{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T01:57:50Z","timestamp":1784858270201,"version":"3.55.0"},"reference-count":222,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","award":["IN607A2022\/07"],"award-info":[{"award-number":["IN607A2022\/07"]}],"id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI22\/00938"],"award-info":[{"award-number":["PI22\/00938"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015496","name":"Biomedical Research Networking Center on Neurodegenerative Diseases","doi-asserted-by":"publisher","award":["CB22\/05\/00067"],"award-info":[{"award-number":["CB22\/05\/00067"]}],"id":[{"id":"10.13039\/501100015496","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Marie Sk\u0142odowska-Curie grant agreement","award":["101066444"],"award-info":[{"award-number":["101066444"]}]},{"name":"INTERREG Atlantic Area","award":["EAPA_791\/2018_ NEUROATLANTIC project"],"award-info":[{"award-number":["EAPA_791\/2018_ NEUROATLANTIC project"]}]},{"name":"INTER-REG V A Espa\u00f1a Portugal (POCTEP)","award":["0624_2IQBIONEURO_6_E"],"award-info":[{"award-number":["0624_2IQBIONEURO_6_E"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJMS"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a progressive neurodegenerative disorder characterized by the accumulation of amyloid-\u03b2 plaques, tau hyperphosphorylation, and chronic neuroinflammation. Emerging evidence suggests a crucial role of lipid signaling pathways in AD pathogenesis, particularly those mediated by autotaxin (ATX) and lysophosphatidic acid (LPA). ATX, an enzyme responsible for LPA production, has been implicated in neuroinflammatory processes, blood\u2013brain barrier dysfunction, and neuronal degeneration. LPA signaling, through its interaction with specific G-protein-coupled receptors, influences neuroinflammation, synaptic plasticity, and tau pathology, all of which contribute to AD progression. This review synthesizes recent findings on the ATX\/LPA axis in AD, exploring its potential as a biomarker and therapeutic target. Understanding the mechanistic links between ATX, LPA, and AD pathology may open new avenues for disease-modifying strategies.<\/jats:p>","DOI":"10.3390\/ijms26157068","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T08:02:06Z","timestamp":1753257726000},"page":"7068","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Unraveling the Role of Autotaxin and Lysophosphatidic Acid in Alzheimer\u2019s Disease: From Molecular Mechanisms to Therapeutic Potential"],"prefix":"10.3390","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1774-4922","authenticated-orcid":false,"given":"Jes\u00fas","family":"Garc\u00eda-de Soto","sequence":"first","affiliation":[{"name":"NeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"},{"name":"Servicio de Neurolog\u00eda, Hospital Universitario Lucus Augusti, 27003 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3590-002X","authenticated-orcid":false,"given":"M\u00f3nica","family":"Castro-Mosquera","sequence":"additional","affiliation":[{"name":"NeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica Mar\u00eda","family":"Pouso-Diz","sequence":"additional","affiliation":[{"name":"NeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, 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Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Camino-Casti\u00f1eiras","sequence":"additional","affiliation":[{"name":"NeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9834-1457","authenticated-orcid":false,"given":"Anxo Manuel","family":"Minguill\u00f3n Pereiro","sequence":"additional","affiliation":[{"name":"NeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1212-9851","authenticated-orcid":false,"given":"Marta","family":"Aramburu-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"NeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7715-1956","authenticated-orcid":false,"given":"Daniel","family":"Romaus-Sanjurjo","sequence":"additional","affiliation":[{"name":"NeuroAging Group (NEURAL), Clinical Neurosciences Research Laboratory (LINC), Health Research Institute of Santiago de Compostela (IDIS), 15706 Santiago de Compostela, Spain"},{"name":"Centro de 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