{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:57:02Z","timestamp":1793055422416,"version":"4.5.0"},"reference-count":77,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Research, Innovation, and Digitization, Core Program","award":["cod 23 07"],"award-info":[{"award-number":["cod 23 07"]}]},{"name":"Ministry of Research, Innovation, and Digitization, Core Program","award":["101140192"],"award-info":[{"award-number":["101140192"]}]},{"name":"Chips Joint Undertaking and its member","award":["cod 23 07"],"award-info":[{"award-number":["cod 23 07"]}]},{"name":"Chips Joint Undertaking and its member","award":["101140192"],"award-info":[{"award-number":["101140192"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>This study investigates the antioxidant, antimicrobial, and antitumor activities of Taraxacum officinale (Dandelion) and Artemisia annua (Sweet Wormwood) extracts, along with their role in the green synthesis of gold (AuNPs) and silver nanoparticles (AgNPs). Bioreduction was achieved using aqueous and ethanolic extracts (100 mg\/mL), enabling solvent-dependent comparisons. Nanoparticles were characterized using ultraviolet\u2013visible spectroscopy (UV\u2013Vis), fluorescence spectroscopy, scanning electron microscopy (SEM), dynamic light scattering (DLS), high-resolution transmission electron microscopy (HRTEM), and zeta potential analysis. Each technique revealed complementary aspects of nanoparticle morphology, size, and stability, with UV\u2013Vis indicating aggregation states and DLS confirming solvent-related size variation even at 3\u20135% ethanol. Gold nanoparticles synthesized from Dandelion showed strong antibacterial activity against Staphylococcus aureus, while silver nanoparticles from both plants were effective against Escherichia coli. Cytotoxicity assays indicated that silver nanoparticles obtained from ethanolic Dandelion extract containing 3% ethanol in aqueous solution (AgNPsEETOH3%-D) significantly reduced LoVo (p = 4.58 \u00d7 10\u22123) and MDA-MB-231 (p = 7.20 \u00d7 10\u22125) cell viability, with high selectivity indices (SI), suggesting low toxicity toward normal cells. Gold nanoparticles synthesized from aqueous Dandelion extract (AuNPsEaq-D) also showed favorable SI values (2.16 for LoVo and 8.41 for MDA-MB-231). Although some formulations demonstrated lower selectivity (SI &lt; 1.5), the findings support the therapeutic potential of these biogenic nanoparticles. Further in vivo studies and pharmacokinetic evaluations are required to validate their clinical applicability.<\/jats:p>","DOI":"10.3390\/ijms26147022","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T14:55:18Z","timestamp":1753109718000},"page":"7022","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Harnessing Plant-Based Nanoparticles for Targeted Therapy: A Green Approach to Cancer and Bacterial Infections"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1307-6624","authenticated-orcid":false,"given":"Mirela Claudia","family":"R\u00eembu","sequence":"first","affiliation":[{"name":"Pharmacy Faculty, \u201cTitu Maiorescu\u201d University, 040314 Bucharest, Romania"},{"name":"Medical Doctoral School, Titu Maiorescu University, 040317 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Cord","sequence":"additional","affiliation":[{"name":"Pharmacy Faculty, \u201cTitu Maiorescu\u201d University, 040314 Bucharest, Romania"},{"name":"Medical Doctoral School, Titu Maiorescu University, 040317 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2239-9115","authenticated-orcid":false,"given":"Mihaela","family":"Savin","sequence":"additional","affiliation":[{"name":"National Institute for Research and Development in Microtechnologies (IMT Bucharest), 072996 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandru","family":"Grigoroiu","sequence":"additional","affiliation":[{"name":"National Institute for Research and Development in Microtechnologies (IMT Bucharest), 072996 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8302-8823","authenticated-orcid":false,"given":"Mirela Antonela","family":"Mih\u0103il\u0103","sequence":"additional","affiliation":[{"name":"Pharmacy Faculty, \u201cTitu Maiorescu\u201d University, 040314 Bucharest, Romania"},{"name":"Stefan S. Nicolau Institute of Virology, 030304 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2623-3307","authenticated-orcid":false,"given":"Mona Luciana","family":"G\u0103l\u0103\u021banu","sequence":"additional","affiliation":[{"name":"Pharmacy Faculty, \u201cTitu Maiorescu\u201d University, 040314 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0391-1697","authenticated-orcid":false,"given":"Viorel","family":"Ordeanu","sequence":"additional","affiliation":[{"name":"Pharmacy Faculty, \u201cTitu Maiorescu\u201d University, 040314 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9932-0463","authenticated-orcid":false,"given":"Mariana","family":"Pan\u021buroiu","sequence":"additional","affiliation":[{"name":"Pharmacy Faculty, \u201cTitu Maiorescu\u201d University, 040314 Bucharest, 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