinal Herbs","volume":"585","author":"Analla","year":"2005","journal-title":"Mutat. Res. Toxicol. Environ. Mutagen."}],"container-title":["International Journal of Molecular Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/14\/6758\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:09:51Z","timestamp":1760033391000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1422-0067\/26\/14\/6758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":140,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2025,7]]}},"alternative-id":["ijms26146758"],"URL":"https:\/\/doi.org\/10.3390\/ijms26146758","relation":{},"ISSN":["1422-0067"],"issn-type":[{"value":"1422-0067","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]}}}